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Protein

Glutathione S-transferase A6

Gene

Gsta6

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.By similarity

Catalytic activityi

RX + glutathione = HX + R-S-glutathione.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei9 – 91GlutathioneBy similarity
Binding sitei45 – 451GlutathioneBy similarity

GO - Molecular functioni

  1. glutathione transferase activity Source: UniProtKB

GO - Biological processi

  1. glutathione metabolic process Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
Glutathione S-transferase A6 (EC:2.5.1.18)
Alternative name(s):
GST class-alpha member 6
Gene namesi
Name:Gsta6
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 9

Organism-specific databases

RGDi1565402. LOC501110.

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 222222Glutathione S-transferase A6PRO_0000288804Add
BLAST

Proteomic databases

PaxDbiQ6AXY0.
PRIDEiQ6AXY0.

Expressioni

Gene expression databases

GenevestigatoriQ6AXY0.

Interactioni

Subunit structurei

Homodimer or heterodimer of GSTA1 and GSTA2.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000031201.

Structurei

3D structure databases

ProteinModelPortaliQ6AXY0.
SMRiQ6AXY0. Positions 2-222.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini3 – 8381GST N-terminalAdd
BLAST
Domaini85 – 208124GST C-terminalAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni54 – 552Glutathione bindingBy similarity
Regioni67 – 682Glutathione bindingBy similarity

Sequence similaritiesi

Belongs to the GST superfamily. Alpha family.Curated
Contains 1 GST C-terminal domain.Curated
Contains 1 GST N-terminal domain.Curated

Phylogenomic databases

eggNOGiNOG266414.
GeneTreeiENSGT00670000097856.
HOGENOMiHOG000115734.
HOVERGENiHBG053749.
InParanoidiQ6AXY0.
KOiK00799.
OMAiHEDNISI.
OrthoDBiEOG79CZ0K.
PhylomeDBiQ6AXY0.
TreeFamiTF105321.

Family and domain databases

Gene3Di1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProiIPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR003080. GST_alpha.
IPR004046. GST_C.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamiPF00043. GST_C. 1 hit.
PF02798. GST_N. 1 hit.
[Graphical view]
PRINTSiPR01266. GSTRNSFRASEA.
SUPFAMiSSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEiPS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6AXY0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEKPLFHYD EARGRMESVR WLLAAAGVEY EEKFIHTNED LEKLRSDGVL
60 70 80 90 100
MFQQVPMVEV DGMKLVQTRA IMNYFSSKYN LYGKDMKERA LIDMYSEGLA
110 120 130 140 150
DLNEMFILYP FDPPGVKEAN IALMKEKATN RYFPAFEKVF ESHGQDYLVG
160 170 180 190 200
NKLSKADVHL VEMIYNMEEL DTNILANFPL LQALKTRISD MPTIKKFLQP
210 220
GSQRQPPVDE KSIQKTRKIF KF
Length:222
Mass (Da):25,808
Last modified:September 13, 2004 - v1
Checksum:iB45C055D23578F77
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC079271 mRNA. Translation: AAH79271.1.
RefSeqiNP_001019532.1. NM_001024361.1.
XP_006244718.1. XM_006244656.2.
XP_006244719.1. XM_006244657.2.
XP_006244720.1. XM_006244658.2.
UniGeneiRn.33233.

Genome annotation databases

EnsembliENSRNOT00000036813; ENSRNOP00000031201; ENSRNOG00000033402.
GeneIDi501110.
KEGGirno:501110.
UCSCiRGD:1565402. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC079271 mRNA. Translation: AAH79271.1.
RefSeqiNP_001019532.1. NM_001024361.1.
XP_006244718.1. XM_006244656.2.
XP_006244719.1. XM_006244657.2.
XP_006244720.1. XM_006244658.2.
UniGeneiRn.33233.

3D structure databases

ProteinModelPortaliQ6AXY0.
SMRiQ6AXY0. Positions 2-222.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000031201.

Proteomic databases

PaxDbiQ6AXY0.
PRIDEiQ6AXY0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000036813; ENSRNOP00000031201; ENSRNOG00000033402.
GeneIDi501110.
KEGGirno:501110.
UCSCiRGD:1565402. rat.

Organism-specific databases

RGDi1565402. LOC501110.

Phylogenomic databases

eggNOGiNOG266414.
GeneTreeiENSGT00670000097856.
HOGENOMiHOG000115734.
HOVERGENiHBG053749.
InParanoidiQ6AXY0.
KOiK00799.
OMAiHEDNISI.
OrthoDBiEOG79CZ0K.
PhylomeDBiQ6AXY0.
TreeFamiTF105321.

Miscellaneous databases

NextBioi708316.

Gene expression databases

GenevestigatoriQ6AXY0.

Family and domain databases

Gene3Di1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProiIPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR003080. GST_alpha.
IPR004046. GST_C.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamiPF00043. GST_C. 1 hit.
PF02798. GST_N. 1 hit.
[Graphical view]
PRINTSiPR01266. GSTRNSFRASEA.
SUPFAMiSSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEiPS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.
  2. Lubec G., Afjehi-Sadat L., Chen W.-Q.
    Submitted (APR-2007) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 21-33 AND 139-152, IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: Sprague-Dawley.
    Tissue: Hippocampus and Spinal cord.

Entry informationi

Entry nameiGSTA6_RAT
AccessioniPrimary (citable) accession number: Q6AXY0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: September 13, 2004
Last modified: January 7, 2015
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.