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Protein

Polyadenylate-binding protein-interacting protein 2

Gene

Paip2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Acts as a repressor in the regulation of translation initiation of poly(A)-containing mRNAs. Its inhibitory activity on translation is mediated via its action on PABPC1. Displaces the interaction of PABPC1 with poly(A) RNA and competes with PAIP1 for binding to PABPC1. Its association with PABPC1 results in disruption of the cytoplasmic poly(A) RNP structure organization (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Translation regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Polyadenylate-binding protein-interacting protein 2
Short name:
PABP-interacting protein 2
Short name:
PAIP-2
Short name:
Poly(A)-binding protein-interacting protein 2
Gene namesi
Name:Paip2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 18

Organism-specific databases

RGDi1359176. Paip2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 124124Polyadenylate-binding protein-interacting protein 2PRO_0000252688Add
BLAST

Post-translational modificationi

Ubiquitinated, leading to its degradation by the proteasome.By similarity

Keywords - PTMi

Ubl conjugation

Proteomic databases

PaxDbiQ6AXZ0.

Expressioni

Gene expression databases

BgeeiENSRNOG00000019934.
GenevisibleiQ6AXZ0. RN.

Interactioni

Subunit structurei

Interacts with the second and third RRM domains and C-terminus regions of PABPC1 in a 2:1 stoichiometry.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000026989.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni22 – 7554PABPC1-interacting motif-1 (PAM1)By similarityAdd
BLAST
Regioni105 – 12016PABPC1-interacting motif-2 (PAM2)By similarityAdd
BLAST

Domaini

Only the PABPC1-interacting motif-1 (PAM1) interferes with the binding of PABPC1 to poly(A) RNA and translation initiation.By similarity

Sequence similaritiesi

Belongs to the PAIP2 family.Curated

Phylogenomic databases

eggNOGiENOG410IW9Y. Eukaryota.
ENOG410Y214. LUCA.
GeneTreeiENSGT00390000017284.
HOGENOMiHOG000008098.
HOVERGENiHBG053493.
InParanoidiQ6AXZ0.
OMAiWTDQIVY.
OrthoDBiEOG091G1372.
PhylomeDBiQ6AXZ0.
TreeFamiTF326855.

Family and domain databases

InterProiIPR009818. Ataxin-2_C.
[Graphical view]
PfamiPF07145. PAM2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6AXZ0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKDPSRSSTS PSIINDDVII NGHSHEEDNP FAEYMWMENE EEFNRQIEEE
60 70 80 90 100
LWEEEFIERC FQEMLEEEEE HEWFIPARDL PQTMDQIQDQ FNDLVISDGS
110 120
SLEDLVVKSN LNPNAKEFVP GVKY
Length:124
Mass (Da):14,700
Last modified:September 13, 2004 - v1
Checksum:i0D1241C3F89C85D8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC079261 mRNA. Translation: AAH79261.1.
RefSeqiNP_001014170.1. NM_001014148.1.
XP_008770266.1. XM_008772044.1.
XP_008770268.1. XM_008772046.1.
XP_008770269.1. XM_008772047.1.
XP_008770270.1. XM_008772048.1.
XP_008770271.1. XM_008772049.1.
UniGeneiRn.1073.

Genome annotation databases

EnsembliENSRNOT00000026989; ENSRNOP00000026989; ENSRNOG00000019934.
GeneIDi361309.
KEGGirno:361309.
UCSCiRGD:1359176. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC079261 mRNA. Translation: AAH79261.1.
RefSeqiNP_001014170.1. NM_001014148.1.
XP_008770266.1. XM_008772044.1.
XP_008770268.1. XM_008772046.1.
XP_008770269.1. XM_008772047.1.
XP_008770270.1. XM_008772048.1.
XP_008770271.1. XM_008772049.1.
UniGeneiRn.1073.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000026989.

Proteomic databases

PaxDbiQ6AXZ0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000026989; ENSRNOP00000026989; ENSRNOG00000019934.
GeneIDi361309.
KEGGirno:361309.
UCSCiRGD:1359176. rat.

Organism-specific databases

CTDi51247.
RGDi1359176. Paip2.

Phylogenomic databases

eggNOGiENOG410IW9Y. Eukaryota.
ENOG410Y214. LUCA.
GeneTreeiENSGT00390000017284.
HOGENOMiHOG000008098.
HOVERGENiHBG053493.
InParanoidiQ6AXZ0.
OMAiWTDQIVY.
OrthoDBiEOG091G1372.
PhylomeDBiQ6AXZ0.
TreeFamiTF326855.

Miscellaneous databases

PROiQ6AXZ0.

Gene expression databases

BgeeiENSRNOG00000019934.
GenevisibleiQ6AXZ0. RN.

Family and domain databases

InterProiIPR009818. Ataxin-2_C.
[Graphical view]
PfamiPF07145. PAM2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPAIP2_RAT
AccessioniPrimary (citable) accession number: Q6AXZ0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 17, 2006
Last sequence update: September 13, 2004
Last modified: September 7, 2016
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.