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Protein

Protein FAM161A

Gene

Fam161a

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Involved in ciliogenesis.By similarity

GO - Biological processi

Keywordsi

Biological processCilium biogenesis/degradation

Names & Taxonomyi

Protein namesi
Recommended name:
Protein FAM161A
Gene namesi
Name:Fam161a
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 14

Organism-specific databases

RGDi1304999. Fam161a.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection, Cilium, Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003290541 – 422Protein FAM161AAdd BLAST422

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki345Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki361Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

PaxDbiQ6AY14.
PRIDEiQ6AY14.

Expressioni

Tissue specificityi

Expressed in the retina and kidney.1 Publication

Gene expression databases

BgeeiENSRNOG00000009881.
ExpressionAtlasiQ6AY14. baseline.

Interactioni

Subunit structurei

Interacts (via C-terminus) with microtubules. Interacts with LCA5, CEP290 and SDCCAG8. Interacts with FAM161B. Interacts with POC1B. Interacts with CEP78.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000013097.

Structurei

3D structure databases

SMRiQ6AY14.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili136 – 198Sequence analysisAdd BLAST63

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi26 – 31Poly-Ser6

Sequence similaritiesi

Belongs to the FAM161 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IEKK. Eukaryota.
ENOG4111HTJ. LUCA.
GeneTreeiENSGT00530000063901.
HOGENOMiHOG000049209.
HOVERGENiHBG107870.
InParanoidiQ6AY14.
KOiK16772.
PhylomeDBiQ6AY14.
TreeFamiTF321199.

Family and domain databases

InterProiView protein in InterPro
IPR019579. UPF0564.
PfamiView protein in Pfam
PF10595. UPF0564. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6AY14-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVKLEKMYQD KLTMKDIQAA LVGDDSSSSA SEKSCSHPAL SATSLSEPDL
60 70 80 90 100
DRSSSLSTTT DELPDLEKKT PGEIGTRSYA KELINNMWND FSVEDYTQYD
110 120 130 140 150
SDLQTAKKNR KKPKAWTPRI TVPVPFEMTV REQKRREKAS DAQETREKML
160 170 180 190 200
KRNEDDAECK KKFRANPVPS RLLLPLYEDL VKQNEERRKK TRERSKAALL
210 220 230 240 250
ASQKPFKFIA REEQKQAIRE KKLRELCRAK KKPKQFKARP VPRFIYRPPA
260 270 280 290 300
NVKPKREELY GDSRTQPKAR DVLQSSPWPS HSTYRAFRDP RSPAMPRGKH
310 320 330 340 350
RHRRLSPSDQ GLEKWKEPFS EQSFRNCPVL CDQCCLYESL CDSNKRQKIL
360 370 380 390 400
ADIRMGEEIL KETRRPNPSP RHKSPRRSAH ASARPCEYSP PMPTASSRGR
410 420
EQAIRRSEKA RMKELARIGG AR
Length:422
Mass (Da):48,869
Last modified:September 13, 2004 - v1
Checksum:i3993D5A40E7F1836
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC079233 mRNA. Translation: AAH79233.1.
RefSeqiNP_001013898.2. NM_001013876.2.
UniGeneiRn.154454.
Rn.228376.

Genome annotation databases

EnsembliENSRNOT00000087091; ENSRNOP00000070570; ENSRNOG00000009881.
GeneIDi289833.
KEGGirno:289833.
UCSCiRGD:1304999. rat.

Similar proteinsi

Entry informationi

Entry nameiF161A_RAT
AccessioniPrimary (citable) accession number: Q6AY14
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: September 13, 2004
Last modified: August 30, 2017
This is version 78 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families