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Q6AXY0

- GSTA6_RAT

UniProt

Q6AXY0 - GSTA6_RAT

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Protein
Glutathione S-transferase A6
Gene
Gsta6
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles By similarity.

Catalytic activityi

RX + glutathione = HX + R-S-glutathione.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei9 – 91Glutathione By similarity
Binding sitei45 – 451Glutathione By similarity

GO - Molecular functioni

  1. glutathione transferase activity Source: UniProtKB

GO - Biological processi

  1. glutathione metabolic process Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
Glutathione S-transferase A6 (EC:2.5.1.18)
Alternative name(s):
GST class-alpha member 6
Gene namesi
Name:Gsta6
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 9

Organism-specific databases

RGDi1565402. LOC501110.

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 222222Glutathione S-transferase A6
PRO_0000288804Add
BLAST

Proteomic databases

PaxDbiQ6AXY0.
PRIDEiQ6AXY0.

Expressioni

Gene expression databases

GenevestigatoriQ6AXY0.

Interactioni

Subunit structurei

Homodimer or heterodimer of GSTA1 and GSTA2 By similarity.

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000031201.

Structurei

3D structure databases

ProteinModelPortaliQ6AXY0.
SMRiQ6AXY0. Positions 2-222.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini3 – 8381GST N-terminal
Add
BLAST
Domaini85 – 208124GST C-terminal
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni54 – 552Glutathione binding By similarity
Regioni67 – 682Glutathione binding By similarity

Sequence similaritiesi

Belongs to the GST superfamily. Alpha family.

Phylogenomic databases

eggNOGiNOG266414.
GeneTreeiENSGT00670000097856.
HOGENOMiHOG000115734.
HOVERGENiHBG053749.
InParanoidiQ6AXY0.
KOiK00799.
OMAiDTNILAN.
OrthoDBiEOG79CZ0K.
PhylomeDBiQ6AXY0.
TreeFamiTF105321.

Family and domain databases

Gene3Di1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProiIPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR003080. GST_alpha.
IPR004046. GST_C.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamiPF00043. GST_C. 1 hit.
PF02798. GST_N. 1 hit.
[Graphical view]
PRINTSiPR01266. GSTRNSFRASEA.
SUPFAMiSSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEiPS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6AXY0-1 [UniParc]FASTAAdd to Basket

« Hide

MAEKPLFHYD EARGRMESVR WLLAAAGVEY EEKFIHTNED LEKLRSDGVL    50
MFQQVPMVEV DGMKLVQTRA IMNYFSSKYN LYGKDMKERA LIDMYSEGLA 100
DLNEMFILYP FDPPGVKEAN IALMKEKATN RYFPAFEKVF ESHGQDYLVG 150
NKLSKADVHL VEMIYNMEEL DTNILANFPL LQALKTRISD MPTIKKFLQP 200
GSQRQPPVDE KSIQKTRKIF KF 222
Length:222
Mass (Da):25,808
Last modified:September 13, 2004 - v1
Checksum:iB45C055D23578F77
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC079271 mRNA. Translation: AAH79271.1.
RefSeqiNP_001019532.1. NM_001024361.1.
XP_006244718.1. XM_006244656.1.
XP_006244719.1. XM_006244657.1.
XP_006244720.1. XM_006244658.1.
UniGeneiRn.33233.

Genome annotation databases

EnsembliENSRNOT00000036813; ENSRNOP00000031201; ENSRNOG00000033402.
GeneIDi501110.
KEGGirno:501110.
UCSCiRGD:1565402. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC079271 mRNA. Translation: AAH79271.1 .
RefSeqi NP_001019532.1. NM_001024361.1.
XP_006244718.1. XM_006244656.1.
XP_006244719.1. XM_006244657.1.
XP_006244720.1. XM_006244658.1.
UniGenei Rn.33233.

3D structure databases

ProteinModelPortali Q6AXY0.
SMRi Q6AXY0. Positions 2-222.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000031201.

Proteomic databases

PaxDbi Q6AXY0.
PRIDEi Q6AXY0.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000036813 ; ENSRNOP00000031201 ; ENSRNOG00000033402 .
GeneIDi 501110.
KEGGi rno:501110.
UCSCi RGD:1565402. rat.

Organism-specific databases

RGDi 1565402. LOC501110.

Phylogenomic databases

eggNOGi NOG266414.
GeneTreei ENSGT00670000097856.
HOGENOMi HOG000115734.
HOVERGENi HBG053749.
InParanoidi Q6AXY0.
KOi K00799.
OMAi DTNILAN.
OrthoDBi EOG79CZ0K.
PhylomeDBi Q6AXY0.
TreeFami TF105321.

Miscellaneous databases

NextBioi 708316.

Gene expression databases

Genevestigatori Q6AXY0.

Family and domain databases

Gene3Di 1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProi IPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR003080. GST_alpha.
IPR004046. GST_C.
IPR012336. Thioredoxin-like_fold.
[Graphical view ]
Pfami PF00043. GST_C. 1 hit.
PF02798. GST_N. 1 hit.
[Graphical view ]
PRINTSi PR01266. GSTRNSFRASEA.
SUPFAMi SSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEi PS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.
  2. Lubec G., Afjehi-Sadat L., Chen W.-Q.
    Submitted (APR-2007) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 21-33 AND 139-152, IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: Sprague-Dawley.
    Tissue: Hippocampus and Spinal cord.

Entry informationi

Entry nameiGSTA6_RAT
AccessioniPrimary (citable) accession number: Q6AXY0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: September 13, 2004
Last modified: June 11, 2014
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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