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Protein

Deoxyhypusine synthase

Gene

Dhps

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a specific lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine residue.By similarity

Catalytic activityi

[eIF5A-precursor]-lysine + spermidine = [eIF5A-precursor]-deoxyhypusine + propane-1,3-diamine.

Cofactori

NAD+By similarity

Pathwayi: eIF5A hypusination

This protein is involved in the pathway eIF5A hypusination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway eIF5A hypusination and in Protein modification.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei137NADBy similarity1
Binding sitei238NADBy similarity1
Binding sitei243SpermidineBy similarity1
Binding sitei283NAD; via amide nitrogenBy similarity1
Binding sitei288SpermidineBy similarity1
Active sitei329NucleophileBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi105 – 109NADBy similarity5
Nucleotide bindingi131 – 133NADBy similarity3
Nucleotide bindingi308 – 309NADBy similarity2
Nucleotide bindingi342 – 343NADBy similarity2

GO - Molecular functioni

  • deoxyhypusine synthase activity Source: RGD
  • identical protein binding Source: Ensembl

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processHypusine biosynthesis
LigandNAD

Enzyme and pathway databases

ReactomeiR-RNO-204626 Hypusine synthesis from eIF5A-lysine
UniPathwayiUPA00354

Names & Taxonomyi

Protein namesi
Recommended name:
Deoxyhypusine synthase (EC:2.5.1.46)
Short name:
DHS
Gene namesi
Name:Dhps
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 19

Organism-specific databases

RGDi1303326 Dhps

Subcellular locationi

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL2539

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001344701 – 369Deoxyhypusine synthaseAdd BLAST369

Proteomic databases

PaxDbiQ6AY53
PRIDEiQ6AY53

Expressioni

Gene expression databases

BgeeiENSRNOG00000004219
GenevisibleiQ6AY53 RN

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ6AY53, 1 interactor
MINTiQ6AY53
STRINGi10116.ENSRNOP00000005656

Chemistry databases

BindingDBiQ6AY53

Structurei

3D structure databases

ProteinModelPortaliQ6AY53
SMRiQ6AY53
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni136 – 137Spermidine bindingBy similarity2
Regioni314 – 316Spermidine bindingBy similarity3
Regioni323 – 329Spermidine bindingBy similarity7

Sequence similaritiesi

Belongs to the deoxyhypusine synthase family.Curated

Phylogenomic databases

eggNOGiKOG2924 Eukaryota
COG1899 LUCA
GeneTreeiENSGT00390000008063
HOGENOMiHOG000228838
HOVERGENiHBG000852
InParanoidiQ6AY53
KOiK00809
OMAiGWEDSTM
OrthoDBiEOG091G09FV
PhylomeDBiQ6AY53
TreeFamiTF300625

Family and domain databases

Gene3Di3.40.910.10, 1 hit
InterProiView protein in InterPro
IPR002773 Deoxyhypusine_synthase
IPR036982 Deoxyhypusine_synthase_sf
IPR029035 DHS-like_NAD/FAD-binding_dom
PANTHERiPTHR11703 PTHR11703, 1 hit
PfamiView protein in Pfam
PF01916 DS, 1 hit
SUPFAMiSSF52467 SSF52467, 1 hit
TIGRFAMsiTIGR00321 dhys, 1 hit

Sequencei

Sequence statusi: Complete.

Q6AY53-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEGTPSGAAP SSALAAVLKH SSALPPESAQ VQGYDFNRGV DYHALLEAYG
60 70 80 90 100
TTGFQATNFG RAVQQVNAMI EKKLEPLAVD EDHHEDLTQS RRPLTGCTIF
110 120 130 140 150
LGYTSNLISS GIRETIRYLV QHNMVDVLVT TAGGVEEDLI KCLAPTYLGE
160 170 180 190 200
FSLRGKELRE NGINRIGNLL VPNDNYCKFE DWLMPILDQM VQEQNTEGVK
210 220 230 240 250
WTPSKMISRL GKEINNPESV YYWAHKNHIP VLSPALTDGS LGDMIFFHSY
260 270 280 290 300
KNPGLVLDIV EDLRLINMQA IFAKRTGMII LGGGVVKHHI ANANLMRNGA
310 320 330 340 350
DYAVYINTAQ EFDGSDSGAR PDEAVSWGKI RMDAQPVKVY ADASLVFPLL
360
VAETFAQKAD AFRAEKNED
Length:369
Mass (Da):40,705
Last modified:September 13, 2004 - v1
Checksum:i8707A21A9E8D5202
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC079188 mRNA Translation: AAH79188.1
RefSeqiNP_001004207.1, NM_001004207.1
UniGeneiRn.105891

Genome annotation databases

EnsembliENSRNOT00000005656; ENSRNOP00000005656; ENSRNOG00000004219
GeneIDi288923
KEGGirno:288923

Similar proteinsi

Entry informationi

Entry nameiDHYS_RAT
AccessioniPrimary (citable) accession number: Q6AY53
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: September 13, 2004
Last modified: May 23, 2018
This is version 100 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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