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Protein

Nicotinamide riboside kinase 1

Gene

Nmrk1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Catalyzes the phosphorylation of nicotinamide riboside (NR) and nicotinic acid riboside (NaR) to form nicotinamide mononucleotide (NMN) and nicotinic acid mononucleotide (NaMN).By similarity

Catalytic activityi

ATP + 1-(beta-D-ribofuranosyl)-nicotinamide = ADP + beta-nicotinamide D-ribonucleotide.By similarity
ATP + beta-D-ribosylnicotinate = ADP + nicotinate beta-D-ribonucleotide.By similarity

Pathwayi: NAD(+) biosynthesis

This protein is involved in the pathway NAD(+) biosynthesis, which is part of Cofactor biosynthesis.By similarity
View all proteins of this organism that are known to be involved in the pathway NAD(+) biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi17 – 171MagnesiumBy similarity
Active sitei36 – 361Proton acceptorBy similarity
Metal bindingi36 – 361MagnesiumBy similarity
Binding sitei128 – 1281ATPBy similarity
Binding sitei129 – 1291SubstrateBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi10 – 189ATPBy similarity
Nucleotide bindingi132 – 1343ATPBy similarity
Nucleotide bindingi172 – 1743ATPBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Pyridine nucleotide biosynthesis

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00253.

Names & Taxonomyi

Protein namesi
Recommended name:
Nicotinamide riboside kinase 1 (EC:2.7.1.22By similarity)
Short name:
NRK 1
Short name:
NmR-K 1
Alternative name(s):
Nicotinic acid riboside kinase 1 (EC:2.7.1.173By similarity)
Ribosylnicotinamide kinase 1
Short name:
RNK 1
Ribosylnicotinic acid kinase 1
Gene namesi
Name:Nmrk1
Synonyms:Nrk1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi1564687. Nmrk1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 195195Nicotinamide riboside kinase 1PRO_0000215893Add
BLAST

Proteomic databases

PaxDbiQ6AY91.
PRIDEiQ6AY91.

Expressioni

Gene expression databases

GenevisibleiQ6AY91. RN.

Interactioni

Subunit structurei

Monomer.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000016930.

Structurei

3D structure databases

ProteinModelPortaliQ6AY91.
SMRiQ6AY91. Positions 2-192.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni36 – 394Substrate bindingBy similarity
Regioni55 – 562Substrate bindingBy similarity
Regioni134 – 1352Substrate bindingBy similarity

Sequence similaritiesi

Belongs to the uridine kinase family. NRK subfamily.Curated

Phylogenomic databases

eggNOGiKOG3308. Eukaryota.
COG0572. LUCA.
GeneTreeiENSGT00510000046782.
HOGENOMiHOG000043899.
HOVERGENiHBG052669.
InParanoidiQ6AY91.
KOiK10524.
OMAiMKTFVIG.
OrthoDBiEOG7JQBPF.
PhylomeDBiQ6AY91.
TreeFamiTF105395.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6AY91-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKTFVIGIGG VTNGGKTTLA KNLQKRLPNC SVISQDDFFK PESEIDIDEN
60 70 80 90 100
GFLQYDVLEA LNMEKMMSAV SCWMENPGSS AGPAALESAQ GVPILIIEGF
110 120 130 140 150
LLFNYKPLDT IWNRSYFLTV PYEECKRRRS TRVYEPPDPP GYFDGHVWPM
160 170 180 190
YLKHRQEMNS ITWDIVYLDG TRSEEDLFSQ VYEDVKQELE KQNGL
Length:195
Mass (Da):22,321
Last modified:September 13, 2004 - v1
Checksum:i5D5155621DEB7E54
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC079144 mRNA. Translation: AAH79144.1.
RefSeqiNP_001019463.1. NM_001024292.1.
UniGeneiRn.19716.

Genome annotation databases

EnsembliENSRNOT00000016930; ENSRNOP00000016930; ENSRNOG00000012665.
GeneIDi499330.
KEGGirno:499330.
UCSCiRGD:1564687. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC079144 mRNA. Translation: AAH79144.1.
RefSeqiNP_001019463.1. NM_001024292.1.
UniGeneiRn.19716.

3D structure databases

ProteinModelPortaliQ6AY91.
SMRiQ6AY91. Positions 2-192.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000016930.

Proteomic databases

PaxDbiQ6AY91.
PRIDEiQ6AY91.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000016930; ENSRNOP00000016930; ENSRNOG00000012665.
GeneIDi499330.
KEGGirno:499330.
UCSCiRGD:1564687. rat.

Organism-specific databases

CTDi54981.
RGDi1564687. Nmrk1.

Phylogenomic databases

eggNOGiKOG3308. Eukaryota.
COG0572. LUCA.
GeneTreeiENSGT00510000046782.
HOGENOMiHOG000043899.
HOVERGENiHBG052669.
InParanoidiQ6AY91.
KOiK10524.
OMAiMKTFVIG.
OrthoDBiEOG7JQBPF.
PhylomeDBiQ6AY91.
TreeFamiTF105395.

Enzyme and pathway databases

UniPathwayiUPA00253.

Miscellaneous databases

PROiQ6AY91.

Gene expression databases

GenevisibleiQ6AY91. RN.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Kidney.

Entry informationi

Entry nameiNRK1_RAT
AccessioniPrimary (citable) accession number: Q6AY91
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 7, 2004
Last sequence update: September 13, 2004
Last modified: June 8, 2016
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.