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Protein

Heat shock 70 kDa protein 14

Gene

Hspa14

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Component of the ribosome-associated complex (RAC), a complex involved in folding or maintaining nascent polypeptides in a folding-competent state. In the RAC complex, binds to the nascent polypeptide chain, while DNAJC2 stimulates its ATPase activity (By similarity).By similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Heat shock 70 kDa protein 14
Gene namesi
Name:Hspa14
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 17

Organism-specific databases

RGDi1303296. Hspa14.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 509509Heat shock 70 kDa protein 14PRO_0000289948Add
BLAST

Proteomic databases

PaxDbiQ6AYB4.
PRIDEiQ6AYB4.

Expressioni

Gene expression databases

BgeeiENSRNOG00000015212.
GenevisibleiQ6AYB4. RN.

Interactioni

Subunit structurei

Component of ribosome-associated complex (RAC), a heterodimer composed of Hsp70/DnaK-type chaperone HSPA14 and Hsp40/DnaJ-type chaperone DNAJC2.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000020854.

Structurei

3D structure databases

ProteinModelPortaliQ6AYB4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the heat shock protein 70 family.Curated

Phylogenomic databases

eggNOGiKOG0101. Eukaryota.
COG0443. LUCA.
GeneTreeiENSGT00820000127001.
HOGENOMiHOG000228135.
HOVERGENiHBG099873.
InParanoidiQ6AYB4.
OMAiSLMIECS.
OrthoDBiEOG091G06RS.
PhylomeDBiQ6AYB4.
TreeFamiTF105045.

Family and domain databases

Gene3Di2.60.34.10. 1 hit.
InterProiIPR018181. Heat_shock_70_CS.
IPR029047. HSP70_peptide-bd.
IPR013126. Hsp_70_fam.
[Graphical view]
PfamiPF00012. HSP70. 1 hit.
[Graphical view]
PRINTSiPR00301. HEATSHOCK70.
SUPFAMiSSF100920. SSF100920. 1 hit.
PROSITEiPS01036. HSP70_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6AYB4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAIGVHLGC TSACVAVYKD GRADVVANDA GDRVTPAVVA YSEREQVVGL
60 70 80 90 100
AAKQSRIRNI SSTVVKVKQI LGRSTADPQA QKYISESKCL VIEKNGKLQY
110 120 130 140 150
EIDTGEETKL VSPEDVARLI FSKMKETAHS VLGSDANDVV VTVPFDFGEK
160 170 180 190 200
QKSALGEAAG AAGFNVLRLI HEPSAALLAY GIGQDCPTGK SNVLVFKLGG
210 220 230 240 250
TSLSLSIMEV NSGMYRVLST NTSDNIGGVH FTDSLAQYLA SEFQRLFKHD
260 270 280 290 300
VRGSARAMMK LMNSAEVAKH SLSTLGSANC FVDSLYEGQD FDCNVSRARF
310 320 330 340 350
ELLCSPLFNK CIEAVRALLQ QSGFTADDIN KVVLCGGSSR IPRLQQLIKD
360 370 380 390 400
LFPAGDLLNS IPPDEVIPIG AAIEAGILVG KESTSGDDSV LIECSARDIL
410 420 430 440 450
VKGVDESGAN RFTVLFPSGT PLPARRQHTL QAPGSISSVC LELYESEGKN
460 470 480 490 500
SVKEETKFAQ VVLQDLDKKE NGLRDILAVL TMKRDGSLQV TCTDQETGKC

EAITVEVAS
Length:509
Mass (Da):54,463
Last modified:September 13, 2004 - v1
Checksum:i124B694373C553AA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC079118 mRNA. Translation: AAH79118.1.
RefSeqiNP_001004257.1. NM_001004257.1.
UniGeneiRn.137392.

Genome annotation databases

EnsembliENSRNOT00000020854; ENSRNOP00000020854; ENSRNOG00000015212.
GeneIDi307133.
KEGGirno:307133.
UCSCiRGD:1303296. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC079118 mRNA. Translation: AAH79118.1.
RefSeqiNP_001004257.1. NM_001004257.1.
UniGeneiRn.137392.

3D structure databases

ProteinModelPortaliQ6AYB4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000020854.

Proteomic databases

PaxDbiQ6AYB4.
PRIDEiQ6AYB4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000020854; ENSRNOP00000020854; ENSRNOG00000015212.
GeneIDi307133.
KEGGirno:307133.
UCSCiRGD:1303296. rat.

Organism-specific databases

CTDi51182.
RGDi1303296. Hspa14.

Phylogenomic databases

eggNOGiKOG0101. Eukaryota.
COG0443. LUCA.
GeneTreeiENSGT00820000127001.
HOGENOMiHOG000228135.
HOVERGENiHBG099873.
InParanoidiQ6AYB4.
OMAiSLMIECS.
OrthoDBiEOG091G06RS.
PhylomeDBiQ6AYB4.
TreeFamiTF105045.

Miscellaneous databases

PROiQ6AYB4.

Gene expression databases

BgeeiENSRNOG00000015212.
GenevisibleiQ6AYB4. RN.

Family and domain databases

Gene3Di2.60.34.10. 1 hit.
InterProiIPR018181. Heat_shock_70_CS.
IPR029047. HSP70_peptide-bd.
IPR013126. Hsp_70_fam.
[Graphical view]
PfamiPF00012. HSP70. 1 hit.
[Graphical view]
PRINTSiPR00301. HEATSHOCK70.
SUPFAMiSSF100920. SSF100920. 1 hit.
PROSITEiPS01036. HSP70_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiHSP7E_RAT
AccessioniPrimary (citable) accession number: Q6AYB4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: September 13, 2004
Last modified: September 7, 2016
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.