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Q6AXW7

- DUS18_RAT

UniProt

Q6AXW7 - DUS18_RAT

Protein

Dual specificity protein phosphatase 18

Gene

Dusp18

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 79 (01 Oct 2014)
      Sequence version 1 (13 Sep 2004)
      Previous versions | rss
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    • Comment

    Functioni

    Can dephosphorylate single and diphosphorylated synthetic MAPK peptides, with preference for the phosphotyrosine and diphosphorylated forms over phosphothreonine.By similarity

    Catalytic activityi

    Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.PROSITE-ProRule annotation
    [a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei104 – 1041Phosphocysteine intermediatePROSITE-ProRule annotation

    GO - Molecular functioni

    1. MAP kinase tyrosine/serine/threonine phosphatase activity Source: InterPro
    2. protein tyrosine/serine/threonine phosphatase activity Source: RefGenome
    3. protein tyrosine phosphatase activity Source: UniProtKB-EC

    GO - Biological processi

    1. peptidyl-tyrosine dephosphorylation Source: RefGenome

    Keywords - Molecular functioni

    Hydrolase, Protein phosphatase

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Dual specificity protein phosphatase 18 (EC:3.1.3.16, EC:3.1.3.48)
    Gene namesi
    Name:Dusp18
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Unplaced

    Organism-specific databases

    RGDi1306929. Dusp18.

    Subcellular locationi

    Cytoplasm By similarity. Nucleus By similarity. Mitochondrion inner membrane 1 Publication; Peripheral membrane protein 1 Publication; Intermembrane side 1 Publication
    Note: Translocates to cytoplasm in response to apoptotic stimuli such as staurosporine treatment.By similarity

    GO - Cellular componenti

    1. extrinsic component of mitochondrial inner membrane Source: RGD
    2. mitochondrial intermembrane space Source: RGD
    3. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm, Membrane, Mitochondrion, Mitochondrion inner membrane, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 204204Dual specificity protein phosphatase 18PRO_0000094831Add
    BLAST

    PTM databases

    PhosphoSiteiQ6AXW7.

    Expressioni

    Gene expression databases

    GenevestigatoriQ6AXW7.

    Interactioni

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000005516.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6AXW7.
    SMRiQ6AXW7. Positions 18-179.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini80 – 14970Tyrosine-protein phosphataseAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni95 – 14147Sufficient for mitochondrial localizationBy similarityAdd
    BLAST

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG2453.
    HOGENOMiHOG000233766.
    HOVERGENiHBG051422.
    InParanoidiQ6AXW7.
    KOiK14165.
    PhylomeDBiQ6AXW7.

    Family and domain databases

    Gene3Di3.90.190.10. 1 hit.
    InterProiIPR020417. Atypical_DUSP.
    IPR020420. Atypical_DUSP_famB.
    IPR000340. Dual-sp_phosphatase_cat-dom.
    IPR020422. Dual-sp_phosphatase_subgr_cat.
    IPR024950. DUSP.
    IPR029021. Prot-tyrosine_phosphatase-like.
    IPR000387. Tyr/Dual-sp_Pase.
    IPR016130. Tyr_Pase_AS.
    [Graphical view]
    PANTHERiPTHR10159. PTHR10159. 1 hit.
    PfamiPF00782. DSPc. 1 hit.
    [Graphical view]
    PRINTSiPR01908. ADSPHPHTASE.
    PR01910. ADSPHPHTASEB.
    SMARTiSM00195. DSPc. 1 hit.
    [Graphical view]
    SUPFAMiSSF52799. SSF52799. 1 hit.
    PROSITEiPS00383. TYR_PHOSPHATASE_1. 1 hit.
    PS50056. TYR_PHOSPHATASE_2. 1 hit.
    PS50054. TYR_PHOSPHATASE_DUAL. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q6AXW7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTSPWSACPV QFPQPSISGL SQITKSLFIS NGAAANDKLL LSSNQITTVI    50
    NVSVEVANTF YEDIQYVQVP VVDAPIARLS DFFDPIADHI HSVEMKQGRT 100
    LLHCAAGVSR SAALCLAYLM KYHVMSLLDA HAWTKSRRPI IRPNSGFWEQ 150
    LIHYEFQLFG KNTMQMVNSP MGLIPDIYEK ETRMMIPLST PDGAFHKGKE 200
    KALL 204
    Length:204
    Mass (Da):22,754
    Last modified:September 13, 2004 - v1
    Checksum:i1A5BBC759522E442
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC079285 mRNA. Translation: AAH79285.1.
    RefSeqiNP_001013146.2. NM_001013128.2.
    UniGeneiRn.19584.

    Genome annotation databases

    GeneIDi305477.
    KEGGirno:305477.
    UCSCiRGD:1306929. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC079285 mRNA. Translation: AAH79285.1 .
    RefSeqi NP_001013146.2. NM_001013128.2.
    UniGenei Rn.19584.

    3D structure databases

    ProteinModelPortali Q6AXW7.
    SMRi Q6AXW7. Positions 18-179.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000005516.

    PTM databases

    PhosphoSitei Q6AXW7.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 305477.
    KEGGi rno:305477.
    UCSCi RGD:1306929. rat.

    Organism-specific databases

    CTDi 150290.
    RGDi 1306929. Dusp18.

    Phylogenomic databases

    eggNOGi COG2453.
    HOGENOMi HOG000233766.
    HOVERGENi HBG051422.
    InParanoidi Q6AXW7.
    KOi K14165.
    PhylomeDBi Q6AXW7.

    Miscellaneous databases

    NextBioi 654674.
    PROi Q6AXW7.

    Gene expression databases

    Genevestigatori Q6AXW7.

    Family and domain databases

    Gene3Di 3.90.190.10. 1 hit.
    InterProi IPR020417. Atypical_DUSP.
    IPR020420. Atypical_DUSP_famB.
    IPR000340. Dual-sp_phosphatase_cat-dom.
    IPR020422. Dual-sp_phosphatase_subgr_cat.
    IPR024950. DUSP.
    IPR029021. Prot-tyrosine_phosphatase-like.
    IPR000387. Tyr/Dual-sp_Pase.
    IPR016130. Tyr_Pase_AS.
    [Graphical view ]
    PANTHERi PTHR10159. PTHR10159. 1 hit.
    Pfami PF00782. DSPc. 1 hit.
    [Graphical view ]
    PRINTSi PR01908. ADSPHPHTASE.
    PR01910. ADSPHPHTASEB.
    SMARTi SM00195. DSPc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52799. SSF52799. 1 hit.
    PROSITEi PS00383. TYR_PHOSPHATASE_1. 1 hit.
    PS50056. TYR_PHOSPHATASE_2. 1 hit.
    PS50054. TYR_PHOSPHATASE_DUAL. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Testis.
    2. "Dual specificity phosphatases 18 and 21 target to opposing sides of the mitochondrial inner membrane."
      Rardin M.J., Wiley S.E., Murphy A.N., Pagliarini D.J., Dixon J.E.
      J. Biol. Chem. 283:15440-15450(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION.

    Entry informationi

    Entry nameiDUS18_RAT
    AccessioniPrimary (citable) accession number: Q6AXW7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 10, 2005
    Last sequence update: September 13, 2004
    Last modified: October 1, 2014
    This is version 79 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3