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Protein

THO complex subunit 6 homolog

Gene

Thoc6

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Acts as component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway. Plays a role in apoptosis negative control involved in brain development (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Apoptosis, mRNA processing, mRNA splicing, mRNA transport, Transport

Keywords - Ligandi

RNA-binding

Enzyme and pathway databases

ReactomeiR-RNO-109688. Cleavage of Growing Transcript in the Termination Region.
R-RNO-159236. Transport of Mature mRNA derived from an Intron-Containing Transcript.
R-RNO-72187. mRNA 3'-end processing.

Names & Taxonomyi

Protein namesi
Recommended name:
THO complex subunit 6 homolog
Alternative name(s):
WD repeat-containing protein 58
Gene namesi
Name:Thoc6
Synonyms:Pdrp, wdr58
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 10

Organism-specific databases

RGDi708553. Thoc6.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002331601 – 341THO complex subunit 6 homologAdd BLAST341

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei180PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ6AY87.
PRIDEiQ6AY87.

PTM databases

iPTMnetiQ6AY87.
PhosphoSitePlusiQ6AY87.

Expressioni

Gene expression databases

BgeeiENSRNOG00000003497.
ExpressionAtlasiQ6AY87. baseline and differential.
GenevisibleiQ6AY87. RN.

Interactioni

Subunit structurei

Component of the THO complex, which is composed of THOC1, THOC2, THOC3, THOC5, THOC6 and THOC7; together with at least ALYREF/THOC4, DDX39B, SARNP/CIP29 and CHTOP, THO forms the transcription/export (TREX) complex which seems to have a dynamic structure involving ATP-dependent remodeling.

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000004672.

Structurei

3D structure databases

ProteinModelPortaliQ6AY87.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati22 – 61WD 1Add BLAST40
Repeati74 – 112WD 2Add BLAST39
Repeati124 – 163WD 3Add BLAST40
Repeati166 – 205WD 4Add BLAST40
Repeati215 – 254WD 5Add BLAST40
Repeati256 – 293WD 6Add BLAST38
Repeati295 – 339WD 7Add BLAST45

Sequence similaritiesi

Belongs to the WD repeat THOC6 family.Curated
Contains 7 WD repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG0649. Eukaryota.
ENOG410XTCD. LUCA.
GeneTreeiENSGT00390000015278.
HOGENOMiHOG000008085.
HOVERGENiHBG079643.
InParanoidiQ6AY87.
KOiK13175.
OMAiGRCVNQW.
OrthoDBiEOG091G0JN9.
PhylomeDBiQ6AY87.
TreeFamiTF324760.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF00400. WD40. 1 hit.
[Graphical view]
SMARTiSM00320. WD40. 3 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS00678. WD_REPEATS_1. 1 hit.
PS50082. WD_REPEATS_2. 1 hit.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6AY87-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEHATPLAVP LGQAEVFQAL QRLHMTIFSQ SVSPCGKFLA AGNNYGQIAI
60 70 80 90 100
FSLSAALSSE AKEESKKPMV TFHAHDGPVY SMVSTDRHLL SAGDGEVKGW
110 120 130 140 150
LWAEILKKGC KELWRRQPPY RTSLEVPEIN ALLLVPKENS LILAGGDCQL
160 170 180 190 200
HTMDLETGTF TRALRGHTDY IHCLALRERS PEVLSGGEDG AVRLWDLRIA
210 220 230 240 250
KEVQTIEVYK HEECSRPHNG RWIGCLATDS DWMVCGGGPA LTLWHLRSST
260 270 280 290 300
PTTVFPIRAP QKHVTFYQDL ILSAGQGCCV NHWQLSGELK AQVPGSSPGL
310 320 330 340
LSLSLNQQPA APECKVLTAS GNSCRVDVFT NLGYRAFSLS F
Length:341
Mass (Da):37,423
Last modified:September 13, 2004 - v1
Checksum:i88BBEA18294B70D3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC079149 mRNA. Translation: AAH79149.1.
RefSeqiNP_077360.2. NM_024384.2.
UniGeneiRn.42184.

Genome annotation databases

EnsembliENSRNOT00000004672; ENSRNOP00000004672; ENSRNOG00000003497.
GeneIDi79227.
KEGGirno:79227.
UCSCiRGD:708553. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC079149 mRNA. Translation: AAH79149.1.
RefSeqiNP_077360.2. NM_024384.2.
UniGeneiRn.42184.

3D structure databases

ProteinModelPortaliQ6AY87.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000004672.

PTM databases

iPTMnetiQ6AY87.
PhosphoSitePlusiQ6AY87.

Proteomic databases

PaxDbiQ6AY87.
PRIDEiQ6AY87.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000004672; ENSRNOP00000004672; ENSRNOG00000003497.
GeneIDi79227.
KEGGirno:79227.
UCSCiRGD:708553. rat.

Organism-specific databases

CTDi79228.
RGDi708553. Thoc6.

Phylogenomic databases

eggNOGiKOG0649. Eukaryota.
ENOG410XTCD. LUCA.
GeneTreeiENSGT00390000015278.
HOGENOMiHOG000008085.
HOVERGENiHBG079643.
InParanoidiQ6AY87.
KOiK13175.
OMAiGRCVNQW.
OrthoDBiEOG091G0JN9.
PhylomeDBiQ6AY87.
TreeFamiTF324760.

Enzyme and pathway databases

ReactomeiR-RNO-109688. Cleavage of Growing Transcript in the Termination Region.
R-RNO-159236. Transport of Mature mRNA derived from an Intron-Containing Transcript.
R-RNO-72187. mRNA 3'-end processing.

Miscellaneous databases

PROiQ6AY87.

Gene expression databases

BgeeiENSRNOG00000003497.
ExpressionAtlasiQ6AY87. baseline and differential.
GenevisibleiQ6AY87. RN.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF00400. WD40. 1 hit.
[Graphical view]
SMARTiSM00320. WD40. 3 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS00678. WD_REPEATS_1. 1 hit.
PS50082. WD_REPEATS_2. 1 hit.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTHOC6_RAT
AccessioniPrimary (citable) accession number: Q6AY87
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 2, 2006
Last sequence update: September 13, 2004
Last modified: November 2, 2016
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.