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Protein
Submitted name:

Protein Sphk2

Gene

Sphk2

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

KinaseImported, Transferase

Enzyme and pathway databases

BRENDAi2.7.1.91. 5301.
ReactomeiR-RNO-1660661. Sphingolipid de novo biosynthesis.

Names & Taxonomyi

Protein namesi
Submitted name:
Protein Sphk2Imported
Submitted name:
RCG53912, isoform CRA_aImported
Submitted name:
Sphingosine kinase 2Imported
Gene namesi
Name:Sphk2Imported
ORF Names:rCG_53912Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi1307757. Sphk2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL1075197.

Expressioni

Gene expression databases

BgeeiENSRNOG00000021032.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000028549.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini143 – 290DAGKcInterPro annotationAdd BLAST148

Phylogenomic databases

eggNOGiKOG1116. Eukaryota.
COG1597. LUCA.
GeneTreeiENSGT00690000101761.
HOGENOMiHOG000111460.
HOVERGENiHBG054796.
KOiK04718.
OMAiLMCLLRG.
OrthoDBiEOG091G06SM.
TreeFamiTF354296.

Family and domain databases

InterProiIPR001206. Diacylglycerol_kinase_cat_dom.
IPR016064. NAD/diacylglycerol_kinase.
[Graphical view]
PfamiPF00781. DAGK_cat. 1 hit.
[Graphical view]
SMARTiSM00046. DAGKc. 1 hit.
[Graphical view]
SUPFAMiSSF111331. SSF111331. 2 hits.
PROSITEiPS50146. DAGK. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6AYB2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPPPLLPVA ASTPILHGEF GSYPAHGPRF ALTLTTQALH IQRLRPKPEA
60 70 80 90 100
RPRDGLVPLD EVSGCGTLQS RSPEDTAAYF CIYTYPRGRR GGRRRATRTF
110 120 130 140 150
RADGAATYVE NRAEAQRWAT ALMCLLRGVP LSGDQEITPE LLPRKPRLLL
160 170 180 190 200
LVNPFGGRGL AWQRCMDHVV PMISEAGLSF NLIQTERQNH ARELVQGLSL
210 220 230 240 250
SEWEGIVTVS GDGLLYEVLN GLLDRPDWED AVRMPIGVLP CGSGNALAGA
260 270 280 290 300
VNHHGGFEQT VGVDLLLNCS LLLCRGGSHP LDLLSVTLAS GSRCFSFLSV
310 320 330 340 350
AWGFLSDVDI HSERFRALGS ARFTLGAVLG LATLHTYRGR LSYLPATTEP
360 370 380 390 400
ALPIPGHGLP RAKSELALAP APAPAATHSP LHRSVSDLPL PLPQPALASP
410 420 430 440 450
GSPEPLPDLS LNGGGPELTG DWGGAGDAPL SPDPLLPSSP NAFKTAQLSP
460 470 480 490 500
IAEGPSEMPA SGLLPPIHNA PEASTWGPAD HLLPPLGSPL PQDWVTIEGE
510 520 530 540 550
FVLMLAILPS HLCADLMAAP HARFDDGVVH LCWVRSGISR AALLRILLAM
560 570 580 590 600
EHGNHFSLGC PHLGYAAARA FRLEPLTPRG VLTVDGELVE YGPIQAQVHP
610
SLATLLTGPA GQKPRA
Length:616
Mass (Da):65,523
Last modified:September 13, 2004 - v1
Checksum:iB0D69D4894C69DB0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC095693 Genomic DNA. No translation available.
BC079120 mRNA. Translation: AAH79120.1.
CH473979 Genomic DNA. Translation: EDM07309.1.
CH473979 Genomic DNA. Translation: EDM07310.1.
CH473979 Genomic DNA. Translation: EDM07311.1.
RefSeqiNP_001012066.1. NM_001012066.1.
XP_006229147.1. XM_006229085.2.
XP_006229150.1. XM_006229088.3.
XP_008757605.1. XM_008759383.2.
XP_008757606.1. XM_008759384.2.
UniGeneiRn.41053.

Genome annotation databases

EnsembliENSRNOT00000028549; ENSRNOP00000028549; ENSRNOG00000021032.
GeneIDi308589.
KEGGirno:308589.
UCSCiRGD:1307757. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC095693 Genomic DNA. No translation available.
BC079120 mRNA. Translation: AAH79120.1.
CH473979 Genomic DNA. Translation: EDM07309.1.
CH473979 Genomic DNA. Translation: EDM07310.1.
CH473979 Genomic DNA. Translation: EDM07311.1.
RefSeqiNP_001012066.1. NM_001012066.1.
XP_006229147.1. XM_006229085.2.
XP_006229150.1. XM_006229088.3.
XP_008757605.1. XM_008759383.2.
XP_008757606.1. XM_008759384.2.
UniGeneiRn.41053.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000028549.

Chemistry databases

ChEMBLiCHEMBL1075197.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000028549; ENSRNOP00000028549; ENSRNOG00000021032.
GeneIDi308589.
KEGGirno:308589.
UCSCiRGD:1307757. rat.

Organism-specific databases

CTDi56848.
RGDi1307757. Sphk2.

Phylogenomic databases

eggNOGiKOG1116. Eukaryota.
COG1597. LUCA.
GeneTreeiENSGT00690000101761.
HOGENOMiHOG000111460.
HOVERGENiHBG054796.
KOiK04718.
OMAiLMCLLRG.
OrthoDBiEOG091G06SM.
TreeFamiTF354296.

Enzyme and pathway databases

BRENDAi2.7.1.91. 5301.
ReactomeiR-RNO-1660661. Sphingolipid de novo biosynthesis.

Gene expression databases

BgeeiENSRNOG00000021032.

Family and domain databases

InterProiIPR001206. Diacylglycerol_kinase_cat_dom.
IPR016064. NAD/diacylglycerol_kinase.
[Graphical view]
PfamiPF00781. DAGK_cat. 1 hit.
[Graphical view]
SMARTiSM00046. DAGKc. 1 hit.
[Graphical view]
SUPFAMiSSF111331. SSF111331. 2 hits.
PROSITEiPS50146. DAGK. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ6AYB2_RAT
AccessioniPrimary (citable) accession number: Q6AYB2
Entry historyi
Integrated into UniProtKB/TrEMBL: September 13, 2004
Last sequence update: September 13, 2004
Last modified: November 30, 2016
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.