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Protein

Glutathione S-transferase A6

Gene

Gsta6

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.By similarity

Catalytic activityi

RX + glutathione = HX + R-S-glutathione.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei9GlutathioneBy similarity1
Binding sitei45GlutathioneBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
Glutathione S-transferase A6 (EC:2.5.1.18)
Alternative name(s):
GST class-alpha member 6
Gene namesi
Name:Gsta6
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 9

Organism-specific databases

RGDi1565402. LOC501110.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002888041 – 222Glutathione S-transferase A6Add BLAST222

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiQ6AXY0.
PRIDEiQ6AXY0.

PTM databases

iPTMnetiQ6AXY0.
PhosphoSitePlusiQ6AXY0.

Expressioni

Gene expression databases

BgeeiENSRNOG00000033402.

Interactioni

Subunit structurei

Homodimer or heterodimer of GSTA1 and GSTA2.By similarity

Protein-protein interaction databases

BioGridi272417. 1 interactor.
STRINGi10116.ENSRNOP00000031201.

Structurei

3D structure databases

ProteinModelPortaliQ6AXY0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini3 – 83GST N-terminalAdd BLAST81
Domaini85 – 208GST C-terminalAdd BLAST124

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni54 – 55Glutathione bindingBy similarity2
Regioni67 – 68Glutathione bindingBy similarity2

Sequence similaritiesi

Belongs to the GST superfamily. Alpha family.Curated
Contains 1 GST C-terminal domain.Curated
Contains 1 GST N-terminal domain.Curated

Phylogenomic databases

eggNOGiKOG1695. Eukaryota.
ENOG4111VAU. LUCA.
GeneTreeiENSGT00670000097856.
HOGENOMiHOG000115734.
HOVERGENiHBG053749.
InParanoidiQ6AXY0.
KOiK00799.
OMAiRMEAIRW.
OrthoDBiEOG091G0O3D.
PhylomeDBiQ6AXY0.
TreeFamiTF105321.

Family and domain databases

Gene3Di1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProiIPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR003080. GST_alpha.
IPR004046. GST_C.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamiPF14497. GST_C_3. 1 hit.
PF02798. GST_N. 1 hit.
[Graphical view]
PRINTSiPR01266. GSTRNSFRASEA.
SUPFAMiSSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEiPS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6AXY0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEKPLFHYD EARGRMESVR WLLAAAGVEY EEKFIHTNED LEKLRSDGVL
60 70 80 90 100
MFQQVPMVEV DGMKLVQTRA IMNYFSSKYN LYGKDMKERA LIDMYSEGLA
110 120 130 140 150
DLNEMFILYP FDPPGVKEAN IALMKEKATN RYFPAFEKVF ESHGQDYLVG
160 170 180 190 200
NKLSKADVHL VEMIYNMEEL DTNILANFPL LQALKTRISD MPTIKKFLQP
210 220
GSQRQPPVDE KSIQKTRKIF KF
Length:222
Mass (Da):25,808
Last modified:September 13, 2004 - v1
Checksum:iB45C055D23578F77
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC079271 mRNA. Translation: AAH79271.1.
RefSeqiNP_001019532.1. NM_001024361.1.
XP_006244718.1. XM_006244656.3.
XP_006244719.1. XM_006244657.3.
XP_006244720.1. XM_006244658.3.
UniGeneiRn.33233.

Genome annotation databases

EnsembliENSRNOT00000036813; ENSRNOP00000031201; ENSRNOG00000033402.
GeneIDi501110.
KEGGirno:501110.
UCSCiRGD:1565402. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC079271 mRNA. Translation: AAH79271.1.
RefSeqiNP_001019532.1. NM_001024361.1.
XP_006244718.1. XM_006244656.3.
XP_006244719.1. XM_006244657.3.
XP_006244720.1. XM_006244658.3.
UniGeneiRn.33233.

3D structure databases

ProteinModelPortaliQ6AXY0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi272417. 1 interactor.
STRINGi10116.ENSRNOP00000031201.

PTM databases

iPTMnetiQ6AXY0.
PhosphoSitePlusiQ6AXY0.

Proteomic databases

PaxDbiQ6AXY0.
PRIDEiQ6AXY0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000036813; ENSRNOP00000031201; ENSRNOG00000033402.
GeneIDi501110.
KEGGirno:501110.
UCSCiRGD:1565402. rat.

Organism-specific databases

RGDi1565402. LOC501110.

Phylogenomic databases

eggNOGiKOG1695. Eukaryota.
ENOG4111VAU. LUCA.
GeneTreeiENSGT00670000097856.
HOGENOMiHOG000115734.
HOVERGENiHBG053749.
InParanoidiQ6AXY0.
KOiK00799.
OMAiRMEAIRW.
OrthoDBiEOG091G0O3D.
PhylomeDBiQ6AXY0.
TreeFamiTF105321.

Miscellaneous databases

PROiQ6AXY0.

Gene expression databases

BgeeiENSRNOG00000033402.

Family and domain databases

Gene3Di1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProiIPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR003080. GST_alpha.
IPR004046. GST_C.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamiPF14497. GST_C_3. 1 hit.
PF02798. GST_N. 1 hit.
[Graphical view]
PRINTSiPR01266. GSTRNSFRASEA.
SUPFAMiSSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEiPS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGSTA6_RAT
AccessioniPrimary (citable) accession number: Q6AXY0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: September 13, 2004
Last modified: November 2, 2016
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.