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Q6AYC8

- SH24A_RAT

UniProt

Q6AYC8 - SH24A_RAT

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Protein

SH2 domain-containing protein 4A

Gene

Sh2d4a

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli

Functioni

Inhibits estrogen-induced cell proliferation by competing with PLCG for binding to ESR1, blocking the effect of estrogen on PLCG and repressing estrogen-induced proliferation. May play a role in T-cell development and function (By similarity).By similarity

GO - Molecular functioni

  1. phosphatase binding Source: UniProtKB

GO - Biological processi

  1. negative regulation of phosphatase activity Source: UniProtKB
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
SH2 domain-containing protein 4A
Gene namesi
Name:Sh2d4a
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 16

Organism-specific databases

RGDi1307991. Sh2d4a.

Subcellular locationi

Cytoplasm By similarity
Note: Located at podocyte foot processes.By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 422422SH2 domain-containing protein 4APRO_0000233135Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei233 – 2331PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ6AYC8.
PRIDEiQ6AYC8.

PTM databases

PhosphoSiteiQ6AYC8.

Expressioni

Gene expression databases

GenevestigatoriQ6AYC8.

Interactioni

Subunit structurei

Interacts with ESR1.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000018543.

Structurei

3D structure databases

ProteinModelPortaliQ6AYC8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini316 – 40893SH2PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 SH2 domain.PROSITE-ProRule annotation

Keywords - Domaini

SH2 domain

Phylogenomic databases

eggNOGiNOG77708.
GeneTreeiENSGT00570000079047.
HOGENOMiHOG000031527.
HOVERGENiHBG057918.
InParanoidiQ6AYC8.
KOiK17577.
OMAiVDYHKEE.
OrthoDBiEOG71P2BD.
PhylomeDBiQ6AYC8.
TreeFamiTF336893.

Family and domain databases

Gene3Di3.30.505.10. 1 hit.
InterProiIPR000980. SH2.
[Graphical view]
PfamiPF00017. SH2. 1 hit.
[Graphical view]
PRINTSiPR00401. SH2DOMAIN.
SMARTiSM00252. SH2. 1 hit.
[Graphical view]
SUPFAMiSSF55550. SSF55550. 1 hit.
PROSITEiPS50001. SH2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6AYC8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLRQILSEMF IDPDLLAELS EEQKQILFYK MREEQIRRWK EREAAMERKE
60 70 80 90 100
SLPVKSRPKK ENGKSVHWKL GADKQVWVWV MGEHHLDKPY DVLCDEILAE
110 120 130 140 150
REHLRAAKDA ELRKAQSLQF TNSLKVKSLN CDLQAVKKTE PQNVTRKAAA
160 170 180 190 200
EEATDQGPRA IPTKKDDKAQ TKDLTKKKDS EELKQTEDEK TKQIYKNWKE
210 220 230 240 250
DSEWQASLRK SKAADEKRRS LAKQAREDYK RLSQRGRSGD GLQNPLTGPQ
260 270 280 290 300
KPKRPPLPPK PQFLQPLGSP PKSLGNQGVI RTKTSSTQED IIRWFKEEQL
310 320 330 340 350
PFRAGYQKNS DTIAPWFHGI LTLKKANELL STGMPGSFLI RVSEKIKGYA
360 370 380 390 400
LSYLSEEGCK HFLIDASANS YSFLGVDQLQ HATLADLVEY HKEEPITSLG
410 420
KELLLFPCGQ QDKPPDYLEL FQ
Length:422
Mass (Da):48,522
Last modified:September 13, 2004 - v1
Checksum:i56CC672C2297F803
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC079100 mRNA. Translation: AAH79100.1.
RefSeqiNP_001012048.1. NM_001012048.1.
XP_006253094.1. XM_006253032.2.
UniGeneiRn.137349.

Genome annotation databases

EnsembliENSRNOT00000018543; ENSRNOP00000018543; ENSRNOG00000013541.
GeneIDi306376.
KEGGirno:306376.
UCSCiRGD:1307991. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC079100 mRNA. Translation: AAH79100.1 .
RefSeqi NP_001012048.1. NM_001012048.1.
XP_006253094.1. XM_006253032.2.
UniGenei Rn.137349.

3D structure databases

ProteinModelPortali Q6AYC8.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000018543.

PTM databases

PhosphoSitei Q6AYC8.

Proteomic databases

PaxDbi Q6AYC8.
PRIDEi Q6AYC8.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000018543 ; ENSRNOP00000018543 ; ENSRNOG00000013541 .
GeneIDi 306376.
KEGGi rno:306376.
UCSCi RGD:1307991. rat.

Organism-specific databases

CTDi 63898.
RGDi 1307991. Sh2d4a.

Phylogenomic databases

eggNOGi NOG77708.
GeneTreei ENSGT00570000079047.
HOGENOMi HOG000031527.
HOVERGENi HBG057918.
InParanoidi Q6AYC8.
KOi K17577.
OMAi VDYHKEE.
OrthoDBi EOG71P2BD.
PhylomeDBi Q6AYC8.
TreeFami TF336893.

Miscellaneous databases

NextBioi 655979.
PROi Q6AYC8.

Gene expression databases

Genevestigatori Q6AYC8.

Family and domain databases

Gene3Di 3.30.505.10. 1 hit.
InterProi IPR000980. SH2.
[Graphical view ]
Pfami PF00017. SH2. 1 hit.
[Graphical view ]
PRINTSi PR00401. SH2DOMAIN.
SMARTi SM00252. SH2. 1 hit.
[Graphical view ]
SUPFAMi SSF55550. SSF55550. 1 hit.
PROSITEi PS50001. SH2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Lung.

Entry informationi

Entry nameiSH24A_RAT
AccessioniPrimary (citable) accession number: Q6AYC8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 2, 2006
Last sequence update: September 13, 2004
Last modified: October 29, 2014
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3