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Q6AY39

- B3GL1_RAT

UniProt

Q6AY39 - B3GL1_RAT

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Protein

UDP-GalNAc:beta-1,3-N-acetylgalactosaminyltransferase 1

Gene

B3galnt1

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Transfers N-acetylgalactosamine onto globotriaosylceramide.By similarity

Catalytic activityi

UDP-N-acetyl-alpha-D-galactosamine + alpha-D-galactosyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide = UDP + N-acetyl-beta-D-galactosaminyl-(1->3)-alpha-D-galactosyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide.

Cofactori

Mg2+By similarity

Pathwayi

GO - Molecular functioni

  1. galactosylgalactosylglucosylceramide beta-D-acetylgalactosaminyltransferase activity Source: UniProtKB-EC
  2. UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity Source: Ensembl

GO - Biological processi

  1. oligosaccharide biosynthetic process Source: Ensembl
  2. protein glycosylation Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Ligandi

Magnesium

Enzyme and pathway databases

UniPathwayiUPA00378.

Protein family/group databases

CAZyiGT31. Glycosyltransferase Family 31.

Names & Taxonomyi

Protein namesi
Recommended name:
UDP-GalNAc:beta-1,3-N-acetylgalactosaminyltransferase 1 (EC:2.4.1.79)
Short name:
Beta-1,3-GalNAc-T1
Alternative name(s):
Beta-1,3-galactosyltransferase 3
Short name:
Beta-1,3-GalTase 3
Short name:
Beta3Gal-T3
Short name:
Beta3GalT3
Short name:
b3Gal-T3
Beta-3-Gx-T3
Galactosylgalactosylglucosylceramide beta-D-acetyl-galactosaminyltransferase
Globoside synthase
UDP-N-acetylgalactosamine:globotriaosylceramide beta-1,3-N-acetylgalactosaminyltransferase
Gene namesi
Name:B3galnt1
Synonyms:B3galt3
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 2

Organism-specific databases

RGDi1304797. B3galnt1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2020CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei21 – 4323Helical; Signal-anchor for type II membrane proteinSequence AnalysisAdd
BLAST
Topological domaini44 – 331288LumenalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. Golgi apparatus Source: UniProtKB-KW
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 331331UDP-GalNAc:beta-1,3-N-acetylgalactosaminyltransferase 1PRO_0000219158Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi72 – 721N-linked (GlcNAc...)Sequence Analysis
Glycosylationi154 – 1541N-linked (GlcNAc...)Sequence Analysis
Glycosylationi198 – 1981N-linked (GlcNAc...)Sequence Analysis
Glycosylationi212 – 2121N-linked (GlcNAc...)Sequence Analysis
Glycosylationi326 – 3261N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PRIDEiQ6AY39.

PTM databases

PhosphoSiteiQ6AY39.

Expressioni

Gene expression databases

GenevestigatoriQ6AY39.

Interactioni

Protein-protein interaction databases

MINTiMINT-4655782.
STRINGi10116.ENSRNOP00000016012.

Structurei

3D structure databases

ProteinModelPortaliQ6AY39.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyltransferase 31 family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG269758.
GeneTreeiENSGT00760000118879.
HOGENOMiHOG000059604.
HOVERGENiHBG101817.
InParanoidiQ6AY39.
KOiK00719.
OMAiCPNAKYI.
OrthoDBiEOG7M3J0F.
PhylomeDBiQ6AY39.
TreeFamiTF318639.

Family and domain databases

InterProiIPR002659. Glyco_trans_31.
[Graphical view]
PANTHERiPTHR11214. PTHR11214. 1 hit.
PfamiPF01762. Galactosyl_T. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6AY39-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAPAVLTAIP NRMSLRSLKW SLLLLSLLSF LVIWYLSLPH YNVIERVNWM
60 70 80 90 100
YFYEYEPIYR QDFQFTLREH SNCSQQNPFL VILVTSRPSD VKARQAIRVT
110 120 130 140 150
WGEKKTWWGH EVLTFFLLGQ EAEREDKVLA LSLEDEHALY GDIIRQDFLD
160 170 180 190 200
TYNNLTLKTI MAFRWVIEFC PNAKYVMKTD TDVFINTGNL VKYLLNLNHS
210 220 230 240 250
EKFFTGYPLI ENYSYRGFFH KNHISYQEYP FKVFPPYCSG LGYIMSGDLV
260 270 280 290 300
PKIYEMMGHV KPIKFEDVYV GICLNLLKVD IHIPEDTNLF FLFRIHLDVC
310 320 330
QLRRVIAAHG FSSKEIITFW QVMLRNTTCH Y
Length:331
Mass (Da):39,215
Last modified:September 13, 2004 - v1
Checksum:iA0BF5A919A99339F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC079206 mRNA. Translation: AAH79206.1.
RefSeqiNP_001013176.1. NM_001013158.1.
XP_008759311.1. XM_008761089.1.
UniGeneiRn.3666.

Genome annotation databases

EnsembliENSRNOT00000016012; ENSRNOP00000016012; ENSRNOG00000012019.
GeneIDi310508.
KEGGirno:310508.
UCSCiRGD:1304797. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC079206 mRNA. Translation: AAH79206.1 .
RefSeqi NP_001013176.1. NM_001013158.1.
XP_008759311.1. XM_008761089.1.
UniGenei Rn.3666.

3D structure databases

ProteinModelPortali Q6AY39.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

MINTi MINT-4655782.
STRINGi 10116.ENSRNOP00000016012.

Protein family/group databases

CAZyi GT31. Glycosyltransferase Family 31.

PTM databases

PhosphoSitei Q6AY39.

Proteomic databases

PRIDEi Q6AY39.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000016012 ; ENSRNOP00000016012 ; ENSRNOG00000012019 .
GeneIDi 310508.
KEGGi rno:310508.
UCSCi RGD:1304797. rat.

Organism-specific databases

CTDi 8706.
RGDi 1304797. B3galnt1.

Phylogenomic databases

eggNOGi NOG269758.
GeneTreei ENSGT00760000118879.
HOGENOMi HOG000059604.
HOVERGENi HBG101817.
InParanoidi Q6AY39.
KOi K00719.
OMAi CPNAKYI.
OrthoDBi EOG7M3J0F.
PhylomeDBi Q6AY39.
TreeFami TF318639.

Enzyme and pathway databases

UniPathwayi UPA00378 .

Miscellaneous databases

NextBioi 662077.
PROi Q6AY39.

Gene expression databases

Genevestigatori Q6AY39.

Family and domain databases

InterProi IPR002659. Glyco_trans_31.
[Graphical view ]
PANTHERi PTHR11214. PTHR11214. 1 hit.
Pfami PF01762. Galactosyl_T. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.

Entry informationi

Entry nameiB3GL1_RAT
AccessioniPrimary (citable) accession number: Q6AY39
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: September 13, 2004
Last modified: November 26, 2014
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3