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Protein

Nicotinamide riboside kinase 1

Gene

Nmrk1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalyzes the phosphorylation of nicotinamide riboside (NR) and nicotinic acid riboside (NaR) to form nicotinamide mononucleotide (NMN) and nicotinic acid mononucleotide (NaMN).By similarity

Catalytic activityi

ATP + 1-(beta-D-ribofuranosyl)-nicotinamide = ADP + beta-nicotinamide D-ribonucleotide.By similarity
ATP + beta-D-ribosylnicotinate = ADP + nicotinate beta-D-ribonucleotide.By similarity

Pathwayi: NAD(+) biosynthesis

This protein is involved in the pathway NAD(+) biosynthesis, which is part of Cofactor biosynthesis.By similarity
View all proteins of this organism that are known to be involved in the pathway NAD(+) biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi17MagnesiumBy similarity1
Active sitei36Proton acceptorBy similarity1
Metal bindingi36MagnesiumBy similarity1
Binding sitei128ATPBy similarity1
Binding sitei129SubstrateBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi10 – 18ATPBy similarity9
Nucleotide bindingi132 – 134ATPBy similarity3
Nucleotide bindingi172 – 174ATPBy similarity3

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
Biological processPyridine nucleotide biosynthesis
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-RNO-196807 Nicotinate metabolism
UniPathwayiUPA00253

Names & Taxonomyi

Protein namesi
Recommended name:
Nicotinamide riboside kinase 1 (EC:2.7.1.22By similarity)
Short name:
NRK 1
Short name:
NmR-K 1
Alternative name(s):
Nicotinic acid riboside kinase 1 (EC:2.7.1.173By similarity)
Ribosylnicotinamide kinase 1
Short name:
RNK 1
Ribosylnicotinic acid kinase 1
Gene namesi
Name:Nmrk1
Synonyms:Nrk1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi1564687 Nmrk1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002158931 – 195Nicotinamide riboside kinase 1Add BLAST195

Proteomic databases

PaxDbiQ6AY91
PRIDEiQ6AY91

Expressioni

Gene expression databases

BgeeiENSRNOG00000012665
GenevisibleiQ6AY91 RN

Interactioni

Subunit structurei

Monomer.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000016930

Structurei

3D structure databases

ProteinModelPortaliQ6AY91
SMRiQ6AY91
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni36 – 39Substrate bindingBy similarity4
Regioni55 – 56Substrate bindingBy similarity2
Regioni134 – 135Substrate bindingBy similarity2

Sequence similaritiesi

Belongs to the uridine kinase family. NRK subfamily.Curated

Phylogenomic databases

eggNOGiKOG3308 Eukaryota
COG0572 LUCA
GeneTreeiENSGT00510000046782
HOGENOMiHOG000043899
HOVERGENiHBG052669
InParanoidiQ6AY91
KOiK10524
OMAiTWEVVYL
OrthoDBiEOG091G0JV5
PhylomeDBiQ6AY91
TreeFamiTF105395

Family and domain databases

InterProiView protein in InterPro
IPR027417 P-loop_NTPase
SUPFAMiSSF52540 SSF52540, 1 hit

Sequencei

Sequence statusi: Complete.

Q6AY91-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKTFVIGIGG VTNGGKTTLA KNLQKRLPNC SVISQDDFFK PESEIDIDEN
60 70 80 90 100
GFLQYDVLEA LNMEKMMSAV SCWMENPGSS AGPAALESAQ GVPILIIEGF
110 120 130 140 150
LLFNYKPLDT IWNRSYFLTV PYEECKRRRS TRVYEPPDPP GYFDGHVWPM
160 170 180 190
YLKHRQEMNS ITWDIVYLDG TRSEEDLFSQ VYEDVKQELE KQNGL
Length:195
Mass (Da):22,321
Last modified:September 13, 2004 - v1
Checksum:i5D5155621DEB7E54
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC079144 mRNA Translation: AAH79144.1
RefSeqiNP_001019463.1, NM_001024292.1
UniGeneiRn.19716

Genome annotation databases

EnsembliENSRNOT00000016930; ENSRNOP00000016930; ENSRNOG00000012665
GeneIDi499330
KEGGirno:499330
UCSCiRGD:1564687 rat

Similar proteinsi

Entry informationi

Entry nameiNRK1_RAT
AccessioniPrimary (citable) accession number: Q6AY91
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 7, 2004
Last sequence update: September 13, 2004
Last modified: May 23, 2018
This is version 82 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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