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Protein

C-X-C motif chemokine 16

Gene

Cxcl16

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Induces a strong chemotactic response. Induces calcium mobilization. Binds to CXCR6/Bonzo. Also acts as a scavenger receptor on macrophages, which specifically binds to OxLDL (oxidized low density lipoprotein), suggesting that it may be involved in pathophysiology such as atherogenesis (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Keywords - Biological processi

Chemotaxis

Enzyme and pathway databases

ReactomeiR-RNO-380108. Chemokine receptors bind chemokines.
R-RNO-418594. G alpha (i) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
C-X-C motif chemokine 16
Alternative name(s):
Small-inducible cytokine B16
Transmembrane chemokine CXCL16
Gene namesi
Name:Cxcl16
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 10

Organism-specific databases

RGDi1562928. Cxcl16.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini27 – 198172ExtracellularSequence analysisAdd
BLAST
Transmembranei199 – 21921HelicalSequence analysisAdd
BLAST
Topological domaini220 – 24728CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2626Sequence analysisAdd
BLAST
Chaini27 – 247221C-X-C motif chemokine 16PRO_0000378193Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi35 ↔ 65By similarity
Disulfide bondi37 ↔ 79By similarity

Post-translational modificationi

Glycosylated.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ6AXU5.
PRIDEiQ6AXU5.

Expressioni

Inductioni

By interleukin-18 and the induction is strongly mediated by an activator protein-1-dependent pathway.1 Publication

Gene expression databases

BgeeiENSRNOG00000026647.
GenevisibleiQ6AXU5. RN.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000037160.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J8A5. Eukaryota.
ENOG4111D6H. LUCA.
GeneTreeiENSGT00390000002148.
HOGENOMiHOG000112116.
InParanoidiQ6AXU5.
KOiK10035.
OMAiVLCKRRR.
OrthoDBiEOG091G0P40.
PhylomeDBiQ6AXU5.
TreeFamiTF337941.

Family and domain databases

InterProiIPR026296. CXCL16.
[Graphical view]
PANTHERiPTHR14385. PTHR14385. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6AXU5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRRGFGPLAL TLFLFFFALL TLPGDGNQGS VAGSCYCDRT IPSGTQIPPA
60 70 80 90 100
TLNHMRKYLK TFHRCQFFIR FQLQSKSVCG GSQDQWVREL VNCFEHKQCG
110 120 130 140 150
IGHGQSFHHQ KHVPQASTRI PEATEGKPPD TSTAVQFQST QQSTFPSGAP
160 170 180 190 200
SLNKELTRHW ETTILPSGYG LEARPVAEAN EKQHKQQKEP GAGAGTQALV
210 220 230 240
PVLSLLAIVF FLVAAMVCVL CNRRVTRQSS SGLQLCYTPV EPRPQGL
Length:247
Mass (Da):27,196
Last modified:September 13, 2004 - v1
Checksum:iEBD43D23E75C7912
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ025528 mRNA. Translation: AAY42602.1.
CH473948 Genomic DNA. Translation: EDM05007.1.
CH473948 Genomic DNA. Translation: EDM05009.1.
BC079312 mRNA. Translation: AAH79312.1.
RefSeqiNP_001017478.1. NM_001017478.1.
UniGeneiRn.7070.

Genome annotation databases

EnsembliENSRNOT00000032926; ENSRNOP00000037160; ENSRNOG00000026647.
GeneIDi497942.
KEGGirno:497942.
UCSCiRGD:1562928. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ025528 mRNA. Translation: AAY42602.1.
CH473948 Genomic DNA. Translation: EDM05007.1.
CH473948 Genomic DNA. Translation: EDM05009.1.
BC079312 mRNA. Translation: AAH79312.1.
RefSeqiNP_001017478.1. NM_001017478.1.
UniGeneiRn.7070.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000037160.

Proteomic databases

PaxDbiQ6AXU5.
PRIDEiQ6AXU5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000032926; ENSRNOP00000037160; ENSRNOG00000026647.
GeneIDi497942.
KEGGirno:497942.
UCSCiRGD:1562928. rat.

Organism-specific databases

CTDi58191.
RGDi1562928. Cxcl16.

Phylogenomic databases

eggNOGiENOG410J8A5. Eukaryota.
ENOG4111D6H. LUCA.
GeneTreeiENSGT00390000002148.
HOGENOMiHOG000112116.
InParanoidiQ6AXU5.
KOiK10035.
OMAiVLCKRRR.
OrthoDBiEOG091G0P40.
PhylomeDBiQ6AXU5.
TreeFamiTF337941.

Enzyme and pathway databases

ReactomeiR-RNO-380108. Chemokine receptors bind chemokines.
R-RNO-418594. G alpha (i) signalling events.

Miscellaneous databases

PROiQ6AXU5.

Gene expression databases

BgeeiENSRNOG00000026647.
GenevisibleiQ6AXU5. RN.

Family and domain databases

InterProiIPR026296. CXCL16.
[Graphical view]
PANTHERiPTHR14385. PTHR14385. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiCXL16_RAT
AccessioniPrimary (citable) accession number: Q6AXU5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 16, 2009
Last sequence update: September 13, 2004
Last modified: September 7, 2016
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.