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Q6AXV9

- GSTO2_RAT

UniProt

Q6AXV9 - GSTO2_RAT

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Protein
Glutathione S-transferase omega-2
Gene
Gsto2
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Exhibits glutathione-dependent thiol transferase activity. Has high dehydroascorbate reductase activity and may contribute to the recycling of ascorbic acid. Participates in the biotransformation of inorganic arsenic and reduces monomethylarsonic acid (MMA) By similarity.

Catalytic activityi

RX + glutathione = HX + R-S-glutathione.
2 glutathione + dehydroascorbate = glutathione disulfide + ascorbate.
Methylarsonate + 2 glutathione = methylarsonite + glutathione disulfide + H2O.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei32 – 321Nucleophile By similarity
Binding sitei59 – 591Glutathione By similarity
Binding sitei72 – 721Glutathione; via amide nitrogen and carbonyl oxygen By similarity

GO - Molecular functioni

  1. glutathione dehydrogenase (ascorbate) activity Source: UniProtKB
  2. glutathione transferase activity Source: UniProtKB-EC
  3. methylarsonate reductase activity Source: UniProtKB-EC
  4. oxidoreductase activity Source: UniProtKB

GO - Biological processi

  1. L-ascorbic acid metabolic process Source: UniProtKB
  2. cellular response to arsenic-containing substance Source: UniProtKB
  3. oxidation-reduction process Source: UniProtKB
  4. xenobiotic metabolic process Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase, Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
Glutathione S-transferase omega-2 (EC:2.5.1.18)
Short name:
GSTO-2
Alternative name(s):
Glutathione S-transferase omega 2-2
Short name:
GSTO 2-2
Glutathione-dependent dehydroascorbate reductase (EC:1.8.5.1)
Monomethylarsonic acid reductase (EC:1.20.4.2)
Short name:
MMA(V) reductase
Gene namesi
Name:Gsto2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 1

Organism-specific databases

RGDi1310764. Gsto2.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: InterPro
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 248248Glutathione S-transferase omega-2
PRO_0000239142Add
BLAST

Proteomic databases

PaxDbiQ6AXV9.
PRIDEiQ6AXV9.

Expressioni

Gene expression databases

GenevestigatoriQ6AXV9.

Structurei

3D structure databases

ProteinModelPortaliQ6AXV9.
SMRiQ6AXV9. Positions 7-242.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini22 – 10180GST N-terminal
Add
BLAST
Domaini106 – 231126GST C-terminal
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni85 – 862Glutathione binding By similarity

Sequence similaritiesi

Belongs to the GST superfamily. Omega family.

Phylogenomic databases

eggNOGiCOG0625.
GeneTreeiENSGT00390000005479.
HOGENOMiHOG000006560.
HOVERGENiHBG051853.
InParanoidiQ6AXV9.
KOiK00799.
OMAiFCNLEEI.
OrthoDBiEOG71CFNG.
PhylomeDBiQ6AXV9.
TreeFamiTF105325.

Family and domain databases

Gene3Di1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProiIPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR004046. GST_C.
IPR005442. GST_omega.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamiPF00043. GST_C. 1 hit.
PF13417. GST_N_3. 1 hit.
[Graphical view]
PRINTSiPR01625. GSTRNSFRASEO.
SUPFAMiSSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEiPS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6AXV9-1 [UniParc]FASTAAdd to Basket

« Hide

MSGDLTRCLG KGSCPPGPVP EGVIRIYSMR FCPYSHRTRL VLKAKSIRHE    50
IININLKNKP DWYYTKHPFG QVPVLENSQC QLIYESVIAC EYLDDVFPGR 100
KLFPYDPYER ARQKMLLELF CKVPQLSKEC LVALRCGRDC TDLKVALRQE 150
LCNLEEILEY QNTTFFGGDS ISMIDYLVWP WFERLDVYGL ADCVNHTPML 200
RLWISSMKQD PAVCALHIDK NIFLGFLNLY FQNNPCAFDF GLCGPIVR 248
Length:248
Mass (Da):28,679
Last modified:September 13, 2004 - v1
Checksum:i2DD551FC7CF1EE47
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC079295 mRNA. Translation: AAH79295.1.
RefSeqiNP_001012071.1. NM_001012071.1.
XP_006231652.1. XM_006231590.1.
XP_006231653.1. XM_006231591.1.
XP_006231654.1. XM_006231592.1.
UniGeneiRn.206114.

Genome annotation databases

EnsembliENSRNOT00000017186; ENSRNOP00000017186; ENSRNOG00000012801.
ENSRNOT00000064023; ENSRNOP00000060669; ENSRNOG00000049964.
GeneIDi309465.
KEGGirno:309465.
UCSCiRGD:1310764. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC079295 mRNA. Translation: AAH79295.1 .
RefSeqi NP_001012071.1. NM_001012071.1.
XP_006231652.1. XM_006231590.1.
XP_006231653.1. XM_006231591.1.
XP_006231654.1. XM_006231592.1.
UniGenei Rn.206114.

3D structure databases

ProteinModelPortali Q6AXV9.
SMRi Q6AXV9. Positions 7-242.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PaxDbi Q6AXV9.
PRIDEi Q6AXV9.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000017186 ; ENSRNOP00000017186 ; ENSRNOG00000012801 .
ENSRNOT00000064023 ; ENSRNOP00000060669 ; ENSRNOG00000049964 .
GeneIDi 309465.
KEGGi rno:309465.
UCSCi RGD:1310764. rat.

Organism-specific databases

CTDi 119391.
RGDi 1310764. Gsto2.

Phylogenomic databases

eggNOGi COG0625.
GeneTreei ENSGT00390000005479.
HOGENOMi HOG000006560.
HOVERGENi HBG051853.
InParanoidi Q6AXV9.
KOi K00799.
OMAi FCNLEEI.
OrthoDBi EOG71CFNG.
PhylomeDBi Q6AXV9.
TreeFami TF105325.

Miscellaneous databases

NextBioi 660856.
PROi Q6AXV9.

Gene expression databases

Genevestigatori Q6AXV9.

Family and domain databases

Gene3Di 1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProi IPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR004046. GST_C.
IPR005442. GST_omega.
IPR012336. Thioredoxin-like_fold.
[Graphical view ]
Pfami PF00043. GST_C. 1 hit.
PF13417. GST_N_3. 1 hit.
[Graphical view ]
PRINTSi PR01625. GSTRNSFRASEO.
SUPFAMi SSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEi PS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.

Entry informationi

Entry nameiGSTO2_RAT
AccessioniPrimary (citable) accession number: Q6AXV9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: September 13, 2004
Last modified: May 14, 2014
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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