Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Protein FAM161A

Gene

Fam161a

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Involved in ciliogenesis.By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cilium biogenesis/degradation

Names & Taxonomyi

Protein namesi
Recommended name:
Protein FAM161A
Gene namesi
Name:Fam161a
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 14

Organism-specific databases

RGDi1304999. Fam161a.

Subcellular locationi

GO - Cellular componenti

  • ciliary basal body Source: UniProtKB
  • cytoplasm Source: UniProtKB-KW
  • photoreceptor connecting cilium Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell projection, Cilium, Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 422422Protein FAM161APRO_0000329054Add
BLAST

Proteomic databases

PaxDbiQ6AY14.
PRIDEiQ6AY14.

Expressioni

Tissue specificityi

Expressed in the retina and kidney.1 Publication

Gene expression databases

ExpressionAtlasiQ6AY14. baseline.

Interactioni

Subunit structurei

Interacts (via C-terminus) with microtubules. Interacts with LCA5, CEP290 and SDCCAG8. Interacts with FAM161B. Interacts with POC1B.By similarity

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili136 – 19863Sequence analysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi26 – 316Poly-Ser

Sequence similaritiesi

Belongs to the FAM161 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IEKK. Eukaryota.
ENOG4111HTJ. LUCA.
GeneTreeiENSGT00530000063901.
HOGENOMiHOG000049209.
HOVERGENiHBG107870.
InParanoidiQ6AY14.
KOiK16772.
OrthoDBiEOG7G7KP8.
PhylomeDBiQ6AY14.
TreeFamiTF321199.

Family and domain databases

InterProiIPR019579. UPF0564.
[Graphical view]
PfamiPF10595. UPF0564. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6AY14-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVKLEKMYQD KLTMKDIQAA LVGDDSSSSA SEKSCSHPAL SATSLSEPDL
60 70 80 90 100
DRSSSLSTTT DELPDLEKKT PGEIGTRSYA KELINNMWND FSVEDYTQYD
110 120 130 140 150
SDLQTAKKNR KKPKAWTPRI TVPVPFEMTV REQKRREKAS DAQETREKML
160 170 180 190 200
KRNEDDAECK KKFRANPVPS RLLLPLYEDL VKQNEERRKK TRERSKAALL
210 220 230 240 250
ASQKPFKFIA REEQKQAIRE KKLRELCRAK KKPKQFKARP VPRFIYRPPA
260 270 280 290 300
NVKPKREELY GDSRTQPKAR DVLQSSPWPS HSTYRAFRDP RSPAMPRGKH
310 320 330 340 350
RHRRLSPSDQ GLEKWKEPFS EQSFRNCPVL CDQCCLYESL CDSNKRQKIL
360 370 380 390 400
ADIRMGEEIL KETRRPNPSP RHKSPRRSAH ASARPCEYSP PMPTASSRGR
410 420
EQAIRRSEKA RMKELARIGG AR
Length:422
Mass (Da):48,869
Last modified:September 13, 2004 - v1
Checksum:i3993D5A40E7F1836
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC079233 mRNA. Translation: AAH79233.1.
RefSeqiNP_001013898.2. NM_001013876.2.
UniGeneiRn.154454.
Rn.228376.

Genome annotation databases

EnsembliENSRNOT00000087091; ENSRNOP00000070570; ENSRNOG00000009881.
GeneIDi289833.
KEGGirno:289833.
UCSCiRGD:1304999. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC079233 mRNA. Translation: AAH79233.1.
RefSeqiNP_001013898.2. NM_001013876.2.
UniGeneiRn.154454.
Rn.228376.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PaxDbiQ6AY14.
PRIDEiQ6AY14.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000087091; ENSRNOP00000070570; ENSRNOG00000009881.
GeneIDi289833.
KEGGirno:289833.
UCSCiRGD:1304999. rat.

Organism-specific databases

CTDi84140.
RGDi1304999. Fam161a.

Phylogenomic databases

eggNOGiENOG410IEKK. Eukaryota.
ENOG4111HTJ. LUCA.
GeneTreeiENSGT00530000063901.
HOGENOMiHOG000049209.
HOVERGENiHBG107870.
InParanoidiQ6AY14.
KOiK16772.
OrthoDBiEOG7G7KP8.
PhylomeDBiQ6AY14.
TreeFamiTF321199.

Miscellaneous databases

NextBioi630414.
PROiQ6AY14.

Gene expression databases

ExpressionAtlasiQ6AY14. baseline.

Family and domain databases

InterProiIPR019579. UPF0564.
[Graphical view]
PfamiPF10595. UPF0564. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.
  2. "FAM161A, associated with retinitis pigmentosa, is a component of the cilia-basal body complex and interacts with proteins involved in ciliopathies."
    Di Gioia S.A., Letteboer S.J., Kostic C., Bandah-Rozenfeld D., Hetterschijt L., Sharon D., Arsenijevic Y., Roepman R., Rivolta C.
    Hum. Mol. Genet. 21:5174-5184(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY, SUBCELLULAR LOCATION.

Entry informationi

Entry nameiF161A_RAT
AccessioniPrimary (citable) accession number: Q6AY14
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: September 13, 2004
Last modified: November 11, 2015
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.