Reviewed, UniProtKB/Swiss-Prot Q6AY23 (P5CR2_RAT)

Names and origin

Protein names

Recommended name:
    Pyrroline-5-carboxylate reductase 2
      Short name=P5C reductase 2
      Short name=P5CR 2
    EC=1.5.1.2

Gene names

Name:

Pycr2

Organism

Rattus norvegicus (Rat)

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	320 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Catalytic activity	L-proline + NAD(P)+ = 1-pyrroline-5-carboxylate + NAD(P)H.
Pathway	Amino-acid biosynthesis; L-proline biosynthesis; L-proline from L-glutamate 5-semialdehyde: step 1/1.
Subunit structure	Homodecamer; composed of 5 homodimers By similarity.
Sequence similarities	Belongs to the pyrroline-5-carboxylate reductase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Proline biosynthesis
Ligand	NADP
Molecular function	Oxidoreductase
PTM	Acetylation Phosphoprotein
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW proline biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	binding Inferred from electronic annotation. Source: InterPro pyrroline-5-carboxylate reductase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed By similarity
	Chain	2 – 320	319	Pyrroline-5-carboxylate reductase 2		PRO_0000187320
Amino acid modifications
	Modified residue	2	1	N-acetylserine By similarity
	Modified residue	304	1	Phosphoserine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q6AY23-1 [UniParc]. Last modified September 13, 2004. Version 1. Checksum: 6434E5A7CBC739A9	FASTA	320	33,673
	10 20 30 40 50 60 MSVGFIGAGQ LACALARGFT AAGVLSAHKI IASSPEMDLP TVSALRKMGV NLTRSNKDTV 70 80 90 100 110 120 RHSDVLFLAV KPHIIPFILD EIGADVQERH IVVSCAAGVT ISSVEKKLMA FQPAPKVIRC 130 140 150 160 170 180 MTNTPVVVRE GATVYATGTH ALVEDGKLLE QLMSSVGFCT EVEEDLIDAI TGLSGSGPAY 190 200 210 220 230 240 AFMALDALAD GGVKMGVPRR LAVRLGAQAL LGAAKMLLDS EDHPGQLKDN VCSPGGATIH 250 260 270 280 290 300 ALHFLESGGF RSLLINAVEA SCIRTRELQS MADQEKVSPA ALKKTLLDRV KLESPTVSTL 310 320 APPSSGKLLT RNPAQGSKRE

References

[1]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Testis.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	BC079222 mRNA. Translation: AAH79222.1.
IPI	IPI00464532.
RefSeq	NP_001012208.1.
UniGene	Rn.137266
3D structure databases
SMR	Q6AY23. Positions 1-275.
ModBase	Search...
Protein-protein interaction databases
STRING	Q6AY23.
PTM databases
PhosphoSite	Q6AY23.
Genome annotation databases
Ensembl	ENSRNOT00000004379; ENSRNOP00000004379; ENSRNOG00000003267; Rattus norvegicus. [Genome view]
GeneID	364064.
KEGG	rno:364064.
NMPDR	fig|10116.3.peg.9681.
UCSC	NM_001012208. rat.
Organism-specific databases
CTD	364064.
RGD	1310074. Pycr2.
Phylogenomic databases
HOVERGEN	Q6AY23.
OMA	SIMAGTT.
Enzyme and pathway databases
BRENDA	1.5.1.2. 248.
Gene expression databases
ArrayExpress	Q6AY23.
Genevestigator	Q6AY23.
GermOnline	ENSRNOG00000003267. Rattus norvegicus.
Family and domain databases
InterPro	IPR016040. NAD(P)-bd_dom. IPR004455. NADP_OxRdtase_F420. IPR000304. P5CR. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
PANTHER	PTHR11645. P5CR. 1 hit.
Pfam	PF03807. F420_oxidored. 1 hit. [Graphical view]
PIRSF	PIRSF000193. Pyrrol-5-carb_rd. 1 hit.
TIGRFAMs	TIGR00112. proC. 1 hit.
PROSITE	PS00521. P5CR. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	684775.

Entry information

Entry name

P5CR2_RAT

Accession

Primary (citable) accession number: Q6AY23

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 1, 2005
Last sequence update:	September 13, 2004
Last modified:	November 3, 2009
This is version 45 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)