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Protein

SH2 domain-containing protein 4A

Gene

Sh2d4a

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Inhibits estrogen-induced cell proliferation by competing with PLCG for binding to ESR1, blocking the effect of estrogen on PLCG and repressing estrogen-induced proliferation. May play a role in T-cell development and function (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
SH2 domain-containing protein 4A
Gene namesi
Name:Sh2d4a
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 16

Organism-specific databases

RGDi1307991. Sh2d4a.

Subcellular locationi

  • Cytoplasm By similarity

  • Note: Located at podocyte foot processes.By similarity

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002331351 – 422SH2 domain-containing protein 4AAdd BLAST422

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei117PhosphoserineBy similarity1
Modified residuei123PhosphoserineBy similarity1
Modified residuei233PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ6AYC8.
PRIDEiQ6AYC8.

PTM databases

iPTMnetiQ6AYC8.
PhosphoSitePlusiQ6AYC8.

Expressioni

Gene expression databases

BgeeiENSRNOG00000013541.
GenevisibleiQ6AYC8. RN.

Interactioni

Subunit structurei

Interacts with ESR1.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000018543.

Structurei

3D structure databases

ProteinModelPortaliQ6AYC8.
SMRiQ6AYC8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini316 – 408SH2PROSITE-ProRule annotationAdd BLAST93

Keywords - Domaini

SH2 domain

Phylogenomic databases

eggNOGiENOG410IEFY. Eukaryota.
ENOG410XPPJ. LUCA.
GeneTreeiENSGT00570000079047.
HOGENOMiHOG000031527.
HOVERGENiHBG057918.
InParanoidiQ6AYC8.
KOiK17577.
OMAiPYDVLCN.
OrthoDBiEOG091G08HG.
PhylomeDBiQ6AYC8.
TreeFamiTF336893.

Family and domain databases

Gene3Di3.30.505.10. 1 hit.
InterProiView protein in InterPro
IPR000980. SH2.
PfamiView protein in Pfam
PF00017. SH2. 1 hit.
PRINTSiPR00401. SH2DOMAIN.
SMARTiView protein in SMART
SM00252. SH2. 1 hit.
SUPFAMiSSF55550. SSF55550. 1 hit.
PROSITEiView protein in PROSITE
PS50001. SH2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6AYC8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLRQILSEMF IDPDLLAELS EEQKQILFYK MREEQIRRWK EREAAMERKE
60 70 80 90 100
SLPVKSRPKK ENGKSVHWKL GADKQVWVWV MGEHHLDKPY DVLCDEILAE
110 120 130 140 150
REHLRAAKDA ELRKAQSLQF TNSLKVKSLN CDLQAVKKTE PQNVTRKAAA
160 170 180 190 200
EEATDQGPRA IPTKKDDKAQ TKDLTKKKDS EELKQTEDEK TKQIYKNWKE
210 220 230 240 250
DSEWQASLRK SKAADEKRRS LAKQAREDYK RLSQRGRSGD GLQNPLTGPQ
260 270 280 290 300
KPKRPPLPPK PQFLQPLGSP PKSLGNQGVI RTKTSSTQED IIRWFKEEQL
310 320 330 340 350
PFRAGYQKNS DTIAPWFHGI LTLKKANELL STGMPGSFLI RVSEKIKGYA
360 370 380 390 400
LSYLSEEGCK HFLIDASANS YSFLGVDQLQ HATLADLVEY HKEEPITSLG
410 420
KELLLFPCGQ QDKPPDYLEL FQ
Length:422
Mass (Da):48,522
Last modified:September 13, 2004 - v1
Checksum:i56CC672C2297F803
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC079100 mRNA. Translation: AAH79100.1.
RefSeqiNP_001012048.1. NM_001012048.1.
XP_006253094.1. XM_006253032.3.
UniGeneiRn.137349.

Genome annotation databases

EnsembliENSRNOT00000018543; ENSRNOP00000018543; ENSRNOG00000013541.
GeneIDi306376.
KEGGirno:306376.
UCSCiRGD:1307991. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC079100 mRNA. Translation: AAH79100.1.
RefSeqiNP_001012048.1. NM_001012048.1.
XP_006253094.1. XM_006253032.3.
UniGeneiRn.137349.

3D structure databases

ProteinModelPortaliQ6AYC8.
SMRiQ6AYC8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000018543.

PTM databases

iPTMnetiQ6AYC8.
PhosphoSitePlusiQ6AYC8.

Proteomic databases

PaxDbiQ6AYC8.
PRIDEiQ6AYC8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000018543; ENSRNOP00000018543; ENSRNOG00000013541.
GeneIDi306376.
KEGGirno:306376.
UCSCiRGD:1307991. rat.

Organism-specific databases

CTDi63898.
RGDi1307991. Sh2d4a.

Phylogenomic databases

eggNOGiENOG410IEFY. Eukaryota.
ENOG410XPPJ. LUCA.
GeneTreeiENSGT00570000079047.
HOGENOMiHOG000031527.
HOVERGENiHBG057918.
InParanoidiQ6AYC8.
KOiK17577.
OMAiPYDVLCN.
OrthoDBiEOG091G08HG.
PhylomeDBiQ6AYC8.
TreeFamiTF336893.

Miscellaneous databases

PROiPR:Q6AYC8.

Gene expression databases

BgeeiENSRNOG00000013541.
GenevisibleiQ6AYC8. RN.

Family and domain databases

Gene3Di3.30.505.10. 1 hit.
InterProiView protein in InterPro
IPR000980. SH2.
PfamiView protein in Pfam
PF00017. SH2. 1 hit.
PRINTSiPR00401. SH2DOMAIN.
SMARTiView protein in SMART
SM00252. SH2. 1 hit.
SUPFAMiSSF55550. SSF55550. 1 hit.
PROSITEiView protein in PROSITE
PS50001. SH2. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiSH24A_RAT
AccessioniPrimary (citable) accession number: Q6AYC8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 2, 2006
Last sequence update: September 13, 2004
Last modified: March 15, 2017
This is version 87 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.