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Protein

E3 ubiquitin-protein ligase RNF133

Gene

Rnf133

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Has E3 ubiquitin-protein ligase activity.By similarity

Catalytic activityi

S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N6-ubiquitinyl-[acceptor protein]-L-lysine.

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri256 – 297RING-type; atypicalPROSITE-ProRule annotationAdd BLAST42

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processUbl conjugation pathway
LigandMetal-binding, Zinc

Enzyme and pathway databases

UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
E3 ubiquitin-protein ligase RNF133 (EC:2.3.2.27)
Alternative name(s):
RING finger protein 133
RING-type E3 ubiquitin transferase RNF133Curated
Gene namesi
Name:Rnf133
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi1596695. Rnf133.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei186 – 208HelicalSequence analysisAdd BLAST23

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003807531 – 381E3 ubiquitin-protein ligase RNF133Add BLAST381

Post-translational modificationi

Auto-ubiquitinated.By similarity

Keywords - PTMi

Ubl conjugation

Proteomic databases

PRIDEiQ6AY01.

PTM databases

PhosphoSitePlusiQ6AY01.

Structurei

3D structure databases

ProteinModelPortaliQ6AY01.
SMRiQ6AY01.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini65 – 167PAAdd BLAST103

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri256 – 297RING-type; atypicalPROSITE-ProRule annotationAdd BLAST42

Keywords - Domaini

Transmembrane, Transmembrane helix, Zinc-finger

Phylogenomic databases

InParanoidiQ6AY01.
KOiK15702.
PhylomeDBiQ6AY01.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
InterProiView protein in InterPro
IPR003137. PA_domain.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
PfamiView protein in Pfam
PF02225. PA. 1 hit.
PF13639. zf-RING_2. 1 hit.
SMARTiView protein in SMART
SM00184. RING. 1 hit.
PROSITEiView protein in PROSITE
PS50089. ZF_RING_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6AY01-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNPLQTGPWQ TSAPSFWLLK FSFIWLVSQN CCTASAVWTA YMNISFHVGN
60 70 80 90 100
RMLSELGETG VFGRSSILKR VAGVVVPPEG KIQNACDPNT SFILPRNKEP
110 120 130 140 150
WIALIERGGC AFTQKIKVAS ENGARGVIIY NFPGTGNQVF PMSHQAFEDI
160 170 180 190 200
VVVMIGNVKG MEILHLIRKG VHVTVMVEVG RKHVIWLNHY FVSFMIVTTA
210 220 230 240 250
TLAYFTFYHI RRLWVARIED RRWKRLTREL KKAFGQLQVR ILKEGDEEVS
260 270 280 290 300
PNADSCVICF EAYKPNEIVR ILTCKHFFHK NCIDPWILAH GTCPMCKCDI
310 320 330 340 350
LKALGIQMDI EDGSDSLQVL MSNELPGTFS AMEEELNNEL PPARTSSKVT
360 370 380
HVQEHPTSVN VGSQPPEAEE TGHPSFGQHD L
Length:381
Mass (Da):42,872
Last modified:September 13, 2004 - v1
Checksum:i181C4291A017657D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC079249 mRNA. Translation: AAH79249.1.
RefSeqiNP_001037743.1. NM_001044278.1.
XP_006236206.1. XM_006236144.3.
UniGeneiRn.225546.

Genome annotation databases

GeneIDi681395.
KEGGirno:681395.
UCSCiRGD:1596695. rat.

Similar proteinsi

Entry informationi

Entry nameiRN133_RAT
AccessioniPrimary (citable) accession number: Q6AY01
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: September 13, 2004
Last modified: November 22, 2017
This is version 96 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways