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Protein

UDP-GalNAc:beta-1,3-N-acetylgalactosaminyltransferase 1

Gene

B3galnt1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Transfers N-acetylgalactosamine onto globotriaosylceramide.By similarity

Catalytic activityi

UDP-N-acetyl-alpha-D-galactosamine + alpha-D-galactosyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide = UDP + N-acetyl-beta-D-galactosaminyl-(1->3)-alpha-D-galactosyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide.By similarity

Cofactori

Mg2+By similarity

Pathwayi: protein glycosylation

This protein is involved in the pathway protein glycosylation, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein glycosylation and in Protein modification.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosyltransferase, Transferase
LigandMagnesium

Enzyme and pathway databases

ReactomeiR-RNO-1660662 Glycosphingolipid metabolism
UniPathwayiUPA00378

Protein family/group databases

CAZyiGT31 Glycosyltransferase Family 31

Names & Taxonomyi

Protein namesi
Recommended name:
UDP-GalNAc:beta-1,3-N-acetylgalactosaminyltransferase 1 (EC:2.4.1.79By similarity)
Short name:
Beta-1,3-GalNAc-T1
Alternative name(s):
Beta-1,3-galactosyltransferase 3
Short name:
Beta-1,3-GalTase 3
Short name:
Beta3Gal-T3
Short name:
Beta3GalT3
Short name:
b3Gal-T3
Beta-3-Gx-T3
Galactosylgalactosylglucosylceramide beta-D-acetyl-galactosaminyltransferase
Globoside synthase
UDP-N-acetylgalactosamine:globotriaosylceramide beta-1,3-N-acetylgalactosaminyltransferase
Gene namesi
Name:B3galnt1
Synonyms:B3galt3
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 2

Organism-specific databases

RGDi1304797 B3galnt1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 20CytoplasmicSequence analysisAdd BLAST20
Transmembranei21 – 43Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST23
Topological domaini44 – 331LumenalSequence analysisAdd BLAST288

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002191581 – 331UDP-GalNAc:beta-1,3-N-acetylgalactosaminyltransferase 1Add BLAST331

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi72N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi154N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi198N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi212N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi326N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ6AY39
PRIDEiQ6AY39

PTM databases

iPTMnetiQ6AY39
PhosphoSitePlusiQ6AY39

Expressioni

Gene expression databases

BgeeiENSRNOG00000012019
GenevisibleiQ6AY39 RN

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000016012

Structurei

3D structure databases

ProteinModelPortaliQ6AY39
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyltransferase 31 family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2287 Eukaryota
ENOG410ZZ1B LUCA
GeneTreeiENSGT00760000118879
HOGENOMiHOG000059604
HOVERGENiHBG101817
InParanoidiQ6AY39
KOiK00719
OMAiRFTLREH
OrthoDBiEOG091G0AXM
PhylomeDBiQ6AY39
TreeFamiTF318639

Family and domain databases

InterProiView protein in InterPro
IPR002659 Glyco_trans_31
PANTHERiPTHR11214 PTHR11214, 1 hit
PfamiView protein in Pfam
PF01762 Galactosyl_T, 1 hit

Sequencei

Sequence statusi: Complete.

Q6AY39-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPAVLTAIP NRMSLRSLKW SLLLLSLLSF LVIWYLSLPH YNVIERVNWM
60 70 80 90 100
YFYEYEPIYR QDFQFTLREH SNCSQQNPFL VILVTSRPSD VKARQAIRVT
110 120 130 140 150
WGEKKTWWGH EVLTFFLLGQ EAEREDKVLA LSLEDEHALY GDIIRQDFLD
160 170 180 190 200
TYNNLTLKTI MAFRWVIEFC PNAKYVMKTD TDVFINTGNL VKYLLNLNHS
210 220 230 240 250
EKFFTGYPLI ENYSYRGFFH KNHISYQEYP FKVFPPYCSG LGYIMSGDLV
260 270 280 290 300
PKIYEMMGHV KPIKFEDVYV GICLNLLKVD IHIPEDTNLF FLFRIHLDVC
310 320 330
QLRRVIAAHG FSSKEIITFW QVMLRNTTCH Y
Length:331
Mass (Da):39,215
Last modified:September 13, 2004 - v1
Checksum:iA0BF5A919A99339F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC079206 mRNA Translation: AAH79206.1
RefSeqiNP_001013176.1, NM_001013158.1
XP_017446356.1, XM_017590867.1
XP_017446357.1, XM_017590868.1
XP_017446358.1, XM_017590869.1
XP_017446359.1, XM_017590870.1
UniGeneiRn.3666

Genome annotation databases

EnsembliENSRNOT00000016012; ENSRNOP00000016012; ENSRNOG00000012019
GeneIDi310508
KEGGirno:310508
UCSCiRGD:1304797 rat

Similar proteinsi

Entry informationi

Entry nameiB3GL1_RAT
AccessioniPrimary (citable) accession number: Q6AY39
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: September 13, 2004
Last modified: May 23, 2018
This is version 106 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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