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Protein

tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRMT61A

Gene

Trmt61a

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic subunit of tRNA (adenine-N(1)-)-methyltransferase, which catalyzes the formation of N(1)-methyladenine at position 58 (m1A58) in initiator methionyl-tRNA.By similarity

Catalytic activityi

S-adenosyl-L-methionine + adenine(58) in tRNA = S-adenosyl-L-homocysteine + N(1)-methyladenine(58) in tRNA.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei87S-adenosyl-L-methionine; via amide nitrogenBy similarity1
Binding sitei135S-adenosyl-L-methioninePROSITE-ProRule annotationBy similarity1
Binding sitei140S-adenosyl-L-methionineBy similarity1
Binding sitei181S-adenosyl-L-methioninePROSITE-ProRule annotationBy similarity1
Binding sitei279SubstrateBy similarity1

GO - Molecular functioni

Keywordsi

Molecular functionMethyltransferase, Transferase
Biological processtRNA processing
LigandS-adenosyl-L-methionine

Names & Taxonomyi

Protein namesi
Recommended name:
tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRMT61A (EC:2.1.1.220By similarity)
Alternative name(s):
tRNA(m1A58)-methyltransferase subunit TRMT61A
Short name:
tRNA(m1A58)MTase subunit TRMT61A
Gene namesi
Name:Trmt61a
Synonyms:Trm61
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 6

Organism-specific databases

RGDi1359191. Trmt61a.

Subcellular locationi

  • Nucleus By similarity

GO - Cellular componenti

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00002330962 – 290tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRMT61AAdd BLAST289

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiQ6AY46.

Expressioni

Gene expression databases

BgeeiENSRNOG00000011398.
GenevisibleiQ6AY46. RN.

Interactioni

Subunit structurei

Heterotetramer; composed of two copies of TRMT6 and two copies of TRMT61A.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000015308.

Structurei

3D structure databases

ProteinModelPortaliQ6AY46.
SMRiQ6AY46.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni20 – 22SubstrateBy similarity3
Regioni35 – 42SubstrateBy similarity8
Regioni64 – 65SubstrateBy similarity2
Regioni85 – 89SubstrateBy similarity5
Regioni110 – 117SubstrateBy similarity8
Regioni114 – 116S-adenosyl-L-methionine bindingBy similarity3
Regioni163 – 164S-adenosyl-L-methionine bindingBy similarity2
Regioni180 – 183SubstrateBy similarity4
Regioni205 – 212SubstrateBy similarity8

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM61 family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG2915. Eukaryota.
COG2519. LUCA.
GeneTreeiENSGT00510000048063.
HOGENOMiHOG000173282.
HOVERGENiHBG061059.
InParanoidiQ6AY46.
KOiK07442.
OMAiTTQMSRL.
PhylomeDBiQ6AY46.
TreeFamiTF315053.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
InterProiView protein in InterPro
IPR029063. SAM-dependent_MTases.
IPR014816. tRNA_MeTrfase_Gcd14.
PANTHERiPTHR12133. PTHR12133. 1 hit.
PfamiView protein in Pfam
PF08704. GCD14. 1 hit.
PIRSFiPIRSF017269. GCD14. 1 hit.
SUPFAMiSSF53335. SSF53335. 1 hit.
PROSITEiView protein in PROSITE
PS51620. SAM_TRM61. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6AY46-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSFVAYEELI KEGDTAILSL GHGSMVAVRV QRGAQTQTRH GVLRHSVDLI
60 70 80 90 100
GRPFGSKVTC SRGGWVYVLH PTPELWTVNL PHRTQILYST DIALITMMLE
110 120 130 140 150
LRPGSVVCES GTGSGSVSHA IIRSIAPTGH LHTVEFHQQR ADKAREEFQQ
160 170 180 190 200
HRVSQWVTVH TQDVCRSGFG VVHVADAVFL DIPSPWEAVG HAWDALKVEG
210 220 230 240 250
GRFCSFSPCI EQVQRTCQAL AAHGFTELST LEVLPQVYNV RTVSLPLPDL
260 270 280 290
GADDLEGNVG SDATPFRSGT PMKETVGHTG YLTFATKTPG
Length:290
Mass (Da):31,619
Last modified:September 13, 2004 - v1
Checksum:i15C7491656F8813C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC079198 mRNA. Translation: AAH79198.1.
RefSeqiNP_001007707.1. NM_001007706.1.
XP_008763160.1. XM_008764938.2.
XP_008763197.1. XM_008764975.2.
XP_008763198.1. XM_008764976.2.
XP_017458788.1. XM_017603299.1.
UniGeneiRn.54722.

Genome annotation databases

EnsembliENSRNOT00000015308; ENSRNOP00000015308; ENSRNOG00000011398.
ENSRNOT00000078211; ENSRNOP00000071623; ENSRNOG00000011398.
ENSRNOT00000086997; ENSRNOP00000072725; ENSRNOG00000011398.
GeneIDi103692719.
314462.
KEGGirno:103692719.
rno:314462.
UCSCiRGD:1359191. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC079198 mRNA. Translation: AAH79198.1.
RefSeqiNP_001007707.1. NM_001007706.1.
XP_008763160.1. XM_008764938.2.
XP_008763197.1. XM_008764975.2.
XP_008763198.1. XM_008764976.2.
XP_017458788.1. XM_017603299.1.
UniGeneiRn.54722.

3D structure databases

ProteinModelPortaliQ6AY46.
SMRiQ6AY46.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000015308.

Proteomic databases

PaxDbiQ6AY46.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000015308; ENSRNOP00000015308; ENSRNOG00000011398.
ENSRNOT00000078211; ENSRNOP00000071623; ENSRNOG00000011398.
ENSRNOT00000086997; ENSRNOP00000072725; ENSRNOG00000011398.
GeneIDi103692719.
314462.
KEGGirno:103692719.
rno:314462.
UCSCiRGD:1359191. rat.

Organism-specific databases

CTDi115708.
RGDi1359191. Trmt61a.

Phylogenomic databases

eggNOGiKOG2915. Eukaryota.
COG2519. LUCA.
GeneTreeiENSGT00510000048063.
HOGENOMiHOG000173282.
HOVERGENiHBG061059.
InParanoidiQ6AY46.
KOiK07442.
OMAiTTQMSRL.
PhylomeDBiQ6AY46.
TreeFamiTF315053.

Miscellaneous databases

PROiPR:Q6AY46.

Gene expression databases

BgeeiENSRNOG00000011398.
GenevisibleiQ6AY46. RN.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
InterProiView protein in InterPro
IPR029063. SAM-dependent_MTases.
IPR014816. tRNA_MeTrfase_Gcd14.
PANTHERiPTHR12133. PTHR12133. 1 hit.
PfamiView protein in Pfam
PF08704. GCD14. 1 hit.
PIRSFiPIRSF017269. GCD14. 1 hit.
SUPFAMiSSF53335. SSF53335. 1 hit.
PROSITEiView protein in PROSITE
PS51620. SAM_TRM61. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiTRM61_RAT
AccessioniPrimary (citable) accession number: Q6AY46
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 2, 2006
Last sequence update: September 13, 2004
Last modified: April 12, 2017
This is version 102 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.