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Q6AXT5

- RAB21_RAT

UniProt

Q6AXT5 - RAB21_RAT

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Protein

Ras-related protein Rab-21

Gene

Rab21

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Regulates integrin internalization and recycling, but does not influence the traffic of endosomally translocated receptors in general. As a result, may regulate cell adhesion and migration. During the mitosis of adherent cells, controls the endosomal trafficking of integrins which is required for the successful completion of cytokinesis (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi24 – 329GTPBy similarity
Nucleotide bindingi72 – 765GTPBy similarity
Nucleotide bindingi130 – 1334GTPBy similarity
Nucleotide bindingi160 – 1623GTPBy similarity

GO - Molecular functioni

  1. GDP binding Source: UniProtKB
  2. GTPase activity Source: UniProtKB
  3. GTP binding Source: UniProtKB

GO - Biological processi

  1. protein transport Source: UniProtKB-KW
  2. small GTPase mediated signal transduction Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Ras-related protein Rab-21
Gene namesi
Name:Rab21
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 7

Organism-specific databases

RGDi1303150. Rab21.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasmic vesicle Source: UniProtKB-KW
  2. endoplasmic reticulum Source: UniProtKB-KW
  3. endosome Source: UniProtKB-KW
  4. extracellular vesicular exosome Source: Ensembl
  5. Golgi apparatus Source: UniProtKB-KW
  6. membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasmic vesicle, Endoplasmic reticulum, Endosome, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedBy similarity
Chaini2 – 220219Ras-related protein Rab-21PRO_0000312571Add
BLAST
Propeptidei221 – 2233Removed in mature formSequence AnalysisPRO_0000370770

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineBy similarity
Lipidationi219 – 2191S-geranylgeranyl cysteineBy similarity
Modified residuei220 – 2201Cysteine methyl esterSequence Analysis
Lipidationi220 – 2201S-geranylgeranyl cysteineBy similarity

Keywords - PTMi

Acetylation, Lipoprotein, Methylation, Prenylation

Proteomic databases

PaxDbiQ6AXT5.
PRIDEiQ6AXT5.

PTM databases

PhosphoSiteiQ6AXT5.

Expressioni

Gene expression databases

GenevestigatoriQ6AXT5.

Interactioni

Subunit structurei

Interacts with the cytoplasmic tail of integrins ITGA1, ITGA2, ITGA5, ITGA6, ITGA11 and ITGB1; this interaction is dependent upon its GDP/GTP cycle.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000005258.

Structurei

3D structure databases

ProteinModelPortaliQ6AXT5.
SMRiQ6AXT5. Positions 15-181.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi46 – 549Effector regionBy similarity

Sequence similaritiesi

Belongs to the small GTPase superfamily. Rab family.Curated

Phylogenomic databases

eggNOGiCOG1100.
GeneTreeiENSGT00760000119101.
HOGENOMiHOG000233968.
HOVERGENiHBG009351.
InParanoidiQ6AXT5.
KOiK07890.
OMAiSHFFASA.
OrthoDBiEOG7RZ5QX.
PhylomeDBiQ6AXT5.
TreeFamiTF300199.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR003579. Small_GTPase_Rab_type.
[Graphical view]
PfamiPF00071. Ras. 1 hit.
[Graphical view]
PRINTSiPR00449. RASTRNSFRMNG.
SMARTiSM00175. RAB. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51419. RAB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6AXT5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAAAGGGAAA AAGRAYSFKV VLLGEGCVGK TSLVLRYCEN KFNDKHITTL
60 70 80 90 100
QASFLTKKLN IGGKRVNLAI WDTAGQERFH ALGPIYYRDS NGAILVYDVT
110 120 130 140 150
DEDSFQKVKN WVKELRKMLG NEICLCIVGN KIDLEKERHV SIQEAESYAE
160 170 180 190 200
SVGAKHYHTS AKQNKGIEEL FLDLCKRMIE TAQVDERAKG NGSSQAGAAR
210 220
RGVQIIDDEP QAQSGSGGCC SSG
Length:223
Mass (Da):24,163
Last modified:September 13, 2004 - v1
Checksum:iBCF6701EC2884D74
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC079323 mRNA. Translation: AAH79323.1.
RefSeqiNP_001004238.1. NM_001004238.1.
UniGeneiRn.162952.

Genome annotation databases

EnsembliENSRNOT00000005258; ENSRNOP00000005258; ENSRNOG00000003923.
GeneIDi299799.
KEGGirno:299799.
UCSCiRGD:1303150. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC079323 mRNA. Translation: AAH79323.1 .
RefSeqi NP_001004238.1. NM_001004238.1.
UniGenei Rn.162952.

3D structure databases

ProteinModelPortali Q6AXT5.
SMRi Q6AXT5. Positions 15-181.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000005258.

PTM databases

PhosphoSitei Q6AXT5.

Proteomic databases

PaxDbi Q6AXT5.
PRIDEi Q6AXT5.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000005258 ; ENSRNOP00000005258 ; ENSRNOG00000003923 .
GeneIDi 299799.
KEGGi rno:299799.
UCSCi RGD:1303150. rat.

Organism-specific databases

CTDi 23011.
RGDi 1303150. Rab21.

Phylogenomic databases

eggNOGi COG1100.
GeneTreei ENSGT00760000119101.
HOGENOMi HOG000233968.
HOVERGENi HBG009351.
InParanoidi Q6AXT5.
KOi K07890.
OMAi SHFFASA.
OrthoDBi EOG7RZ5QX.
PhylomeDBi Q6AXT5.
TreeFami TF300199.

Miscellaneous databases

NextBioi 645786.
PROi Q6AXT5.

Gene expression databases

Genevestigatori Q6AXT5.

Family and domain databases

Gene3Di 3.40.50.300. 1 hit.
InterProi IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR003579. Small_GTPase_Rab_type.
[Graphical view ]
Pfami PF00071. Ras. 1 hit.
[Graphical view ]
PRINTSi PR00449. RASTRNSFRMNG.
SMARTi SM00175. RAB. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
TIGRFAMsi TIGR00231. small_GTP. 1 hit.
PROSITEi PS51419. RAB. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.

Entry informationi

Entry nameiRAB21_RAT
AccessioniPrimary (citable) accession number: Q6AXT5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: September 13, 2004
Last modified: October 29, 2014
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3