Reviewed, UniProtKB/Swiss-Prot Q6AY80 (NQO2_RAT)

Names and origin

Protein names

Recommended name:
    Ribosyldihydronicotinamide dehydrogenase [quinone]
    EC=1.10.99.2
Alternative name(s):
    NRH dehydrogenase [quinone] 2
    NRH:quinone oxidoreductase 2
      Short name=Quinone reductase 2
      Short name=QR2

Gene names

Name:

Nqo2

Organism

Rattus norvegicus (Rat)

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	231 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	The enzyme apparently serves as a quinone reductase in connection with conjugation reactions of hydroquinones involved in detoxification pathways as well as in biosynthetic processes such as the vitamin K-dependent gamma-carboxylation of glutamate residues in prothrombin synthesis By similarity.
Catalytic activity	1-(beta-D-ribofuranosyl)-1,4-dihydronicotinamide + a quinone = 1-(beta-D-ribofuranosyl)nicotinamide + a hydroquinone.
Cofactor	Binds 1 zinc ion per subunit By similarity. FAD By similarity.
Subunit structure	Homodimer By similarity.
Subcellular location	CytoplasmBy similarity.
Miscellaneous	Uses dihydronicotinamide riboside (NRH) rather than NAD(P)H as an electron donor.
Sequence similarities	Belongs to the NAD(P)H dehydrogenase (quinone) family.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	FAD Flavoprotein Metal-binding Zinc
Molecular function	Oxidoreductase
Technical term	Direct protein sequencing
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	coenzyme binding Inferred from electronic annotation. Source: InterPro dihydronicotinamide riboside quinone reductase activity Inferred from electronic annotation. Source: EC electron carrier activity Inferred from electronic annotation. Source: InterPro zinc ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed By similarity
	Chain	2 – 231	230	Ribosyldihydronicotinamide dehydrogenase [quinone]		PRO_0000071629
Sites
	Metal binding	174	1	Zinc By similarity
	Metal binding	178	1	Zinc By similarity
	Metal binding	223	1	Zinc By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q6AY80-1 [UniParc]. Last modified January 23, 2007. Version 3. Checksum: 9B15F21CD005850A	FASTA	231	26,275
	10 20 30 40 50 60 MAGKKVLLVY AHQEPKSFNG SMKQVAVEEL SKQGCTVTVS DLYTMNFEPR ATRNDVTGAL 70 80 90 100 110 120 SNPEVFKYGI EAYEAYKKKA LTSDILEEQR KVQEADLVIF QFPLYWFSVP AILKGWMDRV 130 140 150 160 170 180 LCQGFAFDVP GFYDSGFLKD KLALLSFTTG GTAEMYTKAG VNGDFRYFLW PLQHGTLHFC 190 200 210 220 230 GFKVLAPQIS FGPEVSSEEQ RKVMLASWVQ RLKSIWKEEP IHCTPSWYFQ G

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Kidney.
[2]	Lubec G., Afjehi-Sadat L. Submitted (NOV-2006) to UniProtKB Cited for: PROTEIN SEQUENCE OF 184-201, MASS SPECTROMETRY. Strain: Sprague-Dawley. Tissue: Spinal cord.

Cross-references

Sequence databases
EMBLGenBankDDBJ	BC079157 mRNA. Translation: AAH79157.1.
RefSeq	NP_001004214.1.
UniGene	Rn.7882
3D structure databases
SMR	Q6AY80. Positions 1-228, 2-229.
ModBase	Search...
Genome annotation databases
Ensembl	ENSRNOG00000017820. Rattus norvegicus. [Contig view]
GeneID	291084.
KEGG	rno:291084.
NMPDR	fig|10116.3.peg.13235.
Organism-specific databases
RGD	1303320. Nqo2.
Phylogenomic databases
HOVERGEN	Q6AY80.
Gene expression databases
ArrayExpress	Q6AY80.
GermOnline	ENSRNOG00000017820. Rattus norvegicus.
Family and domain databases
InterPro	IPR003680. Flavodoxin_fold. [Graphical view]
Pfam	PF02525. Flavodoxin_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	632093.

Entry information

Entry name

NQO2_RAT

Accession

Primary (citable) accession number: Q6AY80

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 13, 2005
Last sequence update:	January 23, 2007
Last modified:	November 25, 2008
This is version 36 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)