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Protein

E3 ubiquitin-protein ligase RNF133

Gene

Rnf133

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Has E3 ubiquitin-protein ligase activity.By similarity

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri256 – 29742RING-type; atypicalPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Ubl conjugation pathway

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
E3 ubiquitin-protein ligase RNF133 (EC:6.3.2.-)
Alternative name(s):
RING finger protein 133
Gene namesi
Name:Rnf133
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi1596695. Rnf133.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei186 – 20823HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 381381E3 ubiquitin-protein ligase RNF133PRO_0000380753Add
BLAST

Post-translational modificationi

Auto-ubiquitinated.By similarity

Keywords - PTMi

Ubl conjugation

Proteomic databases

PRIDEiQ6AY01.

PTM databases

PhosphoSiteiQ6AY01.

Structurei

3D structure databases

ProteinModelPortaliQ6AY01.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini65 – 167103PAAdd
BLAST

Sequence similaritiesi

Contains 1 RING-type zinc finger.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri256 – 29742RING-type; atypicalPROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Transmembrane, Transmembrane helix, Zinc-finger

Phylogenomic databases

InParanoidiQ6AY01.
KOiK15702.
PhylomeDBiQ6AY01.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
InterProiIPR003137. PA_domain.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PfamiPF02225. PA. 1 hit.
PF13639. zf-RING_2. 1 hit.
[Graphical view]
SMARTiSM00184. RING. 1 hit.
[Graphical view]
PROSITEiPS50089. ZF_RING_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6AY01-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNPLQTGPWQ TSAPSFWLLK FSFIWLVSQN CCTASAVWTA YMNISFHVGN
60 70 80 90 100
RMLSELGETG VFGRSSILKR VAGVVVPPEG KIQNACDPNT SFILPRNKEP
110 120 130 140 150
WIALIERGGC AFTQKIKVAS ENGARGVIIY NFPGTGNQVF PMSHQAFEDI
160 170 180 190 200
VVVMIGNVKG MEILHLIRKG VHVTVMVEVG RKHVIWLNHY FVSFMIVTTA
210 220 230 240 250
TLAYFTFYHI RRLWVARIED RRWKRLTREL KKAFGQLQVR ILKEGDEEVS
260 270 280 290 300
PNADSCVICF EAYKPNEIVR ILTCKHFFHK NCIDPWILAH GTCPMCKCDI
310 320 330 340 350
LKALGIQMDI EDGSDSLQVL MSNELPGTFS AMEEELNNEL PPARTSSKVT
360 370 380
HVQEHPTSVN VGSQPPEAEE TGHPSFGQHD L
Length:381
Mass (Da):42,872
Last modified:September 13, 2004 - v1
Checksum:i181C4291A017657D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC079249 mRNA. Translation: AAH79249.1.
RefSeqiNP_001037743.1. NM_001044278.1.
XP_006236206.1. XM_006236144.2.
UniGeneiRn.225546.

Genome annotation databases

GeneIDi681395.
KEGGirno:681395.
UCSCiRGD:1596695. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC079249 mRNA. Translation: AAH79249.1.
RefSeqiNP_001037743.1. NM_001044278.1.
XP_006236206.1. XM_006236144.2.
UniGeneiRn.225546.

3D structure databases

ProteinModelPortaliQ6AY01.
ModBaseiSearch...
MobiDBiSearch...

PTM databases

PhosphoSiteiQ6AY01.

Proteomic databases

PRIDEiQ6AY01.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi681395.
KEGGirno:681395.
UCSCiRGD:1596695. rat.

Organism-specific databases

CTDi168433.
RGDi1596695. Rnf133.

Phylogenomic databases

InParanoidiQ6AY01.
KOiK15702.
PhylomeDBiQ6AY01.

Enzyme and pathway databases

UniPathwayiUPA00143.

Miscellaneous databases

PROiQ6AY01.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
InterProiIPR003137. PA_domain.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PfamiPF02225. PA. 1 hit.
PF13639. zf-RING_2. 1 hit.
[Graphical view]
SMARTiSM00184. RING. 1 hit.
[Graphical view]
PROSITEiPS50089. ZF_RING_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.

Entry informationi

Entry nameiRN133_RAT
AccessioniPrimary (citable) accession number: Q6AY01
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: September 13, 2004
Last modified: June 8, 2016
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.