Reviewed, UniProtKB/Swiss-Prot Q6AXY0 (GSTA6_RAT)

Names and origin

Protein names

Recommended name:
    Glutathione S-transferase A6
    EC=2.5.1.18
Alternative name(s):
    GST class-alpha member 6

Gene names

Name:

Gsta6

Organism

Rattus norvegicus (Rat)

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	222 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles By similarity.
Catalytic activity	RX + glutathione = HX + R-S-glutathione.
Subunit structure	Homodimer or heterodimer of GSTA1 and GSTA2 By similarity.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the GST superfamily. Alpha family. Contains 1 GST C-terminal domain. Contains 1 GST N-terminal domain.

Ontologies

Keywords
Cellular component	Cytoplasm
Molecular function	Transferase
Technical term	Direct protein sequencing
Gene Ontology (GO)
Biological process	metabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	glutathione transferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed By similarity
	Chain	2 – 222	221	Glutathione S-transferase A6		PRO_0000288804
Regions
	Domain	3 – 83	81	GST N-terminal
	Domain	85 – 208	124	GST C-terminal

Sequences

	Sequence		Length	Mass (Da)
	Q6AXY0-1 [UniParc]. Last modified September 13, 2004. Version 1. Checksum: B45C055D23578F77	FASTA	222	25,808
	10 20 30 40 50 60 MAEKPLFHYD EARGRMESVR WLLAAAGVEY EEKFIHTNED LEKLRSDGVL MFQQVPMVEV 70 80 90 100 110 120 DGMKLVQTRA IMNYFSSKYN LYGKDMKERA LIDMYSEGLA DLNEMFILYP FDPPGVKEAN 130 140 150 160 170 180 IALMKEKATN RYFPAFEKVF ESHGQDYLVG NKLSKADVHL VEMIYNMEEL DTNILANFPL 190 200 210 220 LQALKTRISD MPTIKKFLQP GSQRQPPVDE KSIQKTRKIF KF

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Testis.
[2]	Lubec G., Afjehi-Sadat L., Chen W.-Q. Submitted (APR-2007) to UniProtKB Cited for: PROTEIN SEQUENCE OF 21-33 AND 139-152, MASS SPECTROMETRY. Strain: Sprague-Dawley. Tissue: Hippocampus and Spinal cord.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	BC079271 mRNA. Translation: AAH79271.1.
IPI	IPI00391161.
RefSeq	NP_001019532.1.
UniGene	Rn.33233
3D structure databases
SMR	Q6AXY0. Positions 2-222.
ModBase	Search...
Protein-protein interaction databases
STRING	Q6AXY0.
Genome annotation databases
Ensembl	ENSRNOT00000036813; ENSRNOP00000031201; ENSRNOG00000033402; Rattus norvegicus. [Genome view]
GeneID	501110.
KEGG	rno:501110.
NMPDR	fig|10116.3.peg.29794.
UCSC	NM_001024361. rat.
Organism-specific databases
RGD	1565402. LOC501110.
Phylogenomic databases
HOVERGEN	Q6AXY0.
OMA	YNMEELD.
Enzyme and pathway databases
BRENDA	2.5.1.18. 248.
Gene expression databases
Genevestigator	Q6AXY0.
Family and domain databases
InterPro	IPR010987. Glutathione-S-Trfase_C-like. IPR004045. Glutathione_S-Trfase_N. IPR017933. Glutathione_S_Trfase/Cl_chnl_C. IPR003080. GST_alpha. IPR004046. GST_C. IPR012335. Thioredoxin_fold. [Graphical view]
Gene3D	G3DSA:1.20.1050.10. GST_C_like. 1 hit. G3DSA:3.40.30.10. Thioredoxin_fold. 1 hit.
PANTHER	PTHR11571:SF4. GST_alpha. 1 hit.
Pfam	PF00043. GST_C. 1 hit. PF02798. GST_N. 1 hit. [Graphical view]
PRINTS	PR01266. GSTRNSFRASEA.
PROSITE	PS50405. GST_CTER. 1 hit. PS50404. GST_NTER. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	708316.

Entry information

Entry name

GSTA6_RAT

Accession

Primary (citable) accession number: Q6AXY0

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 29, 2007
Last sequence update:	September 13, 2004
Last modified:	November 3, 2009
This is version 50 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)