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Protein

E3 ubiquitin-protein ligase RNF181

Gene

Rnf181

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.By similarity

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri88 – 12942RING-type; atypicalPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Ubl conjugation pathway

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
E3 ubiquitin-protein ligase RNF181 (EC:6.3.2.-)
Alternative name(s):
RING finger protein 181
Gene namesi
Name:Rnf181
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 4

Organism-specific databases

RGDi1359698. Rnf181.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 165165E3 ubiquitin-protein ligase RNF181PRO_0000295176Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei165 – 1651PhosphothreonineBy similarity

Post-translational modificationi

Auto-ubiquitinated as part of the enzymatic reaction.By similarity

Keywords - PTMi

Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiQ6AXU4.
PRIDEiQ6AXU4.

Expressioni

Gene expression databases

GenevisibleiQ6AXU4. RN.

Interactioni

Subunit structurei

Directly interacts with ITGA2B and, as a result, with integrin ITGA2B/ITGB3. There is no evidence that integrin ITGA2B/ITGB3 is an endogenous substrate for RNF181-directed ubiquitination (By similarity).By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000016699.

Structurei

3D structure databases

ProteinModelPortaliQ6AXU4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the RNF181 family.Curated
Contains 1 RING-type zinc finger.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri88 – 12942RING-type; atypicalPROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG0800. Eukaryota.
ENOG41121N2. LUCA.
GeneTreeiENSGT00530000062967.
HOGENOMiHOG000031081.
HOVERGENiHBG108412.
InParanoidiQ6AXU4.
OMAiDEHNCEP.
OrthoDBiEOG7M3J20.
PhylomeDBiQ6AXU4.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
InterProiIPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PfamiPF13639. zf-RING_2. 1 hit.
[Graphical view]
SMARTiSM00184. RING. 1 hit.
[Graphical view]
PROSITEiPS50089. ZF_RING_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6AXU4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASYFDEHDC EPLNPEREAR NNMLLELARR VRGAWSWAPG SRSLFNRMDF
60 70 80 90 100
EDLGLVDWEH HLPPPAAKAV VESLPRTVIR SSKAELKCPV CLLEFEEEET
110 120 130 140 150
VIEMPCHHLF HSNCILPWLS KTNSCPLCRH ELPTDDDSYE EHKKDKARRQ
160
QQQHRLENLH GAMYT
Length:165
Mass (Da):19,288
Last modified:September 13, 2004 - v1
Checksum:iD6D76C9926805C1C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC079313 mRNA. Translation: AAH79313.1.
RefSeqiNP_001007648.1. NM_001007647.1.
UniGeneiRn.94883.

Genome annotation databases

EnsembliENSRNOT00000016699; ENSRNOP00000016699; ENSRNOG00000012035.
GeneIDi297337.
KEGGirno:297337.
UCSCiRGD:1359698. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC079313 mRNA. Translation: AAH79313.1.
RefSeqiNP_001007648.1. NM_001007647.1.
UniGeneiRn.94883.

3D structure databases

ProteinModelPortaliQ6AXU4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000016699.

Proteomic databases

PaxDbiQ6AXU4.
PRIDEiQ6AXU4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000016699; ENSRNOP00000016699; ENSRNOG00000012035.
GeneIDi297337.
KEGGirno:297337.
UCSCiRGD:1359698. rat.

Organism-specific databases

CTDi51255.
RGDi1359698. Rnf181.

Phylogenomic databases

eggNOGiKOG0800. Eukaryota.
ENOG41121N2. LUCA.
GeneTreeiENSGT00530000062967.
HOGENOMiHOG000031081.
HOVERGENiHBG108412.
InParanoidiQ6AXU4.
OMAiDEHNCEP.
OrthoDBiEOG7M3J20.
PhylomeDBiQ6AXU4.

Enzyme and pathway databases

UniPathwayiUPA00143.

Miscellaneous databases

NextBioi642113.
PROiQ6AXU4.

Gene expression databases

GenevisibleiQ6AXU4. RN.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
InterProiIPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PfamiPF13639. zf-RING_2. 1 hit.
[Graphical view]
SMARTiSM00184. RING. 1 hit.
[Graphical view]
PROSITEiPS50089. ZF_RING_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.
  2. Lubec G., Kang S.U., Lubec S.
    Submitted (SEP-2007) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 21-29, IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: Sprague-Dawley.
    Tissue: Brain.

Entry informationi

Entry nameiRN181_RAT
AccessioniPrimary (citable) accession number: Q6AXU4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: September 13, 2004
Last modified: May 11, 2016
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.