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Q6AYA1

- GAR1_RAT

UniProt

Q6AYA1 - GAR1_RAT

Protein

H/ACA ribonucleoprotein complex subunit 1

Gene

Gar1

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 74 (01 Oct 2014)
      Sequence version 1 (13 Sep 2004)
      Previous versions | rss
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    Functioni

    Required for ribosome biogenesis and telomere maintenance. Part of the H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Each rRNA can contain up to 100 pseudouridine ("psi") residues, which may serve to stabilize the conformation of rRNAs. May also be required for correct processing or intranuclear trafficking of TERC, the RNA component of the telomerase reverse transcriptase (TERT) holoenzyme By similarity.By similarity

    GO - Molecular functioni

    1. RNA binding Source: UniProtKB-KW

    GO - Biological processi

    1. pseudouridine synthesis Source: InterPro
    2. rRNA processing Source: UniProtKB-KW

    Keywords - Molecular functioni

    Ribonucleoprotein

    Keywords - Biological processi

    Ribosome biogenesis, rRNA processing

    Keywords - Ligandi

    RNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    H/ACA ribonucleoprotein complex subunit 1
    Alternative name(s):
    Nucleolar protein family A member 1
    snoRNP protein GAR1
    Gene namesi
    Name:Gar1
    Synonyms:Nola1
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 2

    Organism-specific databases

    RGDi1563995. Gar1.

    Subcellular locationi

    Nucleusnucleolus By similarity. NucleusCajal body By similarity
    Note: Also localized to Cajal bodies (coiled bodies).By similarity

    GO - Cellular componenti

    1. box H/ACA snoRNP complex Source: InterPro
    2. Cajal body Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 226226H/ACA ribonucleoprotein complex subunit 1PRO_0000208554Add
    BLAST

    Proteomic databases

    PaxDbiQ6AYA1.
    PRIDEiQ6AYA1.

    Expressioni

    Gene expression databases

    GenevestigatoriQ6AYA1.

    Interactioni

    Subunit structurei

    Part of the H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which contains NHP2/NOLA2, GAR1/NOLA1, NOP10/NOLA3, and DKC1/NOLA4, which is presumed to be the catalytic subunit. The complex contains a stable core formed by binding of one or two NOP10-DKC1 heterodimers to NHP2; GAR1 subsequently binds to this core via DKC1. The complex binds a box H/ACA small nucleolar RNA (snoRNA), which may target the specific site of modification within the RNA substrate. The complex also interacts with TERC, which contains a 3'-terminal domain related to the box H/ACA snoRNAs. Specific interactions with snoRNAs or TERC are mediated by GAR1 and NHP2. Associates with NOLC1/NOPP140. H/ACA snoRNPs interact with the SMN complex, consisting of SMN1 or SMN2, GEMIN2/SIP1, DDX20/GEMIN3, and GEMIN4. This is mediated by interaction between GAR1 and SMN1 or SMN2. The SMN complex may be required for correct assembly of the H/ACA snoRNP complex. Component of the telomerase holoenzyme complex at least composed of TERT, DKC1, WRAP53/TCAB1, NOP10, NHP2, GAR1, TEP1, EST1A, POT1 and a telomerase RNA template component (TERC) By similarity.By similarity

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000013149.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6AYA1.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni4 – 5956RGG-box 1Add
    BLAST
    Regioni171 – 22656RGG-box 2Add
    BLAST

    Domaini

    Interaction with SMN1 requires at least one of the RGG-box regions.By similarity

    Sequence similaritiesi

    Belongs to the GAR1 family.Curated

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiCOG3277.
    GeneTreeiENSGT00730000111223.
    InParanoidiQ6AYA1.
    KOiK11128.
    OMAiTHENKVP.
    OrthoDBiEOG78H3WG.
    TreeFamiTF350747.

    Family and domain databases

    InterProiIPR021154. H/ACA_rnp_Gar1.
    IPR007504. H/ACA_rnp_Gar1/Naf1.
    IPR009000. Transl_B-barrel.
    [Graphical view]
    PANTHERiPTHR23237. PTHR23237. 1 hit.
    PfamiPF04410. Gar1. 1 hit.
    [Graphical view]
    ProDomiPD020235. Gar1_RNA_bd. 1 hit.
    [Graphical view] [Entries sharing at least one domain]
    SUPFAMiSSF50447. SSF50447. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q6AYA1-1 [UniParc]FASTAAdd to Basket

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    MSFRGGGRGG FNRGGGGGGF NRGGGSNNHF RGGGGGGGGG GNFRGGGRGG    50
    FGRGGGRGGF NKFQDQGPPE RVVLLGEFMH PCEDDIVCKC TTEENKVPYF 100
    NAPVYLENKE QIGKVDEIFG QLRDFYFSVK LSENMKASSF KKLQKFYIDP 150
    YKLLPLQRFL PRPPGEKGPP RGGGGGGGGG RGGRGGGRGG GGRGGGRGGG 200
    FRGGRGGGGG FRGGRGGGGG FRGRGH 226
    Length:226
    Mass (Da):23,011
    Last modified:September 13, 2004 - v1
    Checksum:iB81ADE63E02F151D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC079131 mRNA. Translation: AAH79131.1.
    RefSeqiNP_001019477.1. NM_001024306.1.
    UniGeneiRn.15522.

    Genome annotation databases

    EnsembliENSRNOT00000013149; ENSRNOP00000013149; ENSRNOG00000009877.
    GeneIDi499709.
    KEGGirno:499709.
    UCSCiRGD:1563995. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC079131 mRNA. Translation: AAH79131.1 .
    RefSeqi NP_001019477.1. NM_001024306.1.
    UniGenei Rn.15522.

    3D structure databases

    ProteinModelPortali Q6AYA1.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000013149.

    Proteomic databases

    PaxDbi Q6AYA1.
    PRIDEi Q6AYA1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000013149 ; ENSRNOP00000013149 ; ENSRNOG00000009877 .
    GeneIDi 499709.
    KEGGi rno:499709.
    UCSCi RGD:1563995. rat.

    Organism-specific databases

    CTDi 54433.
    RGDi 1563995. Gar1.

    Phylogenomic databases

    eggNOGi COG3277.
    GeneTreei ENSGT00730000111223.
    InParanoidi Q6AYA1.
    KOi K11128.
    OMAi THENKVP.
    OrthoDBi EOG78H3WG.
    TreeFami TF350747.

    Miscellaneous databases

    NextBioi 703745.
    PROi Q6AYA1.

    Gene expression databases

    Genevestigatori Q6AYA1.

    Family and domain databases

    InterProi IPR021154. H/ACA_rnp_Gar1.
    IPR007504. H/ACA_rnp_Gar1/Naf1.
    IPR009000. Transl_B-barrel.
    [Graphical view ]
    PANTHERi PTHR23237. PTHR23237. 1 hit.
    Pfami PF04410. Gar1. 1 hit.
    [Graphical view ]
    ProDomi PD020235. Gar1_RNA_bd. 1 hit.
    [Graphical view ] [Entries sharing at least one domain ]
    SUPFAMi SSF50447. SSF50447. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Kidney.

    Entry informationi

    Entry nameiGAR1_RAT
    AccessioniPrimary (citable) accession number: Q6AYA1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 5, 2005
    Last sequence update: September 13, 2004
    Last modified: October 1, 2014
    This is version 74 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3