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Protein

Neuferricin

Gene

Cyb5d2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Heme-binding protein which promotes neuronal but not astrocyte differentiation.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Neurogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Neuferricin
Alternative name(s):
Cytochrome b5 domain-containing protein 2
Gene namesi
Name:Cyb5d2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 10

Organism-specific databases

RGDi1359124. Cyb5d2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222Sequence analysisAdd
BLAST
Chaini23 – 263241NeuferricinPRO_0000312323Add
BLAST

Proteomic databases

PaxDbiQ6AY62.
PRIDEiQ6AY62.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000038452.

Structurei

3D structure databases

ProteinModelPortaliQ6AY62.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini35 – 134100Cytochrome b5 heme-bindingAdd
BLAST

Domaini

The cytochrome b5 heme-binding domain was proven to bind heme, although it lacks the conserved iron-binding His residues at position 73 and 106.By similarity

Sequence similaritiesi

Belongs to the cytochrome b5 family. MAPR subfamily.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG1108. Eukaryota.
ENOG4111JSU. LUCA.
GeneTreeiENSGT00730000110948.
HOVERGENiHBG105428.
InParanoidiQ6AY62.
OMAiGWWGPRA.
OrthoDBiEOG7HXCSZ.
PhylomeDBiQ6AY62.
TreeFamiTF313943.

Family and domain databases

Gene3Di3.10.120.10. 1 hit.
InterProiIPR001199. Cyt_B5-like_heme/steroid-bd.
[Graphical view]
PfamiPF00173. Cyt-b5. 1 hit.
[Graphical view]
SMARTiSM01117. Cyt-b5. 1 hit.
[Graphical view]
SUPFAMiSSF55856. SSF55856. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6AY62-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLRICGLGVV LSLAVAAAAV LAVWLMDWWG SHPSIRLFVP EELARYRGGP
60 70 80 90 100
GDPGLYLALL GRVYDVSSGR KHYEPGAHYS GFAGRDASRA FVTGDYSEAG
110 120 130 140 150
LVDDVNGLSS SEILTLHNWL SFYEKNYVFV GRLIGRFYGK DGLPTSELTQ
160 170 180 190 200
VEAMVTKGME ANEQEQREKQ RFPPCNAEWS SAKGSRLWCS QKSGGVHRDW
210 220 230 240 250
IGVPRKLYKP GAKEPHCVCV RTTGPPSDQQ DNPRHSNRGD LDNPNLEEYT
260
GCPPLAVTCF FPL
Length:263
Mass (Da):29,065
Last modified:September 13, 2004 - v1
Checksum:i57CBF0F66D455159
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC079177 mRNA. Translation: AAH79177.1.
RefSeqiNP_001007672.1. NM_001007671.1.
UniGeneiRn.144924.

Genome annotation databases

EnsembliENSRNOT00000036942; ENSRNOP00000038452; ENSRNOG00000024553.
GeneIDi303293.
KEGGirno:303293.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC079177 mRNA. Translation: AAH79177.1.
RefSeqiNP_001007672.1. NM_001007671.1.
UniGeneiRn.144924.

3D structure databases

ProteinModelPortaliQ6AY62.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000038452.

Proteomic databases

PaxDbiQ6AY62.
PRIDEiQ6AY62.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000036942; ENSRNOP00000038452; ENSRNOG00000024553.
GeneIDi303293.
KEGGirno:303293.

Organism-specific databases

CTDi124936.
RGDi1359124. Cyb5d2.

Phylogenomic databases

eggNOGiKOG1108. Eukaryota.
ENOG4111JSU. LUCA.
GeneTreeiENSGT00730000110948.
HOVERGENiHBG105428.
InParanoidiQ6AY62.
OMAiGWWGPRA.
OrthoDBiEOG7HXCSZ.
PhylomeDBiQ6AY62.
TreeFamiTF313943.

Miscellaneous databases

PROiQ6AY62.

Family and domain databases

Gene3Di3.10.120.10. 1 hit.
InterProiIPR001199. Cyt_B5-like_heme/steroid-bd.
[Graphical view]
PfamiPF00173. Cyt-b5. 1 hit.
[Graphical view]
SMARTiSM01117. Cyt-b5. 1 hit.
[Graphical view]
SUPFAMiSSF55856. SSF55856. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Kidney.

Entry informationi

Entry nameiNEUFC_RAT
AccessioniPrimary (citable) accession number: Q6AY62
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: September 13, 2004
Last modified: June 8, 2016
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.