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Protein

THO complex subunit 6 homolog

Gene

Thoc6

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Acts as component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway. Plays a role in apoptosis negative control involved in brain development (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, RNA-binding
Biological processApoptosis, mRNA processing, mRNA splicing, mRNA transport, Transport

Enzyme and pathway databases

ReactomeiR-RNO-109688 Cleavage of Growing Transcript in the Termination Region
R-RNO-159236 Transport of Mature mRNA derived from an Intron-Containing Transcript
R-RNO-72187 mRNA 3'-end processing

Names & Taxonomyi

Protein namesi
Recommended name:
THO complex subunit 6 homolog
Alternative name(s):
WD repeat-containing protein 58
Gene namesi
Name:Thoc6
Synonyms:Pdrp, wdr58
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 10

Organism-specific databases

RGDi708553 Thoc6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002331601 – 341THO complex subunit 6 homologAdd BLAST341

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei180PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ6AY87
PRIDEiQ6AY87

PTM databases

iPTMnetiQ6AY87
PhosphoSitePlusiQ6AY87

Expressioni

Gene expression databases

BgeeiENSRNOG00000003497
ExpressionAtlasiQ6AY87 baseline and differential
GenevisibleiQ6AY87 RN

Interactioni

Subunit structurei

Component of the THO complex, which is composed of THOC1, THOC2, THOC3, THOC5, THOC6 and THOC7; together with at least ALYREF/THOC4, DDX39B, SARNP/CIP29 and CHTOP, THO forms the transcription/export (TREX) complex which seems to have a dynamic structure involving ATP-dependent remodeling.

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000004672

Structurei

3D structure databases

ProteinModelPortaliQ6AY87
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati22 – 61WD 1Add BLAST40
Repeati74 – 112WD 2Add BLAST39
Repeati124 – 163WD 3Add BLAST40
Repeati166 – 205WD 4Add BLAST40
Repeati215 – 254WD 5Add BLAST40
Repeati256 – 293WD 6Add BLAST38
Repeati295 – 339WD 7Add BLAST45

Sequence similaritiesi

Belongs to the WD repeat THOC6 family.Curated

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG0649 Eukaryota
ENOG410XTCD LUCA
GeneTreeiENSGT00390000015278
HOGENOMiHOG000008085
HOVERGENiHBG079643
InParanoidiQ6AY87
KOiK13175
OMAiDWLLCGG
OrthoDBiEOG091G0JN9
PhylomeDBiQ6AY87
TreeFamiTF324760

Family and domain databases

Gene3Di2.130.10.10, 1 hit
InterProiView protein in InterPro
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR019775 WD40_repeat_CS
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
PfamiView protein in Pfam
PF00400 WD40, 1 hit
SMARTiView protein in SMART
SM00320 WD40, 3 hits
SUPFAMiSSF50978 SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS00678 WD_REPEATS_1, 1 hit
PS50082 WD_REPEATS_2, 1 hit
PS50294 WD_REPEATS_REGION, 1 hit

Sequencei

Sequence statusi: Complete.

Q6AY87-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEHATPLAVP LGQAEVFQAL QRLHMTIFSQ SVSPCGKFLA AGNNYGQIAI
60 70 80 90 100
FSLSAALSSE AKEESKKPMV TFHAHDGPVY SMVSTDRHLL SAGDGEVKGW
110 120 130 140 150
LWAEILKKGC KELWRRQPPY RTSLEVPEIN ALLLVPKENS LILAGGDCQL
160 170 180 190 200
HTMDLETGTF TRALRGHTDY IHCLALRERS PEVLSGGEDG AVRLWDLRIA
210 220 230 240 250
KEVQTIEVYK HEECSRPHNG RWIGCLATDS DWMVCGGGPA LTLWHLRSST
260 270 280 290 300
PTTVFPIRAP QKHVTFYQDL ILSAGQGCCV NHWQLSGELK AQVPGSSPGL
310 320 330 340
LSLSLNQQPA APECKVLTAS GNSCRVDVFT NLGYRAFSLS F
Length:341
Mass (Da):37,423
Last modified:September 13, 2004 - v1
Checksum:i88BBEA18294B70D3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC079149 mRNA Translation: AAH79149.1
RefSeqiNP_077360.2, NM_024384.2
UniGeneiRn.42184

Genome annotation databases

EnsembliENSRNOT00000004672; ENSRNOP00000004672; ENSRNOG00000003497
GeneIDi79227
KEGGirno:79227
UCSCiRGD:708553 rat

Similar proteinsi

Entry informationi

Entry nameiTHOC6_RAT
AccessioniPrimary (citable) accession number: Q6AY87
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 2, 2006
Last sequence update: September 13, 2004
Last modified: May 23, 2018
This is version 108 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health