Reviewed, UniProtKB/Swiss-Prot Q6AY91 (NRK1_RAT)

Names and origin

Protein names

Recommended name:
    Nicotinamide riboside kinase 1
      Short name=NmR-K 1
      Short name=NRK 1
    EC=2.7.1.22
Alternative name(s):
    Ribosylnicotinamide kinase 1
      Short name=RNK 1
    Nicotinic acid riboside kinase 1
    EC=2.7.1.n4
    Ribosylnicotinic acid kinase 1

Gene names

Name:

Nrk1

Organism

Rattus norvegicus (Rat)

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	195 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Catalyzes the phosphorylation of nicotinamide riboside (NR) and nicotinic acid riboside (NaR) to form nicotinamide mononucleotide (NMN) and nicotinic acid mononucleotide (NaMN) By similarity.
Catalytic activity	ATP + N-ribosylnicotinamide = ADP + nicotinamide ribonucleotide. ATP + D-ribosylnicotinate = ADP + nicotinate D-ribonucleotide.
Pathway	Cofactor biosynthesis; NAD(+) biosynthesis.
Subunit structure	Monomer By similarity.
Sequence similarities	Belongs to the uridine kinase family. NRK subfamily.

Ontologies

Keywords
Biological process	Pyridine nucleotide biosynthesis
Ligand	ATP-binding Magnesium Metal-binding Nucleotide-binding
Molecular function	Kinase Transferase
Gene Ontology (GO)
Biological process	pyridine nucleotide biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW magnesium ion binding Inferred from electronic annotation. Source: UniProtKB-KW ribosylnicotinamide kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 195	195	Nicotinamide riboside kinase 1		PRO_0000215893
Regions
	Nucleotide binding	10 – 18	9	ATP By similarity
	Nucleotide binding	172 – 174	3	ATP By similarity
Sites
	Active site	36	1	Proton acceptor By similarity
	Metal binding	17	1	Magnesium By similarity
	Metal binding	36	1	Magnesium By similarity
	Binding site	56	1	Substrate By similarity
	Binding site	128	1	ATP By similarity
	Binding site	129	1	Substrate By similarity
	Binding site	132	1	ATP By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q6AY91-1 [UniParc]. Last modified September 13, 2004. Version 1. Checksum: 5D5155621DEB7E54	FASTA	195	22,321
	10 20 30 40 50 60 MKTFVIGIGG VTNGGKTTLA KNLQKRLPNC SVISQDDFFK PESEIDIDEN GFLQYDVLEA 70 80 90 100 110 120 LNMEKMMSAV SCWMENPGSS AGPAALESAQ GVPILIIEGF LLFNYKPLDT IWNRSYFLTV 130 140 150 160 170 180 PYEECKRRRS TRVYEPPDPP GYFDGHVWPM YLKHRQEMNS ITWDIVYLDG TRSEEDLFSQ 190 VYEDVKQELE KQNGL

References

[1]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Kidney.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	BC079144 mRNA. Translation: AAH79144.1.
IPI	IPI00464638.
RefSeq	NP_001019463.1.
UniGene	Rn.19716
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q6AY91.
Proteomic databases
PRIDE	Q6AY91.
Genome annotation databases
Ensembl	ENSRNOT00000016930; ENSRNOP00000016930; ENSRNOG00000012665; Rattus norvegicus. [Genome view]
GeneID	499330.
KEGG	rno:499330.
UCSC	NM_001024292. rat.
Organism-specific databases
RGD	1564687. LOC499330.
Phylogenomic databases
HOVERGEN	Q6AY91.
Gene expression databases
Genevestigator	Q6AY91.
Family and domain databases
ProtoNet	Search...
Other Resources
NextBio	702573.

Entry information

Entry name

NRK1_RAT

Accession

Primary (citable) accession number: Q6AY91

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 7, 2004
Last sequence update:	September 13, 2004
Last modified:	October 13, 2009
This is version 33 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)