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Q6AXT5

- RAB21_RAT

UniProt

Q6AXT5 - RAB21_RAT

Protein

Ras-related protein Rab-21

Gene

Rab21

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 86 (01 Oct 2014)
      Sequence version 1 (13 Sep 2004)
      Previous versions | rss
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    Functioni

    Regulates integrin internalization and recycling, but does not influence the traffic of endosomally translocated receptors in general. As a result, may regulate cell adhesion and migration. During the mitosis of adherent cells, controls the endosomal trafficking of integrins which is required for the successful completion of cytokinesis By similarity.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi24 – 329GTPBy similarity
    Nucleotide bindingi72 – 765GTPBy similarity
    Nucleotide bindingi130 – 1334GTPBy similarity
    Nucleotide bindingi160 – 1623GTPBy similarity

    GO - Molecular functioni

    1. GDP binding Source: UniProtKB
    2. GTPase activity Source: UniProtKB
    3. GTP binding Source: UniProtKB

    GO - Biological processi

    1. protein transport Source: UniProtKB-KW
    2. small GTPase mediated signal transduction Source: InterPro

    Keywords - Biological processi

    Protein transport, Transport

    Keywords - Ligandi

    GTP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ras-related protein Rab-21
    Gene namesi
    Name:Rab21
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 7

    Organism-specific databases

    RGDi1303150. Rab21.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasmic vesicle membrane Source: UniProtKB-SubCell
    2. early endosome membrane Source: UniProtKB-SubCell
    3. endoplasmic reticulum membrane Source: UniProtKB-SubCell
    4. Golgi membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasmic vesicle, Endoplasmic reticulum, Endosome, Golgi apparatus, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 220219Ras-related protein Rab-21PRO_0000312571Add
    BLAST
    Propeptidei221 – 2233Removed in mature formSequence AnalysisPRO_0000370770

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylalanineBy similarity
    Lipidationi219 – 2191S-geranylgeranyl cysteineBy similarity
    Modified residuei220 – 2201Cysteine methyl esterSequence Analysis
    Lipidationi220 – 2201S-geranylgeranyl cysteineBy similarity

    Keywords - PTMi

    Acetylation, Lipoprotein, Methylation, Prenylation

    Proteomic databases

    PaxDbiQ6AXT5.
    PRIDEiQ6AXT5.

    PTM databases

    PhosphoSiteiQ6AXT5.

    Expressioni

    Gene expression databases

    GenevestigatoriQ6AXT5.

    Interactioni

    Subunit structurei

    Interacts with the cytoplasmic tail of integrins ITGA1, ITGA2, ITGA5, ITGA6, ITGA11 and ITGB1; this interaction is dependent upon its GDP/GTP cycle.By similarity

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000005258.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6AXT5.
    SMRiQ6AXT5. Positions 15-181.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi46 – 549Effector regionBy similarity

    Sequence similaritiesi

    Belongs to the small GTPase superfamily. Rab family.Curated

    Phylogenomic databases

    eggNOGiCOG1100.
    GeneTreeiENSGT00640000091439.
    HOGENOMiHOG000233968.
    HOVERGENiHBG009351.
    InParanoidiQ6AXT5.
    KOiK07890.
    OMAiSHFFASA.
    OrthoDBiEOG7RZ5QX.
    PhylomeDBiQ6AXT5.
    TreeFamiTF300199.

    Family and domain databases

    Gene3Di3.40.50.300. 1 hit.
    InterProiIPR027417. P-loop_NTPase.
    IPR005225. Small_GTP-bd_dom.
    IPR001806. Small_GTPase.
    IPR003579. Small_GTPase_Rab_type.
    [Graphical view]
    PfamiPF00071. Ras. 1 hit.
    [Graphical view]
    PRINTSiPR00449. RASTRNSFRMNG.
    SMARTiSM00175. RAB. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    TIGRFAMsiTIGR00231. small_GTP. 1 hit.
    PROSITEiPS51419. RAB. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q6AXT5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAAAGGGAAA AAGRAYSFKV VLLGEGCVGK TSLVLRYCEN KFNDKHITTL    50
    QASFLTKKLN IGGKRVNLAI WDTAGQERFH ALGPIYYRDS NGAILVYDVT 100
    DEDSFQKVKN WVKELRKMLG NEICLCIVGN KIDLEKERHV SIQEAESYAE 150
    SVGAKHYHTS AKQNKGIEEL FLDLCKRMIE TAQVDERAKG NGSSQAGAAR 200
    RGVQIIDDEP QAQSGSGGCC SSG 223
    Length:223
    Mass (Da):24,163
    Last modified:September 13, 2004 - v1
    Checksum:iBCF6701EC2884D74
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC079323 mRNA. Translation: AAH79323.1.
    RefSeqiNP_001004238.1. NM_001004238.1.
    UniGeneiRn.162952.

    Genome annotation databases

    EnsembliENSRNOT00000005258; ENSRNOP00000005258; ENSRNOG00000003923.
    GeneIDi299799.
    KEGGirno:299799.
    UCSCiRGD:1303150. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC079323 mRNA. Translation: AAH79323.1 .
    RefSeqi NP_001004238.1. NM_001004238.1.
    UniGenei Rn.162952.

    3D structure databases

    ProteinModelPortali Q6AXT5.
    SMRi Q6AXT5. Positions 15-181.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000005258.

    PTM databases

    PhosphoSitei Q6AXT5.

    Proteomic databases

    PaxDbi Q6AXT5.
    PRIDEi Q6AXT5.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000005258 ; ENSRNOP00000005258 ; ENSRNOG00000003923 .
    GeneIDi 299799.
    KEGGi rno:299799.
    UCSCi RGD:1303150. rat.

    Organism-specific databases

    CTDi 23011.
    RGDi 1303150. Rab21.

    Phylogenomic databases

    eggNOGi COG1100.
    GeneTreei ENSGT00640000091439.
    HOGENOMi HOG000233968.
    HOVERGENi HBG009351.
    InParanoidi Q6AXT5.
    KOi K07890.
    OMAi SHFFASA.
    OrthoDBi EOG7RZ5QX.
    PhylomeDBi Q6AXT5.
    TreeFami TF300199.

    Miscellaneous databases

    NextBioi 645786.
    PROi Q6AXT5.

    Gene expression databases

    Genevestigatori Q6AXT5.

    Family and domain databases

    Gene3Di 3.40.50.300. 1 hit.
    InterProi IPR027417. P-loop_NTPase.
    IPR005225. Small_GTP-bd_dom.
    IPR001806. Small_GTPase.
    IPR003579. Small_GTPase_Rab_type.
    [Graphical view ]
    Pfami PF00071. Ras. 1 hit.
    [Graphical view ]
    PRINTSi PR00449. RASTRNSFRMNG.
    SMARTi SM00175. RAB. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    TIGRFAMsi TIGR00231. small_GTP. 1 hit.
    PROSITEi PS51419. RAB. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Testis.

    Entry informationi

    Entry nameiRAB21_RAT
    AccessioniPrimary (citable) accession number: Q6AXT5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 4, 2007
    Last sequence update: September 13, 2004
    Last modified: October 1, 2014
    This is version 86 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3