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Q6AY39 (B3GL1_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 85. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
UDP-GalNAc:beta-1,3-N-acetylgalactosaminyltransferase 1

Short name=Beta-1,3-GalNAc-T1
EC=2.4.1.79
Alternative name(s):
Beta-1,3-galactosyltransferase 3
Short name=Beta-1,3-GalTase 3
Short name=Beta3Gal-T3
Short name=Beta3GalT3
Short name=b3Gal-T3
Beta-3-Gx-T3
Galactosylgalactosylglucosylceramide beta-D-acetyl-galactosaminyltransferase
Globoside synthase
UDP-N-acetylgalactosamine:globotriaosylceramide beta-1,3-N-acetylgalactosaminyltransferase
Gene names
Name:B3galnt1
Synonyms:B3galt3
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length331 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Transfers N-acetylgalactosamine onto globotriaosylceramide By similarity.

Catalytic activity

UDP-N-acetyl-alpha-D-galactosamine + alpha-D-galactosyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide = UDP + N-acetyl-beta-D-galactosaminyl-(1->3)-alpha-D-galactosyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide.

Cofactor

Magnesium By similarity.

Pathway

Protein modification; protein glycosylation.

Subcellular location

Golgi apparatus membrane; Single-pass type II membrane protein By similarity.

Sequence similarities

Belongs to the glycosyltransferase 31 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 331331UDP-GalNAc:beta-1,3-N-acetylgalactosaminyltransferase 1
PRO_0000219158

Regions

Topological domain1 – 2020Cytoplasmic Potential
Transmembrane21 – 4323Helical; Signal-anchor for type II membrane protein; Potential
Topological domain44 – 331288Lumenal Potential

Amino acid modifications

Glycosylation721N-linked (GlcNAc...) Potential
Glycosylation1541N-linked (GlcNAc...) Potential
Glycosylation1981N-linked (GlcNAc...) Potential
Glycosylation2121N-linked (GlcNAc...) Potential
Glycosylation3261N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
Q6AY39 [UniParc].

Last modified September 13, 2004. Version 1.
Checksum: A0BF5A919A99339F

FASTA33139,215
        10         20         30         40         50         60 
MAPAVLTAIP NRMSLRSLKW SLLLLSLLSF LVIWYLSLPH YNVIERVNWM YFYEYEPIYR 

        70         80         90        100        110        120 
QDFQFTLREH SNCSQQNPFL VILVTSRPSD VKARQAIRVT WGEKKTWWGH EVLTFFLLGQ 

       130        140        150        160        170        180 
EAEREDKVLA LSLEDEHALY GDIIRQDFLD TYNNLTLKTI MAFRWVIEFC PNAKYVMKTD 

       190        200        210        220        230        240 
TDVFINTGNL VKYLLNLNHS EKFFTGYPLI ENYSYRGFFH KNHISYQEYP FKVFPPYCSG 

       250        260        270        280        290        300 
LGYIMSGDLV PKIYEMMGHV KPIKFEDVYV GICLNLLKVD IHIPEDTNLF FLFRIHLDVC 

       310        320        330 
QLRRVIAAHG FSSKEIITFW QVMLRNTTCH Y 

« Hide

References

[1]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Testis.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC079206 mRNA. Translation: AAH79206.1.
RefSeqNP_001013176.1. NM_001013158.1.
UniGeneRn.3666.

3D structure databases

ProteinModelPortalQ6AY39.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

MINTMINT-4655782.
STRING10116.ENSRNOP00000016012.

Protein family/group databases

CAZyGT31. Glycosyltransferase Family 31.

PTM databases

PhosphoSiteQ6AY39.

Proteomic databases

PRIDEQ6AY39.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000016012; ENSRNOP00000016012; ENSRNOG00000012019.
GeneID310508.
KEGGrno:310508.
UCSCRGD:1304797. rat.

Organism-specific databases

CTD8706.
RGD1304797. B3galnt1.

Phylogenomic databases

eggNOGNOG269758.
GeneTreeENSGT00740000114871.
HOGENOMHOG000059604.
HOVERGENHBG101817.
InParanoidQ6AY39.
KOK00719.
OMACPNAKYI.
OrthoDBEOG7M3J0F.
PhylomeDBQ6AY39.
TreeFamTF318639.

Enzyme and pathway databases

UniPathwayUPA00378.

Gene expression databases

GenevestigatorQ6AY39.

Family and domain databases

InterProIPR002659. Glyco_trans_31.
[Graphical view]
PANTHERPTHR11214. PTHR11214. 1 hit.
PfamPF01762. Galactosyl_T. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio662077.
PROQ6AY39.

Entry information

Entry nameB3GL1_RAT
AccessionPrimary (citable) accession number: Q6AY39
Entry history
Integrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: September 13, 2004
Last modified: April 16, 2014
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways