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Protein

Arfaptin-2

Gene

Arfip2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Putative target protein of ADP-ribosylation factor. Involved in membrane ruffling (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-RNO-6811440. Retrograde transport at the Trans-Golgi-Network.

Names & Taxonomyi

Protein namesi
Recommended name:
Arfaptin-2
Alternative name(s):
ADP-ribosylation factor-interacting protein 2
Gene namesi
Name:Arfip2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi1303204. Arfip2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 341341Arfaptin-2PRO_0000064669Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei72 – 721PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ6AY65.
PRIDEiQ6AY65.

Expressioni

Gene expression databases

BgeeiENSRNOG00000018440.
GenevisibleiQ6AY65. RN.

Interactioni

Subunit structurei

Interacts with RAC1 by binding directly to it. Specifically binds to GTP-bound ARF1 and ARF6, but binds to RAC1.GTP and RAC1.GDP with similar affinities (By similarity). Directly interacts with ARL1 GTP-bound form; this interaction leads to an increase in the amount of bound GTP at steady state level (By similarity).By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000025159.

Structurei

3D structure databases

ProteinModelPortaliQ6AY65.
SMRiQ6AY65. Positions 119-319.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini121 – 321201AHPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 AH domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG3876. Eukaryota.
ENOG410YJUM. LUCA.
GeneTreeiENSGT00500000044828.
HOGENOMiHOG000236308.
HOVERGENiHBG050564.
InParanoidiQ6AY65.
KOiK20314.
OMAiYFSGNQQ.
OrthoDBiEOG091G0H30.
PhylomeDBiQ6AY65.
TreeFamiTF314945.

Family and domain databases

Gene3Di1.20.1270.60. 1 hit.
InterProiIPR027267. AH/BAR-dom.
IPR010504. AH_dom.
IPR030798. Arfaptin_fam.
[Graphical view]
PANTHERiPTHR12141. PTHR12141. 1 hit.
PfamiPF06456. Arfaptin. 1 hit.
[Graphical view]
SMARTiSM01015. Arfaptin. 1 hit.
[Graphical view]
PROSITEiPS50870. AH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6AY65-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTDGILGKAA TMEIPIHGNG EAGQLPEDDG LEQDLQQVMV SGPNLNETSI
60 70 80 90 100
VSGGYGGSGD GLIPTGSGRH PSHSTSPSGP GDEVARGIAG EKFDIVKKWG
110 120 130 140 150
INTYKCTKQL LSERFGRGSR TVDLELELQI ELLRETKRKY ESVLQLGRAL
160 170 180 190 200
TAHLYSLLQT QHALGDAFAD LSQKSPELQE EFGYNAETQK LLCKNGETLL
210 220 230 240 250
GAVNFFVSSI NTLVTKTMED TLMTVKQYEA ARLEYDAYRT DLEELSLGPR
260 270 280 290 300
DAGTRGRLES AQATFQTHRD KYEKLRGDVA IKLKFLEENK IKVMHKQLLL
310 320 330 340
FHNAVSAYFA GNQKQLEQTL QQFNIKLRPP GAEKPSWLEE Q
Length:341
Mass (Da):37,773
Last modified:September 13, 2004 - v1
Checksum:iAA3BE39EF0C75037
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC079174 mRNA. Translation: AAH79174.1.
RefSeqiNP_001004222.1. NM_001004222.1.
XP_006229995.1. XM_006229933.2.
UniGeneiRn.73878.

Genome annotation databases

EnsembliENSRNOT00000025159; ENSRNOP00000025159; ENSRNOG00000018440.
GeneIDi293344.
KEGGirno:293344.
UCSCiRGD:1303204. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC079174 mRNA. Translation: AAH79174.1.
RefSeqiNP_001004222.1. NM_001004222.1.
XP_006229995.1. XM_006229933.2.
UniGeneiRn.73878.

3D structure databases

ProteinModelPortaliQ6AY65.
SMRiQ6AY65. Positions 119-319.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000025159.

Proteomic databases

PaxDbiQ6AY65.
PRIDEiQ6AY65.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000025159; ENSRNOP00000025159; ENSRNOG00000018440.
GeneIDi293344.
KEGGirno:293344.
UCSCiRGD:1303204. rat.

Organism-specific databases

CTDi23647.
RGDi1303204. Arfip2.

Phylogenomic databases

eggNOGiKOG3876. Eukaryota.
ENOG410YJUM. LUCA.
GeneTreeiENSGT00500000044828.
HOGENOMiHOG000236308.
HOVERGENiHBG050564.
InParanoidiQ6AY65.
KOiK20314.
OMAiYFSGNQQ.
OrthoDBiEOG091G0H30.
PhylomeDBiQ6AY65.
TreeFamiTF314945.

Enzyme and pathway databases

ReactomeiR-RNO-6811440. Retrograde transport at the Trans-Golgi-Network.

Miscellaneous databases

PROiQ6AY65.

Gene expression databases

BgeeiENSRNOG00000018440.
GenevisibleiQ6AY65. RN.

Family and domain databases

Gene3Di1.20.1270.60. 1 hit.
InterProiIPR027267. AH/BAR-dom.
IPR010504. AH_dom.
IPR030798. Arfaptin_fam.
[Graphical view]
PANTHERiPTHR12141. PTHR12141. 1 hit.
PfamiPF06456. Arfaptin. 1 hit.
[Graphical view]
SMARTiSM01015. Arfaptin. 1 hit.
[Graphical view]
PROSITEiPS50870. AH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiARFP2_RAT
AccessioniPrimary (citable) accession number: Q6AY65
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: September 13, 2004
Last modified: September 7, 2016
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.