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Protein

Secernin-1

Gene

Scrn1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Regulates exocytosis in mast cells. Increases both the extent of secretion and the sensitivity of mast cells to stimulation with calcium (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Exocytosis

Names & Taxonomyi

Protein namesi
Recommended name:
Secernin-1
Gene namesi
Name:Scrn1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 4

Organism-specific databases

RGDi1560999. Scrn1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 414413Secernin-1PRO_0000271394Add
BLAST

Proteomic databases

PaxDbiQ6AY84.
PRIDEiQ6AY84.

PTM databases

iPTMnetiQ6AY84.

Expressioni

Gene expression databases

GenevisibleiQ6AY84. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000013088.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG410IGQK. Eukaryota.
COG4690. LUCA.
GeneTreeiENSGT00390000013474.
HOGENOMiHOG000223307.
HOVERGENiHBG056050.
InParanoidiQ6AY84.
KOiK14358.
OMAiDTELKFF.
OrthoDBiEOG7W1545.
PhylomeDBiQ6AY84.
TreeFamiTF323890.

Family and domain databases

InterProiIPR005322. Peptidase_C69.
[Graphical view]
PfamiPF03577. Peptidase_C69. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6AY84-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGAPPSYSF VALPPRAKDG LVVFGKNSAR PRDEVQEVVY FPAVDHEAES
60 70 80 90 100
KVECTYISID QVPRTHAIVI SRPAWLWGAE MGANEHGVCI ANEAINAREP
110 120 130 140 150
AAETEALLGM DLVRLGLERG TTAKEALDII VSLLDEHGQG GNYYEDAHSC
160 170 180 190 200
HSFQSAYLLV DRDEAWVLET VGKYWAAERI TEGVRCICNH LSLTTKMDEE
210 220 230 240 250
HPELRTYAQS QGWWTGEDEF NFAQVFSPAD DHLDCCAGKD SLEKQEESIT
260 270 280 290 300
VQTMINILRD KASGVCIDSE SFLTTASIVS VLPQNRSSPC IHYFTGTPDP
310 320 330 340 350
SRSIFKPFIF VDDVKLVPKA QSPCFGDDDP AKKEPRFQEK PDRRHELYKA
360 370 380 390 400
HEWARAVIES DQEQGRTLRK TMLELEKQGL EAMEEILSSP EPPDPAEVGD
410
LFYDCVDTEM KFFK
Length:414
Mass (Da):46,396
Last modified:September 13, 2004 - v1
Checksum:iA636EA15FD189CA3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC079152 mRNA. Translation: AAH79152.1.
RefSeqiNP_001020234.1. NM_001025063.1.
XP_006236574.1. XM_006236512.2.
XP_008761138.1. XM_008762916.1.
UniGeneiRn.154317.

Genome annotation databases

EnsembliENSRNOT00000013088; ENSRNOP00000013088; ENSRNOG00000009636.
GeneIDi502776.
KEGGirno:502776.
UCSCiRGD:1560999. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC079152 mRNA. Translation: AAH79152.1.
RefSeqiNP_001020234.1. NM_001025063.1.
XP_006236574.1. XM_006236512.2.
XP_008761138.1. XM_008762916.1.
UniGeneiRn.154317.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000013088.

PTM databases

iPTMnetiQ6AY84.

Proteomic databases

PaxDbiQ6AY84.
PRIDEiQ6AY84.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000013088; ENSRNOP00000013088; ENSRNOG00000009636.
GeneIDi502776.
KEGGirno:502776.
UCSCiRGD:1560999. rat.

Organism-specific databases

CTDi9805.
RGDi1560999. Scrn1.

Phylogenomic databases

eggNOGiENOG410IGQK. Eukaryota.
COG4690. LUCA.
GeneTreeiENSGT00390000013474.
HOGENOMiHOG000223307.
HOVERGENiHBG056050.
InParanoidiQ6AY84.
KOiK14358.
OMAiDTELKFF.
OrthoDBiEOG7W1545.
PhylomeDBiQ6AY84.
TreeFamiTF323890.

Miscellaneous databases

PROiQ6AY84.

Gene expression databases

GenevisibleiQ6AY84. RN.

Family and domain databases

InterProiIPR005322. Peptidase_C69.
[Graphical view]
PfamiPF03577. Peptidase_C69. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Kidney.
  2. Lubec G., Afjehi-Sadat L., Kang S.U.
    Submitted (JUL-2007) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 303-315 AND 356-366, IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: Sprague-Dawley.
    Tissue: Brain and Spinal cord.

Entry informationi

Entry nameiSCRN1_RAT
AccessioniPrimary (citable) accession number: Q6AY84
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: September 13, 2004
Last modified: July 6, 2016
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

'Secern' is an archaic English term meaning 'secrete'.

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.