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Q6AYA1

- GAR1_RAT

UniProt

Q6AYA1 - GAR1_RAT

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Protein
H/ACA ribonucleoprotein complex subunit 1
Gene
Gar1, Nola1
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Required for ribosome biogenesis and telomere maintenance. Part of the H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Each rRNA can contain up to 100 pseudouridine ("psi") residues, which may serve to stabilize the conformation of rRNAs. May also be required for correct processing or intranuclear trafficking of TERC, the RNA component of the telomerase reverse transcriptase (TERT) holoenzyme By similarity.

GO - Molecular functioni

  1. RNA binding Source: UniProtKB-KW

GO - Biological processi

  1. pseudouridine synthesis Source: InterPro
  2. rRNA processing Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein

Keywords - Biological processi

Ribosome biogenesis, rRNA processing

Keywords - Ligandi

RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
H/ACA ribonucleoprotein complex subunit 1
Alternative name(s):
Nucleolar protein family A member 1
snoRNP protein GAR1
Gene namesi
Name:Gar1
Synonyms:Nola1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 2

Organism-specific databases

RGDi1563995. Gar1.

Subcellular locationi

Nucleusnucleolus By similarity. NucleusCajal body By similarity
Note: Also localized to Cajal bodies (coiled bodies) By similarity.

GO - Cellular componenti

  1. Cajal body Source: UniProtKB-SubCell
  2. box H/ACA snoRNP complex Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 226226H/ACA ribonucleoprotein complex subunit 1
PRO_0000208554Add
BLAST

Proteomic databases

PaxDbiQ6AYA1.
PRIDEiQ6AYA1.

Expressioni

Gene expression databases

GenevestigatoriQ6AYA1.

Interactioni

Subunit structurei

Part of the H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which contains NHP2/NOLA2, GAR1/NOLA1, NOP10/NOLA3, and DKC1/NOLA4, which is presumed to be the catalytic subunit. The complex contains a stable core formed by binding of one or two NOP10-DKC1 heterodimers to NHP2; GAR1 subsequently binds to this core via DKC1. The complex binds a box H/ACA small nucleolar RNA (snoRNA), which may target the specific site of modification within the RNA substrate. The complex also interacts with TERC, which contains a 3'-terminal domain related to the box H/ACA snoRNAs. Specific interactions with snoRNAs or TERC are mediated by GAR1 and NHP2. Associates with NOLC1/NOPP140. H/ACA snoRNPs interact with the SMN complex, consisting of SMN1 or SMN2, GEMIN2/SIP1, DDX20/GEMIN3, and GEMIN4. This is mediated by interaction between GAR1 and SMN1 or SMN2. The SMN complex may be required for correct assembly of the H/ACA snoRNP complex. Component of the telomerase holoenzyme complex at least composed of TERT, DKC1, WRAP53/TCAB1, NOP10, NHP2, GAR1, TEP1, EST1A, POT1 and a telomerase RNA template component (TERC) By similarity.

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000013149.

Structurei

3D structure databases

ProteinModelPortaliQ6AYA1.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni4 – 5956RGG-box 1
Add
BLAST
Regioni171 – 22656RGG-box 2
Add
BLAST

Domaini

Interaction with SMN1 requires at least one of the RGG-box regions By similarity.

Sequence similaritiesi

Belongs to the GAR1 family.

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiCOG3277.
GeneTreeiENSGT00730000111223.
InParanoidiQ6AYA1.
KOiK11128.
OMAiTHENKVP.
OrthoDBiEOG78H3WG.
TreeFamiTF350747.

Family and domain databases

InterProiIPR021154. H/ACA_rnp_Gar1.
IPR007504. H/ACA_rnp_Gar1/Naf1.
IPR009000. Transl_B-barrel.
[Graphical view]
PANTHERiPTHR23237. PTHR23237. 1 hit.
PfamiPF04410. Gar1. 1 hit.
[Graphical view]
ProDomiPD020235. Gar1_RNA_bd. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF50447. SSF50447. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6AYA1-1 [UniParc]FASTAAdd to Basket

« Hide

MSFRGGGRGG FNRGGGGGGF NRGGGSNNHF RGGGGGGGGG GNFRGGGRGG    50
FGRGGGRGGF NKFQDQGPPE RVVLLGEFMH PCEDDIVCKC TTEENKVPYF 100
NAPVYLENKE QIGKVDEIFG QLRDFYFSVK LSENMKASSF KKLQKFYIDP 150
YKLLPLQRFL PRPPGEKGPP RGGGGGGGGG RGGRGGGRGG GGRGGGRGGG 200
FRGGRGGGGG FRGGRGGGGG FRGRGH 226
Length:226
Mass (Da):23,011
Last modified:September 13, 2004 - v1
Checksum:iB81ADE63E02F151D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC079131 mRNA. Translation: AAH79131.1.
RefSeqiNP_001019477.1. NM_001024306.1.
UniGeneiRn.15522.

Genome annotation databases

EnsembliENSRNOT00000013149; ENSRNOP00000013149; ENSRNOG00000009877.
GeneIDi499709.
KEGGirno:499709.
UCSCiRGD:1563995. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC079131 mRNA. Translation: AAH79131.1 .
RefSeqi NP_001019477.1. NM_001024306.1.
UniGenei Rn.15522.

3D structure databases

ProteinModelPortali Q6AYA1.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000013149.

Proteomic databases

PaxDbi Q6AYA1.
PRIDEi Q6AYA1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000013149 ; ENSRNOP00000013149 ; ENSRNOG00000009877 .
GeneIDi 499709.
KEGGi rno:499709.
UCSCi RGD:1563995. rat.

Organism-specific databases

CTDi 54433.
RGDi 1563995. Gar1.

Phylogenomic databases

eggNOGi COG3277.
GeneTreei ENSGT00730000111223.
InParanoidi Q6AYA1.
KOi K11128.
OMAi THENKVP.
OrthoDBi EOG78H3WG.
TreeFami TF350747.

Miscellaneous databases

NextBioi 703745.
PROi Q6AYA1.

Gene expression databases

Genevestigatori Q6AYA1.

Family and domain databases

InterProi IPR021154. H/ACA_rnp_Gar1.
IPR007504. H/ACA_rnp_Gar1/Naf1.
IPR009000. Transl_B-barrel.
[Graphical view ]
PANTHERi PTHR23237. PTHR23237. 1 hit.
Pfami PF04410. Gar1. 1 hit.
[Graphical view ]
ProDomi PD020235. Gar1_RNA_bd. 1 hit.
[Graphical view ] [Entries sharing at least one domain ]
SUPFAMi SSF50447. SSF50447. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Kidney.

Entry informationi

Entry nameiGAR1_RAT
AccessioniPrimary (citable) accession number: Q6AYA1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: September 13, 2004
Last modified: May 14, 2014
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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