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Q6AXS5

- PAIRB_RAT

UniProt

Q6AXS5 - PAIRB_RAT

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Protein

Plasminogen activator inhibitor 1 RNA-binding protein

Gene

Serbp1

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

May play a role in the regulation of mRNA stability. Binds to the 3'-most 134 nt of the SERPINE1/PAI1 mRNA, a region which confers cyclic nucleotide regulation of message decay (By similarity).By similarity

GO - Molecular functioni

  1. mRNA 3'-UTR binding Source: HGNC

GO - Biological processi

  1. regulation of apoptotic process Source: RGD
Complete GO annotation...

Keywords - Ligandi

RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Plasminogen activator inhibitor 1 RNA-binding protein
Alternative name(s):
PAI1 RNA-binding protein 1
Short name:
PAI-RBP1
RDA288
SERPINE1 mRNA-binding protein 1
Cleaved into the following chain:
Gene namesi
Name:Serbp1
Synonyms:Pairbp1, Rda288
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 4

Organism-specific databases

RGDi619907. Serbp1.

Subcellular locationi

Cytoplasm By similarity. Nucleus By similarity. Cytoplasmperinuclear region By similarity

GO - Cellular componenti

  1. cytoplasm Source: RGD
  2. extracellular vesicular exosome Source: Ensembl
  3. nucleus Source: UniProtKB-KW
  4. plasma membrane Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 407407Plasminogen activator inhibitor 1 RNA-binding proteinPRO_0000058184Add
BLAST
Initiator methioninei1 – 11Removed; alternateBy similarity
Chaini2 – 407406Plasminogen activator inhibitor 1 RNA-binding protein, N-terminally processedPRO_0000421791Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei25 – 251PhosphoserineBy similarity
Modified residuei52 – 521N6-acetyllysineBy similarity
Modified residuei68 – 681N6-acetyllysineBy similarity
Modified residuei122 – 1221N6-acetyllysineBy similarity
Modified residuei140 – 1401N6-acetyllysineBy similarity
Modified residuei211 – 2111N6-acetyllysineBy similarity
Modified residuei234 – 2341PhosphoserineBy similarity
Modified residuei328 – 3281N6-acetyllysineBy similarity
Modified residuei329 – 3291PhosphoserineBy similarity
Modified residuei391 – 3911PhosphoserineBy similarity
Modified residuei393 – 3931PhosphoserineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ6AXS5.
PRIDEiQ6AXS5.

PTM databases

PhosphoSiteiQ6AXS5.

Expressioni

Gene expression databases

GenevestigatoriQ6AXS5.

Interactioni

Subunit structurei

Interacts with CHD3 and TDRD3. Interacts with SPIN1 (By similarity).By similarity

Protein-protein interaction databases

IntActiQ6AXS5. 2 interactions.
MINTiMINT-1346644.
STRINGi10116.ENSRNOP00000009503.

Family & Domainsi

Phylogenomic databases

eggNOGiNOG321910.
GeneTreeiENSGT00520000055591.
HOGENOMiHOG000220826.
HOVERGENiHBG056357.
InParanoidiQ6AXS5.
KOiK13199.
OMAiPNRGIRT.
OrthoDBiEOG71P2BG.
PhylomeDBiQ6AXS5.
TreeFamiTF318374.

Family and domain databases

InterProiIPR006861. HABP4_PAIRBP1-bd.
IPR027205. SERBP1.
[Graphical view]
PANTHERiPTHR12299:SF22. PTHR12299:SF22. 1 hit.
PfamiPF04774. HABP4_PAI-RBP1. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q6AXS5-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPGHLQEGFG CVVTNRFDQL FDDESDPFEV LKAAENKKKE AGGGGVGGPG
60 70 80 90 100
AKSAAQAAAQ TNSNAAGKQL RKESQKDRKN PLPPSVGVAD KKEETQPPVA
110 120 130 140 150
LKKEGIRRVG RRPDQQLQGD GKIIDRRPER RPPRERRFEK PLEEKGEGGE
160 170 180 190 200
FSVDRPIIER PIRGRGGLGR GRGGRGRGMG RGDGFDSRGK REFDRHSGSD
210 220 230 240 250
RSSFSHYSGL KHEDKRGGSG SHNWGTVKDE LTESPKYIQK QISYNCSDLE
260 270 280 290 300
QSNVTEETPE GEEHPVADTE NKENEVEEVK EEGPKEMTLD EWKAIQNKDR
310 320 330 340 350
AKVEFNIRKP NEGADGQWKK GFVLHKSKSE EAHAEDSVMD HHFRKPANDI
360 370 380 390 400
TSQLEINFGD LGRPGRGGRG GRGGRGRGGR PNRGSRTDKS SASAPDVDDP

EAFPALA
Length:407
Mass (Da):44,754
Last modified:September 27, 2004 - v2
Checksum:i0553B5D4DED617A9
GO
Isoform 2 (identifier: Q6AXS5-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     233-247: Missing.

Show »
Length:392
Mass (Da):42,984
Checksum:iFE74FB0091096BD4
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti55 – 551A → V.1 Publication

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei233 – 24715Missing in isoform 2. 2 PublicationsVSP_011636Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF388527 mRNA. Translation: AAL57768.1.
BC079337 mRNA. Translation: AAH79337.1.
RefSeqiNP_659554.1. NM_145086.1. [Q6AXS5-2]
XP_006236678.1. XM_006236616.1. [Q6AXS5-1]
UniGeneiRn.203108.

Genome annotation databases

EnsembliENSRNOT00000009503; ENSRNOP00000009503; ENSRNOG00000005890. [Q6AXS5-1]
GeneIDi246303.
KEGGirno:246303.
UCSCiRGD:619907. rat. [Q6AXS5-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF388527 mRNA. Translation: AAL57768.1 .
BC079337 mRNA. Translation: AAH79337.1 .
RefSeqi NP_659554.1. NM_145086.1. [Q6AXS5-2 ]
XP_006236678.1. XM_006236616.1. [Q6AXS5-1 ]
UniGenei Rn.203108.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q6AXS5. 2 interactions.
MINTi MINT-1346644.
STRINGi 10116.ENSRNOP00000009503.

PTM databases

PhosphoSitei Q6AXS5.

Proteomic databases

PaxDbi Q6AXS5.
PRIDEi Q6AXS5.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000009503 ; ENSRNOP00000009503 ; ENSRNOG00000005890 . [Q6AXS5-1 ]
GeneIDi 246303.
KEGGi rno:246303.
UCSCi RGD:619907. rat. [Q6AXS5-1 ]

Organism-specific databases

CTDi 26135.
RGDi 619907. Serbp1.

Phylogenomic databases

eggNOGi NOG321910.
GeneTreei ENSGT00520000055591.
HOGENOMi HOG000220826.
HOVERGENi HBG056357.
InParanoidi Q6AXS5.
KOi K13199.
OMAi PNRGIRT.
OrthoDBi EOG71P2BG.
PhylomeDBi Q6AXS5.
TreeFami TF318374.

Miscellaneous databases

NextBioi 623710.
PROi Q6AXS5.

Gene expression databases

Genevestigatori Q6AXS5.

Family and domain databases

InterProi IPR006861. HABP4_PAIRBP1-bd.
IPR027205. SERBP1.
[Graphical view ]
PANTHERi PTHR12299:SF22. PTHR12299:SF22. 1 hit.
Pfami PF04774. HABP4_PAI-RBP1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), VARIANT VAL-55.
    Strain: Sprague-Dawley.
    Tissue: Oligodendrocyte.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Kidney.
  3. "Identification and cDNA cloning of a novel RNA-binding protein that interacts with the cyclic nucleotide-responsive sequence in the type-1 plasminogen activator inhibitor mRNA."
    Heaton J.H., Dlakic W.M., Dlakic M., Gelehrter T.D.
    J. Biol. Chem. 276:3341-3347(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 1-19.
  4. "Involvement of an unnamed protein, RDA288, in the mechanism through which progesterone mediates its antiapoptotic action in spontaneously immortalized granulosa cells."
    Peluso J.J., Pappalardo A., Fernandez G., Wu C.A.
    Endocrinology 145:3014-3022(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 17-32; 40-67; 79-91; 93-102; 112-122; 137-145; 209-216; 225-236; 286-293 AND 329-344, IDENTIFICATION OF ISOFORM 1, FUNCTION.

Entry informationi

Entry nameiPAIRB_RAT
AccessioniPrimary (citable) accession number: Q6AXS5
Secondary accession number(s): Q8VHU3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 27, 2004
Last sequence update: September 27, 2004
Last modified: October 29, 2014
This is version 81 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

External Data

Dasty 3