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Protein

Inactive serine protease 54

Gene

Prss54

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Caution

Although related to peptidase S1 family, lacks the essential His, Asp, and Ser residues of the catalytic triad at positions 73, 119 and 210 and is therefore predicted to have lost protease activity.Curated

GO - Molecular functioni

Keywordsi

Molecular functionSerine protease homolog

Protein family/group databases

MEROPSiS01.992

Names & Taxonomyi

Protein namesi
Recommended name:
Inactive serine protease 54
Alternative name(s):
Plasma kallikrein-like protein 4
Gene namesi
Name:Prss54
Synonyms:Klkbl4
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 19

Organism-specific databases

RGDi1307877 Prss54

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_000028880221 – 382Inactive serine protease 54Add BLAST362

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi113N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi154 ↔ 216PROSITE-ProRule annotation
Disulfide bondi185 ↔ 195PROSITE-ProRule annotation
Disulfide bondi206 ↔ 237PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ6AY28
PRIDEiQ6AY28

Expressioni

Gene expression databases

BgeeiENSRNOG00000023092

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000036855

Structurei

3D structure databases

ProteinModelPortaliQ6AY28
SMRiQ6AY28
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini29 – 258Peptidase S1PROSITE-ProRule annotationAdd BLAST230

Sequence similaritiesi

Belongs to the peptidase S1 family. Plasma kallikrein subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3627 Eukaryota
COG5640 LUCA
GeneTreeiENSGT00770000120569
HOVERGENiHBG106642
InParanoidiQ6AY28
OMAiGWNPTSA
OrthoDBiEOG091G0EH9
PhylomeDBiQ6AY28
TreeFamiTF338267

Family and domain databases

InterProiView protein in InterPro
IPR009003 Peptidase_S1_PA
IPR001254 Trypsin_dom
PfamiView protein in Pfam
PF00089 Trypsin, 1 hit
SMARTiView protein in SMART
SM00020 Tryp_SPc, 1 hit
SUPFAMiSSF50494 SSF50494, 1 hit
PROSITEiView protein in PROSITE
PS50240 TRYPSIN_DOM, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6AY28-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAELRGILLL LLYMSHSSSA ICGIQKANIV DQLHENLVSS TEFPWVVSIQ
60 70 80 90 100
DKQYTHLAFG CILSEFWILS TASALQNRKE VIAVVGIANM DPRNADHKEY
110 120 130 140 150
SINAIIPHEN FNNNSMRNNI ALLRTDSAIH FDDLVQPICF LGKSLHKPTA
160 170 180 190 200
LKNCWVAGWN PTSATGNHMT MSILRRISVN DIEVCPLHRQ QKTECASHTN
210 220 230 240 250
KDSNVCLGEP GNPMMCQVKK LDLWILRGLL AYGSDLCPGL LLYTSVDDYS
260 270 280 290 300
NWIIAKTRKA GPPLSSIHPW EKLVLELPFH QSNIALTKNS YSVHSYAWPQ
310 320 330 340 350
SYSQGLRMST MYDKQKDVWQ NLRVNGQQEA GRPSNVAIQP MYYDYYGGEA
360 370 380
GEGRAVAGQN RLHWSQERIL MSFVLVFLGS GV
Length:382
Mass (Da):42,921
Last modified:September 13, 2004 - v1
Checksum:i5E24760879834BF1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC079217 mRNA Translation: AAH79217.1
RefSeqiNP_001013910.1, NM_001013888.1
XP_008770495.1, XM_008772273.2
UniGeneiRn.160028

Genome annotation databases

EnsembliENSRNOT00000033953; ENSRNOP00000036855; ENSRNOG00000023092
GeneIDi291846
KEGGirno:291846
UCSCiRGD:1307877 rat

Similar proteinsi

Entry informationi

Entry nameiPRS54_RAT
AccessioniPrimary (citable) accession number: Q6AY28
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: September 13, 2004
Last modified: May 23, 2018
This is version 93 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

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