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Protein

Rho GTPase-activating protein 15

Gene

Arhgap15

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Has activity toward RAC1. Overexpression results in an increase in actin stress fibers and cell contraction (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

GTPase activation

Enzyme and pathway databases

ReactomeiR-RNO-194840. Rho GTPase cycle.

Names & Taxonomyi

Protein namesi
Recommended name:
Rho GTPase-activating protein 15
Alternative name(s):
ArhGAP15
Rho-type GTPase-activating protein 15
Gene namesi
Name:Arhgap15
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 3

Organism-specific databases

RGDi1359304. Arhgap15.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 482482Rho GTPase-activating protein 15PRO_0000317576Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei51 – 511PhosphoserineBy similarity
Modified residuei111 – 1111PhosphoserineBy similarity
Modified residuei205 – 2051PhosphoserineCombined sources
Modified residuei208 – 2081PhosphoserineCombined sources
Modified residuei250 – 2501PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ6AYC5.

PTM databases

iPTMnetiQ6AYC5.

Expressioni

Gene expression databases

GenevisibleiQ6AYC5. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000043804.

Structurei

3D structure databases

ProteinModelPortaliQ6AYC5.
SMRiQ6AYC5. Positions 269-477.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini87 – 198112PHPROSITE-ProRule annotationAdd
BLAST
Domaini288 – 477190Rho-GAPPROSITE-ProRule annotationAdd
BLAST

Domaini

The PH domain is required for localization to the membrane.By similarity

Sequence similaritiesi

Contains 1 PH domain.PROSITE-ProRule annotation
Contains 1 Rho-GAP domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG1450. Eukaryota.
ENOG410ZP6T. LUCA.
GeneTreeiENSGT00840000129684.
HOGENOMiHOG000294167.
HOVERGENiHBG005328.
InParanoidiQ6AYC5.
OMAiQDNATRI.
OrthoDBiEOG7CZK7R.
PhylomeDBiQ6AYC5.
TreeFamiTF329345.

Family and domain databases

Gene3Di1.10.555.10. 1 hit.
2.30.29.30. 1 hit.
InterProiIPR011993. PH_dom-like.
IPR001849. PH_domain.
IPR015767. Rho_GTPase_act.
IPR008936. Rho_GTPase_activation_prot.
IPR000198. RhoGAP_dom.
[Graphical view]
PANTHERiPTHR23181. PTHR23181. 1 hit.
PfamiPF00169. PH. 1 hit.
PF00620. RhoGAP. 1 hit.
[Graphical view]
SMARTiSM00233. PH. 1 hit.
SM00324. RhoGAP. 1 hit.
[Graphical view]
SUPFAMiSSF48350. SSF48350. 1 hit.
SSF50729. SSF50729. 1 hit.
PROSITEiPS50003. PH_DOMAIN. 1 hit.
PS50238. RHOGAP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6AYC5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEKRTSCSVQ TSTNCDNSLE TLNSAHQATG AVQMRIKNAN SHPDRQSQTK
60 70 80 90 100
SMILTDAGKV TEPISRHRRN HSQHVLKDVI PPLEHPMVEK EGYLQKAKIA
110 120 130 140 150
DGGKKLRKNW STSWIVLSGR KLEFYKDPKQ QALPNVKPRP NAESVDLCGA
160 170 180 190 200
HIEWAAKDKS SKKSVFQITT ASGNEFLLQS DIDFLILDWF HAIKNAIDRL
210 220 230 240 250
PKNPSFGSLE LFSFQRSSSS EQPSHCHIDR KEQKPENRKS FMFRLHHSVS
260 270 280 290 300
DTSDKNRVKS RLKKFISRRP SLKTLQEKGI IKDQIFGSHL HTVCEREHST
310 320 330 340 350
VPWFVKQCIE AVEKRGLEVD GIYRVSGNLA TIQKLRFIVN QEEKLNLDDS
360 370 380 390 400
QWEDIHVVTG ALKMFFRELS EPLFPYSFFE RFVEAIKKQD SDAKIETMKS
410 420 430 440 450
LVKSLPPPNH DTMKILFGHL TKIVAKAAQN LMSTQSLGIV FGPTLLRAEN
460 470 480
ESGNVAVHMV YQNQVAEFML TEYDKIFSSE ED
Length:482
Mass (Da):55,014
Last modified:September 13, 2004 - v1
Checksum:iCC8F711F5B7C58E4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC079103 mRNA. Translation: AAH79103.1.
RefSeqiNP_001013939.1. NM_001013917.1.
UniGeneiRn.15607.

Genome annotation databases

EnsembliENSRNOT00000049884; ENSRNOP00000043804; ENSRNOG00000031168.
GeneIDi295635.
KEGGirno:295635.
UCSCiRGD:1359304. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC079103 mRNA. Translation: AAH79103.1.
RefSeqiNP_001013939.1. NM_001013917.1.
UniGeneiRn.15607.

3D structure databases

ProteinModelPortaliQ6AYC5.
SMRiQ6AYC5. Positions 269-477.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000043804.

PTM databases

iPTMnetiQ6AYC5.

Proteomic databases

PaxDbiQ6AYC5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000049884; ENSRNOP00000043804; ENSRNOG00000031168.
GeneIDi295635.
KEGGirno:295635.
UCSCiRGD:1359304. rat.

Organism-specific databases

CTDi55843.
RGDi1359304. Arhgap15.

Phylogenomic databases

eggNOGiKOG1450. Eukaryota.
ENOG410ZP6T. LUCA.
GeneTreeiENSGT00840000129684.
HOGENOMiHOG000294167.
HOVERGENiHBG005328.
InParanoidiQ6AYC5.
OMAiQDNATRI.
OrthoDBiEOG7CZK7R.
PhylomeDBiQ6AYC5.
TreeFamiTF329345.

Enzyme and pathway databases

ReactomeiR-RNO-194840. Rho GTPase cycle.

Miscellaneous databases

PROiQ6AYC5.

Gene expression databases

GenevisibleiQ6AYC5. RN.

Family and domain databases

Gene3Di1.10.555.10. 1 hit.
2.30.29.30. 1 hit.
InterProiIPR011993. PH_dom-like.
IPR001849. PH_domain.
IPR015767. Rho_GTPase_act.
IPR008936. Rho_GTPase_activation_prot.
IPR000198. RhoGAP_dom.
[Graphical view]
PANTHERiPTHR23181. PTHR23181. 1 hit.
PfamiPF00169. PH. 1 hit.
PF00620. RhoGAP. 1 hit.
[Graphical view]
SMARTiSM00233. PH. 1 hit.
SM00324. RhoGAP. 1 hit.
[Graphical view]
SUPFAMiSSF48350. SSF48350. 1 hit.
SSF50729. SSF50729. 1 hit.
PROSITEiPS50003. PH_DOMAIN. 1 hit.
PS50238. RHOGAP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Lung.
  2. "Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues."
    Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C., Olsen J.V.
    Nat. Commun. 3:876-876(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-205; SER-208 AND SER-250, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiRHG15_RAT
AccessioniPrimary (citable) accession number: Q6AYC5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: September 13, 2004
Last modified: June 8, 2016
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.