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Q6AXT5 (RAB21_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 85. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ras-related protein Rab-21
Gene names
Name:Rab21
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length223 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Regulates integrin internalization and recycling, but does not influence the traffic of endosomally translocated receptors in general. As a result, may regulate cell adhesion and migration. During the mitosis of adherent cells, controls the endosomal trafficking of integrins which is required for the successful completion of cytokinesis By similarity.

Subunit structure

Interacts with the cytoplasmic tail of integrins ITGA1, ITGA2, ITGA5, ITGA6, ITGA11 and ITGB1; this interaction is dependent upon its GDP/GTP cycle By similarity.

Subcellular location

Endoplasmic reticulum membrane; Lipid-anchor. Golgi apparatus membrane. Early endosome membrane. Cytoplasmic vesicle membrane By similarity.

Sequence similarities

Belongs to the small GTPase superfamily. Rab family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 220219Ras-related protein Rab-21
PRO_0000312571
Propeptide221 – 2233Removed in mature form Potential
PRO_0000370770

Regions

Nucleotide binding24 – 329GTP By similarity
Nucleotide binding72 – 765GTP By similarity
Nucleotide binding130 – 1334GTP By similarity
Nucleotide binding160 – 1623GTP By similarity
Motif46 – 549Effector region By similarity

Amino acid modifications

Modified residue21N-acetylalanine By similarity
Modified residue2201Cysteine methyl ester Potential
Lipidation2191S-geranylgeranyl cysteine By similarity
Lipidation2201S-geranylgeranyl cysteine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q6AXT5 [UniParc].

Last modified September 13, 2004. Version 1.
Checksum: BCF6701EC2884D74

FASTA22324,163
        10         20         30         40         50         60 
MAAAGGGAAA AAGRAYSFKV VLLGEGCVGK TSLVLRYCEN KFNDKHITTL QASFLTKKLN 

        70         80         90        100        110        120 
IGGKRVNLAI WDTAGQERFH ALGPIYYRDS NGAILVYDVT DEDSFQKVKN WVKELRKMLG 

       130        140        150        160        170        180 
NEICLCIVGN KIDLEKERHV SIQEAESYAE SVGAKHYHTS AKQNKGIEEL FLDLCKRMIE 

       190        200        210        220 
TAQVDERAKG NGSSQAGAAR RGVQIIDDEP QAQSGSGGCC SSG 

« Hide

References

[1]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Testis.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC079323 mRNA. Translation: AAH79323.1.
RefSeqNP_001004238.1. NM_001004238.1.
UniGeneRn.162952.

3D structure databases

ProteinModelPortalQ6AXT5.
SMRQ6AXT5. Positions 15-181.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10116.ENSRNOP00000005258.

PTM databases

PhosphoSiteQ6AXT5.

Proteomic databases

PaxDbQ6AXT5.
PRIDEQ6AXT5.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000005258; ENSRNOP00000005258; ENSRNOG00000003923.
GeneID299799.
KEGGrno:299799.
UCSCRGD:1303150. rat.

Organism-specific databases

CTD23011.
RGD1303150. Rab21.

Phylogenomic databases

eggNOGCOG1100.
GeneTreeENSGT00640000091439.
HOGENOMHOG000233968.
HOVERGENHBG009351.
InParanoidQ6AXT5.
KOK07890.
OMASHFFASA.
OrthoDBEOG7RZ5QX.
PhylomeDBQ6AXT5.
TreeFamTF300199.

Gene expression databases

GenevestigatorQ6AXT5.

Family and domain databases

Gene3D3.40.50.300. 1 hit.
InterProIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR003579. Small_GTPase_Rab_type.
[Graphical view]
PfamPF00071. Ras. 1 hit.
[Graphical view]
PRINTSPR00449. RASTRNSFRMNG.
SMARTSM00175. RAB. 1 hit.
[Graphical view]
SUPFAMSSF52540. SSF52540. 1 hit.
TIGRFAMsTIGR00231. small_GTP. 1 hit.
PROSITEPS51419. RAB. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio645786.
PROQ6AXT5.

Entry information

Entry nameRAB21_RAT
AccessionPrimary (citable) accession number: Q6AXT5
Entry history
Integrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: September 13, 2004
Last modified: April 16, 2014
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families