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Q6AYC8

- SH24A_RAT

UniProt

Q6AYC8 - SH24A_RAT

Protein

SH2 domain-containing protein 4A

Gene

Sh2d4a

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 74 (01 Oct 2014)
      Sequence version 1 (13 Sep 2004)
      Previous versions | rss
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    Functioni

    Inhibits estrogen-induced cell proliferation by competing with PLCG for binding to ESR1, blocking the effect of estrogen on PLCG and repressing estrogen-induced proliferation. May play a role in T-cell development and function By similarity.By similarity

    GO - Molecular functioni

    1. phosphatase binding Source: UniProtKB

    GO - Biological processi

    1. negative regulation of phosphatase activity Source: UniProtKB

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    SH2 domain-containing protein 4A
    Gene namesi
    Name:Sh2d4a
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 16

    Organism-specific databases

    RGDi1307991. Sh2d4a.

    Subcellular locationi

    Cytoplasm By similarity
    Note: Located at podocyte foot processes.By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB
    2. nucleus Source: Ensembl

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 422422SH2 domain-containing protein 4APRO_0000233135Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei233 – 2331PhosphoserineBy similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PaxDbiQ6AYC8.
    PRIDEiQ6AYC8.

    PTM databases

    PhosphoSiteiQ6AYC8.

    Expressioni

    Gene expression databases

    GenevestigatoriQ6AYC8.

    Interactioni

    Subunit structurei

    Interacts with ESR1.By similarity

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000018543.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6AYC8.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini316 – 40893SH2PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 SH2 domain.PROSITE-ProRule annotation

    Keywords - Domaini

    SH2 domain

    Phylogenomic databases

    eggNOGiNOG77708.
    GeneTreeiENSGT00570000079047.
    HOGENOMiHOG000031527.
    HOVERGENiHBG057918.
    InParanoidiQ6AYC8.
    KOiK17577.
    OMAiVDYHKEE.
    OrthoDBiEOG71P2BD.
    PhylomeDBiQ6AYC8.
    TreeFamiTF336893.

    Family and domain databases

    Gene3Di3.30.505.10. 1 hit.
    InterProiIPR000980. SH2.
    [Graphical view]
    PfamiPF00017. SH2. 1 hit.
    [Graphical view]
    PRINTSiPR00401. SH2DOMAIN.
    SMARTiSM00252. SH2. 1 hit.
    [Graphical view]
    SUPFAMiSSF55550. SSF55550. 1 hit.
    PROSITEiPS50001. SH2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q6AYC8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLRQILSEMF IDPDLLAELS EEQKQILFYK MREEQIRRWK EREAAMERKE    50
    SLPVKSRPKK ENGKSVHWKL GADKQVWVWV MGEHHLDKPY DVLCDEILAE 100
    REHLRAAKDA ELRKAQSLQF TNSLKVKSLN CDLQAVKKTE PQNVTRKAAA 150
    EEATDQGPRA IPTKKDDKAQ TKDLTKKKDS EELKQTEDEK TKQIYKNWKE 200
    DSEWQASLRK SKAADEKRRS LAKQAREDYK RLSQRGRSGD GLQNPLTGPQ 250
    KPKRPPLPPK PQFLQPLGSP PKSLGNQGVI RTKTSSTQED IIRWFKEEQL 300
    PFRAGYQKNS DTIAPWFHGI LTLKKANELL STGMPGSFLI RVSEKIKGYA 350
    LSYLSEEGCK HFLIDASANS YSFLGVDQLQ HATLADLVEY HKEEPITSLG 400
    KELLLFPCGQ QDKPPDYLEL FQ 422
    Length:422
    Mass (Da):48,522
    Last modified:September 13, 2004 - v1
    Checksum:i56CC672C2297F803
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC079100 mRNA. Translation: AAH79100.1.
    RefSeqiNP_001012048.1. NM_001012048.1.
    XP_006253094.1. XM_006253032.1.
    UniGeneiRn.137349.

    Genome annotation databases

    EnsembliENSRNOT00000018543; ENSRNOP00000018543; ENSRNOG00000013541.
    GeneIDi306376.
    KEGGirno:306376.
    UCSCiRGD:1307991. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC079100 mRNA. Translation: AAH79100.1 .
    RefSeqi NP_001012048.1. NM_001012048.1.
    XP_006253094.1. XM_006253032.1.
    UniGenei Rn.137349.

    3D structure databases

    ProteinModelPortali Q6AYC8.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000018543.

    PTM databases

    PhosphoSitei Q6AYC8.

    Proteomic databases

    PaxDbi Q6AYC8.
    PRIDEi Q6AYC8.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000018543 ; ENSRNOP00000018543 ; ENSRNOG00000013541 .
    GeneIDi 306376.
    KEGGi rno:306376.
    UCSCi RGD:1307991. rat.

    Organism-specific databases

    CTDi 63898.
    RGDi 1307991. Sh2d4a.

    Phylogenomic databases

    eggNOGi NOG77708.
    GeneTreei ENSGT00570000079047.
    HOGENOMi HOG000031527.
    HOVERGENi HBG057918.
    InParanoidi Q6AYC8.
    KOi K17577.
    OMAi VDYHKEE.
    OrthoDBi EOG71P2BD.
    PhylomeDBi Q6AYC8.
    TreeFami TF336893.

    Miscellaneous databases

    NextBioi 655979.
    PROi Q6AYC8.

    Gene expression databases

    Genevestigatori Q6AYC8.

    Family and domain databases

    Gene3Di 3.30.505.10. 1 hit.
    InterProi IPR000980. SH2.
    [Graphical view ]
    Pfami PF00017. SH2. 1 hit.
    [Graphical view ]
    PRINTSi PR00401. SH2DOMAIN.
    SMARTi SM00252. SH2. 1 hit.
    [Graphical view ]
    SUPFAMi SSF55550. SSF55550. 1 hit.
    PROSITEi PS50001. SH2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Lung.

    Entry informationi

    Entry nameiSH24A_RAT
    AccessioniPrimary (citable) accession number: Q6AYC8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 2, 2006
    Last sequence update: September 13, 2004
    Last modified: October 1, 2014
    This is version 74 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3