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Protein
Submitted name:

Aldo-keto reductase family 1, member B10 (Aldose reductase)

Gene

Akr1b10

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei49 – 491Proton donorUniRule annotation
Sitei78 – 781Lowers pKa of active site TyrUniRule annotation
Binding sitei111 – 1111SubstrateUniRule annotation

GO - Molecular functioni

  • alditol:NADP+ 1-oxidoreductase activity Source: RGD
  • NADP+ binding Source: RGD
  • NADPH binding Source: RGD
  • NADP-retinol dehydrogenase activity Source: RGD
  • retinal binding Source: RGD

GO - Biological processi

  • polyol metabolic process Source: RGD
  • retinal metabolic process Source: RGD
  • retinol metabolic process Source: RGD
Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-RNO-193144. Estrogen biosynthesis.
R-RNO-975634. Retinoid metabolism and transport.

Names & Taxonomyi

Protein namesi
Submitted name:
Aldo-keto reductase family 1, member B10 (Aldose reductase)Imported
Submitted name:
Protein Akr1b10Imported
Submitted name:
RCG27939, isoform CRA_bImported
Gene namesi
Name:Akr1b10Imported
ORF Names:rCG_27939Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 4

Organism-specific databases

RGDi1308277. Akr1b10.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: RGD
Complete GO annotation...

PTM / Processingi

PTM databases

PhosphoSiteiQ6AY99.

Expressioni

Gene expression databases

BgeeiENSRNOG00000046247.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000065713.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini16 – 290275Aldo_ket_redInterPro annotationAdd
BLAST

Phylogenomic databases

eggNOGiKOG1577. Eukaryota.
COG0656. LUCA.
GeneTreeiENSGT00760000119041.
HOGENOMiHOG000250272.
HOVERGENiHBG000020.
KOiK00011.
OrthoDBiEOG091G0D69.
TreeFamiTF106492.

Family and domain databases

CDDicd06660. Aldo_ket_red. 1 hit.
Gene3Di3.20.20.100. 1 hit.
InterProiIPR001395. Aldo/ket_red/Kv-b.
IPR018170. Aldo/ket_reductase_CS.
IPR020471. Aldo/keto_reductase.
IPR023210. NADP_OxRdtase_dom.
[Graphical view]
PANTHERiPTHR11732. PTHR11732. 2 hits.
PfamiPF00248. Aldo_ket_red. 1 hit.
[Graphical view]
PIRSFiPIRSF000097. AKR. 1 hit.
PRINTSiPR00069. ALDKETRDTASE.
SUPFAMiSSF51430. SSF51430. 1 hit.
PROSITEiPS00798. ALDOKETO_REDUCTASE_1. 1 hit.
PS00062. ALDOKETO_REDUCTASE_2. 1 hit.
PS00063. ALDOKETO_REDUCTASE_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6AY99-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAFVKLSTK AKMPIVGLGT WKSPPDKVKE AVKAAIDAGY RHFDCAYVYQ
60 70 80 90 100
NESEVGEAIQ EKIKEKAVRR EDLFIVSKLW PTFFEKSLVK KAFQKTLLDL
110 120 130 140 150
KLDYLDLYLI HWPQGFQSGN VFLPTDDKGN VLTSKYTFLD AWEGMEELVD
160 170 180 190 200
QGLVKALGVS NFNHFQIERL LNKPGLKHKP VTNQVECHPY LTQEKLIQYC
210 220 230 240 250
HSKGIVVTAY SPLGSPDRPS AKPEDPVLLE IPKIKEIASK HKKTAAQVLI
260 270 280 290 300
RFHIERNVAV IPKSVTPSRI QENIQVFDFQ LSEEDMAAIL SFNRNWRACG
310
LFAASRNEDF PFHSEY
Length:316
Mass (Da):35,999
Last modified:September 13, 2004 - v1
Checksum:i1303C237C566C475
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07072999 Genomic DNA. No translation available.
AC133322 Genomic DNA. No translation available.
BC079133 mRNA. Translation: AAH79133.1.
CH473959 Genomic DNA. Translation: EDM15306.1.
RefSeqiNP_001013102.1. NM_001013084.1.
UniGeneiRn.228771.

Genome annotation databases

EnsembliENSRNOT00000074951; ENSRNOP00000065713; ENSRNOG00000009734.
GeneIDi296972.
KEGGirno:296972.
UCSCiRGD:1308277. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07072999 Genomic DNA. No translation available.
AC133322 Genomic DNA. No translation available.
BC079133 mRNA. Translation: AAH79133.1.
CH473959 Genomic DNA. Translation: EDM15306.1.
RefSeqiNP_001013102.1. NM_001013084.1.
UniGeneiRn.228771.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000065713.

PTM databases

PhosphoSiteiQ6AY99.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000074951; ENSRNOP00000065713; ENSRNOG00000009734.
GeneIDi296972.
KEGGirno:296972.
UCSCiRGD:1308277. rat.

Organism-specific databases

CTDi57016.
RGDi1308277. Akr1b10.

Phylogenomic databases

eggNOGiKOG1577. Eukaryota.
COG0656. LUCA.
GeneTreeiENSGT00760000119041.
HOGENOMiHOG000250272.
HOVERGENiHBG000020.
KOiK00011.
OrthoDBiEOG091G0D69.
TreeFamiTF106492.

Enzyme and pathway databases

ReactomeiR-RNO-193144. Estrogen biosynthesis.
R-RNO-975634. Retinoid metabolism and transport.

Gene expression databases

BgeeiENSRNOG00000046247.

Family and domain databases

CDDicd06660. Aldo_ket_red. 1 hit.
Gene3Di3.20.20.100. 1 hit.
InterProiIPR001395. Aldo/ket_red/Kv-b.
IPR018170. Aldo/ket_reductase_CS.
IPR020471. Aldo/keto_reductase.
IPR023210. NADP_OxRdtase_dom.
[Graphical view]
PANTHERiPTHR11732. PTHR11732. 2 hits.
PfamiPF00248. Aldo_ket_red. 1 hit.
[Graphical view]
PIRSFiPIRSF000097. AKR. 1 hit.
PRINTSiPR00069. ALDKETRDTASE.
SUPFAMiSSF51430. SSF51430. 1 hit.
PROSITEiPS00798. ALDOKETO_REDUCTASE_1. 1 hit.
PS00062. ALDOKETO_REDUCTASE_2. 1 hit.
PS00063. ALDOKETO_REDUCTASE_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ6AY99_RAT
AccessioniPrimary (citable) accession number: Q6AY99
Entry historyi
Integrated into UniProtKB/TrEMBL: September 13, 2004
Last sequence update: September 13, 2004
Last modified: September 7, 2016
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.