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Protein

Glutathione S-transferase omega-2

Gene

Gsto2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Exhibits glutathione-dependent thiol transferase activity. Has high dehydroascorbate reductase activity and may contribute to the recycling of ascorbic acid. Participates in the biotransformation of inorganic arsenic and reduces monomethylarsonic acid (MMA).By similarity

Catalytic activityi

RX + glutathione = HX + R-S-glutathione.By similarity
2 glutathione + dehydroascorbate = glutathione disulfide + ascorbate.By similarity
Methylarsonate + 2 glutathione = methylarsonite + glutathione disulfide + H2O.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei32NucleophileBy similarity1
Binding sitei59GlutathioneBy similarity1
Binding sitei72Glutathione; via amide nitrogen and carbonyl oxygenBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase, Transferase

Enzyme and pathway databases

ReactomeiR-RNO-156590 Glutathione conjugation
R-RNO-196836 Vitamin C (ascorbate) metabolism

Names & Taxonomyi

Protein namesi
Recommended name:
Glutathione S-transferase omega-2 (EC:2.5.1.18By similarity)
Short name:
GSTO-2
Alternative name(s):
Glutathione S-transferase omega 2-2
Short name:
GSTO 2-2
Glutathione-dependent dehydroascorbate reductase (EC:1.8.5.1By similarity)
Monomethylarsonic acid reductase (EC:1.20.4.2By similarity)
Short name:
MMA(V) reductase
Gene namesi
Name:Gsto2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi1310764 Gsto2

Subcellular locationi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002391421 – 248Glutathione S-transferase omega-2Add BLAST248

Proteomic databases

PaxDbiQ6AXV9
PRIDEiQ6AXV9

Expressioni

Gene expression databases

BgeeiENSRNOG00000012801
ExpressionAtlasiQ6AXV9 baseline
GenevisibleiQ6AXV9 RN

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000060669

Structurei

3D structure databases

ProteinModelPortaliQ6AXV9
SMRiQ6AXV9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini22 – 101GST N-terminalAdd BLAST80
Domaini106 – 231GST C-terminalAdd BLAST126

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni85 – 86Glutathione bindingBy similarity2

Sequence similaritiesi

Belongs to the GST superfamily. Omega family.Curated

Phylogenomic databases

eggNOGiKOG0406 Eukaryota
ENOG410XSIX LUCA
GeneTreeiENSGT00390000005479
HOGENOMiHOG000006560
HOVERGENiHBG051853
InParanoidiQ6AXV9
KOiK00799
OMAiDCVSHTP
OrthoDBiEOG091G0IEA
PhylomeDBiQ6AXV9
TreeFamiTF105325

Family and domain databases

InterProiView protein in InterPro
IPR010987 Glutathione-S-Trfase_C-like
IPR036282 Glutathione-S-Trfase_C_sf
IPR004045 Glutathione_S-Trfase_N
IPR005442 GST_omega
IPR036249 Thioredoxin-like_sf
PfamiView protein in Pfam
PF13417 GST_N_3, 1 hit
PRINTSiPR01625 GSTRNSFRASEO
SUPFAMiSSF47616 SSF47616, 1 hit
SSF52833 SSF52833, 1 hit
PROSITEiView protein in PROSITE
PS50405 GST_CTER, 1 hit
PS50404 GST_NTER, 1 hit

Sequencei

Sequence statusi: Complete.

Q6AXV9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGDLTRCLG KGSCPPGPVP EGVIRIYSMR FCPYSHRTRL VLKAKSIRHE
60 70 80 90 100
IININLKNKP DWYYTKHPFG QVPVLENSQC QLIYESVIAC EYLDDVFPGR
110 120 130 140 150
KLFPYDPYER ARQKMLLELF CKVPQLSKEC LVALRCGRDC TDLKVALRQE
160 170 180 190 200
LCNLEEILEY QNTTFFGGDS ISMIDYLVWP WFERLDVYGL ADCVNHTPML
210 220 230 240
RLWISSMKQD PAVCALHIDK NIFLGFLNLY FQNNPCAFDF GLCGPIVR
Length:248
Mass (Da):28,679
Last modified:September 13, 2004 - v1
Checksum:i2DD551FC7CF1EE47
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC079295 mRNA Translation: AAH79295.1
RefSeqiNP_001012071.1, NM_001012071.1
XP_006231652.1, XM_006231590.2
XP_006231653.1, XM_006231591.2
XP_006231654.1, XM_006231592.1
XP_008758721.1, XM_008760499.2
XP_017444784.1, XM_017589295.1
UniGeneiRn.206114

Genome annotation databases

EnsembliENSRNOT00000017186; ENSRNOP00000017186; ENSRNOG00000012801
ENSRNOT00000064023; ENSRNOP00000060669; ENSRNOG00000049964
GeneIDi103690044
309465
KEGGirno:103690044
rno:309465
UCSCiRGD:1310764 rat

Similar proteinsi

Entry informationi

Entry nameiGSTO2_RAT
AccessioniPrimary (citable) accession number: Q6AXV9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: September 13, 2004
Last modified: May 23, 2018
This is version 109 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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