Reviewed, UniProtKB/Swiss-Prot Q6AY63 (NUDT5_RAT)

Names and origin

Protein names

Recommended name:
    ADP-sugar pyrophosphatase
    EC=3.6.1.13
    EC=3.6.1.-
Alternative name(s):
    Nucleoside diphosphate-linked moiety X motif 5
      Short name=Nudix motif 5

Gene names

Name:

Nudt5

Organism

Rattus norvegicus (Rat)

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	219 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Hydrolyzes with similar activities ADP-ribose, ADP-mannose, and ADP-glucose. Can also hydrolyze other nucleotide sugars with low activity By similarity.
Catalytic activity	ADP-ribose + H2O = AMP + D-ribose 5-phosphate. ADP-sugar + H2O = AMP + alpha-D-aldose 5-phosphate.
Cofactor	Magnesium By similarity.
Subunit structure	Homodimer By similarity.
Sequence similarities	Belongs to the Nudix hydrolase family.

Ontologies

Keywords
Ligand	Magnesium
Molecular function	Hydrolase
PTM	Phosphoprotein
Gene Ontology (GO)
Molecular function	ADP-ribose diphosphatase activity Inferred from electronic annotation. Source: EC magnesium ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 219	219	ADP-sugar pyrophosphatase		PRO_0000250703
Regions
	Motif	97 – 118	22	Nudix box
Amino acid modifications
	Modified residue	9	1	Phosphoserine By similarity
	Modified residue	10	1	Phosphoserine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q6AY63-1 [UniParc]. Last modified September 13, 2004. Version 1. Checksum: 87AFCD2BDD6E4B04	FASTA	219	24,117
	10 20 30 40 50 60 METQEPKDSS PPTEQRILSE ELISEGKWVK FEKTTYMDPT GKTRTWETVK LTTRKGKSAD 70 80 90 100 110 120 AVSVIPVLQR TLHHECIVLV KQFRPPMGGY CLEFPAGLIE DGESPEAAAL RELEEETGYK 130 140 150 160 170 180 GDIAECSPAV CMDPGLSNCT THVVTVTING DDAGNVRPKP KPGDGEFVEV ISLPKNDLLT 190 200 210 RLDALGAEDR LTVDARVYAY ALALKHANAK PFEVPFLKF

References

[1]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Kidney.

Cross-references

Sequence databases
EMBLGenBankDDBJ	BC079176 mRNA. Translation: AAH79176.1.
IPI	IPI00364928.
RefSeq	NP_001007734.1.
UniGene	Rn.55388
3D structure databases
SMR	Q6AY63. Positions 14-219.
ModBase	Search...
Genome annotation databases
Ensembl	ENSRNOG00000017741. Rattus norvegicus. [Contig view]
GeneID	361274.
KEGG	rno:361274.
Organism-specific databases
RGD	1359284. Nudt5.
Phylogenomic databases
HOVERGEN	Q6AY63.
Enzyme and pathway databases
BRENDA	3.6.1.13. 248.
Gene expression databases
ArrayExpress	Q6AY63.
GermOnline	ENSRNOG00000017741. Rattus norvegicus.
Family and domain databases
InterPro	IPR000086. NUDIX_hydrolase_core. [Graphical view]
Gene3D	G3DSA:3.90.79.10. NUDIX_hydrolase. 1 hit.
Pfam	PF00293. NUDIX. 1 hit. [Graphical view]
PROSITE	PS00893. NUDIX. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	675785.

Entry information

Entry name

NUDT5_RAT

Accession

Primary (citable) accession number: Q6AY63

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 3, 2006
Last sequence update:	September 13, 2004
Last modified:	June 16, 2009
This is version 41 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)