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Protein

Autophagy-related protein 101

Gene

Atg101

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Autophagy factor required for autophagosome formation. Stabilizes ATG13, protecting it from proteasomal degradation.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processAutophagy

Enzyme and pathway databases

ReactomeiR-RNO-1632852. Macroautophagy.

Names & Taxonomyi

Protein namesi
Recommended name:
Autophagy-related protein 101
Gene namesi
Name:Atg101
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 7

Organism-specific databases

RGDi1359310. Atg101.

Subcellular locationi

  • Cytoplasm By similarity
  • Preautophagosomal structure By similarity

  • Note: Under starvation conditions, it is localized to puncate structures primarily representing the isolation membrane; the isolation membrane sequesters a portion of the cytoplasm resulting in autophagosome formation.By similarity

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002943241 – 218Autophagy-related protein 101Add BLAST218

Proteomic databases

PaxDbiQ6AY69.

PTM databases

PhosphoSitePlusiQ6AY69.

Expressioni

Gene expression databases

BgeeiENSRNOG00000007756.
GenevisibleiQ6AY69. RN.

Interactioni

Subunit structurei

Interacts with ATG13. Associates with a complex composed of ATG13, ULK1 and RB1CC1; the association with this complex requires the presence of ATG13.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000010195.

Structurei

3D structure databases

SMRiQ6AY69.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni152 – 156Important for interaction with ATG13By similarity5

Sequence similaritiesi

Belongs to the ATG101 family.Curated

Phylogenomic databases

eggNOGiKOG4493. Eukaryota.
ENOG410XP6A. LUCA.
GeneTreeiENSGT00390000016511.
HOGENOMiHOG000008086.
InParanoidiQ6AY69.
KOiK19730.
OMAiMGQISLE.
OrthoDBiEOG091G076X.
PhylomeDBiQ6AY69.
TreeFamiTF320996.

Family and domain databases

InterProiView protein in InterPro
IPR012445. ATG101.
PANTHERiPTHR13292. PTHR13292. 1 hit.
PfamiView protein in Pfam
PF07855. ATG101. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6AY69-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNCRSEVLEV SVEGRQVEEA MLAVLHTVLL HRSTGKFHYK KEGTYSIGTV
60 70 80 90 100
GIQDVDCDFI DFTYVRVSSE ELDRALRKVV GEFKDALRNS GGDGLGQMSL
110 120 130 140 150
EFYQKKKSRW PFSDECIPWE VWTVKVHVVA LATEQERQIC REKVGEKLCE
160 170 180 190 200
KIINIVEVMS RHEYLPKMPT QSELDNVFDT GLRDVQPYLY KISFQITEAL
210
GTSVTTTMRR LIKDTLAL
Length:218
Mass (Da):25,016
Last modified:September 13, 2004 - v1
Checksum:i41E2844EFED0CB56
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC079170 mRNA. Translation: AAH79170.1.
RefSeqiNP_001007660.2. NM_001007659.2.
NP_001258043.1. NM_001271114.1.
XP_006242386.1. XM_006242324.3.
UniGeneiRn.4038.

Genome annotation databases

EnsembliENSRNOT00000010194; ENSRNOP00000010195; ENSRNOG00000007756.
ENSRNOT00000087415; ENSRNOP00000071030; ENSRNOG00000007756.
GeneIDi300240.
KEGGirno:300240.
UCSCiRGD:1359310. rat.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiATGA1_RAT
AccessioniPrimary (citable) accession number: Q6AY69
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: September 13, 2004
Last modified: May 10, 2017
This is version 80 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families