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Protein

AarF domain-containing protein kinase 4

Gene

Adck4

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May play a role in CoQ10 (COQ10A and/or COQ10B) biosynthesis, which is required for podocyte migration.By similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
AarF domain-containing protein kinase 4 (EC:2.7.11.-)
Gene namesi
Name:Adck4
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi1311356. Adck4.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei93 – 10917HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane, Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 528528AarF domain-containing protein kinase 4PRO_0000271799Add
BLAST

Proteomic databases

PaxDbiQ6AY19.
PRIDEiQ6AY19.

Expressioni

Tissue specificityi

In the kidney, expressed in glomeruli, predominantly in podocyte foot precesses, as well as in proximal tubules and collecting ducts (at protein level).1 Publication

Gene expression databases

BgeeiENSRNOG00000020848.
GenevisibleiQ6AY19. RN.

Interactioni

Subunit structurei

Homodimer; homodimerizes via its transmembrane region. Interacts with COQ6 and COQ7.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000028290.

Structurei

3D structure databases

ProteinModelPortaliQ6AY19.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini187 – 419233Protein kinaseAdd
BLAST

Sequence similaritiesi

Contains 1 protein kinase domain.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1234. Eukaryota.
COG0661. LUCA.
GeneTreeiENSGT00550000074739.
HOGENOMiHOG000201140.
HOVERGENiHBG061318.
InParanoidiQ6AY19.
KOiK08869.
OMAiPCGGSWA.
OrthoDBiEOG091G02P9.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR004147. UbiB_dom.
[Graphical view]
PfamiPF03109. ABC1. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 2 hits.

Sequencei

Sequence statusi: Complete.

Q6AY19-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MWLELGAMLR TTCGPLGRAV RLPCAGALRL RPHWWGPCRD CLAQRVHQDQ
60 70 80 90 100
PGRGLTEDEI RRAREARLRK APRPQLSDRS RERKVPASRI SRLASFGGLA
110 120 130 140 150
VGLGLGALAE VTKKSLPGGS LQHEGSSPFL TEANAERIVQ TLCTVRGAAL
160 170 180 190 200
KIGQMLSIQD NSLISPQLQR VFERVRQSAD FMPRWQMMKV LEEELGKDWQ
210 220 230 240 250
DKVASLEEVP FAAASIGQVH QGVLKDGTEV AVKIQYPGVA ESIQSDVQNL
260 270 280 290 300
LALLKMSVGL PEGLFAEQSL QTLQQELAWE CDYRREAACA QTFKKLLADD
310 320 330 340 350
PFFRVPAVVE ELCTTRVLGM ELAGGIPLDQ CQGLSQDIRN QICFQLLRLC
360 370 380 390 400
LRELFEFRFM QTDPNWANFL YDASSHKVTL LDFGASRAFG TEFTDHYIEV
410 420 430 440 450
VKAAADGDRD RVLQKSQDLK FLTGFETKAF SDAHVEAVMI LGEPFAASGS
460 470 480 490 500
YDFGAGETAR RIQGLIPVLL RHRLRPPPEE TYALHRKLAG AFLACARLHA
510 520
HIACRDLFQD TYHRYWASRQ TLPLPAAS
Length:528
Mass (Da):58,905
Last modified:September 13, 2004 - v1
Checksum:i6ECBC3DD231B16B7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC079227 mRNA. Translation: AAH79227.1.
RefSeqiNP_001012065.1. NM_001012065.1.
UniGeneiRn.11549.

Genome annotation databases

EnsembliENSRNOT00000028290; ENSRNOP00000028290; ENSRNOG00000020848.
GeneIDi308453.
KEGGirno:308453.
UCSCiRGD:1311356. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC079227 mRNA. Translation: AAH79227.1.
RefSeqiNP_001012065.1. NM_001012065.1.
UniGeneiRn.11549.

3D structure databases

ProteinModelPortaliQ6AY19.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000028290.

Proteomic databases

PaxDbiQ6AY19.
PRIDEiQ6AY19.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000028290; ENSRNOP00000028290; ENSRNOG00000020848.
GeneIDi308453.
KEGGirno:308453.
UCSCiRGD:1311356. rat.

Organism-specific databases

CTDi79934.
RGDi1311356. Adck4.

Phylogenomic databases

eggNOGiKOG1234. Eukaryota.
COG0661. LUCA.
GeneTreeiENSGT00550000074739.
HOGENOMiHOG000201140.
HOVERGENiHBG061318.
InParanoidiQ6AY19.
KOiK08869.
OMAiPCGGSWA.
OrthoDBiEOG091G02P9.

Miscellaneous databases

PROiQ6AY19.

Gene expression databases

BgeeiENSRNOG00000020848.
GenevisibleiQ6AY19. RN.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR004147. UbiB_dom.
[Graphical view]
PfamiPF03109. ABC1. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 2 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiADCK4_RAT
AccessioniPrimary (citable) accession number: Q6AY19
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: September 13, 2004
Last modified: September 7, 2016
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.