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Protein

Endomucin

Gene

Emcn

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Endothelial sialomucin, also called endomucin or mucin-like sialoglycoprotein, which interferes with the assembly of focal adhesion complexes and inhibits interaction between cells and the extracellular matrix.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Endomucin
Gene namesi
Name:Emcn
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 2

Organism-specific databases

RGDi1303218. Emcn.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei180 – 20021HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020Sequence analysisAdd
BLAST
Chaini21 – 250230EndomucinPRO_0000249727Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi46 – 461N-linked (GlcNAc...)Sequence analysis
Glycosylationi115 – 1151N-linked (GlcNAc...)Sequence analysis
Glycosylationi119 – 1191N-linked (GlcNAc...)Sequence analysis
Modified residuei226 – 2261PhosphoserineBy similarity

Post-translational modificationi

Highly O-glycosylated. Sialic acid-rich glycoprotein (By similarity).By similarity

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ6AY82.
PRIDEiQ6AY82.

Expressioni

Gene expression databases

GenevisibleiQ6AY82. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000033031.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi27 – 174148Thr-richAdd
BLAST

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J0MP. Eukaryota.
ENOG4111AC7. LUCA.
GeneTreeiENSGT00390000012139.
HOGENOMiHOG000013126.
HOVERGENiHBG052537.
InParanoidiQ6AY82.
KOiK16664.
OMAiTTDVRKN.
OrthoDBiEOG7CNZH6.
PhylomeDBiQ6AY82.
TreeFamiTF337783.

Family and domain databases

InterProiIPR010740. Endomucin.
[Graphical view]
PANTHERiPTHR15869. PTHR15869. 1 hit.
PfamiPF07010. Endomucin. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6AY82-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRLLQVTALF FLLSNSLCRG ENSKALTETS TTKASATTPD MVSITNKSTG
60 70 80 90 100
GTPPKGTTNS ATPKTPLMPA LDSPTTPKHE TTTRGVIKNE VSTIKTTVAN
110 120 130 140 150
PTISNAVSTL SSPQNKTENQ SSIRTTEISG TNQLPDDQKP KTTETPSASL
160 170 180 190 200
TTAKTISQIQ DTEDGKITAT TSTTPSYSSV ILPVVIALIV ITVLVFTLVG
210 220 230 240 250
LYRICWKRDP GTPESGNDQP QSDKESVKLL TVKTISHESG EHSAQGKAKN
Length:250
Mass (Da):26,516
Last modified:September 13, 2004 - v1
Checksum:i5E84CFC5CCEA4B30
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC079155 mRNA. Translation: AAH79155.1.
RefSeqiNP_001004228.1. NM_001004228.1.
UniGeneiRn.8542.

Genome annotation databases

EnsembliENSRNOT00000035700; ENSRNOP00000033031; ENSRNOG00000022910.
GeneIDi295490.
KEGGirno:295490.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC079155 mRNA. Translation: AAH79155.1.
RefSeqiNP_001004228.1. NM_001004228.1.
UniGeneiRn.8542.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000033031.

Proteomic databases

PaxDbiQ6AY82.
PRIDEiQ6AY82.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000035700; ENSRNOP00000033031; ENSRNOG00000022910.
GeneIDi295490.
KEGGirno:295490.

Organism-specific databases

CTDi51705.
RGDi1303218. Emcn.

Phylogenomic databases

eggNOGiENOG410J0MP. Eukaryota.
ENOG4111AC7. LUCA.
GeneTreeiENSGT00390000012139.
HOGENOMiHOG000013126.
HOVERGENiHBG052537.
InParanoidiQ6AY82.
KOiK16664.
OMAiTTDVRKN.
OrthoDBiEOG7CNZH6.
PhylomeDBiQ6AY82.
TreeFamiTF337783.

Miscellaneous databases

PROiQ6AY82.

Gene expression databases

GenevisibleiQ6AY82. RN.

Family and domain databases

InterProiIPR010740. Endomucin.
[Graphical view]
PANTHERiPTHR15869. PTHR15869. 1 hit.
PfamiPF07010. Endomucin. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Kidney.

Entry informationi

Entry nameiMUCEN_RAT
AccessioniPrimary (citable) accession number: Q6AY82
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 19, 2006
Last sequence update: September 13, 2004
Last modified: June 8, 2016
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.