Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

SH2 domain-containing protein 4A

Gene

Sh2d4a

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Inhibits estrogen-induced cell proliferation by competing with PLCG for binding to ESR1, blocking the effect of estrogen on PLCG and repressing estrogen-induced proliferation. May play a role in T-cell development and function (By similarity).By similarity

GO - Molecular functioni

  1. phosphatase binding Source: UniProtKB

GO - Biological processi

  1. negative regulation of phosphatase activity Source: UniProtKB
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
SH2 domain-containing protein 4A
Gene namesi
Name:Sh2d4a
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494 Componenti: Chromosome 16

Organism-specific databases

RGDi1307991. Sh2d4a.

Subcellular locationi

Cytoplasm By similarity
Note: Located at podocyte foot processes.By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 422422SH2 domain-containing protein 4APRO_0000233135Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei123 – 1231PhosphoserineBy similarity
Modified residuei233 – 2331PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ6AYC8.
PRIDEiQ6AYC8.

PTM databases

PhosphoSiteiQ6AYC8.

Expressioni

Gene expression databases

GenevestigatoriQ6AYC8.

Interactioni

Subunit structurei

Interacts with ESR1.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000018543.

Structurei

3D structure databases

ProteinModelPortaliQ6AYC8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini316 – 40893SH2PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 SH2 domain.PROSITE-ProRule annotation

Keywords - Domaini

SH2 domain

Phylogenomic databases

eggNOGiNOG77708.
GeneTreeiENSGT00570000079047.
HOGENOMiHOG000031527.
HOVERGENiHBG057918.
InParanoidiQ6AYC8.
KOiK17577.
OMAiVDYHKEE.
OrthoDBiEOG71P2BD.
PhylomeDBiQ6AYC8.
TreeFamiTF336893.

Family and domain databases

Gene3Di3.30.505.10. 1 hit.
InterProiIPR000980. SH2.
[Graphical view]
PfamiPF00017. SH2. 1 hit.
[Graphical view]
PRINTSiPR00401. SH2DOMAIN.
SMARTiSM00252. SH2. 1 hit.
[Graphical view]
SUPFAMiSSF55550. SSF55550. 1 hit.
PROSITEiPS50001. SH2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6AYC8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLRQILSEMF IDPDLLAELS EEQKQILFYK MREEQIRRWK EREAAMERKE
60 70 80 90 100
SLPVKSRPKK ENGKSVHWKL GADKQVWVWV MGEHHLDKPY DVLCDEILAE
110 120 130 140 150
REHLRAAKDA ELRKAQSLQF TNSLKVKSLN CDLQAVKKTE PQNVTRKAAA
160 170 180 190 200
EEATDQGPRA IPTKKDDKAQ TKDLTKKKDS EELKQTEDEK TKQIYKNWKE
210 220 230 240 250
DSEWQASLRK SKAADEKRRS LAKQAREDYK RLSQRGRSGD GLQNPLTGPQ
260 270 280 290 300
KPKRPPLPPK PQFLQPLGSP PKSLGNQGVI RTKTSSTQED IIRWFKEEQL
310 320 330 340 350
PFRAGYQKNS DTIAPWFHGI LTLKKANELL STGMPGSFLI RVSEKIKGYA
360 370 380 390 400
LSYLSEEGCK HFLIDASANS YSFLGVDQLQ HATLADLVEY HKEEPITSLG
410 420
KELLLFPCGQ QDKPPDYLEL FQ
Length:422
Mass (Da):48,522
Last modified:September 13, 2004 - v1
Checksum:i56CC672C2297F803
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC079100 mRNA. Translation: AAH79100.1.
RefSeqiNP_001012048.1. NM_001012048.1.
XP_006253094.1. XM_006253032.2.
UniGeneiRn.137349.

Genome annotation databases

EnsembliENSRNOT00000018543; ENSRNOP00000018543; ENSRNOG00000013541.
GeneIDi306376.
KEGGirno:306376.
UCSCiRGD:1307991. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC079100 mRNA. Translation: AAH79100.1.
RefSeqiNP_001012048.1. NM_001012048.1.
XP_006253094.1. XM_006253032.2.
UniGeneiRn.137349.

3D structure databases

ProteinModelPortaliQ6AYC8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000018543.

PTM databases

PhosphoSiteiQ6AYC8.

Proteomic databases

PaxDbiQ6AYC8.
PRIDEiQ6AYC8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000018543; ENSRNOP00000018543; ENSRNOG00000013541.
GeneIDi306376.
KEGGirno:306376.
UCSCiRGD:1307991. rat.

Organism-specific databases

CTDi63898.
RGDi1307991. Sh2d4a.

Phylogenomic databases

eggNOGiNOG77708.
GeneTreeiENSGT00570000079047.
HOGENOMiHOG000031527.
HOVERGENiHBG057918.
InParanoidiQ6AYC8.
KOiK17577.
OMAiVDYHKEE.
OrthoDBiEOG71P2BD.
PhylomeDBiQ6AYC8.
TreeFamiTF336893.

Miscellaneous databases

NextBioi655979.
PROiQ6AYC8.

Gene expression databases

GenevestigatoriQ6AYC8.

Family and domain databases

Gene3Di3.30.505.10. 1 hit.
InterProiIPR000980. SH2.
[Graphical view]
PfamiPF00017. SH2. 1 hit.
[Graphical view]
PRINTSiPR00401. SH2DOMAIN.
SMARTiSM00252. SH2. 1 hit.
[Graphical view]
SUPFAMiSSF55550. SSF55550. 1 hit.
PROSITEiPS50001. SH2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Lung.

Entry informationi

Entry nameiSH24A_RAT
AccessioniPrimary (citable) accession number: Q6AYC8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 2, 2006
Last sequence update: September 13, 2004
Last modified: March 4, 2015
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.