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Protein

Cation-dependent mannose-6-phosphate receptor

Gene

M6pr

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes. Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6-phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelyosomal compartment where the low pH mediates the dissociation of the complex (By similarity).By similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Transport

Enzyme and pathway databases

ReactomeiR-RNO-432720. Lysosome Vesicle Biogenesis.
R-RNO-6811440. Retrograde transport at the Trans-Golgi-Network.
R-RNO-8856825. Cargo recognition for clathrin-mediated endocytosis.
R-RNO-8856828. Clathrin-mediated endocytosis.

Names & Taxonomyi

Protein namesi
Recommended name:
Cation-dependent mannose-6-phosphate receptor
Short name:
CD Man-6-P receptor
Short name:
CD-MPR
Gene namesi
Name:M6pr
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componentsi: Chromosome 4, Chromosome X

Organism-specific databases

RGDi1359355. M6pr.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini22 – 188LumenalSequence analysisAdd BLAST167
Transmembranei189 – 209HelicalSequence analysisAdd BLAST21
Topological domaini210 – 278CytoplasmicSequence analysisAdd BLAST69

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Lysosome, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21By similarityAdd BLAST21
ChainiPRO_000024971222 – 278Cation-dependent mannose-6-phosphate receptorAdd BLAST257

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi58N-linked (GlcNAc...)Sequence analysis1
Glycosylationi84N-linked (GlcNAc...)Sequence analysis1
Glycosylationi95N-linked (GlcNAc...)Sequence analysis1
Glycosylationi108N-linked (GlcNAc...)Sequence analysis1
Glycosylationi114N-linked (GlcNAc...)Sequence analysis1
Modified residuei268PhosphoserineCombined sources1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ6AY20.
PRIDEiQ6AY20.

PTM databases

iPTMnetiQ6AY20.
PhosphoSitePlusiQ6AY20.
UniCarbKBiQ6AY20.

Expressioni

Gene expression databases

BgeeiENSRNOG00000014992.
GenevisibleiQ6AY20. RN.

Interactioni

Subunit structurei

Homodimer. Binds GGA1, GGA2 and GGA3 (By similarity).By similarity

Protein-protein interaction databases

MINTiMINT-4655771.
STRINGi10116.ENSRNOP00000020364.

Structurei

3D structure databases

ProteinModelPortaliQ6AY20.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

The extracellular domain is homologous to the repeating units (of approximately 147 AA) of the cation-independent mannose 6-phosphate receptor.By similarity

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IK0D. Eukaryota.
ENOG4111GED. LUCA.
GeneTreeiENSGT00390000002109.
HOGENOMiHOG000013085.
HOVERGENiHBG006395.
InParanoidiQ6AY20.
KOiK10089.
OMAiINETQVF.
OrthoDBiEOG091G0WP5.
PhylomeDBiQ6AY20.
TreeFamiTF328910.

Family and domain databases

Gene3Di2.70.130.10. 1 hit.
InterProiIPR028927. Man-6-P_rcpt.
IPR009011. Man6P_isomerase_rcpt-bd_dom.
IPR000296. Man_6_P_rcpt.
[Graphical view]
PfamiPF02157. Man-6-P_recep. 1 hit.
[Graphical view]
PRINTSiPR00715. MAN6PRECEPTR.
SUPFAMiSSF50911. SSF50911. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6AY20-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFPLSGCWRT ELLLLLLLAV AVRESWQIEE KSCDLVGEKD KESKNEVALL
60 70 80 90 100
ERLRPLFNKS FESTVGQGSD TYSYIFRVCR EAGNHSSGAG LVQINKSNEK
110 120 130 140 150
ETVVGRINET HIFNGSNWIM LIYKGGDEYD NHCGKEQRRA VVMISCNRHT
160 170 180 190 200
LAGNFNPVSE ERGKIQDCFY LFEMDSSLAC SPEVSHLSVG SILLVIFASL
210 220 230 240 250
VAVYIIGGFL YQRLVVGAKG MEQFPHLAFW QDLGNLVADG CDFVCRSKPR
260 270
SVPAAYRGVG DDQLGEESEE RDDHLLPM
Length:278
Mass (Da):31,095
Last modified:September 13, 2004 - v1
Checksum:iEA628873BB2D1198
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC079226 mRNA. Translation: AAH79226.1.
RefSeqiNP_001007701.1. NM_001007700.1.
XP_003752148.1. XM_003752100.1.
XP_006257263.1. XM_006257201.2.
XP_006257264.1. XM_006257202.1.
XP_008761469.1. XM_008763247.2.
UniGeneiRn.91427.

Genome annotation databases

EnsembliENSRNOT00000020364; ENSRNOP00000020364; ENSRNOG00000014992.
ENSRNOT00000088728; ENSRNOP00000069840; ENSRNOG00000059373.
GeneIDi100909548.
312689.
KEGGirno:100909548.
rno:312689.
UCSCiRGD:1359355. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC079226 mRNA. Translation: AAH79226.1.
RefSeqiNP_001007701.1. NM_001007700.1.
XP_003752148.1. XM_003752100.1.
XP_006257263.1. XM_006257201.2.
XP_006257264.1. XM_006257202.1.
XP_008761469.1. XM_008763247.2.
UniGeneiRn.91427.

3D structure databases

ProteinModelPortaliQ6AY20.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-4655771.
STRINGi10116.ENSRNOP00000020364.

PTM databases

iPTMnetiQ6AY20.
PhosphoSitePlusiQ6AY20.
UniCarbKBiQ6AY20.

Proteomic databases

PaxDbiQ6AY20.
PRIDEiQ6AY20.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000020364; ENSRNOP00000020364; ENSRNOG00000014992.
ENSRNOT00000088728; ENSRNOP00000069840; ENSRNOG00000059373.
GeneIDi100909548.
312689.
KEGGirno:100909548.
rno:312689.
UCSCiRGD:1359355. rat.

Organism-specific databases

CTDi4074.
RGDi1359355. M6pr.

Phylogenomic databases

eggNOGiENOG410IK0D. Eukaryota.
ENOG4111GED. LUCA.
GeneTreeiENSGT00390000002109.
HOGENOMiHOG000013085.
HOVERGENiHBG006395.
InParanoidiQ6AY20.
KOiK10089.
OMAiINETQVF.
OrthoDBiEOG091G0WP5.
PhylomeDBiQ6AY20.
TreeFamiTF328910.

Enzyme and pathway databases

ReactomeiR-RNO-432720. Lysosome Vesicle Biogenesis.
R-RNO-6811440. Retrograde transport at the Trans-Golgi-Network.
R-RNO-8856825. Cargo recognition for clathrin-mediated endocytosis.
R-RNO-8856828. Clathrin-mediated endocytosis.

Miscellaneous databases

PROiQ6AY20.

Gene expression databases

BgeeiENSRNOG00000014992.
GenevisibleiQ6AY20. RN.

Family and domain databases

Gene3Di2.70.130.10. 1 hit.
InterProiIPR028927. Man-6-P_rcpt.
IPR009011. Man6P_isomerase_rcpt-bd_dom.
IPR000296. Man_6_P_rcpt.
[Graphical view]
PfamiPF02157. Man-6-P_recep. 1 hit.
[Graphical view]
PRINTSiPR00715. MAN6PRECEPTR.
SUPFAMiSSF50911. SSF50911. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiMPRD_RAT
AccessioniPrimary (citable) accession number: Q6AY20
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 19, 2006
Last sequence update: September 13, 2004
Last modified: November 30, 2016
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

This receptor has optimal binding in the presence of divalent cations.By similarity

Keywords - Technical termi

Complete proteome, Reference proteome

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.