Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Glutathione S-transferase A6

Gene

Gsta6

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.By similarity

Catalytic activityi

RX + glutathione = HX + R-S-glutathione.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei9GlutathioneBy similarity1
Binding sitei45GlutathioneBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase

Enzyme and pathway databases

ReactomeiR-RNO-156590. Glutathione conjugation.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutathione S-transferase A6 (EC:2.5.1.18)
Alternative name(s):
GST class-alpha member 6
Gene namesi
Name:Gsta6
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 9

Organism-specific databases

RGDi1565402. LOC501110.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002888041 – 222Glutathione S-transferase A6Add BLAST222

Proteomic databases

PaxDbiQ6AXY0.
PRIDEiQ6AXY0.

PTM databases

iPTMnetiQ6AXY0.
PhosphoSitePlusiQ6AXY0.

Expressioni

Gene expression databases

BgeeiENSRNOG00000033402.

Interactioni

Subunit structurei

Homodimer or heterodimer of GSTA1 and GSTA2.By similarity

Protein-protein interaction databases

BioGridi272417. 1 interactor.
STRINGi10116.ENSRNOP00000031201.

Structurei

3D structure databases

ProteinModelPortaliQ6AXY0.
SMRiQ6AXY0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini3 – 83GST N-terminalAdd BLAST81
Domaini85 – 208GST C-terminalAdd BLAST124

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni54 – 55Glutathione bindingBy similarity2
Regioni67 – 68Glutathione bindingBy similarity2

Sequence similaritiesi

Belongs to the GST superfamily. Alpha family.Curated

Phylogenomic databases

eggNOGiKOG1695. Eukaryota.
ENOG4111VAU. LUCA.
GeneTreeiENSGT00670000097856.
HOGENOMiHOG000115734.
HOVERGENiHBG053749.
InParanoidiQ6AXY0.
KOiK00799.
OMAiHRNERAV.
OrthoDBiEOG091G0O3D.
PhylomeDBiQ6AXY0.
TreeFamiTF105321.

Family and domain databases

InterProiView protein in InterPro
IPR010987. Glutathione-S-Trfase_C-like.
IPR036282. Glutathione-S-Trfase_C_sf.
IPR004045. Glutathione_S-Trfase_N.
IPR003080. GST_alpha.
IPR004046. GST_C.
IPR036249. Thioredoxin-like_sf.
PfamiView protein in Pfam
PF14497. GST_C_3. 1 hit.
PF02798. GST_N. 1 hit.
PRINTSiPR01266. GSTRNSFRASEA.
SUPFAMiSSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEiView protein in PROSITE
PS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6AXY0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEKPLFHYD EARGRMESVR WLLAAAGVEY EEKFIHTNED LEKLRSDGVL
60 70 80 90 100
MFQQVPMVEV DGMKLVQTRA IMNYFSSKYN LYGKDMKERA LIDMYSEGLA
110 120 130 140 150
DLNEMFILYP FDPPGVKEAN IALMKEKATN RYFPAFEKVF ESHGQDYLVG
160 170 180 190 200
NKLSKADVHL VEMIYNMEEL DTNILANFPL LQALKTRISD MPTIKKFLQP
210 220
GSQRQPPVDE KSIQKTRKIF KF
Length:222
Mass (Da):25,808
Last modified:September 13, 2004 - v1
Checksum:iB45C055D23578F77
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC079271 mRNA. Translation: AAH79271.1.
RefSeqiNP_001019532.1. NM_001024361.1.
XP_006244718.1. XM_006244656.3.
XP_006244719.1. XM_006244657.3.
XP_006244720.1. XM_006244658.3.
UniGeneiRn.33233.

Genome annotation databases

EnsembliENSRNOT00000036813; ENSRNOP00000031201; ENSRNOG00000033402.
GeneIDi501110.
KEGGirno:501110.
UCSCiRGD:1565402. rat.

Similar proteinsi

Entry informationi

Entry nameiGSTA6_RAT
AccessioniPrimary (citable) accession number: Q6AXY0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: September 13, 2004
Last modified: November 22, 2017
This is version 110 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families