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Q6AYC8

- SH24A_RAT

UniProt

Q6AYC8 - SH24A_RAT

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Protein
SH2 domain-containing protein 4A
Gene
Sh2d4a
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at transcript leveli

Functioni

Inhibits estrogen-induced cell proliferation by competing with PLCG for binding to ESR1, blocking the effect of estrogen on PLCG and repressing estrogen-induced proliferation. May play a role in T-cell development and function By similarity.

GO - Molecular functioni

  1. phosphatase binding Source: UniProtKB
Complete GO annotation...

GO - Biological processi

  1. negative regulation of phosphatase activity Source: UniProtKB
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
SH2 domain-containing protein 4A
Gene namesi
Name:Sh2d4a
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 16

Organism-specific databases

RGDi1307991. Sh2d4a.

Subcellular locationi

Cytoplasm By similarity
Note: Located at podocyte foot processes By similarity.

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB
  2. nucleus Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 422422SH2 domain-containing protein 4A
PRO_0000233135Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei233 – 2331Phosphoserine By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ6AYC8.
PRIDEiQ6AYC8.

PTM databases

PhosphoSiteiQ6AYC8.

Expressioni

Gene expression databases

GenevestigatoriQ6AYC8.

Interactioni

Subunit structurei

Interacts with ESR1 By similarity.

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000018543.

Structurei

3D structure databases

ProteinModelPortaliQ6AYC8.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini316 – 40893SH2
Add
BLAST

Sequence similaritiesi

Contains 1 SH2 domain.

Keywords - Domaini

SH2 domain

Phylogenomic databases

eggNOGiNOG77708.
GeneTreeiENSGT00570000079047.
HOGENOMiHOG000031527.
HOVERGENiHBG057918.
InParanoidiQ6AYC8.
KOiK17577.
OMAiVDYHKEE.
OrthoDBiEOG71P2BD.
PhylomeDBiQ6AYC8.
TreeFamiTF336893.

Family and domain databases

Gene3Di3.30.505.10. 1 hit.
InterProiIPR000980. SH2.
[Graphical view]
PfamiPF00017. SH2. 1 hit.
[Graphical view]
PRINTSiPR00401. SH2DOMAIN.
SMARTiSM00252. SH2. 1 hit.
[Graphical view]
SUPFAMiSSF55550. SSF55550. 1 hit.
PROSITEiPS50001. SH2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6AYC8-1 [UniParc]FASTAAdd to Basket

« Hide

MLRQILSEMF IDPDLLAELS EEQKQILFYK MREEQIRRWK EREAAMERKE    50
SLPVKSRPKK ENGKSVHWKL GADKQVWVWV MGEHHLDKPY DVLCDEILAE 100
REHLRAAKDA ELRKAQSLQF TNSLKVKSLN CDLQAVKKTE PQNVTRKAAA 150
EEATDQGPRA IPTKKDDKAQ TKDLTKKKDS EELKQTEDEK TKQIYKNWKE 200
DSEWQASLRK SKAADEKRRS LAKQAREDYK RLSQRGRSGD GLQNPLTGPQ 250
KPKRPPLPPK PQFLQPLGSP PKSLGNQGVI RTKTSSTQED IIRWFKEEQL 300
PFRAGYQKNS DTIAPWFHGI LTLKKANELL STGMPGSFLI RVSEKIKGYA 350
LSYLSEEGCK HFLIDASANS YSFLGVDQLQ HATLADLVEY HKEEPITSLG 400
KELLLFPCGQ QDKPPDYLEL FQ 422
Length:422
Mass (Da):48,522
Last modified:September 13, 2004 - v1
Checksum:i56CC672C2297F803
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC079100 mRNA. Translation: AAH79100.1.
RefSeqiNP_001012048.1. NM_001012048.1.
XP_006253094.1. XM_006253032.1.
UniGeneiRn.137349.

Genome annotation databases

EnsembliENSRNOT00000018543; ENSRNOP00000018543; ENSRNOG00000013541.
GeneIDi306376.
KEGGirno:306376.
UCSCiRGD:1307991. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC079100 mRNA. Translation: AAH79100.1 .
RefSeqi NP_001012048.1. NM_001012048.1.
XP_006253094.1. XM_006253032.1.
UniGenei Rn.137349.

3D structure databases

ProteinModelPortali Q6AYC8.
ModBasei Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000018543.

PTM databases

PhosphoSitei Q6AYC8.

Proteomic databases

PaxDbi Q6AYC8.
PRIDEi Q6AYC8.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000018543 ; ENSRNOP00000018543 ; ENSRNOG00000013541 .
GeneIDi 306376.
KEGGi rno:306376.
UCSCi RGD:1307991. rat.

Organism-specific databases

CTDi 63898.
RGDi 1307991. Sh2d4a.

Phylogenomic databases

eggNOGi NOG77708.
GeneTreei ENSGT00570000079047.
HOGENOMi HOG000031527.
HOVERGENi HBG057918.
InParanoidi Q6AYC8.
KOi K17577.
OMAi VDYHKEE.
OrthoDBi EOG71P2BD.
PhylomeDBi Q6AYC8.
TreeFami TF336893.

Miscellaneous databases

NextBioi 655979.
PROi Q6AYC8.

Gene expression databases

Genevestigatori Q6AYC8.

Family and domain databases

Gene3Di 3.30.505.10. 1 hit.
InterProi IPR000980. SH2.
[Graphical view ]
Pfami PF00017. SH2. 1 hit.
[Graphical view ]
PRINTSi PR00401. SH2DOMAIN.
SMARTi SM00252. SH2. 1 hit.
[Graphical view ]
SUPFAMi SSF55550. SSF55550. 1 hit.
PROSITEi PS50001. SH2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Lung.

Entry informationi

Entry nameiSH24A_RAT
AccessioniPrimary (citable) accession number: Q6AYC8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 2, 2006
Last sequence update: September 13, 2004
Last modified: May 14, 2014
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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