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Q6AY20 (MPRD_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified November 16, 2011. Version 59. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Cation-dependent mannose-6-phosphate receptor
Short name=CD Man-6-P receptor
Short name=CD-MPR
Gene names
Name:M6pr
OrganismRattus norvegicus (Rat)
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length278 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes. Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6-phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelyosomal compartment where the low pH mediates the dissociation of the complex By similarity.

Subunit structure

Homodimer. Binds GGA1, GGA2 and GGA3 By similarity.

Subcellular location

Lysosome membrane; Single-pass type I membrane protein By similarity.

Domain

The extracellular domain is homologous to the repeating units (of approximately 147 AA) of the cation-independent mannose 6-phosphate receptor By similarity.

Miscellaneous

This receptor has optimal binding in the presence of divalent cations By similarity.

Ontologies

Keywords
   Biological processTransport
   Cellular componentLysosome
Membrane
   DomainSignal
Transmembrane
Transmembrane helix
   Molecular functionReceptor
   PTMGlycoprotein
Phosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular componentintegral to membrane

Inferred from electronic annotation. Source: UniProtKB-KW

lysosomal membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionmannose binding

Inferred from electronic annotation. Source: InterPro

mannose transmembrane transporter activity

Inferred from electronic annotation. Source: InterPro

receptor activity

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2121 By similarity
Chain22 – 278257Cation-dependent mannose-6-phosphate receptor
PRO_0000249712

Regions

Topological domain22 – 188167Lumenal Potential
Transmembrane189 – 20921Helical; Potential
Topological domain210 – 27869Cytoplasmic Potential

Amino acid modifications

Modified residue2681Phosphoserine By similarity
Glycosylation581N-linked (GlcNAc...) Potential
Glycosylation841N-linked (GlcNAc...) Potential
Glycosylation951N-linked (GlcNAc...) Potential
Glycosylation1081N-linked (GlcNAc...) Potential
Glycosylation1141N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
Q6AY20 [UniParc].

Last modified September 13, 2004. Version 1.
Checksum: EA628873BB2D1198

FASTA27831,095
        10         20         30         40         50         60 
MFPLSGCWRT ELLLLLLLAV AVRESWQIEE KSCDLVGEKD KESKNEVALL ERLRPLFNKS 

        70         80         90        100        110        120 
FESTVGQGSD TYSYIFRVCR EAGNHSSGAG LVQINKSNEK ETVVGRINET HIFNGSNWIM 

       130        140        150        160        170        180 
LIYKGGDEYD NHCGKEQRRA VVMISCNRHT LAGNFNPVSE ERGKIQDCFY LFEMDSSLAC 

       190        200        210        220        230        240 
SPEVSHLSVG SILLVIFASL VAVYIIGGFL YQRLVVGAKG MEQFPHLAFW QDLGNLVADG 

       250        260        270 
CDFVCRSKPR SVPAAYRGVG DDQLGEESEE RDDHLLPM

« Hide

References

[1]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Testis.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		BC079226 mRNA. Translation: AAH79226.1.
IPIIPI00365669.
RefSeqNP_001007701.1. NM_001007700.1.
UniGeneRn.91427.

3D structure databases

HSSPHSSP built from PDB template 1M6P based on UniProtKB P11456.
ProteinModelPortalQ6AY20.
SMRQ6AY20. Positions 29-181.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ6AY20.

Proteomic databases

PRIDEQ6AY20.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000020364; ENSRNOP00000020364; ENSRNOG00000014992.
GeneID312689.
KEGGrno:312689.
NMPDRfig|10116.3.peg.22139.
UCSCNM_001007700. rat.

Organism-specific databases

CTD4074.
RGD1359355. M6pr.

Phylogenomic databases

eggNOGroNOG13645.
GeneTreeENSGT00390000002109.
HOVERGENHBG006395.
InParanoidQ6AY20.
OMANETHVFN.
OrthoDBEOG43FGXF.
PhylomeDBQ6AY20.

Gene expression databases

ArrayExpressQ6AY20.
GenevestigatorQ6AY20.
GermOnlineENSRNOG00000014992. Rattus norvegicus.

Family and domain databases

InterProIPR009011. Man6P_isomerase_rcpt-bd.
IPR000296. Man_6_P_rcpt.
[Graphical view]
KOK10089.
PRINTSPR00715. MAN6PRECEPTR.
SUPFAMSSF50911. Man6php_recept. 1 hit.
ProtoNetSearch...

Other

NextBio665152.

Entry information

Entry nameMPRD_RAT
AccessionPrimary (citable) accession number: Q6AY20
Entry history
Integrated into UniProtKB/Swiss-Prot: September 19, 2006
Last sequence update: September 13, 2004
Last modified: November 16, 2011
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
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