Q6AXY0 (GSTA6_RAT) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Glutathione S-transferase A6
EC=2.5.1.18

Alternative name(s):
GST class-alpha member 6

Gene names

Name:

Gsta6

Organism

Rattus norvegicus (Rat) [Reference proteome]

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	222 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles By similarity.
Catalytic activity	RX + glutathione = HX + R-S-glutathione.
Subunit structure	Homodimer or heterodimer of GSTA1 and GSTA2 By similarity.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the GST superfamily. Alpha family. Contains 1 GST C-terminal domain. Contains 1 GST N-terminal domain.

Ontologies

Keywords
Cellular component	Cytoplasm
Molecular function	Transferase
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological_process	glutathione metabolic process Inferred from sequence or structural similarity. Source: UniProtKB
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	glutathione transferase activity Inferred from sequence or structural similarity. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed By similarity
	Chain	2 – 222	221	Glutathione S-transferase A6		PRO_0000288804
Regions
	Domain	3 – 83	81	GST N-terminal
	Domain	85 – 208	124	GST C-terminal
	Region	54 – 55	2	Glutathione binding By similarity
	Region	67 – 68	2	Glutathione binding By similarity
Sites
	Binding site	9	1	Glutathione By similarity
	Binding site	45	1	Glutathione By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q6AXY0 [UniParc]. Last modified September 13, 2004. Version 1. Checksum: B45C055D23578F77	FASTA	222	25,808
	10 20 30 40 50 60 MAEKPLFHYD EARGRMESVR WLLAAAGVEY EEKFIHTNED LEKLRSDGVL MFQQVPMVEV 70 80 90 100 110 120 DGMKLVQTRA IMNYFSSKYN LYGKDMKERA LIDMYSEGLA DLNEMFILYP FDPPGVKEAN 130 140 150 160 170 180 IALMKEKATN RYFPAFEKVF ESHGQDYLVG NKLSKADVHL VEMIYNMEEL DTNILANFPL 190 200 210 220 LQALKTRISD MPTIKKFLQP GSQRQPPVDE KSIQKTRKIF KF

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Testis.
[2]	Lubec G., Afjehi-Sadat L., Chen W.-Q. Submitted (APR-2007) to UniProtKB Cited for: PROTEIN SEQUENCE OF 21-33 AND 139-152, MASS SPECTROMETRY. Strain: Sprague-Dawley. Tissue: Hippocampus and Spinal cord.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC079271 mRNA. Translation: AAH79271.1.
IPI	IPI00391161.
RefSeq	NP_001019532.1. NM_001024361.1.
UniGene	Rn.33233.
3D structure databases
HSSP	HSSP built from PDB template 1K3O based on UniProtKB P08263.
ProteinModelPortal	Q6AXY0.
SMR	Q6AXY0. Positions 2-222.
ModBase	Search...
Protein-protein interaction databases
STRING	10116.ENSRNOP00000031201.
Proteomic databases
PaxDb	Q6AXY0.
PRIDE	Q6AXY0.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSRNOT00000036813; ENSRNOP00000031201; ENSRNOG00000033402.
GeneID	501110.
KEGG	rno:501110.
UCSC	RGD:1565402. rat.
Organism-specific databases
RGD	1565402. LOC501110.
Phylogenomic databases
eggNOG	NOG266414.
GeneTree	ENSGT00670000097856.
HOGENOM	HOG000115734.
HOVERGEN	HBG053749.
InParanoid	Q6AXY0.
KO	K00799.
OMA	DTNILAN.
OrthoDB	EOG49ZXQ6.
Gene expression databases
Genevestigator	Q6AXY0.
Family and domain databases
Gene3D	1.20.1050.10. 1 hit. 3.40.30.10. 1 hit.
InterPro	IPR010987. Glutathione-S-Trfase_C-like. IPR004045. Glutathione_S-Trfase_N. IPR017933. Glutathione_S_Trfase/Cl_chnl_C. IPR003080. GST_alpha. IPR004046. GST_C. IPR012336. Thioredoxin-like_fold. [Graphical view]
PANTHER	PTHR11571:SF4. PTHR11571:SF4. 1 hit.
Pfam	PF00043. GST_C. 1 hit. PF02798. GST_N. 1 hit. [Graphical view]
PRINTS	PR01266. GSTRNSFRASEA.
SUPFAM	SSF47616. GST_C_like. 1 hit. SSF52833. Thiordxn-like_fd. 1 hit.
PROSITE	PS50405. GST_CTER. 1 hit. PS50404. GST_NTER. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	708316.

Entry information

Entry name

GSTA6_RAT

Accession

Primary (citable) accession number: Q6AXY0

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 29, 2007
Last sequence update:	September 13, 2004
Last modified:	April 3, 2013
This is version 75 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program