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Protein

Autophagy-related protein 101

Gene

Atg101

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Autophagy factor required for autophagosome formation. Stabilizes ATG13, protecting it from proteasomal degradation.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processAutophagy

Enzyme and pathway databases

ReactomeiR-RNO-1632852 Macroautophagy

Names & Taxonomyi

Protein namesi
Recommended name:
Autophagy-related protein 101
Gene namesi
Name:Atg101
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 7

Organism-specific databases

RGDi1359310 Atg101

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002943241 – 218Autophagy-related protein 101Add BLAST218

Proteomic databases

PaxDbiQ6AY69

PTM databases

PhosphoSitePlusiQ6AY69

Expressioni

Gene expression databases

BgeeiENSRNOG00000007756
GenevisibleiQ6AY69 RN

Interactioni

Subunit structurei

Interacts with ATG13. Associates with a complex composed of ATG13, ULK1 and RB1CC1; the association with this complex requires the presence of ATG13.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000010195

Structurei

3D structure databases

SMRiQ6AY69
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni152 – 156Important for interaction with ATG13By similarity5

Sequence similaritiesi

Belongs to the ATG101 family.Curated

Phylogenomic databases

eggNOGiKOG4493 Eukaryota
ENOG410XP6A LUCA
GeneTreeiENSGT00390000016511
HOGENOMiHOG000008086
InParanoidiQ6AY69
KOiK19730
OMAiIDCDFID
OrthoDBiEOG091G076X
PhylomeDBiQ6AY69
TreeFamiTF320996

Family and domain databases

InterProiView protein in InterPro
IPR012445 ATG101
PANTHERiPTHR13292 PTHR13292, 1 hit
PfamiView protein in Pfam
PF07855 ATG101, 1 hit

Sequencei

Sequence statusi: Complete.

Q6AY69-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNCRSEVLEV SVEGRQVEEA MLAVLHTVLL HRSTGKFHYK KEGTYSIGTV
60 70 80 90 100
GIQDVDCDFI DFTYVRVSSE ELDRALRKVV GEFKDALRNS GGDGLGQMSL
110 120 130 140 150
EFYQKKKSRW PFSDECIPWE VWTVKVHVVA LATEQERQIC REKVGEKLCE
160 170 180 190 200
KIINIVEVMS RHEYLPKMPT QSELDNVFDT GLRDVQPYLY KISFQITEAL
210
GTSVTTTMRR LIKDTLAL
Length:218
Mass (Da):25,016
Last modified:September 13, 2004 - v1
Checksum:i41E2844EFED0CB56
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC079170 mRNA Translation: AAH79170.1
RefSeqiNP_001007660.2, NM_001007659.2
NP_001258043.1, NM_001271114.1
XP_006242386.1, XM_006242324.3
UniGeneiRn.4038

Genome annotation databases

EnsembliENSRNOT00000010194; ENSRNOP00000010195; ENSRNOG00000007756
ENSRNOT00000087415; ENSRNOP00000071030; ENSRNOG00000007756
GeneIDi300240
KEGGirno:300240
UCSCiRGD:1359310 rat

Similar proteinsi

Entry informationi

Entry nameiATGA1_RAT
AccessioniPrimary (citable) accession number: Q6AY69
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: September 13, 2004
Last modified: April 25, 2018
This is version 84 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health