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Q6AY63 (NUDT5_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified November 16, 2011. Version 62. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
ADP-sugar pyrophosphatase

EC=3.6.1.-
EC=3.6.1.13
Alternative name(s):
Nucleoside diphosphate-linked moiety X motif 5
Short name=Nudix motif 5
Gene names
Name:Nudt5
OrganismRattus norvegicus (Rat)
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length219 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Hydrolyzes with similar activities ADP-ribose, ADP-mannose, and ADP-glucose. Can also hydrolyze other nucleotide sugars with low activity By similarity.

Catalytic activity

ADP-ribose + H2O = AMP + D-ribose 5-phosphate.

ADP-sugar + H2O = AMP + alpha-D-aldose 5-phosphate.

Cofactor

Binds 3 magnesium ions per subunit By similarity.

Subunit structure

Homodimer By similarity.

Sequence similarities

Belongs to the Nudix hydrolase family.

Contains 1 nudix hydrolase domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 219219ADP-sugar pyrophosphatase
PRO_0000250703

Regions

Domain57 – 197141Nudix hydrolase
Region46 – 472Substrate binding; shared with dimeric partner By similarity
Motif97 – 11822Nudix box

Sites

Metal binding961Magnesium 1; via carbonyl oxygen By similarity
Metal binding1121Magnesium 2 By similarity
Metal binding1121Magnesium 3 By similarity
Metal binding1161Magnesium 1 By similarity
Metal binding1161Magnesium 3 By similarity
Metal binding1661Magnesium 3 By similarity
Binding site281Substrate By similarity
Binding site841Substrate By similarity
Binding site981Substrate; via amide nitrogen By similarity
Binding site1331Substrate By similarity

Amino acid modifications

Modified residue11N-acetylmethionine By similarity
Modified residue91Phosphoserine By similarity
Modified residue101Phosphoserine By similarity
Modified residue421N6-acetyllysine By similarity
Modified residue2101N6-acetyllysine By similarity
Modified residue2181N6-acetyllysine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q6AY63 [UniParc].

Last modified September 13, 2004. Version 1.
Checksum: 87AFCD2BDD6E4B04

FASTA21924,117
        10         20         30         40         50         60 
METQEPKDSS PPTEQRILSE ELISEGKWVK FEKTTYMDPT GKTRTWETVK LTTRKGKSAD 

        70         80         90        100        110        120 
AVSVIPVLQR TLHHECIVLV KQFRPPMGGY CLEFPAGLIE DGESPEAAAL RELEEETGYK 

       130        140        150        160        170        180 
GDIAECSPAV CMDPGLSNCT THVVTVTING DDAGNVRPKP KPGDGEFVEV ISLPKNDLLT 

       190        200        210 
RLDALGAEDR LTVDARVYAY ALALKHANAK PFEVPFLKF 

« Hide

References

[1]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Kidney.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC079176 mRNA. Translation: AAH79176.1.
IPIIPI00364928.
RefSeqNP_001007734.1. NM_001007733.1.
UniGeneRn.55388.

3D structure databases

ProteinModelPortalQ6AY63.
SMRQ6AY63. Positions 14-219.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ6AY63.

Proteomic databases

PRIDEQ6AY63.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000068551; ENSRNOP00000060464; ENSRNOG00000017741.
GeneID361274.
KEGGrno:361274.
UCSCNM_001007733. rat.

Organism-specific databases

CTD11164.
RGD1359284. Nudt5.

Phylogenomic databases

eggNOGroNOG08100.
GeneTreeENSGT00390000006280.
HOVERGENHBG052691.
InParanoidQ6AY63.
OrthoDBEOG46Q6TG.
PhylomeDBQ6AY63.

Gene expression databases

ArrayExpressQ6AY63.
GenevestigatorQ6AY63.
GermOnlineENSRNOG00000017741. Rattus norvegicus.

Family and domain databases

InterProIPR020476. Nudix_hydrolase.
IPR020084. NUDIX_hydrolase_CS.
IPR000086. NUDIX_hydrolase_dom.
IPR015797. NUDIX_hydrolase_dom-like.
[Graphical view]
Gene3DG3DSA:3.90.79.10. NUDIX_hydrolase. 1 hit.
KOK13987.
PfamPF00293. NUDIX. 1 hit.
[Graphical view]
PRINTSPR00502. NUDIXFAMILY.
SUPFAMSSF55811. NUDIX_hydrolase. 1 hit.
PROSITEPS51462. NUDIX. 1 hit.
PS00893. NUDIX_BOX. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio675785.

Entry information

Entry nameNUDT5_RAT
AccessionPrimary (citable) accession number: Q6AY63
Entry history
Integrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: September 13, 2004
Last modified: November 16, 2011
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families