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Q6AXY0 (GSTA6_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 83. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glutathione S-transferase A6

EC=2.5.1.18
Alternative name(s):
GST class-alpha member 6
Gene names
Name:Gsta6
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length222 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles By similarity.

Catalytic activity

RX + glutathione = HX + R-S-glutathione.

Subunit structure

Homodimer or heterodimer of GSTA1 and GSTA2 By similarity.

Subcellular location

Cytoplasm By similarity.

Sequence similarities

Belongs to the GST superfamily. Alpha family.

Contains 1 GST C-terminal domain.

Contains 1 GST N-terminal domain.

Ontologies

Keywords
   Cellular componentCytoplasm
   Molecular functionTransferase
   Technical termComplete proteome
Direct protein sequencing
Reference proteome
Gene Ontology (GO)
   Biological_processglutathione metabolic process

Inferred from sequence or structural similarity. Source: UniProtKB

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionglutathione transferase activity

Inferred from sequence or structural similarity. Source: UniProtKB

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 222222Glutathione S-transferase A6
PRO_0000288804

Regions

Domain3 – 8381GST N-terminal
Domain85 – 208124GST C-terminal
Region54 – 552Glutathione binding By similarity
Region67 – 682Glutathione binding By similarity

Sites

Binding site91Glutathione By similarity
Binding site451Glutathione By similarity

Sequences

Sequence LengthMass (Da)Tools
Q6AXY0 [UniParc].

Last modified September 13, 2004. Version 1.
Checksum: B45C055D23578F77

FASTA22225,808
        10         20         30         40         50         60 
MAEKPLFHYD EARGRMESVR WLLAAAGVEY EEKFIHTNED LEKLRSDGVL MFQQVPMVEV 

        70         80         90        100        110        120 
DGMKLVQTRA IMNYFSSKYN LYGKDMKERA LIDMYSEGLA DLNEMFILYP FDPPGVKEAN 

       130        140        150        160        170        180 
IALMKEKATN RYFPAFEKVF ESHGQDYLVG NKLSKADVHL VEMIYNMEEL DTNILANFPL 

       190        200        210        220 
LQALKTRISD MPTIKKFLQP GSQRQPPVDE KSIQKTRKIF KF 

« Hide

References

« Hide 'large scale' references
[1]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Testis.
[2]Lubec G., Afjehi-Sadat L., Chen W.-Q.
Submitted (APR-2007) to UniProtKB
Cited for: PROTEIN SEQUENCE OF 21-33 AND 139-152, IDENTIFICATION BY MASS SPECTROMETRY.
Strain: Sprague-Dawley.
Tissue: Hippocampus and Spinal cord.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC079271 mRNA. Translation: AAH79271.1.
RefSeqNP_001019532.1. NM_001024361.1.
XP_006244718.1. XM_006244656.1.
XP_006244719.1. XM_006244657.1.
XP_006244720.1. XM_006244658.1.
UniGeneRn.33233.

3D structure databases

ProteinModelPortalQ6AXY0.
SMRQ6AXY0. Positions 2-222.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10116.ENSRNOP00000031201.

Proteomic databases

PaxDbQ6AXY0.
PRIDEQ6AXY0.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000036813; ENSRNOP00000031201; ENSRNOG00000033402.
GeneID501110.
KEGGrno:501110.
UCSCRGD:1565402. rat.

Organism-specific databases

RGD1565402. LOC501110.

Phylogenomic databases

eggNOGNOG266414.
GeneTreeENSGT00670000097856.
HOGENOMHOG000115734.
HOVERGENHBG053749.
InParanoidQ6AXY0.
KOK00799.
OMADTNILAN.
OrthoDBEOG79CZ0K.
PhylomeDBQ6AXY0.
TreeFamTF105321.

Gene expression databases

GenevestigatorQ6AXY0.

Family and domain databases

Gene3D1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProIPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR003080. GST_alpha.
IPR004046. GST_C.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PANTHERPTHR11571:SF4. PTHR11571:SF4. 1 hit.
PfamPF00043. GST_C. 1 hit.
PF02798. GST_N. 1 hit.
[Graphical view]
PRINTSPR01266. GSTRNSFRASEA.
SUPFAMSSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEPS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio708316.

Entry information

Entry nameGSTA6_RAT
AccessionPrimary (citable) accession number: Q6AXY0
Entry history
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: September 13, 2004
Last modified: April 16, 2014
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families