Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q6AYC8 (SH24A_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 73. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
SH2 domain-containing protein 4A
Gene names
Name:Sh2d4a
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length422 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Inhibits estrogen-induced cell proliferation by competing with PLCG for binding to ESR1, blocking the effect of estrogen on PLCG and repressing estrogen-induced proliferation. May play a role in T-cell development and function By similarity.

Subunit structure

Interacts with ESR1 By similarity.

Subcellular location

Cytoplasm By similarity. Note: Located at podocyte foot processes By similarity.

Sequence similarities

Contains 1 SH2 domain.

Ontologies

Keywords
   Cellular componentCytoplasm
   DomainSH2 domain
   PTMPhosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processnegative regulation of phosphatase activity

Inferred from sequence or structural similarity. Source: UniProtKB

   Cellular_componentcytoplasm

Inferred from sequence or structural similarity. Source: UniProtKB

nucleus

Inferred from electronic annotation. Source: Ensembl

   Molecular_functionphosphatase binding

Inferred from sequence or structural similarity. Source: UniProtKB

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 422422SH2 domain-containing protein 4A
PRO_0000233135

Regions

Domain316 – 40893SH2

Amino acid modifications

Modified residue2331Phosphoserine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q6AYC8 [UniParc].

Last modified September 13, 2004. Version 1.
Checksum: 56CC672C2297F803

FASTA42248,522
        10         20         30         40         50         60 
MLRQILSEMF IDPDLLAELS EEQKQILFYK MREEQIRRWK EREAAMERKE SLPVKSRPKK 

        70         80         90        100        110        120 
ENGKSVHWKL GADKQVWVWV MGEHHLDKPY DVLCDEILAE REHLRAAKDA ELRKAQSLQF 

       130        140        150        160        170        180 
TNSLKVKSLN CDLQAVKKTE PQNVTRKAAA EEATDQGPRA IPTKKDDKAQ TKDLTKKKDS 

       190        200        210        220        230        240 
EELKQTEDEK TKQIYKNWKE DSEWQASLRK SKAADEKRRS LAKQAREDYK RLSQRGRSGD 

       250        260        270        280        290        300 
GLQNPLTGPQ KPKRPPLPPK PQFLQPLGSP PKSLGNQGVI RTKTSSTQED IIRWFKEEQL 

       310        320        330        340        350        360 
PFRAGYQKNS DTIAPWFHGI LTLKKANELL STGMPGSFLI RVSEKIKGYA LSYLSEEGCK 

       370        380        390        400        410        420 
HFLIDASANS YSFLGVDQLQ HATLADLVEY HKEEPITSLG KELLLFPCGQ QDKPPDYLEL 


FQ 

« Hide

References

[1]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Lung.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC079100 mRNA. Translation: AAH79100.1.
RefSeqNP_001012048.1. NM_001012048.1.
XP_006253094.1. XM_006253032.1.
UniGeneRn.137349.

3D structure databases

ProteinModelPortalQ6AYC8.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10116.ENSRNOP00000018543.

PTM databases

PhosphoSiteQ6AYC8.

Proteomic databases

PaxDbQ6AYC8.
PRIDEQ6AYC8.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000018543; ENSRNOP00000018543; ENSRNOG00000013541.
GeneID306376.
KEGGrno:306376.
UCSCRGD:1307991. rat.

Organism-specific databases

CTD63898.
RGD1307991. Sh2d4a.

Phylogenomic databases

eggNOGNOG77708.
GeneTreeENSGT00570000079047.
HOGENOMHOG000031527.
HOVERGENHBG057918.
InParanoidQ6AYC8.
KOK17577.
OMAVDYHKEE.
OrthoDBEOG71P2BD.
PhylomeDBQ6AYC8.
TreeFamTF336893.

Gene expression databases

GenevestigatorQ6AYC8.

Family and domain databases

Gene3D3.30.505.10. 1 hit.
InterProIPR000980. SH2.
[Graphical view]
PfamPF00017. SH2. 1 hit.
[Graphical view]
PRINTSPR00401. SH2DOMAIN.
SMARTSM00252. SH2. 1 hit.
[Graphical view]
SUPFAMSSF55550. SSF55550. 1 hit.
PROSITEPS50001. SH2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio655979.
PROQ6AYC8.

Entry information

Entry nameSH24A_RAT
AccessionPrimary (citable) accession number: Q6AYC8
Entry history
Integrated into UniProtKB/Swiss-Prot: May 2, 2006
Last sequence update: September 13, 2004
Last modified: May 14, 2014
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families