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Protein

Four and a half LIM domains protein 5

Gene

Fhl5

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in the regulation of spermatogenesis. Stimulates CREM transcriptional activity in a phosphorylation-independent manner (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri8 – 3225C4-typeSequence analysisAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Four and a half LIM domains protein 5
Short name:
FHL-5
Gene namesi
Name:Fhl5
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 5

Organism-specific databases

RGDi1307056. Fhl5.

Subcellular locationi

  • Nucleus By similarity

  • Note: Nuclei of round and elongated spermatids.By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 284284Four and a half LIM domains protein 5PRO_0000075744Add
BLAST

Proteomic databases

PaxDbiQ6AXT1.

Interactioni

Subunit structurei

Interacts with CREM (via the third LIM domain). Interacts (via second LIM domain) with SPAG8.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000047630.

Structurei

3D structure databases

ProteinModelPortaliQ6AXT1.
SMRiQ6AXT1. Positions 99-160, 222-284.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini39 – 10062LIM zinc-binding 1PROSITE-ProRule annotationAdd
BLAST
Domaini101 – 16060LIM zinc-binding 2PROSITE-ProRule annotationAdd
BLAST
Domaini161 – 22060LIM zinc-binding 3PROSITE-ProRule annotationAdd
BLAST
Domaini221 – 28363LIM zinc-binding 4PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 4 LIM zinc-binding domains.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri8 – 3225C4-typeSequence analysisAdd
BLAST

Keywords - Domaini

LIM domain, Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1704. Eukaryota.
ENOG410XP0W. LUCA.
GeneTreeiENSGT00760000118910.
HOGENOMiHOG000231075.
HOVERGENiHBG074526.
InParanoidiQ6AXT1.
OMAiYCVSCYD.
OrthoDBiEOG7P8P7M.
PhylomeDBiQ6AXT1.
TreeFamiTF314113.

Family and domain databases

Gene3Di2.10.110.10. 5 hits.
InterProiIPR001781. Znf_LIM.
[Graphical view]
PfamiPF00412. LIM. 4 hits.
[Graphical view]
SMARTiSM00132. LIM. 4 hits.
[Graphical view]
PROSITEiPS00478. LIM_DOMAIN_1. 4 hits.
PS50023. LIM_DOMAIN_2. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6AXT1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTSTQFDCQY CTASLLGKKY VLKDDNLYCI SCYDRIFSNY CEQCKEPIES
60 70 80 90 100
DSKDLCYKNR HWHEGCFRCN KCHHSLVEKP FVAKDERLLC TDCYSNECSS
110 120 130 140 150
KCFHCKRTIM PGSRKMEFKG NYWHETCFVC EHCRQPIGTK PLISKESGNY
160 170 180 190 200
CVPCFEKEFA HYCNFCKKVI TSGGITFRDQ IWHKECFLCS GCRKELYEEA
210 220 230 240 250
FMSKDDFPFC LDCYNHLYAK KCAACTKPIT GLRGAKFICF QDRQWHSECF
260 270 280
NCGKCSVSLV GEGFLTQNME ILCRKCGSGA DTDM
Length:284
Mass (Da):32,970
Last modified:September 13, 2004 - v1
Checksum:i6FA46146D7410005
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC079327 mRNA. Translation: AAH79327.1.
RefSeqiNP_001013106.1. NM_001013088.1.
UniGeneiRn.109490.

Genome annotation databases

EnsembliENSRNOT00000046595; ENSRNOP00000047630; ENSRNOG00000007680.
GeneIDi297954.
KEGGirno:297954.
UCSCiRGD:1307056. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC079327 mRNA. Translation: AAH79327.1.
RefSeqiNP_001013106.1. NM_001013088.1.
UniGeneiRn.109490.

3D structure databases

ProteinModelPortaliQ6AXT1.
SMRiQ6AXT1. Positions 99-160, 222-284.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000047630.

Proteomic databases

PaxDbiQ6AXT1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000046595; ENSRNOP00000047630; ENSRNOG00000007680.
GeneIDi297954.
KEGGirno:297954.
UCSCiRGD:1307056. rat.

Organism-specific databases

CTDi9457.
RGDi1307056. Fhl5.

Phylogenomic databases

eggNOGiKOG1704. Eukaryota.
ENOG410XP0W. LUCA.
GeneTreeiENSGT00760000118910.
HOGENOMiHOG000231075.
HOVERGENiHBG074526.
InParanoidiQ6AXT1.
OMAiYCVSCYD.
OrthoDBiEOG7P8P7M.
PhylomeDBiQ6AXT1.
TreeFamiTF314113.

Miscellaneous databases

PROiQ6AXT1.

Family and domain databases

Gene3Di2.10.110.10. 5 hits.
InterProiIPR001781. Znf_LIM.
[Graphical view]
PfamiPF00412. LIM. 4 hits.
[Graphical view]
SMARTiSM00132. LIM. 4 hits.
[Graphical view]
PROSITEiPS00478. LIM_DOMAIN_1. 4 hits.
PS50023. LIM_DOMAIN_2. 4 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.

Entry informationi

Entry nameiFHL5_RAT
AccessioniPrimary (citable) accession number: Q6AXT1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: September 13, 2004
Last modified: June 8, 2016
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.