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Protein

Four and a half LIM domains protein 5

Gene

Fhl5

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May be involved in the regulation of spermatogenesis. Stimulates CREM transcriptional activity in a phosphorylation-independent manner (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri8 – 32C4-typeSequence analysisAdd BLAST25

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Four and a half LIM domains protein 5
Short name:
FHL-5
Gene namesi
Name:Fhl5
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 5

Organism-specific databases

RGDi1307056 Fhl5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000757441 – 284Four and a half LIM domains protein 5Add BLAST284

Proteomic databases

PaxDbiQ6AXT1

Expressioni

Gene expression databases

BgeeiENSRNOG00000007680

Interactioni

Subunit structurei

Interacts with CREM (via the third LIM domain). Interacts (via second LIM domain) with SPAG8.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000047630

Structurei

3D structure databases

ProteinModelPortaliQ6AXT1
SMRiQ6AXT1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini39 – 100LIM zinc-binding 1PROSITE-ProRule annotationAdd BLAST62
Domaini101 – 160LIM zinc-binding 2PROSITE-ProRule annotationAdd BLAST60
Domaini161 – 220LIM zinc-binding 3PROSITE-ProRule annotationAdd BLAST60
Domaini221 – 283LIM zinc-binding 4PROSITE-ProRule annotationAdd BLAST63

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri8 – 32C4-typeSequence analysisAdd BLAST25

Keywords - Domaini

LIM domain, Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1704 Eukaryota
ENOG410XP0W LUCA
GeneTreeiENSGT00760000118910
HOGENOMiHOG000231075
HOVERGENiHBG074526
InParanoidiQ6AXT1
OMAiYCVSCYD
OrthoDBiEOG091G07C5
PhylomeDBiQ6AXT1
TreeFamiTF314113

Family and domain databases

InterProiView protein in InterPro
IPR037987 FHL2/3/5
IPR001781 Znf_LIM
PANTHERiPTHR24205 PTHR24205, 1 hit
PfamiView protein in Pfam
PF00412 LIM, 4 hits
SMARTiView protein in SMART
SM00132 LIM, 4 hits
PROSITEiView protein in PROSITE
PS00478 LIM_DOMAIN_1, 4 hits
PS50023 LIM_DOMAIN_2, 4 hits

Sequencei

Sequence statusi: Complete.

Q6AXT1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTSTQFDCQY CTASLLGKKY VLKDDNLYCI SCYDRIFSNY CEQCKEPIES
60 70 80 90 100
DSKDLCYKNR HWHEGCFRCN KCHHSLVEKP FVAKDERLLC TDCYSNECSS
110 120 130 140 150
KCFHCKRTIM PGSRKMEFKG NYWHETCFVC EHCRQPIGTK PLISKESGNY
160 170 180 190 200
CVPCFEKEFA HYCNFCKKVI TSGGITFRDQ IWHKECFLCS GCRKELYEEA
210 220 230 240 250
FMSKDDFPFC LDCYNHLYAK KCAACTKPIT GLRGAKFICF QDRQWHSECF
260 270 280
NCGKCSVSLV GEGFLTQNME ILCRKCGSGA DTDM
Length:284
Mass (Da):32,970
Last modified:September 13, 2004 - v1
Checksum:i6FA46146D7410005
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC079327 mRNA Translation: AAH79327.1
RefSeqiNP_001013106.1, NM_001013088.1
XP_008761817.2, XM_008763595.2
XP_017448722.1, XM_017593233.1
UniGeneiRn.109490

Genome annotation databases

EnsembliENSRNOT00000046595; ENSRNOP00000047630; ENSRNOG00000007680
GeneIDi297954
KEGGirno:297954
UCSCiRGD:1307056 rat

Similar proteinsi

Entry informationi

Entry nameiFHL5_RAT
AccessioniPrimary (citable) accession number: Q6AXT1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: September 13, 2004
Last modified: March 28, 2018
This is version 94 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health