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Reviewed, UniProtKB/Swiss-Prot Q6AXW7 (DUS18_RAT)

Last modified October 13, 2009. Version 43. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Dual specificity protein phosphatase 18
    EC=3.1.3.48
    EC=3.1.3.16
Gene names
Name: Dusp18
OrganismRattus norvegicus (Rat)
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length204 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at transcript level.

General annotation (Comments)

Function

Can dephosphorylate single and diphosphorylated synthetic MAPK peptides, with preference for the phosphotyrosine and diphosphorylated forms over phosphothreonine By similarity.

Catalytic activity

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.

A phosphoprotein + H2O = a protein + phosphate.

Subcellular location

Cytoplasm By similarity. Nucleus By similarity.

Sequence similarities

Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.

Contains 1 tyrosine-protein phosphatase domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 204204Dual specificity protein phosphatase 18
PRO_0000094831

Regions

Domain80 – 14970Tyrosine-protein phosphatase

Sites

Active site1041Phosphocysteine intermediate By similarity

Sequences

Sequence LengthMass (Da)Tools
Q6AXW7-1 [UniParc].

Last modified September 13, 2004. Version 1.
Checksum: 1A5BBC759522E442

FASTA20422,754
        10         20         30         40         50         60 
MTSPWSACPV QFPQPSISGL SQITKSLFIS NGAAANDKLL LSSNQITTVI NVSVEVANTF 

        70         80         90        100        110        120 
YEDIQYVQVP VVDAPIARLS DFFDPIADHI HSVEMKQGRT LLHCAAGVSR SAALCLAYLM 

       130        140        150        160        170        180 
KYHVMSLLDA HAWTKSRRPI IRPNSGFWEQ LIHYEFQLFG KNTMQMVNSP MGLIPDIYEK 

       190        200 
ETRMMIPLST PDGAFHKGKE KALL 

« Hide

References

[1]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Testis.
+Additional computationally mapped references.

Cross-references

Sequence databases

BC079285 mRNA. Translation: AAH79285.1.
IPIIPI00464600.
RefSeqNP_001013146.1.
UniGeneRn.19584

3D structure databases

SMRQ6AXW7. Positions 18-179.
ModBaseSearch...

Genome annotation databases

EnsemblENSRNOT00000005516; ENSRNOP00000005516; ENSRNOG00000024945; Rattus norvegicus. [Genome view]
GeneID305477.
KEGGrno:305477.
UCSCNM_001013128. rat.

Organism-specific databases

CTD305477.
RGD1306929. Dusp18.

Phylogenomic databases

HOVERGENQ6AXW7.

Enzyme and pathway databases

BRENDA3.1.3.16. 248.
3.1.3.48. 248.

Gene expression databases

ArrayExpressQ6AXW7.
GenevestigatorQ6AXW7.
GermOnlineENSRNOG00000024945. Rattus norvegicus.

Family and domain databases

InterProIPR000387. Dual-sp/Tyr_phosphatase.
IPR020417. Dual-sp_phosphatase.
IPR000340. Dual-sp_phosphatase_cat-dom.
IPR020420. Dual-sp_phosphatase_famB.
IPR020422. Dual-sp_phosphatase_subgr_cat.
IPR016130. Tyr_Pase_AS.
[Graphical view]
PfamPF00782. DSPc. 1 hit.
[Graphical view]
PRINTSPR01908. ADSPHPHTASE.
PR01910. ADSPHPHTASEB.
SMARTSM00195. DSPc. 1 hit.
[Graphical view]
PROSITEPS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50054. TYR_PHOSPHATASE_DUAL. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio654674.

Entry information

Entry nameDUS18_RAT
AccessionPrimary (citable) accession number: Q6AXW7
Entry history
Integrated into UniProtKB/Swiss-Prot: May 10, 2005
Last sequence update: September 13, 2004
Last modified: October 13, 2009
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

Relevant documents

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents