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Q6AXY0

- GSTA6_RAT

UniProt

Q6AXY0 - GSTA6_RAT

Protein

Glutathione S-transferase A6

Gene

Gsta6

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 85 (01 Oct 2014)
      Sequence version 1 (13 Sep 2004)
      Previous versions | rss
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    Functioni

    Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.By similarity

    Catalytic activityi

    RX + glutathione = HX + R-S-glutathione.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei9 – 91GlutathioneBy similarity
    Binding sitei45 – 451GlutathioneBy similarity

    GO - Molecular functioni

    1. glutathione transferase activity Source: UniProtKB

    GO - Biological processi

    1. glutathione metabolic process Source: UniProtKB

    Keywords - Molecular functioni

    Transferase

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glutathione S-transferase A6 (EC:2.5.1.18)
    Alternative name(s):
    GST class-alpha member 6
    Gene namesi
    Name:Gsta6
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 9

    Organism-specific databases

    RGDi1565402. LOC501110.

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 222222Glutathione S-transferase A6PRO_0000288804Add
    BLAST

    Proteomic databases

    PaxDbiQ6AXY0.
    PRIDEiQ6AXY0.

    Expressioni

    Gene expression databases

    GenevestigatoriQ6AXY0.

    Interactioni

    Subunit structurei

    Homodimer or heterodimer of GSTA1 and GSTA2.By similarity

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000031201.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6AXY0.
    SMRiQ6AXY0. Positions 2-222.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini3 – 8381GST N-terminalAdd
    BLAST
    Domaini85 – 208124GST C-terminalAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni54 – 552Glutathione bindingBy similarity
    Regioni67 – 682Glutathione bindingBy similarity

    Sequence similaritiesi

    Belongs to the GST superfamily. Alpha family.Curated
    Contains 1 GST C-terminal domain.Curated
    Contains 1 GST N-terminal domain.Curated

    Phylogenomic databases

    eggNOGiNOG266414.
    GeneTreeiENSGT00670000097856.
    HOGENOMiHOG000115734.
    HOVERGENiHBG053749.
    InParanoidiQ6AXY0.
    KOiK00799.
    OMAiDTNILAN.
    OrthoDBiEOG79CZ0K.
    PhylomeDBiQ6AXY0.
    TreeFamiTF105321.

    Family and domain databases

    Gene3Di1.20.1050.10. 1 hit.
    3.40.30.10. 1 hit.
    InterProiIPR010987. Glutathione-S-Trfase_C-like.
    IPR004045. Glutathione_S-Trfase_N.
    IPR003080. GST_alpha.
    IPR004046. GST_C.
    IPR012336. Thioredoxin-like_fold.
    [Graphical view]
    PfamiPF00043. GST_C. 1 hit.
    PF02798. GST_N. 1 hit.
    [Graphical view]
    PRINTSiPR01266. GSTRNSFRASEA.
    SUPFAMiSSF47616. SSF47616. 1 hit.
    SSF52833. SSF52833. 1 hit.
    PROSITEiPS50405. GST_CTER. 1 hit.
    PS50404. GST_NTER. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q6AXY0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAEKPLFHYD EARGRMESVR WLLAAAGVEY EEKFIHTNED LEKLRSDGVL    50
    MFQQVPMVEV DGMKLVQTRA IMNYFSSKYN LYGKDMKERA LIDMYSEGLA 100
    DLNEMFILYP FDPPGVKEAN IALMKEKATN RYFPAFEKVF ESHGQDYLVG 150
    NKLSKADVHL VEMIYNMEEL DTNILANFPL LQALKTRISD MPTIKKFLQP 200
    GSQRQPPVDE KSIQKTRKIF KF 222
    Length:222
    Mass (Da):25,808
    Last modified:September 13, 2004 - v1
    Checksum:iB45C055D23578F77
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC079271 mRNA. Translation: AAH79271.1.
    RefSeqiNP_001019532.1. NM_001024361.1.
    XP_006244718.1. XM_006244656.1.
    XP_006244719.1. XM_006244657.1.
    XP_006244720.1. XM_006244658.1.
    UniGeneiRn.33233.

    Genome annotation databases

    EnsembliENSRNOT00000036813; ENSRNOP00000031201; ENSRNOG00000033402.
    GeneIDi501110.
    KEGGirno:501110.
    UCSCiRGD:1565402. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC079271 mRNA. Translation: AAH79271.1 .
    RefSeqi NP_001019532.1. NM_001024361.1.
    XP_006244718.1. XM_006244656.1.
    XP_006244719.1. XM_006244657.1.
    XP_006244720.1. XM_006244658.1.
    UniGenei Rn.33233.

    3D structure databases

    ProteinModelPortali Q6AXY0.
    SMRi Q6AXY0. Positions 2-222.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000031201.

    Proteomic databases

    PaxDbi Q6AXY0.
    PRIDEi Q6AXY0.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000036813 ; ENSRNOP00000031201 ; ENSRNOG00000033402 .
    GeneIDi 501110.
    KEGGi rno:501110.
    UCSCi RGD:1565402. rat.

    Organism-specific databases

    RGDi 1565402. LOC501110.

    Phylogenomic databases

    eggNOGi NOG266414.
    GeneTreei ENSGT00670000097856.
    HOGENOMi HOG000115734.
    HOVERGENi HBG053749.
    InParanoidi Q6AXY0.
    KOi K00799.
    OMAi DTNILAN.
    OrthoDBi EOG79CZ0K.
    PhylomeDBi Q6AXY0.
    TreeFami TF105321.

    Miscellaneous databases

    NextBioi 708316.

    Gene expression databases

    Genevestigatori Q6AXY0.

    Family and domain databases

    Gene3Di 1.20.1050.10. 1 hit.
    3.40.30.10. 1 hit.
    InterProi IPR010987. Glutathione-S-Trfase_C-like.
    IPR004045. Glutathione_S-Trfase_N.
    IPR003080. GST_alpha.
    IPR004046. GST_C.
    IPR012336. Thioredoxin-like_fold.
    [Graphical view ]
    Pfami PF00043. GST_C. 1 hit.
    PF02798. GST_N. 1 hit.
    [Graphical view ]
    PRINTSi PR01266. GSTRNSFRASEA.
    SUPFAMi SSF47616. SSF47616. 1 hit.
    SSF52833. SSF52833. 1 hit.
    PROSITEi PS50405. GST_CTER. 1 hit.
    PS50404. GST_NTER. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Testis.
    2. Lubec G., Afjehi-Sadat L., Chen W.-Q.
      Submitted (APR-2007) to UniProtKB
      Cited for: PROTEIN SEQUENCE OF 21-33 AND 139-152, IDENTIFICATION BY MASS SPECTROMETRY.
      Strain: Sprague-Dawley.
      Tissue: Hippocampus and Spinal cord.

    Entry informationi

    Entry nameiGSTA6_RAT
    AccessioniPrimary (citable) accession number: Q6AXY0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 29, 2007
    Last sequence update: September 13, 2004
    Last modified: October 1, 2014
    This is version 85 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3