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Protein

CCR4-NOT transcription complex subunit 6

Gene

Cnot6

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Poly(A) nuclease with 3'-5' RNase activity. Catalytic component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Involved in mRNA decay mediated by the major-protein-coding determinant of instability (mCRD) of the FOS gene in the cytoplasm. In the presence of ZNF335, enhances ligand-dependent transcriptional activity of nuclear hormone receptors. Mediates cell proliferation and cell survival and prevents cellular senescence (By similarity).By similarity

Catalytic activityi

Exonucleolytic cleavage of poly(A) to 5'-AMP.

Cofactori

Mg2+By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei240By similarity1
Metal bindingi240MagnesiumBy similarity1
Metal bindingi240Magnesium 1By similarity1
Metal bindingi412Magnesium 2By similarity1
Metal bindingi414Magnesium 2By similarity1
Active sitei491By similarity1
Active sitei531By similarity1
Metal bindingi531Magnesium 2By similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Activator, Exonuclease, Hydrolase, Nuclease

Keywords - Biological processi

RNA-mediated gene silencing, Transcription, Transcription regulation, Translation regulation

Keywords - Ligandi

Magnesium, Metal-binding, RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
CCR4-NOT transcription complex subunit 6 (EC:3.1.13.4)
Alternative name(s):
CCR4 carbon catabolite repression 4-like
Carbon catabolite repressor protein 4 homolog
Cytoplasmic deadenylase
Gene namesi
Name:Cnot6
Synonyms:Ccr4
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi1310783. Cnot6.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002185751 – 557CCR4-NOT transcription complex subunit 6Add BLAST557

Proteomic databases

PaxDbiQ6AXU9.

PTM databases

PhosphoSitePlusiQ6AXU9.

Interactioni

Subunit structurei

Component of the CCR4-NOT complex; distinct complexes seem to exist that differ in the participation of probably mutually exclusive catalytic subunits; the complex contains two deadenylase subunits, CNOT6 or CNOT6L, and CNOT7 or CNOT8. Interacts with CNOT7 and CNOT8. Interacts with UNR. Interacts with ZFP36L1 (via N-terminus). Interacts with ZNF335.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000003752.

Structurei

3D structure databases

ProteinModelPortaliQ6AXU9.
SMRiQ6AXU9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati52 – 73LRR 1Add BLAST22
Repeati75 – 96LRR 2Add BLAST22
Repeati98 – 120LRR 3Add BLAST23
Repeati121 – 143LRR 4Add BLAST23

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni153 – 557Nuclease domainBy similarityAdd BLAST405

Sequence similaritiesi

Belongs to the CCR4/nocturin family.Curated
Contains 4 LRR (leucine-rich) repeats.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat

Phylogenomic databases

eggNOGiKOG0620. Eukaryota.
COG4886. LUCA.
COG5239. LUCA.
HOGENOMiHOG000294222.
HOVERGENiHBG052641.
InParanoidiQ6AXU9.
KOiK12603.
PhylomeDBiQ6AXU9.

Family and domain databases

Gene3Di3.60.10.10. 2 hits.
3.80.10.10. 1 hit.
InterProiIPR005135. Endo/exonuclease/phosphatase.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
[Graphical view]
PfamiPF03372. Exo_endo_phos. 1 hit.
PF13855. LRR_8. 1 hit.
[Graphical view]
SMARTiSM00369. LRR_TYP. 3 hits.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 1 hit.
SSF56219. SSF56219. 2 hits.
PROSITEiPS51450. LRR. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6AXU9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPKEKYEPPD PRRMYTIMSS EEAANGKKSH WAELEISGKV RSLSSSLWSL
60 70 80 90 100
THLTALHLSD NSLSCIPSDI AKLHNLVYLD LSHNQIQSLP AELGNMVSLR
110 120 130 140 150
ELHLNYNQLR VLPFELGKLF QLQTLSLKGN PLTQDILNLC LEPDGTRRLL
160 170 180 190 200
NYLLDNLSGT AKRISTEQPP PRSWIMLQEP DRTRPTALFS VMCYNVLCDK
210 220 230 240 250
YATRQLYGYC PSWALNWDYR KKAIIQEILS CNADIISLQE VETEQYYSFF
260 270 280 290 300
LVELKERGYN GFFSPKSRAR TMSEQERKHV DGCAIFFKTE KFTLVQKHTV
310 320 330 340 350
EFNQLAMANS EGSEAMLNRV MTKDNIGVAV LLELRKELIE MSSGKPHLGT
360 370 380 390 400
EKQLILVANA HMHWDPEYSD VKLVQTMMFL SEVKNIIDKA SRSLKSSVLG
410 420 430 440 450
ECGTIPLVLC ADLNSLPDSG VVEYLSTGGV ETNHKDFKEL RYNESLTNFS
460 470 480 490 500
CNGKNGMTNG RITHGFKLKS AYENGLMPYT NYTFDFKGII DYIFYSKPQL
510 520 530 540 550
NTLAILGPLD HHWLVENNIS GCPHPLIPSD HFSLFAQLEL LLPFLPQVNG

IHLPGRR
Length:557
Mass (Da):63,304
Last modified:September 13, 2004 - v1
Checksum:iE2780FC2D56EF3F7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC079308 mRNA. Translation: AAH79308.1.
RefSeqiNP_001013878.1. NM_001013856.1.
UniGeneiRn.93562.

Genome annotation databases

GeneIDi287249.
KEGGirno:287249.
UCSCiRGD:1310783. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC079308 mRNA. Translation: AAH79308.1.
RefSeqiNP_001013878.1. NM_001013856.1.
UniGeneiRn.93562.

3D structure databases

ProteinModelPortaliQ6AXU9.
SMRiQ6AXU9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000003752.

PTM databases

PhosphoSitePlusiQ6AXU9.

Proteomic databases

PaxDbiQ6AXU9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi287249.
KEGGirno:287249.
UCSCiRGD:1310783. rat.

Organism-specific databases

CTDi57472.
RGDi1310783. Cnot6.

Phylogenomic databases

eggNOGiKOG0620. Eukaryota.
COG4886. LUCA.
COG5239. LUCA.
HOGENOMiHOG000294222.
HOVERGENiHBG052641.
InParanoidiQ6AXU9.
KOiK12603.
PhylomeDBiQ6AXU9.

Miscellaneous databases

PROiQ6AXU9.

Family and domain databases

Gene3Di3.60.10.10. 2 hits.
3.80.10.10. 1 hit.
InterProiIPR005135. Endo/exonuclease/phosphatase.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
[Graphical view]
PfamiPF03372. Exo_endo_phos. 1 hit.
PF13855. LRR_8. 1 hit.
[Graphical view]
SMARTiSM00369. LRR_TYP. 3 hits.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 1 hit.
SSF56219. SSF56219. 2 hits.
PROSITEiPS51450. LRR. 4 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCNOT6_RAT
AccessioniPrimary (citable) accession number: Q6AXU9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: September 13, 2004
Last modified: November 2, 2016
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.