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Protein

Sorting and assembly machinery component 50 homolog

Gene

Samm50

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Plays a crucial role in the maintenance of the structure of mitochondrial cristae and the proper assembly of the mitochondrial respiratory chain complexes. Required for the assembly of TOMM40 into the TOM complex.By similarity

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Sorting and assembly machinery component 50 homolog
Gene namesi
Name:Samm50
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 7

Organism-specific databases

RGDi1303219. Samm50.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Membrane, Mitochondrion, Mitochondrion outer membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 469469Sorting and assembly machinery component 50 homologPRO_0000286400Add
BLAST

Proteomic databases

PaxDbiQ6AXV4.
PRIDEiQ6AXV4.

PTM databases

iPTMnetiQ6AXV4.
PhosphoSiteiQ6AXV4.

Expressioni

Gene expression databases

BgeeiENSRNOG00000011952.
GenevisibleiQ6AXV4. RN.

Interactioni

Subunit structurei

Associates with the mitochondrial contact site and cristae organizing system (MICOS) complex, composed of at least MINOS1/MIC10, CHCHD3/MIC19, CHCHD6/MIC25, APOOL/MIC27, IMMT/MIC60, APOO/MIC23/MIC26 and QIL1/MIC13. This complex was also known under the names MINOS or MitOS complex. The MICOS complex associates with mitochondrial outer membrane proteins SAMM50, MTX1, MTX2 and DNAJC11, mitochondrial inner membrane protein TMEM11 and with HSPA9. Found in a complex with IMMT/MIC60 and CHCHD3/MIC19 termed mitochondrial intermembrane space bridging (MIB) complex. Interacts with IMMT/MIC60. Interacts with CHCHD3/MIC19.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000016520.

Structurei

3D structure databases

ProteinModelPortaliQ6AXV4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini45 – 12581POTRAPROSITE-ProRule annotationAdd
BLAST

Domaini

Its C-terminal part seems to contain many membrane-spanning sided beta-sheets, that have the potential to adopt a transmembrane beta-barrel type structure.By similarity

Sequence similaritiesi

Belongs to the SAM50/omp85 family.Curated
Contains 1 POTRA domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane beta strand

Phylogenomic databases

eggNOGiKOG2602. Eukaryota.
COG4775. LUCA.
GeneTreeiENSGT00390000011355.
HOGENOMiHOG000015411.
HOVERGENiHBG054614.
InParanoidiQ6AXV4.
KOiK07277.
OMAiWDQTSEV.
OrthoDBiEOG091G0IAD.
PhylomeDBiQ6AXV4.
TreeFamiTF106126.

Family and domain databases

InterProiIPR000184. Bac_surfAg_D15.
[Graphical view]
PfamiPF01103. Bac_surface_Ag. 1 hit.
[Graphical view]
PROSITEiPS51779. POTRA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6AXV4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGTVHARSLE PLPSSGTDFG ALGEEAEFVE VEPEAKQEIL ENKDVVVQHV
60 70 80 90 100
HFDGLERTKD DIIICEIGEV FKAKNLIEVM RRSHEAREKL LRLGIFRQVD
110 120 130 140 150
VLIDTCHGED ALPNGLDVTF EVTELRRLTG SYNTMVGNNE GSMVLGLKLP
160 170 180 190 200
NLLGRAEKVT FQFSYGTKET SYGLSFFKPQ PGNFEKNFSV NLYKVTGQFP
210 220 230 240 250
WSSLRETDRG VSAEYSFPLC KTSHTVKWEG VWRELGCLAR TASFAVRKES
260 270 280 290 300
GHSLKSSLSH AMVIDSRNSS ILPRRGALLK VNQELAGYTG GDVSFIKEDF
310 320 330 340 350
ELQLNKPLVL DSVFSTSLWG GMLVPIGDKL SSIADRFYLG GPTSVRGFSM
360 370 380 390 400
HSIGPQSEGD YLGGEAYWAG GLHLYTPLPF RPGQGGFGEL FRTHFFLNAG
410 420 430 440 450
NLCNLNYGEG PRAHIRKLAE CIRWSYGAGI VLRLGNIARL ELNYCIPMGV
460
QRGDRICDGV QFGAGIRFL
Length:469
Mass (Da):51,960
Last modified:September 13, 2004 - v1
Checksum:i600F6CC96DA5297F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC079302 mRNA. Translation: AAH79302.1.
RefSeqiNP_001004241.1. NM_001004241.1.
UniGeneiRn.12611.

Genome annotation databases

EnsembliENSRNOT00000016520; ENSRNOP00000016520; ENSRNOG00000011952.
GeneIDi300111.
KEGGirno:300111.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC079302 mRNA. Translation: AAH79302.1.
RefSeqiNP_001004241.1. NM_001004241.1.
UniGeneiRn.12611.

3D structure databases

ProteinModelPortaliQ6AXV4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000016520.

PTM databases

iPTMnetiQ6AXV4.
PhosphoSiteiQ6AXV4.

Proteomic databases

PaxDbiQ6AXV4.
PRIDEiQ6AXV4.

Protocols and materials databases

DNASUi300111.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000016520; ENSRNOP00000016520; ENSRNOG00000011952.
GeneIDi300111.
KEGGirno:300111.

Organism-specific databases

CTDi25813.
RGDi1303219. Samm50.

Phylogenomic databases

eggNOGiKOG2602. Eukaryota.
COG4775. LUCA.
GeneTreeiENSGT00390000011355.
HOGENOMiHOG000015411.
HOVERGENiHBG054614.
InParanoidiQ6AXV4.
KOiK07277.
OMAiWDQTSEV.
OrthoDBiEOG091G0IAD.
PhylomeDBiQ6AXV4.
TreeFamiTF106126.

Miscellaneous databases

PROiQ6AXV4.

Gene expression databases

BgeeiENSRNOG00000011952.
GenevisibleiQ6AXV4. RN.

Family and domain databases

InterProiIPR000184. Bac_surfAg_D15.
[Graphical view]
PfamiPF01103. Bac_surface_Ag. 1 hit.
[Graphical view]
PROSITEiPS51779. POTRA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSAM50_RAT
AccessioniPrimary (citable) accession number: Q6AXV4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: September 13, 2004
Last modified: September 7, 2016
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.