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Reviewed, UniProtKB/Swiss-Prot Q6AY63 (NUDT5_RAT)

Last modified June 16, 2009. Version 41. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    ADP-sugar pyrophosphatase
    EC=3.6.1.13
    EC=3.6.1.-
Alternative name(s):
    Nucleoside diphosphate-linked moiety X motif 5
      Short name=Nudix motif 5
Gene names
Name: Nudt5
OrganismRattus norvegicus (Rat)
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length219 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at transcript level.

General annotation (Comments)

Function

Hydrolyzes with similar activities ADP-ribose, ADP-mannose, and ADP-glucose. Can also hydrolyze other nucleotide sugars with low activity By similarity.

Catalytic activity

ADP-ribose + H2O = AMP + D-ribose 5-phosphate.

ADP-sugar + H2O = AMP + alpha-D-aldose 5-phosphate.

Cofactor

Magnesium By similarity.

Subunit structure

Homodimer By similarity.

Sequence similarities

Belongs to the Nudix hydrolase family.

Ontologies

Keywords
   LigandMagnesium
   Molecular functionHydrolase
   PTMPhosphoprotein
Gene Ontology (GO)
   Molecular functionADP-ribose diphosphatase activity

Inferred from electronic annotation. Source: EC

magnesium ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 219219ADP-sugar pyrophosphatase
PRO_0000250703

Regions

Motif97 – 11822Nudix box

Amino acid modifications

Modified residue91Phosphoserine By similarity
Modified residue101Phosphoserine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q6AY63-1 [UniParc].

Last modified September 13, 2004. Version 1.
Checksum: 87AFCD2BDD6E4B04

FASTA21924,117
        10         20         30         40         50         60 
METQEPKDSS PPTEQRILSE ELISEGKWVK FEKTTYMDPT GKTRTWETVK LTTRKGKSAD 

        70         80         90        100        110        120 
AVSVIPVLQR TLHHECIVLV KQFRPPMGGY CLEFPAGLIE DGESPEAAAL RELEEETGYK 

       130        140        150        160        170        180 
GDIAECSPAV CMDPGLSNCT THVVTVTING DDAGNVRPKP KPGDGEFVEV ISLPKNDLLT 

       190        200        210 
RLDALGAEDR LTVDARVYAY ALALKHANAK PFEVPFLKF 

« Hide

References

[1]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Kidney.

Cross-references

Sequence databases

BC079176 mRNA. Translation: AAH79176.1.
IPIIPI00364928.
RefSeqNP_001007734.1.
UniGeneRn.55388

3D structure databases

SMRQ6AY63. Positions 14-219.
ModBaseSearch...

Genome annotation databases

EnsemblENSRNOG00000017741. Rattus norvegicus. [Contig view]
GeneID361274.
KEGGrno:361274.

Organism-specific databases

RGD1359284. Nudt5.

Phylogenomic databases

HOVERGENQ6AY63.

Enzyme and pathway databases

BRENDA3.6.1.13. 248.

Gene expression databases

ArrayExpressQ6AY63.
GermOnlineENSRNOG00000017741. Rattus norvegicus.

Family and domain databases

InterProIPR000086. NUDIX_hydrolase_core.
[Graphical view]
Gene3DG3DSA:3.90.79.10. NUDIX_hydrolase. 1 hit.
PfamPF00293. NUDIX. 1 hit.
[Graphical view]
PROSITEPS00893. NUDIX. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio675785.

Entry information

Entry nameNUDT5_RAT
AccessionPrimary (citable) accession number: Q6AY63
Entry history
Integrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: September 13, 2004
Last modified: June 16, 2009
This is version 41 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

Relevant documents

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents