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Protein

Cation-dependent mannose-6-phosphate receptor

Gene

M6pr

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes. Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6-phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelyosomal compartment where the low pH mediates the dissociation of the complex (By similarity).By similarity

Miscellaneous

This receptor has optimal binding in the presence of divalent cations.By similarity

GO - Molecular functioni

Keywordsi

Molecular functionReceptor
Biological processTransport

Enzyme and pathway databases

ReactomeiR-RNO-432720 Lysosome Vesicle Biogenesis
R-RNO-6811440 Retrograde transport at the Trans-Golgi-Network
R-RNO-8856825 Cargo recognition for clathrin-mediated endocytosis
R-RNO-8856828 Clathrin-mediated endocytosis

Names & Taxonomyi

Protein namesi
Recommended name:
Cation-dependent mannose-6-phosphate receptor
Short name:
CD Man-6-P receptor
Short name:
CD-MPR
Gene namesi
Name:M6pr
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componentsi: Chromosome 4, Chromosome X

Organism-specific databases

RGDi1359355 M6pr

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini22 – 188LumenalSequence analysisAdd BLAST167
Transmembranei189 – 209HelicalSequence analysisAdd BLAST21
Topological domaini210 – 278CytoplasmicSequence analysisAdd BLAST69

Keywords - Cellular componenti

Lysosome, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21By similarityAdd BLAST21
ChainiPRO_000024971222 – 278Cation-dependent mannose-6-phosphate receptorAdd BLAST257

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi58N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi84N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi95N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi108N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi114N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei268PhosphoserineCombined sources1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ6AY20
PRIDEiQ6AY20

PTM databases

iPTMnetiQ6AY20
PhosphoSitePlusiQ6AY20
UniCarbKBiQ6AY20

Expressioni

Gene expression databases

BgeeiENSRNOG00000014992
GenevisibleiQ6AY20 RN

Interactioni

Subunit structurei

Homodimer. Binds GGA1, GGA2 and GGA3 (By similarity).By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000020364

Structurei

3D structure databases

ProteinModelPortaliQ6AY20
SMRiQ6AY20
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

The extracellular domain is homologous to the repeating units (of approximately 147 AA) of the cation-independent mannose 6-phosphate receptor.By similarity

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IK0D Eukaryota
ENOG4111GED LUCA
GeneTreeiENSGT00390000002109
HOGENOMiHOG000013085
HOVERGENiHBG006395
InParanoidiQ6AY20
KOiK10089
OMAiSDWIMLI
OrthoDBiEOG091G0WP5
PhylomeDBiQ6AY20
TreeFamiTF328910

Family and domain databases

Gene3Di2.70.130.10, 1 hit
InterProiView protein in InterPro
IPR028927 Man-6-P_rcpt
IPR000296 Man-6-P_rcpt_cation_dep
IPR009011 Man6P_isomerase_rcpt-bd_dom_sf
PANTHERiPTHR15071:SF9 PTHR15071:SF9, 1 hit
PfamiView protein in Pfam
PF02157 Man-6-P_recep, 1 hit
PRINTSiPR00715 MAN6PRECEPTR

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6AY20-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFPLSGCWRT ELLLLLLLAV AVRESWQIEE KSCDLVGEKD KESKNEVALL
60 70 80 90 100
ERLRPLFNKS FESTVGQGSD TYSYIFRVCR EAGNHSSGAG LVQINKSNEK
110 120 130 140 150
ETVVGRINET HIFNGSNWIM LIYKGGDEYD NHCGKEQRRA VVMISCNRHT
160 170 180 190 200
LAGNFNPVSE ERGKIQDCFY LFEMDSSLAC SPEVSHLSVG SILLVIFASL
210 220 230 240 250
VAVYIIGGFL YQRLVVGAKG MEQFPHLAFW QDLGNLVADG CDFVCRSKPR
260 270
SVPAAYRGVG DDQLGEESEE RDDHLLPM
Length:278
Mass (Da):31,095
Last modified:September 13, 2004 - v1
Checksum:iEA628873BB2D1198
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC079226 mRNA Translation: AAH79226.1
RefSeqiNP_001007701.1, NM_001007700.1
XP_003752148.1, XM_003752100.1
XP_006257263.1, XM_006257201.2
XP_006257264.1, XM_006257202.1
XP_008761469.1, XM_008763247.2
UniGeneiRn.91427

Genome annotation databases

EnsembliENSRNOT00000020364; ENSRNOP00000020364; ENSRNOG00000014992
ENSRNOT00000088728; ENSRNOP00000069840; ENSRNOG00000059373
GeneIDi100909548
312689
KEGGirno:100909548
rno:312689
UCSCiRGD:1359355 rat

Similar proteinsi

Entry informationi

Entry nameiMPRD_RAT
AccessioniPrimary (citable) accession number: Q6AY20
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 19, 2006
Last sequence update: September 13, 2004
Last modified: May 23, 2018
This is version 108 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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