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Protein

Heterogeneous nuclear ribonucleoprotein H2

Gene

Hnrnph2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

This protein is a component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes which provide the substrate for the processing events that pre-mRNAs undergo before becoming functional, translatable mRNAs in the cytoplasm. Binds poly(RG) (By similarity).By similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein

Keywords - Ligandi

RNA-binding

Enzyme and pathway databases

ReactomeiR-RNO-72163. mRNA Splicing - Major Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Heterogeneous nuclear ribonucleoprotein H2
Short name:
hnRNP H2
Alternative name(s):
Heterogeneous nuclear ribonucleoprotein H'
Short name:
hnRNP H'
Cleaved into the following chain:
Gene namesi
Name:Hnrnph2
Synonyms:Hnrph2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome X

Organism-specific databases

RGDi1549784. Hnrnph2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 449449Heterogeneous nuclear ribonucleoprotein H2PRO_0000271397Add
BLAST
Initiator methionineiRemoved; alternateBy similarity
Chaini2 – 449448Heterogeneous nuclear ribonucleoprotein H2, N-terminally processedPRO_0000434388Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineBy similarity
Modified residuei2 – 21N-acetylmethionine; in Heterogeneous nuclear ribonucleoprotein H2, N-terminally processedBy similarity
Modified residuei23 – 231PhosphoserineBy similarity
Modified residuei54 – 541PhosphoserineBy similarity
Modified residuei63 – 631PhosphoserineBy similarity
Modified residuei90 – 901PhosphoserineBy similarity
Modified residuei233 – 2331Dimethylated arginine; alternateBy similarity
Modified residuei233 – 2331Omega-N-methylarginine; alternateBy similarity
Modified residuei246 – 2461PhosphotyrosineBy similarity
Modified residuei310 – 3101PhosphoserineBy similarity

Keywords - PTMi

Acetylation, Methylation, Phosphoprotein

Proteomic databases

PaxDbiQ6AY09.
PRIDEiQ6AY09.

PTM databases

iPTMnetiQ6AY09.
PhosphoSiteiQ6AY09.

Expressioni

Gene expression databases

BgeeiENSRNOG00000011661.

Interactioni

Subunit structurei

Interacts with TXNL4/DIM1.By similarity

Protein-protein interaction databases

BioGridi259096. 2 interactions.
IntActiQ6AY09. 1 interaction.
STRINGi10116.ENSRNOP00000015518.

Structurei

3D structure databases

ProteinModelPortaliQ6AY09.
SMRiQ6AY09. Positions 1-193, 283-365.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini11 – 9080RRM 1PROSITE-ProRule annotationAdd
BLAST
Domaini111 – 18878RRM 2PROSITE-ProRule annotationAdd
BLAST
Repeati234 – 249161-1Add
BLAST
Domaini289 – 36476RRM 3PROSITE-ProRule annotationAdd
BLAST
Repeati354 – 372192-1Add
BLAST
Repeati374 – 392192-2Add
BLAST
Repeati418 – 433161-2Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni234 – 4332002 X 16 AA Gly-rich approximate repeatsAdd
BLAST
Regioni354 – 392392 X 19 AA perfect repeatsAdd
BLAST

Sequence similaritiesi

Contains 3 RRM (RNA recognition motif) domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG4211. Eukaryota.
ENOG410Z6M0. LUCA.
GeneTreeiENSGT00760000119102.
HOGENOMiHOG000220896.
HOVERGENiHBG055557.
InParanoidiQ6AY09.
KOiK12898.
OMAiPPRKLMT.
OrthoDBiEOG091G0CTJ.
PhylomeDBiQ6AY09.
TreeFamiTF316157.

Family and domain databases

Gene3Di3.30.70.330. 3 hits.
InterProiIPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
IPR012996. Znf_CHHC.
[Graphical view]
PfamiPF00076. RRM_1. 3 hits.
PF08080. zf-RNPHF. 1 hit.
[Graphical view]
SMARTiSM00360. RRM. 3 hits.
[Graphical view]
SUPFAMiSSF54928. SSF54928. 3 hits.
PROSITEiPS50102. RRM. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6AY09-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMLSTEGREG FVVKVRGLPW SCSAEEVMRF FSDCKIQNGT SGVRFIYTRE
60 70 80 90 100
GRPSGEAFVE LESEDEVKLA LKKDRETMGH RYVEVFKSNS VEMDWVLKHT
110 120 130 140 150
GPNSPDTAND GFVRLRGLPF GCSKEEIVQF FSGLEIVPNG MTLPVDFQGR
160 170 180 190 200
STGEAFVQFA SQEIAEKALK KHKERIGHRY IEIFKSSRAE VRTHYDPPRK
210 220 230 240 250
LMTMQRPGPY DRPGAGRGYN SIGRGAGFER MRRGAYGGGY GGYDDYGGYN
260 270 280 290 300
DGYGFGSDRF GRDLNYCFSG MSDHRYGDGG SSFQSTTGHC VHMRGLPYRA
310 320 330 340 350
TENDIYNFFS PLNPMRVHIE IGPDGRVTGE ADVEFATHED AVAAMAKDKA
360 370 380 390 400
NMQHRYVELF LNSTAGTSGG AYDHSYVELF LNSTAGASGG AYGSQMMGGM
410 420 430 440
GLSNQSSYGG PASQQLSAGY GGGYGGQSSM SGYDQVLQEN SSDYQSNLA
Length:449
Mass (Da):49,294
Last modified:September 13, 2004 - v1
Checksum:i748F07A87A7EDF58
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC079240 mRNA. Translation: AAH79240.1.
RefSeqiNP_001014041.1. NM_001014019.1.
XP_006257281.1. XM_006257219.2.
XP_006257282.1. XM_006257220.2.
XP_006257283.1. XM_006257221.2.
UniGeneiRn.229731.

Genome annotation databases

EnsembliENSRNOT00000015518; ENSRNOP00000015518; ENSRNOG00000011661.
GeneIDi308650.
KEGGirno:308650.
UCSCiRGD:1549784. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC079240 mRNA. Translation: AAH79240.1.
RefSeqiNP_001014041.1. NM_001014019.1.
XP_006257281.1. XM_006257219.2.
XP_006257282.1. XM_006257220.2.
XP_006257283.1. XM_006257221.2.
UniGeneiRn.229731.

3D structure databases

ProteinModelPortaliQ6AY09.
SMRiQ6AY09. Positions 1-193, 283-365.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi259096. 2 interactions.
IntActiQ6AY09. 1 interaction.
STRINGi10116.ENSRNOP00000015518.

PTM databases

iPTMnetiQ6AY09.
PhosphoSiteiQ6AY09.

Proteomic databases

PaxDbiQ6AY09.
PRIDEiQ6AY09.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000015518; ENSRNOP00000015518; ENSRNOG00000011661.
GeneIDi308650.
KEGGirno:308650.
UCSCiRGD:1549784. rat.

Organism-specific databases

CTDi3188.
RGDi1549784. Hnrnph2.

Phylogenomic databases

eggNOGiKOG4211. Eukaryota.
ENOG410Z6M0. LUCA.
GeneTreeiENSGT00760000119102.
HOGENOMiHOG000220896.
HOVERGENiHBG055557.
InParanoidiQ6AY09.
KOiK12898.
OMAiPPRKLMT.
OrthoDBiEOG091G0CTJ.
PhylomeDBiQ6AY09.
TreeFamiTF316157.

Enzyme and pathway databases

ReactomeiR-RNO-72163. mRNA Splicing - Major Pathway.

Miscellaneous databases

PROiQ6AY09.

Gene expression databases

BgeeiENSRNOG00000011661.

Family and domain databases

Gene3Di3.30.70.330. 3 hits.
InterProiIPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
IPR012996. Znf_CHHC.
[Graphical view]
PfamiPF00076. RRM_1. 3 hits.
PF08080. zf-RNPHF. 1 hit.
[Graphical view]
SMARTiSM00360. RRM. 3 hits.
[Graphical view]
SUPFAMiSSF54928. SSF54928. 3 hits.
PROSITEiPS50102. RRM. 3 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiHNRH2_RAT
AccessioniPrimary (citable) accession number: Q6AY09
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: September 13, 2004
Last modified: September 7, 2016
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.