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Protein

DNA polymerase delta subunit 2

Gene

Pold2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).

GO - Molecular functioni

  • DNA binding Source: InterPro
  • DNA-directed DNA polymerase activity Source: RGD

GO - Biological processi

  • DNA biosynthetic process Source: GOC
  • DNA-dependent DNA replication Source: RGD
  • DNA replication Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

DNA-directed DNA polymerase, Nucleotidyltransferase, Transferase

Keywords - Biological processi

DNA replication

Enzyme and pathway databases

ReactomeiR-RNO-110314. Recognition of DNA damage by PCNA-containing replication complex.
R-RNO-174411. Polymerase switching on the C-strand of the telomere.
R-RNO-174414. Processive synthesis on the C-strand of the telomere.
R-RNO-174417. Telomere C-strand (Lagging Strand) Synthesis.
R-RNO-174437. Removal of the Flap Intermediate from the C-strand.
R-RNO-5358565. Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha).
R-RNO-5358606. Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta).
R-RNO-5651801. PCNA-Dependent Long Patch Base Excision Repair.
R-RNO-5656169. Termination of translesion DNA synthesis.
R-RNO-5685942. HDR through Homologous Recombination (HRR).
R-RNO-5696397. Gap-filling DNA repair synthesis and ligation in GG-NER.
R-RNO-5696400. Dual Incision in GG-NER.
R-RNO-6782135. Dual incision in TC-NER.
R-RNO-6782210. Gap-filling DNA repair synthesis and ligation in TC-NER.
R-RNO-69091. Polymerase switching.
R-RNO-69109. Leading Strand Synthesis.
R-RNO-69166. Removal of the Flap Intermediate.
R-RNO-69183. Processive synthesis on the lagging strand.

Names & Taxonomyi

Protein namesi
Recommended name:
DNA polymerase delta subunit 2 (EC:2.7.7.7)
Alternative name(s):
DNA polymerase delta subunit p50
Gene namesi
Name:Pold2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 14

Organism-specific databases

RGDi1304954. Pold2.

Subcellular locationi

GO - Cellular componenti

  • delta DNA polymerase complex Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 469469DNA polymerase delta subunit 2PRO_0000248589Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineBy similarity
Modified residuei15 – 151PhosphoserineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ6AXY4.
PRIDEiQ6AXY4.

PTM databases

SwissPalmiQ6AXY4.

Expressioni

Gene expression databases

GenevisibleiQ6AXY4. RN.

Interactioni

Subunit structurei

Heterotetramer composed of subunits of 125 kDa, 50 kDa, 66 kDa and 12 kDa. Interacts with KCTD13/POLDIP1, POLDIP2, POLDIP3 and with WRNIP1. Interacts with POLD4 (By similarity). Interacts with KCTD10.By similarity1 Publication

Protein-protein interaction databases

BioGridi253015. 1 interaction.
STRINGi10116.ENSRNOP00000019288.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG2732. Eukaryota.
COG1311. LUCA.
GeneTreeiENSGT00390000006780.
HOGENOMiHOG000189057.
HOVERGENiHBG051396.
InParanoidiQ6AXY4.
KOiK02328.
OMAiTRLIQMR.
OrthoDBiEOG7RZ5PQ.
PhylomeDBiQ6AXY4.
TreeFamiTF101073.

Family and domain databases

InterProiIPR007185. DNA_pol_alpha/epsilon_bsu.
IPR024826. DNA_pol_delta/II_ssu.
[Graphical view]
PANTHERiPTHR10416. PTHR10416. 1 hit.
PfamiPF04042. DNA_pol_E_B. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6AXY4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFSEQAAQRA HTLLSPPSAS NATFARVPVA TYTNSSQPFR LGERSFNRQY
60 70 80 90 100
AHIYATRLIQ MRPFLVSRAQ QHWGSQVEVK KLCELQPGEQ CCVVGTLFKA
110 120 130 140 150
MPLQPSILRE ISEEHNLIPQ PPRSKYIHPD DELVLEDELQ RIKLKGTIDV
160 170 180 190 200
SKLVTGTVLA VFGSVKDDGK FQVEDHCFAD LAPQNPVPPL DTDRFVLLVS
210 220 230 240 250
GLGLGGGGGE SLLGTQLLVD VVTGQLGDEG EQCSAAHVSR VILAGNLLSH
260 270 280 290 300
NTQSRDSINK AKYLTKKTQA ASVEAVKMLD EILLQLSASV PVDVMPGEFD
310 320 330 340 350
PTNYTLPQQP LHPCMFPLAT AYATLQLVTN PYQATIDGVR FLGTSGQNVS
360 370 380 390 400
DIFRYSSMED HLEILEWTLR VRHISPTAPD TLGCYPFYKT DPFIFAECPH
410 420 430 440 450
VYFCGNTPSF GSKVIRGPED QAVLLVAVPD FSSTQTACLV NLRGLTCQPI
460
SFAGFGAEQD DLEDLGLGP
Length:469
Mass (Da):51,346
Last modified:September 13, 2004 - v1
Checksum:iE6619AD76045911A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC079267 mRNA. Translation: AAH79267.1.
RefSeqiNP_001013068.1. NM_001013050.1.
UniGeneiRn.22989.

Genome annotation databases

EnsembliENSRNOT00000019288; ENSRNOP00000019288; ENSRNOG00000014098.
ENSRNOT00000084633; ENSRNOP00000072093; ENSRNOG00000014098.
GeneIDi289758.
KEGGirno:289758.
UCSCiRGD:1304954. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC079267 mRNA. Translation: AAH79267.1.
RefSeqiNP_001013068.1. NM_001013050.1.
UniGeneiRn.22989.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi253015. 1 interaction.
STRINGi10116.ENSRNOP00000019288.

PTM databases

SwissPalmiQ6AXY4.

Proteomic databases

PaxDbiQ6AXY4.
PRIDEiQ6AXY4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000019288; ENSRNOP00000019288; ENSRNOG00000014098.
ENSRNOT00000084633; ENSRNOP00000072093; ENSRNOG00000014098.
GeneIDi289758.
KEGGirno:289758.
UCSCiRGD:1304954. rat.

Organism-specific databases

CTDi5425.
RGDi1304954. Pold2.

Phylogenomic databases

eggNOGiKOG2732. Eukaryota.
COG1311. LUCA.
GeneTreeiENSGT00390000006780.
HOGENOMiHOG000189057.
HOVERGENiHBG051396.
InParanoidiQ6AXY4.
KOiK02328.
OMAiTRLIQMR.
OrthoDBiEOG7RZ5PQ.
PhylomeDBiQ6AXY4.
TreeFamiTF101073.

Enzyme and pathway databases

ReactomeiR-RNO-110314. Recognition of DNA damage by PCNA-containing replication complex.
R-RNO-174411. Polymerase switching on the C-strand of the telomere.
R-RNO-174414. Processive synthesis on the C-strand of the telomere.
R-RNO-174417. Telomere C-strand (Lagging Strand) Synthesis.
R-RNO-174437. Removal of the Flap Intermediate from the C-strand.
R-RNO-5358565. Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha).
R-RNO-5358606. Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta).
R-RNO-5651801. PCNA-Dependent Long Patch Base Excision Repair.
R-RNO-5656169. Termination of translesion DNA synthesis.
R-RNO-5685942. HDR through Homologous Recombination (HRR).
R-RNO-5696397. Gap-filling DNA repair synthesis and ligation in GG-NER.
R-RNO-5696400. Dual Incision in GG-NER.
R-RNO-6782135. Dual incision in TC-NER.
R-RNO-6782210. Gap-filling DNA repair synthesis and ligation in TC-NER.
R-RNO-69091. Polymerase switching.
R-RNO-69109. Leading Strand Synthesis.
R-RNO-69166. Removal of the Flap Intermediate.
R-RNO-69183. Processive synthesis on the lagging strand.

Miscellaneous databases

PROiQ6AXY4.

Gene expression databases

GenevisibleiQ6AXY4. RN.

Family and domain databases

InterProiIPR007185. DNA_pol_alpha/epsilon_bsu.
IPR024826. DNA_pol_delta/II_ssu.
[Graphical view]
PANTHERiPTHR10416. PTHR10416. 1 hit.
PfamiPF04042. DNA_pol_E_B. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.
  2. "A novel PDIP1-related protein, KCTD10, that interacts with proliferating cell nuclear antigen and DNA polymerase delta."
    Zhou J., Ren K., Liu X., Xiong X., Hu X., Zhang J.
    Biochim. Biophys. Acta 1729:200-203(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH KCTD10.
    Strain: Wistar.

Entry informationi

Entry nameiDPOD2_RAT
AccessioniPrimary (citable) accession number: Q6AXY4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 5, 2006
Last sequence update: September 13, 2004
Last modified: June 8, 2016
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.