Reviewed, UniProtKB/Swiss-Prot Q6AXW7 (DUS18_RAT)

Names and origin

Protein names

Recommended name:
    Dual specificity protein phosphatase 18
    EC=3.1.3.48
    EC=3.1.3.16

Gene names

Name:

Dusp18

Organism

Rattus norvegicus (Rat)

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	204 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Can dephosphorylate single and diphosphorylated synthetic MAPK peptides, with preference for the phosphotyrosine and diphosphorylated forms over phosphothreonine By similarity.
Catalytic activity	Protein tyrosine phosphate + H2O = protein tyrosine + phosphate. A phosphoprotein + H2O = a protein + phosphate.
Subcellular location	Cytoplasm By similarity. Nucleus By similarity.
Sequence similarities	Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily. Contains 1 tyrosine-protein phosphatase domain.

Ontologies

Keywords
Cellular component	Cytoplasm Nucleus
Molecular function	Hydrolase Protein phosphatase
Gene Ontology (GO)
Biological process	protein amino acid dephosphorylation Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	protein tyrosine phosphatase activity Inferred from electronic annotation. Source: EC protein tyrosine/serine/threonine phosphatase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 204	204	Dual specificity protein phosphatase 18		PRO_0000094831
Regions
	Domain	80 – 149	70	Tyrosine-protein phosphatase
Sites
	Active site	104	1	Phosphocysteine intermediate By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q6AXW7-1 [UniParc]. Last modified September 13, 2004. Version 1. Checksum: 1A5BBC759522E442	FASTA	204	22,754
	10 20 30 40 50 60 MTSPWSACPV QFPQPSISGL SQITKSLFIS NGAAANDKLL LSSNQITTVI NVSVEVANTF 70 80 90 100 110 120 YEDIQYVQVP VVDAPIARLS DFFDPIADHI HSVEMKQGRT LLHCAAGVSR SAALCLAYLM 130 140 150 160 170 180 KYHVMSLLDA HAWTKSRRPI IRPNSGFWEQ LIHYEFQLFG KNTMQMVNSP MGLIPDIYEK 190 200 ETRMMIPLST PDGAFHKGKE KALL

References

[1]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Testis.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	BC079285 mRNA. Translation: AAH79285.1.
IPI	IPI00464600.
RefSeq	NP_001013146.1.
UniGene	Rn.19584
3D structure databases
SMR	Q6AXW7. Positions 18-179.
ModBase	Search...
Genome annotation databases
Ensembl	ENSRNOT00000005516; ENSRNOP00000005516; ENSRNOG00000024945; Rattus norvegicus. [Genome view]
GeneID	305477.
KEGG	rno:305477.
UCSC	NM_001013128. rat.
Organism-specific databases
CTD	305477.
RGD	1306929. Dusp18.
Phylogenomic databases
HOVERGEN	Q6AXW7.
Enzyme and pathway databases
BRENDA	3.1.3.16. 248. 3.1.3.48. 248.
Gene expression databases
ArrayExpress	Q6AXW7.
Genevestigator	Q6AXW7.
GermOnline	ENSRNOG00000024945. Rattus norvegicus.
Family and domain databases
InterPro	IPR000387. Dual-sp/Tyr_phosphatase. IPR020417. Dual-sp_phosphatase. IPR000340. Dual-sp_phosphatase_cat-dom. IPR020420. Dual-sp_phosphatase_famB. IPR020422. Dual-sp_phosphatase_subgr_cat. IPR016130. Tyr_Pase_AS. [Graphical view]
Pfam	PF00782. DSPc. 1 hit. [Graphical view]
PRINTS	PR01908. ADSPHPHTASE. PR01910. ADSPHPHTASEB.
SMART	SM00195. DSPc. 1 hit. [Graphical view]
PROSITE	PS00383. TYR_PHOSPHATASE_1. 1 hit. PS50056. TYR_PHOSPHATASE_2. 1 hit. PS50054. TYR_PHOSPHATASE_DUAL. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	654674.

Entry information

Entry name

DUS18_RAT

Accession

Primary (citable) accession number: Q6AXW7

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 10, 2005
Last sequence update:	September 13, 2004
Last modified:	October 13, 2009
This is version 43 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)