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Protein

Putative C->U-editing enzyme APOBEC-4

Gene

Apobec4

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Putative C to U editing enzyme whose physiological substrate is not yet known.By similarity

Cofactori

Zn2+By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi92 – 921Zinc; catalyticBy similarity
Active sitei94 – 941Proton donorBy similarity
Metal bindingi126 – 1261Zinc; catalyticBy similarity
Metal bindingi133 – 1331Zinc; catalyticBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

mRNA processing

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Putative C->U-editing enzyme APOBEC-4 (EC:3.5.4.-)
Alternative name(s):
Apolipoprotein B mRNA-editing enzyme catalytic polypeptide-like 4
Gene namesi
Name:Apobec4
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 13

Organism-specific databases

RGDi1560256. Apobec4.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 388388Putative C->U-editing enzyme APOBEC-4PRO_0000239358Add
BLAST

Proteomic databases

PaxDbiQ6AXX9.
PRIDEiQ6AXX9.

Expressioni

Gene expression databases

BgeeiENSRNOG00000028089.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000034180.

Structurei

3D structure databases

ProteinModelPortaliQ6AXX9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini60 – 176117CMP/dCMP-type deaminasePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 CMP/dCMP-type deaminase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG410II65. Eukaryota.
ENOG4111QES. LUCA.
GeneTreeiENSGT00390000014243.
HOGENOMiHOG000033767.
HOVERGENiHBG080811.
InParanoidiQ6AXX9.
KOiK18773.
OMAiTIVKPYY.
OrthoDBiEOG091G0T9Y.
PhylomeDBiQ6AXX9.
TreeFamiTF338173.

Family and domain databases

InterProiIPR013158. APOBEC_N.
IPR002125. CMP_dCMP_Zn-bd.
[Graphical view]
PfamiPF08210. APOBEC_N. 1 hit.
[Graphical view]
PROSITEiPS51747. CYT_DCMP_DEAMINASES_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6AXX9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEPLYEEYLT HSGTIVKPYY WLSVSLNCTN CPYHIRTGEE ARVPYTEFHQ
60 70 80 90 100
TFGFPWSTYP QTKHLTFYEL RSSSGNLIQK GLASNCTGSH THPESMLFER
110 120 130 140 150
DGYLDSLIFH DSNIRHIILY SNNSPCDEAN HCCISKMYNF LMNYPEVTLS
160 170 180 190 200
VFFSQLYHTE NQFPTSAWNR EALRGLASLW PQVTLSAISG GIWQSILETF
210 220 230 240 250
VSGISEGLTA VRPFTAGRTL TDRYNAYEIN CITEVKPYFT DALHSWQKEN
260 270 280 290 300
QDQKVWAASE NQPLHNTTPA QWQPDMSQDC RTPAVFMLVP YRDLPPIHVN
310 320 330 340 350
PSPQKPRTVV RHLNTLQLSA SKVKALRKSP SGRPVKKEEA RKGSTRSQEA
360 370 380
NETNKSKWKK QTLFIKSNIC HLLEREQKKI GILSSWSV
Length:388
Mass (Da):44,519
Last modified:September 13, 2004 - v1
Checksum:iBCA0DA5452C94F1E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC079272 mRNA. Translation: AAH79272.1.
RefSeqiNP_001017492.1. NM_001017492.1.
XP_008767888.1. XM_008769666.1.
XP_008767889.1. XM_008769667.1.
UniGeneiRn.162330.

Genome annotation databases

EnsembliENSRNOT00000036906; ENSRNOP00000034180; ENSRNOG00000028089.
GeneIDi498251.
KEGGirno:498251.
UCSCiRGD:1560256. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC079272 mRNA. Translation: AAH79272.1.
RefSeqiNP_001017492.1. NM_001017492.1.
XP_008767888.1. XM_008769666.1.
XP_008767889.1. XM_008769667.1.
UniGeneiRn.162330.

3D structure databases

ProteinModelPortaliQ6AXX9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000034180.

Proteomic databases

PaxDbiQ6AXX9.
PRIDEiQ6AXX9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000036906; ENSRNOP00000034180; ENSRNOG00000028089.
GeneIDi498251.
KEGGirno:498251.
UCSCiRGD:1560256. rat.

Organism-specific databases

CTDi403314.
RGDi1560256. Apobec4.

Phylogenomic databases

eggNOGiENOG410II65. Eukaryota.
ENOG4111QES. LUCA.
GeneTreeiENSGT00390000014243.
HOGENOMiHOG000033767.
HOVERGENiHBG080811.
InParanoidiQ6AXX9.
KOiK18773.
OMAiTIVKPYY.
OrthoDBiEOG091G0T9Y.
PhylomeDBiQ6AXX9.
TreeFamiTF338173.

Miscellaneous databases

PROiQ6AXX9.

Gene expression databases

BgeeiENSRNOG00000028089.

Family and domain databases

InterProiIPR013158. APOBEC_N.
IPR002125. CMP_dCMP_Zn-bd.
[Graphical view]
PfamiPF08210. APOBEC_N. 1 hit.
[Graphical view]
PROSITEiPS51747. CYT_DCMP_DEAMINASES_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiABEC4_RAT
AccessioniPrimary (citable) accession number: Q6AXX9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 13, 2006
Last sequence update: September 13, 2004
Last modified: September 7, 2016
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.