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Q6AXW7 (DUS18_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 77. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Dual specificity protein phosphatase 18

EC=3.1.3.16
EC=3.1.3.48
Gene names
Name:Dusp18
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length204 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Can dephosphorylate single and diphosphorylated synthetic MAPK peptides, with preference for the phosphotyrosine and diphosphorylated forms over phosphothreonine By similarity.

Catalytic activity

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Subcellular location

Cytoplasm By similarity. Nucleus By similarity. Mitochondrion inner membrane; Peripheral membrane protein; Intermembrane side. Note: Translocates to cytoplasm in response to apoptotic stimuli such as staurosporine treatment By similarity. Ref.2

Sequence similarities

Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.

Contains 1 tyrosine-protein phosphatase domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 204204Dual specificity protein phosphatase 18
PRO_0000094831

Regions

Domain80 – 14970Tyrosine-protein phosphatase
Region95 – 14147Sufficient for mitochondrial localization By similarity

Sites

Active site1041Phosphocysteine intermediate By similarity

Sequences

Sequence LengthMass (Da)Tools
Q6AXW7 [UniParc].

Last modified September 13, 2004. Version 1.
Checksum: 1A5BBC759522E442

FASTA20422,754
        10         20         30         40         50         60 
MTSPWSACPV QFPQPSISGL SQITKSLFIS NGAAANDKLL LSSNQITTVI NVSVEVANTF 

        70         80         90        100        110        120 
YEDIQYVQVP VVDAPIARLS DFFDPIADHI HSVEMKQGRT LLHCAAGVSR SAALCLAYLM 

       130        140        150        160        170        180 
KYHVMSLLDA HAWTKSRRPI IRPNSGFWEQ LIHYEFQLFG KNTMQMVNSP MGLIPDIYEK 

       190        200 
ETRMMIPLST PDGAFHKGKE KALL 

« Hide

References

« Hide 'large scale' references
[1]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Testis.
[2]"Dual specificity phosphatases 18 and 21 target to opposing sides of the mitochondrial inner membrane."
Rardin M.J., Wiley S.E., Murphy A.N., Pagliarini D.J., Dixon J.E.
J. Biol. Chem. 283:15440-15450(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC079285 mRNA. Translation: AAH79285.1.
RefSeqNP_001013146.2. NM_001013128.2.
UniGeneRn.19584.

3D structure databases

ProteinModelPortalQ6AXW7.
SMRQ6AXW7. Positions 18-179.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10116.ENSRNOP00000005516.

PTM databases

PhosphoSiteQ6AXW7.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID305477.
KEGGrno:305477.
UCSCRGD:1306929. rat.

Organism-specific databases

CTD150290.
RGD1306929. Dusp18.

Phylogenomic databases

eggNOGCOG2453.
HOGENOMHOG000233766.
HOVERGENHBG051422.
InParanoidQ6AXW7.
KOK14165.
PhylomeDBQ6AXW7.

Gene expression databases

GenevestigatorQ6AXW7.

Family and domain databases

InterProIPR020417. Atypical_DUSP.
IPR020420. Atypical_DUSP_famB.
IPR000340. Dual-sp_phosphatase_cat-dom.
IPR020422. Dual-sp_phosphatase_subgr_cat.
IPR024950. DUSP.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
[Graphical view]
PANTHERPTHR10159. PTHR10159. 1 hit.
PfamPF00782. DSPc. 1 hit.
[Graphical view]
PRINTSPR01908. ADSPHPHTASE.
PR01910. ADSPHPHTASEB.
SMARTSM00195. DSPc. 1 hit.
[Graphical view]
PROSITEPS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50054. TYR_PHOSPHATASE_DUAL. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio654674.
PROQ6AXW7.

Entry information

Entry nameDUS18_RAT
AccessionPrimary (citable) accession number: Q6AXW7
Entry history
Integrated into UniProtKB/Swiss-Prot: May 10, 2005
Last sequence update: September 13, 2004
Last modified: April 16, 2014
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families