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Protein

Molybdopterin synthase catalytic subunit

Gene

Mocs2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic subunit of the molybdopterin synthase complex, a complex that catalyzes the conversion of precursor Z into molybdopterin. Acts by mediating the incorporation of 2 sulfur atoms from thiocarboxylated MOCS2A into precursor Z to generate a dithiolene group.UniRule annotation

Catalytic activityi

Cyclic pyranopterin phosphate + 2 [molybdopterin-synthase sulfur-carrier protein]-Gly-NH-CH(2)-C(O)SH + H2O = molybdopterin + 2 [molybdopterin-synthase sulfur-carrier protein].UniRule annotation

Pathwayi: molybdopterin biosynthesis

This protein is involved in the pathway molybdopterin biosynthesis, which is part of Cofactor biosynthesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway molybdopterin biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei170 – 1701SubstrateUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Molybdenum cofactor biosynthesis

Enzyme and pathway databases

ReactomeiR-RNO-947581. Molybdenum cofactor biosynthesis.
UniPathwayiUPA00344.

Names & Taxonomyi

Protein namesi
Recommended name:
Molybdopterin synthase catalytic subunitUniRule annotation (EC:2.8.1.12UniRule annotation)
Alternative name(s):
Molybdenum cofactor synthesis protein 2 large subunitUniRule annotation
Molybdenum cofactor synthesis protein 2BUniRule annotation
Short name:
MOCS2BUniRule annotation
Gene namesi
Name:Mocs2UniRule annotation
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 2

Organism-specific databases

RGDi1359477. Mocs2.

Subcellular locationi

  • Cytoplasmcytosol UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 200200Molybdopterin synthase catalytic subunitPRO_0000369327Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei20 – 201PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ6AY59.
PRIDEiQ6AY59.

Expressioni

Gene expression databases

GenevisibleiQ6AY59. RN.

Interactioni

Subunit structurei

Heterotetramer; composed of 2 small (MOCS2A) and 2 large (MOCS2B) subunits.UniRule annotation

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000015781.

Structurei

3D structure databases

ProteinModelPortaliQ6AY59.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni154 – 1552Substrate bindingUniRule annotation
Regioni177 – 1793Substrate bindingUniRule annotation

Sequence similaritiesi

Belongs to the MoaE family. MOCS2B subfamily.UniRule annotation

Phylogenomic databases

eggNOGiKOG3307. Eukaryota.
COG0314. LUCA.
GeneTreeiENSGT00510000047669.
HOGENOMiHOG000280877.
InParanoidiQ6AY59.
KOiK03635.
OMAiRTMLTIC.
OrthoDBiEOG70088J.
PhylomeDBiQ6AY59.
TreeFamiTF314334.

Family and domain databases

Gene3Di3.90.1170.40. 1 hit.
HAMAPiMF_03052. MOC2B.
InterProiIPR028888. MOCS2B_euk.
IPR003448. Mopterin_biosynth_MoaE.
[Graphical view]
PANTHERiPTHR23404:SF2. PTHR23404:SF2. 1 hit.
PfamiPF02391. MoaE. 1 hit.
[Graphical view]
SUPFAMiSSF54690. SSF54690. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6AY59-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSLEINNSC FSLETKLPSS HQSVEDSASE PSGYEAKDPP QDTLKDVDDV
60 70 80 90 100
LEKPKDIIQF TAKKLSVGEV SQLVVSPLCG AVSLFVGTTR NNFEGKKVIS
110 120 130 140 150
LEYEAYLPMA ENEIRKICND IRQKWPVRHI AVFHRLGLVP VSEASTVIAV
160 170 180 190 200
SSAHRAASLE AVSYAIDSLK AKVPIWKKEI YEESTSSWKR NKECFWAADD
Length:200
Mass (Da):22,233
Last modified:September 13, 2004 - v1
Checksum:i8CCEF5D50263F879
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC079181 mRNA. Translation: AAH79181.1.
RefSeqiNP_001007634.1. NM_001007633.2.
NP_001155885.1. NM_001162413.1.
UniGeneiRn.13568.

Genome annotation databases

EnsembliENSRNOT00000082990; ENSRNOP00000073722; ENSRNOG00000056325.
ENSRNOT00000083668; ENSRNOP00000069073; ENSRNOG00000056325.
GeneIDi294753.
KEGGirno:294753.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC079181 mRNA. Translation: AAH79181.1.
RefSeqiNP_001007634.1. NM_001007633.2.
NP_001155885.1. NM_001162413.1.
UniGeneiRn.13568.

3D structure databases

ProteinModelPortaliQ6AY59.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000015781.

Proteomic databases

PaxDbiQ6AY59.
PRIDEiQ6AY59.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000082990; ENSRNOP00000073722; ENSRNOG00000056325.
ENSRNOT00000083668; ENSRNOP00000069073; ENSRNOG00000056325.
GeneIDi294753.
KEGGirno:294753.

Organism-specific databases

CTDi4338.
RGDi1359477. Mocs2.

Phylogenomic databases

eggNOGiKOG3307. Eukaryota.
COG0314. LUCA.
GeneTreeiENSGT00510000047669.
HOGENOMiHOG000280877.
InParanoidiQ6AY59.
KOiK03635.
OMAiRTMLTIC.
OrthoDBiEOG70088J.
PhylomeDBiQ6AY59.
TreeFamiTF314334.

Enzyme and pathway databases

UniPathwayiUPA00344.
ReactomeiR-RNO-947581. Molybdenum cofactor biosynthesis.

Miscellaneous databases

PROiQ6AY59.

Gene expression databases

GenevisibleiQ6AY59. RN.

Family and domain databases

Gene3Di3.90.1170.40. 1 hit.
HAMAPiMF_03052. MOC2B.
InterProiIPR028888. MOCS2B_euk.
IPR003448. Mopterin_biosynth_MoaE.
[Graphical view]
PANTHERiPTHR23404:SF2. PTHR23404:SF2. 1 hit.
PfamiPF02391. MoaE. 1 hit.
[Graphical view]
SUPFAMiSSF54690. SSF54690. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Kidney.

Entry informationi

Entry nameiMOC2B_RAT
AccessioniPrimary (citable) accession number: Q6AY59
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: September 13, 2004
Last modified: June 8, 2016
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

This protein is produced by a bicistronic gene which also produces the small subunit (MOCS2A) from an overlapping reading frame.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.