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Protein
Submitted name:

Aldo-keto reductase family 1 member B10

Gene

Akr1b10

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei49Proton donorUniRule annotation1
Sitei78Lowers pKa of active site TyrUniRule annotation1
Binding sitei111SubstrateUniRule annotation1

GO - Molecular functioni

  • alditol:NADP+ 1-oxidoreductase activity Source: RGD
  • NADP+ binding Source: RGD
  • NADPH binding Source: RGD
  • NADP-retinol dehydrogenase activity Source: RGD
  • retinal binding Source: RGD

GO - Biological processi

  • polyol metabolic process Source: RGD
  • retinal metabolic process Source: RGD
  • retinol metabolic process Source: RGD

Enzyme and pathway databases

ReactomeiR-RNO-193144. Estrogen biosynthesis.
R-RNO-975634. Retinoid metabolism and transport.

Names & Taxonomyi

Protein namesi
Submitted name:
Aldo-keto reductase family 1 member B10Imported
Submitted name:
Aldo-keto reductase family 1, member B10 (Aldose reductase)Imported
Submitted name:
RCG27939, isoform CRA_bImported
Gene namesi
Name:Akr1b10Imported
ORF Names:rCG_27939Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 4

Organism-specific databases

RGDi1308277. Akr1b10.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Expressioni

Gene expression databases

BgeeiENSRNOG00000009734.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000065713.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini16 – 290Aldo_ket_redInterPro annotationAdd BLAST275

Phylogenomic databases

eggNOGiKOG1577. Eukaryota.
COG0656. LUCA.
GeneTreeiENSGT00760000119041.
HOGENOMiHOG000250272.
HOVERGENiHBG000020.
KOiK00011.
OrthoDBiEOG091G0D69.
TreeFamiTF106492.

Family and domain databases

CDDicd06660. Aldo_ket_red. 1 hit.
Gene3Di3.20.20.100. 1 hit.
InterProiView protein in InterPro
IPR018170. Aldo/ket_reductase_CS.
IPR020471. Aldo/keto_reductase.
IPR023210. NADP_OxRdtase_dom.
PANTHERiPTHR11732. PTHR11732. 1 hit.
PfamiView protein in Pfam
PF00248. Aldo_ket_red. 1 hit.
PIRSFiPIRSF000097. AKR. 1 hit.
PRINTSiPR00069. ALDKETRDTASE.
SUPFAMiSSF51430. SSF51430. 1 hit.
PROSITEiView protein in PROSITE
PS00798. ALDOKETO_REDUCTASE_1. 1 hit.
PS00062. ALDOKETO_REDUCTASE_2. 1 hit.
PS00063. ALDOKETO_REDUCTASE_3. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6AY99-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAFVKLSTK AKMPIVGLGT WKSPPDKVKE AVKAAIDAGY RHFDCAYVYQ
60 70 80 90 100
NESEVGEAIQ EKIKEKAVRR EDLFIVSKLW PTFFEKSLVK KAFQKTLLDL
110 120 130 140 150
KLDYLDLYLI HWPQGFQSGN VFLPTDDKGN VLTSKYTFLD AWEGMEELVD
160 170 180 190 200
QGLVKALGVS NFNHFQIERL LNKPGLKHKP VTNQVECHPY LTQEKLIQYC
210 220 230 240 250
HSKGIVVTAY SPLGSPDRPS AKPEDPVLLE IPKIKEIASK HKKTAAQVLI
260 270 280 290 300
RFHIERNVAV IPKSVTPSRI QENIQVFDFQ LSEEDMAAIL SFNRNWRACG
310
LFAASRNEDF PFHSEY
Length:316
Mass (Da):35,999
Last modified:September 13, 2004 - v1
Checksum:i1303C237C566C475
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07072999 Genomic DNA. No translation available.
AC133322 Genomic DNA. No translation available.
BC079133 mRNA. Translation: AAH79133.1.
CH473959 Genomic DNA. Translation: EDM15306.1.
RefSeqiNP_001013102.1. NM_001013084.1.
UniGeneiRn.228771.

Genome annotation databases

EnsembliENSRNOT00000074951; ENSRNOP00000065713; ENSRNOG00000009734.
GeneIDi296972.
KEGGirno:296972.
UCSCiRGD:1308277. rat.

Similar proteinsi

Entry informationi

Entry nameiQ6AY99_RAT
AccessioniPrimary (citable) accession number: Q6AY99
Entry historyiIntegrated into UniProtKB/TrEMBL: September 13, 2004
Last sequence update: September 13, 2004
Last modified: August 30, 2017
This is version 107 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported