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Q6AXV9

- GSTO2_RAT

UniProt

Q6AXV9 - GSTO2_RAT

Protein

Glutathione S-transferase omega-2

Gene

Gsto2

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 81 (01 Oct 2014)
      Sequence version 1 (13 Sep 2004)
      Previous versions | rss
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    Functioni

    Exhibits glutathione-dependent thiol transferase activity. Has high dehydroascorbate reductase activity and may contribute to the recycling of ascorbic acid. Participates in the biotransformation of inorganic arsenic and reduces monomethylarsonic acid (MMA) By similarity.By similarity

    Catalytic activityi

    RX + glutathione = HX + R-S-glutathione.
    2 glutathione + dehydroascorbate = glutathione disulfide + ascorbate.
    Methylarsonate + 2 glutathione = methylarsonite + glutathione disulfide + H2O.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei32 – 321NucleophileBy similarity
    Binding sitei59 – 591GlutathioneBy similarity
    Binding sitei72 – 721Glutathione; via amide nitrogen and carbonyl oxygenBy similarity

    GO - Molecular functioni

    1. glutathione dehydrogenase (ascorbate) activity Source: UniProtKB
    2. glutathione transferase activity Source: UniProtKB-EC
    3. methylarsonate reductase activity Source: UniProtKB-EC
    4. oxidoreductase activity Source: UniProtKB

    GO - Biological processi

    1. cellular response to arsenic-containing substance Source: UniProtKB
    2. L-ascorbic acid metabolic process Source: UniProtKB
    3. oxidation-reduction process Source: UniProtKB
    4. xenobiotic metabolic process Source: UniProtKB

    Keywords - Molecular functioni

    Oxidoreductase, Transferase

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glutathione S-transferase omega-2 (EC:2.5.1.18)
    Short name:
    GSTO-2
    Alternative name(s):
    Glutathione S-transferase omega 2-2
    Short name:
    GSTO 2-2
    Glutathione-dependent dehydroascorbate reductase (EC:1.8.5.1)
    Monomethylarsonic acid reductase (EC:1.20.4.2)
    Short name:
    MMA(V) reductase
    Gene namesi
    Name:Gsto2
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 1

    Organism-specific databases

    RGDi1310764. Gsto2.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: InterPro

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 248248Glutathione S-transferase omega-2PRO_0000239142Add
    BLAST

    Proteomic databases

    PaxDbiQ6AXV9.
    PRIDEiQ6AXV9.

    Expressioni

    Gene expression databases

    GenevestigatoriQ6AXV9.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6AXV9.
    SMRiQ6AXV9. Positions 7-242.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini22 – 10180GST N-terminalAdd
    BLAST
    Domaini106 – 231126GST C-terminalAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni85 – 862Glutathione bindingBy similarity

    Sequence similaritiesi

    Belongs to the GST superfamily. Omega family.Curated
    Contains 1 GST C-terminal domain.Curated
    Contains 1 GST N-terminal domain.Curated

    Phylogenomic databases

    eggNOGiCOG0625.
    GeneTreeiENSGT00390000005479.
    HOGENOMiHOG000006560.
    HOVERGENiHBG051853.
    InParanoidiQ6AXV9.
    KOiK00799.
    OMAiFCNLEEI.
    OrthoDBiEOG71CFNG.
    PhylomeDBiQ6AXV9.
    TreeFamiTF105325.

    Family and domain databases

    Gene3Di1.20.1050.10. 1 hit.
    3.40.30.10. 1 hit.
    InterProiIPR010987. Glutathione-S-Trfase_C-like.
    IPR004045. Glutathione_S-Trfase_N.
    IPR004046. GST_C.
    IPR005442. GST_omega.
    IPR012336. Thioredoxin-like_fold.
    [Graphical view]
    PfamiPF00043. GST_C. 1 hit.
    PF13417. GST_N_3. 1 hit.
    [Graphical view]
    PRINTSiPR01625. GSTRNSFRASEO.
    SUPFAMiSSF47616. SSF47616. 1 hit.
    SSF52833. SSF52833. 1 hit.
    PROSITEiPS50405. GST_CTER. 1 hit.
    PS50404. GST_NTER. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q6AXV9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSGDLTRCLG KGSCPPGPVP EGVIRIYSMR FCPYSHRTRL VLKAKSIRHE    50
    IININLKNKP DWYYTKHPFG QVPVLENSQC QLIYESVIAC EYLDDVFPGR 100
    KLFPYDPYER ARQKMLLELF CKVPQLSKEC LVALRCGRDC TDLKVALRQE 150
    LCNLEEILEY QNTTFFGGDS ISMIDYLVWP WFERLDVYGL ADCVNHTPML 200
    RLWISSMKQD PAVCALHIDK NIFLGFLNLY FQNNPCAFDF GLCGPIVR 248
    Length:248
    Mass (Da):28,679
    Last modified:September 13, 2004 - v1
    Checksum:i2DD551FC7CF1EE47
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC079295 mRNA. Translation: AAH79295.1.
    RefSeqiNP_001012071.1. NM_001012071.1.
    XP_006231652.1. XM_006231590.1.
    XP_006231653.1. XM_006231591.1.
    XP_006231654.1. XM_006231592.1.
    UniGeneiRn.206114.

    Genome annotation databases

    EnsembliENSRNOT00000017186; ENSRNOP00000017186; ENSRNOG00000012801.
    ENSRNOT00000064023; ENSRNOP00000060669; ENSRNOG00000049964.
    GeneIDi309465.
    KEGGirno:309465.
    UCSCiRGD:1310764. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC079295 mRNA. Translation: AAH79295.1 .
    RefSeqi NP_001012071.1. NM_001012071.1.
    XP_006231652.1. XM_006231590.1.
    XP_006231653.1. XM_006231591.1.
    XP_006231654.1. XM_006231592.1.
    UniGenei Rn.206114.

    3D structure databases

    ProteinModelPortali Q6AXV9.
    SMRi Q6AXV9. Positions 7-242.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PaxDbi Q6AXV9.
    PRIDEi Q6AXV9.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000017186 ; ENSRNOP00000017186 ; ENSRNOG00000012801 .
    ENSRNOT00000064023 ; ENSRNOP00000060669 ; ENSRNOG00000049964 .
    GeneIDi 309465.
    KEGGi rno:309465.
    UCSCi RGD:1310764. rat.

    Organism-specific databases

    CTDi 119391.
    RGDi 1310764. Gsto2.

    Phylogenomic databases

    eggNOGi COG0625.
    GeneTreei ENSGT00390000005479.
    HOGENOMi HOG000006560.
    HOVERGENi HBG051853.
    InParanoidi Q6AXV9.
    KOi K00799.
    OMAi FCNLEEI.
    OrthoDBi EOG71CFNG.
    PhylomeDBi Q6AXV9.
    TreeFami TF105325.

    Miscellaneous databases

    NextBioi 660856.
    PROi Q6AXV9.

    Gene expression databases

    Genevestigatori Q6AXV9.

    Family and domain databases

    Gene3Di 1.20.1050.10. 1 hit.
    3.40.30.10. 1 hit.
    InterProi IPR010987. Glutathione-S-Trfase_C-like.
    IPR004045. Glutathione_S-Trfase_N.
    IPR004046. GST_C.
    IPR005442. GST_omega.
    IPR012336. Thioredoxin-like_fold.
    [Graphical view ]
    Pfami PF00043. GST_C. 1 hit.
    PF13417. GST_N_3. 1 hit.
    [Graphical view ]
    PRINTSi PR01625. GSTRNSFRASEO.
    SUPFAMi SSF47616. SSF47616. 1 hit.
    SSF52833. SSF52833. 1 hit.
    PROSITEi PS50405. GST_CTER. 1 hit.
    PS50404. GST_NTER. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Testis.

    Entry informationi

    Entry nameiGSTO2_RAT
    AccessioniPrimary (citable) accession number: Q6AXV9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2006
    Last sequence update: September 13, 2004
    Last modified: October 1, 2014
    This is version 81 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3