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Protein

UDP-N-acetylglucosamine transferase subunit ALG14 homolog

Gene

Alg14

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Involved in protein N-glycosylation. Essential for the second step of the dolichol-linked oligosaccharide pathway. Anchors the catalytic subunit ALG13 to the ER (By similarity).By similarity

Enzyme and pathway databases

ReactomeiR-RNO-446193. Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein.

Names & Taxonomyi

Protein namesi
Recommended name:
UDP-N-acetylglucosamine transferase subunit ALG14 homolog
Gene namesi
Name:Alg14
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 2

Organism-specific databases

RGDi1312003. Alg14.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 33LumenalBy similarity
Transmembranei4 – 2421HelicalSequence analysisAdd
BLAST
Topological domaini25 – 216192CytoplasmicBy similarityAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 216216UDP-N-acetylglucosamine transferase subunit ALG14 homologPRO_0000265118Add
BLAST

Proteomic databases

PaxDbiQ6AY85.
PRIDEiQ6AY85.

PTM databases

PhosphoSiteiQ6AY85.

Expressioni

Gene expression databases

BgeeiENSRNOG00000011528.
GenevisibleiQ6AY85. RN.

Interactioni

Subunit structurei

Heterodimer with ALG13 to form a functional enzyme.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000015355.

Structurei

3D structure databases

ProteinModelPortaliQ6AY85.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ALG14 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3339. Eukaryota.
ENOG4111QSM. LUCA.
GeneTreeiENSGT00390000002579.
HOGENOMiHOG000182099.
HOVERGENiHBG059605.
InParanoidiQ6AY85.
KOiK07441.
OMAiFTPRFYI.
OrthoDBiEOG091G0K4A.
PhylomeDBiQ6AY85.
TreeFamiTF105628.

Family and domain databases

InterProiIPR013969. Oligosacch_biosynth_Alg14.
[Graphical view]
PANTHERiPTHR12154. PTHR12154. 1 hit.
PfamiPF08660. Alg14. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6AY85-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVCVLTLAAS AGGLAVLLIV RLWAVLRSHP VTPRQSLGLL IVAGSGGHTA
60 70 80 90 100
EILRLVGSLS GAYSPRHYVI AESDEMSAKK IHSLELARAQ NDSTTEHTEY
110 120 130 140 150
YLHRIPRSRE VRQSWLSSVF TTLYSIWFSF PLVHRIKPDL VLCNGPGTCV
160 170 180 190 200
PICVSALLLG ILGIKKVIIV YVESICRVET LSLSGKILWH LSDYFIVQWP
210
TLKEKYPKSV YLGRIV
Length:216
Mass (Da):23,979
Last modified:September 13, 2004 - v1
Checksum:i803B2963B4D10A58
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC079151 mRNA. Translation: AAH79151.1.
RefSeqiNP_001014198.1. NM_001014176.2.
UniGeneiRn.136923.

Genome annotation databases

EnsembliENSRNOT00000015354; ENSRNOP00000015355; ENSRNOG00000011528.
GeneIDi362031.
KEGGirno:362031.
UCSCiRGD:1312003. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC079151 mRNA. Translation: AAH79151.1.
RefSeqiNP_001014198.1. NM_001014176.2.
UniGeneiRn.136923.

3D structure databases

ProteinModelPortaliQ6AY85.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000015355.

PTM databases

PhosphoSiteiQ6AY85.

Proteomic databases

PaxDbiQ6AY85.
PRIDEiQ6AY85.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000015354; ENSRNOP00000015355; ENSRNOG00000011528.
GeneIDi362031.
KEGGirno:362031.
UCSCiRGD:1312003. rat.

Organism-specific databases

CTDi199857.
RGDi1312003. Alg14.

Phylogenomic databases

eggNOGiKOG3339. Eukaryota.
ENOG4111QSM. LUCA.
GeneTreeiENSGT00390000002579.
HOGENOMiHOG000182099.
HOVERGENiHBG059605.
InParanoidiQ6AY85.
KOiK07441.
OMAiFTPRFYI.
OrthoDBiEOG091G0K4A.
PhylomeDBiQ6AY85.
TreeFamiTF105628.

Enzyme and pathway databases

ReactomeiR-RNO-446193. Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein.

Miscellaneous databases

PROiQ6AY85.

Gene expression databases

BgeeiENSRNOG00000011528.
GenevisibleiQ6AY85. RN.

Family and domain databases

InterProiIPR013969. Oligosacch_biosynth_Alg14.
[Graphical view]
PANTHERiPTHR12154. PTHR12154. 1 hit.
PfamiPF08660. Alg14. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiALG14_RAT
AccessioniPrimary (citable) accession number: Q6AY85
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: September 13, 2004
Last modified: September 7, 2016
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.