Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Endomucin

Gene

Emcn

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Endothelial sialomucin, also called endomucin or mucin-like sialoglycoprotein, which interferes with the assembly of focal adhesion complexes and inhibits interaction between cells and the extracellular matrix.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Endomucin
Gene namesi
Name:Emcn
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 2

Organism-specific databases

RGDi1303218. Emcn.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei180 – 200HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_000024972721 – 250EndomucinAdd BLAST230

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi46N-linked (GlcNAc...)Sequence analysis1
Glycosylationi115N-linked (GlcNAc...)Sequence analysis1
Glycosylationi119N-linked (GlcNAc...)Sequence analysis1
Modified residuei226PhosphoserineBy similarity1

Post-translational modificationi

Highly O-glycosylated. Sialic acid-rich glycoprotein (By similarity).By similarity

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ6AY82.
PRIDEiQ6AY82.

Expressioni

Gene expression databases

BgeeiENSRNOG00000022910.
GenevisibleiQ6AY82. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000033031.

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi27 – 174Thr-richAdd BLAST148

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J0MP. Eukaryota.
ENOG4111AC7. LUCA.
GeneTreeiENSGT00390000012139.
HOGENOMiHOG000013126.
HOVERGENiHBG052537.
InParanoidiQ6AY82.
KOiK16664.
OMAiTTDVRKN.
OrthoDBiEOG091G16TF.
PhylomeDBiQ6AY82.
TreeFamiTF337783.

Family and domain databases

InterProiIPR010740. Endomucin.
[Graphical view]
PANTHERiPTHR15869. PTHR15869. 1 hit.
PfamiPF07010. Endomucin. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6AY82-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRLLQVTALF FLLSNSLCRG ENSKALTETS TTKASATTPD MVSITNKSTG
60 70 80 90 100
GTPPKGTTNS ATPKTPLMPA LDSPTTPKHE TTTRGVIKNE VSTIKTTVAN
110 120 130 140 150
PTISNAVSTL SSPQNKTENQ SSIRTTEISG TNQLPDDQKP KTTETPSASL
160 170 180 190 200
TTAKTISQIQ DTEDGKITAT TSTTPSYSSV ILPVVIALIV ITVLVFTLVG
210 220 230 240 250
LYRICWKRDP GTPESGNDQP QSDKESVKLL TVKTISHESG EHSAQGKAKN
Length:250
Mass (Da):26,516
Last modified:September 13, 2004 - v1
Checksum:i5E84CFC5CCEA4B30
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC079155 mRNA. Translation: AAH79155.1.
RefSeqiNP_001004228.1. NM_001004228.1.
UniGeneiRn.8542.

Genome annotation databases

EnsembliENSRNOT00000035700; ENSRNOP00000033031; ENSRNOG00000022910.
GeneIDi295490.
KEGGirno:295490.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC079155 mRNA. Translation: AAH79155.1.
RefSeqiNP_001004228.1. NM_001004228.1.
UniGeneiRn.8542.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000033031.

Proteomic databases

PaxDbiQ6AY82.
PRIDEiQ6AY82.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000035700; ENSRNOP00000033031; ENSRNOG00000022910.
GeneIDi295490.
KEGGirno:295490.

Organism-specific databases

CTDi51705.
RGDi1303218. Emcn.

Phylogenomic databases

eggNOGiENOG410J0MP. Eukaryota.
ENOG4111AC7. LUCA.
GeneTreeiENSGT00390000012139.
HOGENOMiHOG000013126.
HOVERGENiHBG052537.
InParanoidiQ6AY82.
KOiK16664.
OMAiTTDVRKN.
OrthoDBiEOG091G16TF.
PhylomeDBiQ6AY82.
TreeFamiTF337783.

Miscellaneous databases

PROiQ6AY82.

Gene expression databases

BgeeiENSRNOG00000022910.
GenevisibleiQ6AY82. RN.

Family and domain databases

InterProiIPR010740. Endomucin.
[Graphical view]
PANTHERiPTHR15869. PTHR15869. 1 hit.
PfamiPF07010. Endomucin. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMUCEN_RAT
AccessioniPrimary (citable) accession number: Q6AY82
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 19, 2006
Last sequence update: September 13, 2004
Last modified: September 7, 2016
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.