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Protein

Ras-related protein Rab-21

Gene

Rab21

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Regulates integrin internalization and recycling, but does not influence the traffic of endosomally translocated receptors in general. As a result, may regulate cell adhesion and migration. During the mitosis of adherent cells, controls the endosomal trafficking of integrins which is required for the successful completion of cytokinesis (By similarity). Involved in neurite growth (PubMed:19745841).By similarity1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi24 – 329GTPBy similarity
Nucleotide bindingi72 – 765GTPBy similarity
Nucleotide bindingi130 – 1334GTPBy similarity
Nucleotide bindingi160 – 1623GTPBy similarity

GO - Molecular functioni

  1. GDP binding Source: UniProtKB
  2. GTPase activity Source: UniProtKB
  3. GTP binding Source: UniProtKB

GO - Biological processi

  1. anterograde axon cargo transport Source: UniProtKB
  2. intracellular protein transport Source: GO_Central
  3. metabolic process Source: GOC
  4. positive regulation of early endosome to late endosome transport Source: Ensembl
  5. positive regulation of receptor-mediated endocytosis Source: Ensembl
  6. Rab protein signal transduction Source: GO_Central
  7. regulation of axon extension Source: UniProtKB
  8. regulation of endocytosis Source: GO_Central
Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Ras-related protein Rab-21
Gene namesi
Name:Rab21
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494 Componenti: Chromosome 7

Organism-specific databases

RGDi1303150. Rab21.

Subcellular locationi

  1. Endoplasmic reticulum membrane; Lipid-anchor
  2. Golgi apparatus membrane
  3. Early endosome membrane
  4. Cytoplasmic vesicle membrane By similarity

  5. Note: Colocalizes with ANKRD27 and VAMP7 in neurites (PubMed:19745841).1 Publication

GO - Cellular componenti

  1. cytoplasmic side of early endosome membrane Source: Ensembl
  2. cytoplasmic side of plasma membrane Source: Ensembl
  3. cytoplasmic vesicle membrane Source: UniProtKB-SubCell
  4. early endosome Source: GO_Central
  5. endoplasmic reticulum membrane Source: UniProtKB-SubCell
  6. extracellular vesicular exosome Source: Ensembl
  7. focal adhesion Source: Ensembl
  8. Golgi cisterna membrane Source: Ensembl
  9. neuron projection Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasmic vesicle, Endoplasmic reticulum, Endosome, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedBy similarity
Chaini2 – 220219Ras-related protein Rab-21PRO_0000312571Add
BLAST
Propeptidei221 – 2233Removed in mature formSequence AnalysisPRO_0000370770

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineBy similarity
Lipidationi219 – 2191S-geranylgeranyl cysteineBy similarity
Modified residuei220 – 2201Cysteine methyl esterSequence Analysis
Lipidationi220 – 2201S-geranylgeranyl cysteineBy similarity

Keywords - PTMi

Acetylation, Lipoprotein, Methylation, Prenylation

Proteomic databases

PaxDbiQ6AXT5.
PRIDEiQ6AXT5.

PTM databases

PhosphoSiteiQ6AXT5.

Expressioni

Gene expression databases

GenevestigatoriQ6AXT5.

Interactioni

Subunit structurei

Interacts with the cytoplasmic tail of integrins ITGA1, ITGA2, ITGA5, ITGA6, ITGA11 and ITGB1; this interaction is dependent upon its GDP/GTP cycle. Interacts with ANKRD27 (By similarity).By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000005258.

Structurei

3D structure databases

ProteinModelPortaliQ6AXT5.
SMRiQ6AXT5. Positions 15-181.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi46 – 549Effector regionBy similarity

Sequence similaritiesi

Belongs to the small GTPase superfamily. Rab family.Curated

Phylogenomic databases

eggNOGiCOG1100.
GeneTreeiENSGT00760000119101.
HOGENOMiHOG000233968.
HOVERGENiHBG009351.
InParanoidiQ6AXT5.
KOiK07890.
OMAiSHFFASA.
OrthoDBiEOG7RZ5QX.
PhylomeDBiQ6AXT5.
TreeFamiTF300199.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR003579. Small_GTPase_Rab_type.
[Graphical view]
PfamiPF00071. Ras. 1 hit.
[Graphical view]
PRINTSiPR00449. RASTRNSFRMNG.
SMARTiSM00175. RAB. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51419. RAB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6AXT5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAAGGGAAA AAGRAYSFKV VLLGEGCVGK TSLVLRYCEN KFNDKHITTL
60 70 80 90 100
QASFLTKKLN IGGKRVNLAI WDTAGQERFH ALGPIYYRDS NGAILVYDVT
110 120 130 140 150
DEDSFQKVKN WVKELRKMLG NEICLCIVGN KIDLEKERHV SIQEAESYAE
160 170 180 190 200
SVGAKHYHTS AKQNKGIEEL FLDLCKRMIE TAQVDERAKG NGSSQAGAAR
210 220
RGVQIIDDEP QAQSGSGGCC SSG
Length:223
Mass (Da):24,163
Last modified:September 13, 2004 - v1
Checksum:iBCF6701EC2884D74
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC079323 mRNA. Translation: AAH79323.1.
RefSeqiNP_001004238.1. NM_001004238.1.
UniGeneiRn.162952.

Genome annotation databases

EnsembliENSRNOT00000005258; ENSRNOP00000005258; ENSRNOG00000003923.
GeneIDi299799.
KEGGirno:299799.
UCSCiRGD:1303150. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC079323 mRNA. Translation: AAH79323.1.
RefSeqiNP_001004238.1. NM_001004238.1.
UniGeneiRn.162952.

3D structure databases

ProteinModelPortaliQ6AXT5.
SMRiQ6AXT5. Positions 15-181.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000005258.

PTM databases

PhosphoSiteiQ6AXT5.

Proteomic databases

PaxDbiQ6AXT5.
PRIDEiQ6AXT5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000005258; ENSRNOP00000005258; ENSRNOG00000003923.
GeneIDi299799.
KEGGirno:299799.
UCSCiRGD:1303150. rat.

Organism-specific databases

CTDi23011.
RGDi1303150. Rab21.

Phylogenomic databases

eggNOGiCOG1100.
GeneTreeiENSGT00760000119101.
HOGENOMiHOG000233968.
HOVERGENiHBG009351.
InParanoidiQ6AXT5.
KOiK07890.
OMAiSHFFASA.
OrthoDBiEOG7RZ5QX.
PhylomeDBiQ6AXT5.
TreeFamiTF300199.

Miscellaneous databases

NextBioi645786.
PROiQ6AXT5.

Gene expression databases

GenevestigatoriQ6AXT5.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR003579. Small_GTPase_Rab_type.
[Graphical view]
PfamiPF00071. Ras. 1 hit.
[Graphical view]
PRINTSiPR00449. RASTRNSFRMNG.
SMARTiSM00175. RAB. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51419. RAB. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.
  2. "Role of Varp, a Rab21 exchange factor and TI-VAMP/VAMP7 partner, in neurite growth."
    Burgo A., Sotirakis E., Simmler M.C., Verraes A., Chamot C., Simpson J.C., Lanzetti L., Proux-Gillardeaux V., Galli T.
    EMBO Rep. 10:1117-1124(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION.

Entry informationi

Entry nameiRAB21_RAT
AccessioniPrimary (citable) accession number: Q6AXT5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: September 13, 2004
Last modified: April 1, 2015
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.