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Q6AXV9 (GSTO2_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 79. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glutathione S-transferase omega-2

Short name=GSTO-2
EC=2.5.1.18
Alternative name(s):
Glutathione S-transferase omega 2-2
Short name=GSTO 2-2
Glutathione-dependent dehydroascorbate reductase
EC=1.8.5.1
Monomethylarsonic acid reductase
Short name=MMA(V) reductase
EC=1.20.4.2
Gene names
Name:Gsto2
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length248 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Exhibits glutathione-dependent thiol transferase activity. Has high dehydroascorbate reductase activity and may contribute to the recycling of ascorbic acid. Participates in the biotransformation of inorganic arsenic and reduces monomethylarsonic acid (MMA) By similarity.

Catalytic activity

RX + glutathione = HX + R-S-glutathione.

2 glutathione + dehydroascorbate = glutathione disulfide + ascorbate.

Methylarsonate + 2 glutathione = methylarsonite + glutathione disulfide + H2O.

Sequence similarities

Belongs to the GST superfamily. Omega family.

Contains 1 GST C-terminal domain.

Contains 1 GST N-terminal domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 248248Glutathione S-transferase omega-2
PRO_0000239142

Regions

Domain22 – 10180GST N-terminal
Domain106 – 231126GST C-terminal
Region85 – 862Glutathione binding By similarity

Sites

Active site321Nucleophile By similarity
Binding site591Glutathione By similarity
Binding site721Glutathione; via amide nitrogen and carbonyl oxygen By similarity

Sequences

Sequence LengthMass (Da)Tools
Q6AXV9 [UniParc].

Last modified September 13, 2004. Version 1.
Checksum: 2DD551FC7CF1EE47

FASTA24828,679
        10         20         30         40         50         60 
MSGDLTRCLG KGSCPPGPVP EGVIRIYSMR FCPYSHRTRL VLKAKSIRHE IININLKNKP 

        70         80         90        100        110        120 
DWYYTKHPFG QVPVLENSQC QLIYESVIAC EYLDDVFPGR KLFPYDPYER ARQKMLLELF 

       130        140        150        160        170        180 
CKVPQLSKEC LVALRCGRDC TDLKVALRQE LCNLEEILEY QNTTFFGGDS ISMIDYLVWP 

       190        200        210        220        230        240 
WFERLDVYGL ADCVNHTPML RLWISSMKQD PAVCALHIDK NIFLGFLNLY FQNNPCAFDF 


GLCGPIVR 

« Hide

References

[1]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Testis.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC079295 mRNA. Translation: AAH79295.1.
RefSeqNP_001012071.1. NM_001012071.1.
XP_006231652.1. XM_006231590.1.
XP_006231653.1. XM_006231591.1.
XP_006231654.1. XM_006231592.1.
UniGeneRn.206114.

3D structure databases

ProteinModelPortalQ6AXV9.
SMRQ6AXV9. Positions 7-242.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PaxDbQ6AXV9.
PRIDEQ6AXV9.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000017186; ENSRNOP00000017186; ENSRNOG00000012801.
ENSRNOT00000064023; ENSRNOP00000060669; ENSRNOG00000049964.
GeneID309465.
KEGGrno:100909560.
rno:309465.
UCSCRGD:1310764. rat.

Organism-specific databases

CTD119391.
RGD1310764. Gsto2.

Phylogenomic databases

eggNOGCOG0625.
GeneTreeENSGT00390000005479.
HOGENOMHOG000006560.
HOVERGENHBG051853.
InParanoidQ6AXV9.
KOK00799.
OMAFCNLEEI.
OrthoDBEOG71CFNG.
PhylomeDBQ6AXV9.
TreeFamTF105325.

Gene expression databases

GenevestigatorQ6AXV9.

Family and domain databases

Gene3D1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProIPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR004046. GST_C.
IPR005442. GST_omega.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamPF00043. GST_C. 1 hit.
PF13417. GST_N_3. 1 hit.
[Graphical view]
PRINTSPR01625. GSTRNSFRASEO.
SUPFAMSSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEPS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio660856.
PROQ6AXV9.

Entry information

Entry nameGSTO2_RAT
AccessionPrimary (citable) accession number: Q6AXV9
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: September 13, 2004
Last modified: April 16, 2014
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families