Reviewed, UniProtKB/Swiss-Prot Q6AY30 (SCPDH_RAT)

Names and origin

Protein names

Recommended name:
    Probable saccharopine dehydrogenase
    EC=1.5.1.9

Gene names

Name:

Sccpdh

Organism

Rattus norvegicus (Rat)

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	429 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Catalytic activity	N(6)-(L-1,3-dicarboxypropyl)-L-lysine + NAD+ + H2O = L-glutamate + 2-aminoadipate 6-semialdehyde + NADH.
Pathway	Amino-acid degradation; L-lysine degradation via saccharopine pathway; glutaryl-CoA from L-lysine: step 2/6.
Sequence similarities	Belongs to the saccharopine dehydrogenase family.

Ontologies

Keywords
Ligand	NAD
Molecular function	Oxidoreductase
PTM	Acetylation
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	binding Inferred from electronic annotation. Source: InterPro saccharopine dehydrogenase (NAD+, L-glutamate-forming) activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed By similarity
	Chain	2 – 429	428	Probable saccharopine dehydrogenase		PRO_0000212843
Amino acid modifications
	Modified residue	2	1	N-acetylalanine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q6AY30-1 [UniParc]. Last modified September 13, 2004. Version 1. Checksum: D16F3BE0BBF8D300	FASTA	429	47,088
	10 20 30 40 50 60 MATEQRPFQL VVFGASGFTG QFVTEEVARE QMASEQSSRL PWAVAGRSKE KLQQVLEKAA 70 80 90 100 110 120 QKLGRATLSS EVGIIICDIS NPASLDEMAK KATLVLNCVG PYRFYGEPVV KACIENGTSC 130 140 150 160 170 180 IDICGEPQFL ELMHVKYHEK AAEKGVYIIG SSGFDSIPAD LGVLYTRNQM NGTLTAVESF 190 200 210 220 230 240 LTINSGPEGL CIHDGTWKSA IYGFGDKGSL RKLRSVSNLK PVPVIGSKLK RRWPVSYCRE 250 260 270 280 290 300 LNSYAIPFLG SDMSVVKRTQ RYLHENLEDS PVQYAAYITV GGITSVIKLM FAGLFFLFFV 310 320 330 340 350 360 KFSIGRQLLV KFPWLFSFGY FSKRGPTQKQ MDESSFTMTF FGQGYSHGVS AEKNKPNIRI 370 380 390 400 410 420 CTQVKGPEAG YVATPIAMVQ AAVTFLNDAS DLPKGGGVFT PGAAFSRTKL IDRLNQHGIQ FSVISSSEV

References

[1]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Testis.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC079215 mRNA. Translation: AAH79215.1.
IPI	IPI00372804.
RefSeq	NP_001014007.1.
UniGene	Rn.23989
3D structure databases
ModBase	Search...
PTM databases
PhosphoSite	Q6AY30.
Genome annotation databases
Ensembl	ENSRNOT00000003791; ENSRNOP00000003791; ENSRNOG00000037984; Rattus norvegicus. [Genome view]
GeneID	305021.
KEGG	rno:305021.
NMPDR	fig|10116.3.peg.9663.
UCSC	NM_001013985. rat.
Organism-specific databases
CTD	305021.
RGD	1311440. Sccpdh.
Phylogenomic databases
eggNOG	roNOG13655.
HOVERGEN	Q6AY30.
InParanoid	Q6AY30.
OMA	GTSCIDI.
OrthoDB	EOG937V0Q.
Enzyme and pathway databases
BRENDA	1.5.1.9. 248.
Gene expression databases
ArrayExpress	Q6AY30.
Genevestigator	Q6AY30.
GermOnline	ENSRNOG00000037984. Rattus norvegicus.
Family and domain databases
InterPro	IPR016040. NAD(P)-bd_dom. IPR005097. Saccharopine_DH/HSpermid_syn. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
Pfam	PF03435. Saccharop_dh. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	653990.

Entry information

Entry name

SCPDH_RAT

Accession

Primary (citable) accession number: Q6AY30

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 30, 2005
Last sequence update:	September 13, 2004
Last modified:	February 9, 2010
This is version 47 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)