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Protein

Macrophage-capping protein

Gene

Capg

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Calcium-sensitive protein which reversibly blocks the barbed ends of actin filaments but does not sever preformed actin filaments. May play an important role in macrophage function. May play a role in regulating cytoplasmic and/or nuclear structures through potential interactions with actin. May bind DNA. Uncapping occurs either when Ca2+ falls or when the concentration of polyphosphoinositide rises, both at low and high Ca2+ (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActin capping, Actin-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Macrophage-capping protein
Alternative name(s):
Actin regulatory protein CAP-G
Gene namesi
Name:Capg
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 4

Organism-specific databases

RGDi1311724 Capg

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002713921 – 349Macrophage-capping proteinAdd BLAST349

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1
Modified residuei338PhosphoserineCombined sources1

Post-translational modificationi

Phosphorylated.By similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ6AYC4
PRIDEiQ6AYC4

PTM databases

iPTMnetiQ6AYC4
PhosphoSitePlusiQ6AYC4

Expressioni

Gene expression databases

BgeeiENSRNOG00000013668
GenevisibleiQ6AYC4 RN

Interactioni

Subunit structurei

Interacts with NUP62. Interacts with NUTF2 and RAN; involved in CAPG nuclear import.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000018562

Structurei

3D structure databases

ProteinModelPortaliQ6AYC4
SMRiQ6AYC4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati28 – 107Gelsolin-like 1Add BLAST80
Repeati147 – 222Gelsolin-like 2Add BLAST76
Repeati264 – 342Gelsolin-like 3Add BLAST79

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi138 – 147Nuclear localization signalSequence analysis10

Sequence similaritiesi

Belongs to the villin/gelsolin family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0443 Eukaryota
ENOG410XR0A LUCA
GeneTreeiENSGT00760000119111
HOGENOMiHOG000235030
HOVERGENiHBG001093
InParanoidiQ6AYC4
KOiK10368
OMAiHNGPEEV
OrthoDBiEOG091G05SC
PhylomeDBiQ6AYC4
TreeFamiTF313468

Family and domain databases

Gene3Di3.40.20.10, 3 hits
InterProiView protein in InterPro
IPR029006 ADF-H/Gelsolin-like_dom_sf
IPR029917 CapG
IPR007123 Gelsolin-like_dom
IPR007122 Villin/Gelsolin
PANTHERiPTHR11977 PTHR11977, 1 hit
PTHR11977:SF13 PTHR11977:SF13, 1 hit
PfamiView protein in Pfam
PF00626 Gelsolin, 3 hits
PRINTSiPR00597 GELSOLIN
SMARTiView protein in SMART
SM00262 GEL, 3 hits

Sequencei

Sequence statusi: Complete.

Q6AYC4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYTPIPQSGS PFPASVQDPG LHIWRVEKLK PVPIARENHG IFFSGDSYLV
60 70 80 90 100
LHNGPEEASH LHLWIGQQSS RDEQGACAVL AVHLNTLLGE RPVQHREVQG
110 120 130 140 150
NESDLFMSYF PQGLKYREGG VESAFHKTTS GTTPAAIRKL YQVKGKKNIR
160 170 180 190 200
ATERALSWDS FNTGDCFILD LGQNIFAWCG GKSNILERNK ARDLALAIRD
210 220 230 240 250
SERQGKAQVE IITDGEEPAE MIQVLGPKPA LKEGNPEEDI TADQTNAQAA
260 270 280 290 300
ALYKVSDATG QMNLTKVADS SPFASELLIP DDCFVLDNGL CGKIYIWKGR
310 320 330 340
KANEKERQAA LQVADGFISR MRYSPNTQVE ILPQGRESPI FKQFFKDWK
Length:349
Mass (Da):38,799
Last modified:September 13, 2004 - v1
Checksum:iB1F327DE344BCD22
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC079104 mRNA Translation: AAH79104.1
RefSeqiNP_001013104.1, NM_001013086.1
XP_006236723.1, XM_006236661.3
XP_006236724.1, XM_006236662.3
XP_006236725.1, XM_006236663.3
XP_017448026.1, XM_017592537.1
XP_017448027.1, XM_017592538.1
XP_017448028.1, XM_017592539.1
XP_017448029.1, XM_017592540.1
XP_017448030.1, XM_017592541.1
UniGeneiRn.8945

Genome annotation databases

EnsembliENSRNOT00000018562; ENSRNOP00000018562; ENSRNOG00000013668
GeneIDi297339
KEGGirno:297339
UCSCiRGD:1311724 rat

Similar proteinsi

Entry informationi

Entry nameiCAPG_RAT
AccessioniPrimary (citable) accession number: Q6AYC4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: September 13, 2004
Last modified: May 23, 2018
This is version 107 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

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