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Protein

Plasminogen activator inhibitor 1 RNA-binding protein

Gene

Serbp1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May play a role in the regulation of mRNA stability. Binds to the 3'-most 134 nt of the SERPINE1/PAI1 mRNA, a region which confers cyclic nucleotide regulation of message decay (By similarity).By similarity1 Publication

GO - Molecular functioni

GO - Biological processi

  • regulation of apoptotic process Source: RGD
Complete GO annotation...

Keywords - Ligandi

RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Plasminogen activator inhibitor 1 RNA-binding protein
Alternative name(s):
PAI1 RNA-binding protein 1
Short name:
PAI-RBP1
RDA288
SERPINE1 mRNA-binding protein 1
Cleaved into the following chain:
Gene namesi
Name:Serbp1
Synonyms:Pairbp1, Rda288
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 4

Organism-specific databases

RGDi619907. Serbp1.

Subcellular locationi

GO - Cellular componenti

  • cell-cell adherens junction Source: Ensembl
  • cytoplasm Source: RGD
  • extracellular exosome Source: Ensembl
  • nucleus Source: UniProtKB-SubCell
  • perinuclear region of cytoplasm Source: UniProtKB-SubCell
  • plasma membrane Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000581841 – 407Plasminogen activator inhibitor 1 RNA-binding proteinAdd BLAST407
Initiator methionineiRemoved; alternateBy similarity
ChainiPRO_00004217912 – 407Plasminogen activator inhibitor 1 RNA-binding protein, N-terminally processedAdd BLAST406

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei25PhosphoserineCombined sources1
Modified residuei52N6-acetyllysine; alternateBy similarity1
Cross-linki52Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternateBy similarity
Modified residuei68N6-acetyllysineBy similarity1
Cross-linki102Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei122N6-acetyllysineBy similarity1
Modified residuei140N6-acetyllysineBy similarity1
Modified residuei165Omega-N-methylarginineBy similarity1
Modified residuei188Omega-N-methylarginineBy similarity1
Modified residuei197PhosphoserineCombined sources1
Modified residuei203PhosphoserineCombined sources1
Modified residuei205PhosphoserineBy similarity1
Modified residuei208PhosphoserineBy similarity1
Modified residuei211N6-acetyllysineBy similarity1
Modified residuei216Omega-N-methylarginineBy similarity1
Modified residuei221PhosphoserineBy similarity1
Cross-linki228Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)By similarity
Cross-linki228Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei234PhosphoserineCombined sources1
Cross-linki280Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei328N6-acetyllysineBy similarity1
Modified residuei329PhosphoserineCombined sources1
Modified residuei363Omega-N-methylarginineBy similarity1
Modified residuei366Omega-N-methylarginineBy similarity1
Modified residuei369Omega-N-methylarginineBy similarity1
Modified residuei391PhosphoserineBy similarity1
Modified residuei393PhosphoserineBy similarity1
Isoform 2 (identifier: Q6AXS5-2)
Modified residuei237PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiQ6AXS5.
PRIDEiQ6AXS5.

PTM databases

iPTMnetiQ6AXS5.
PhosphoSitePlusiQ6AXS5.

Expressioni

Gene expression databases

BgeeiENSRNOG00000005890.
GenevisibleiQ6AXS5. RN.

Interactioni

Subunit structurei

Interacts with CHD3 and TDRD3. Interacts with SPIN1 (By similarity).By similarity

Protein-protein interaction databases

IntActiQ6AXS5. 2 interactors.
MINTiMINT-1346644.
STRINGi10116.ENSRNOP00000009503.

Family & Domainsi

Phylogenomic databases

eggNOGiKOG2945. Eukaryota.
ENOG410YBHR. LUCA.
GeneTreeiENSGT00520000055591.
HOGENOMiHOG000220826.
HOVERGENiHBG056357.
InParanoidiQ6AXS5.
KOiK13199.
OMAiPNRGIRT.
OrthoDBiEOG091G0UA9.
PhylomeDBiQ6AXS5.
TreeFamiTF318374.

Family and domain databases

InterProiIPR006861. HABP4_PAIRBP1-bd.
IPR032381. IHABP4_N.
IPR027205. SERBP1.
[Graphical view]
PANTHERiPTHR12299:SF29. PTHR12299:SF29. 1 hit.
PfamiPF04774. HABP4_PAI-RBP1. 1 hit.
PF16174. IHABP4_N. 1 hit.
[Graphical view]
SMARTiSM01233. HABP4_PAI-RBP1. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6AXS5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPGHLQEGFG CVVTNRFDQL FDDESDPFEV LKAAENKKKE AGGGGVGGPG
60 70 80 90 100
AKSAAQAAAQ TNSNAAGKQL RKESQKDRKN PLPPSVGVAD KKEETQPPVA
110 120 130 140 150
LKKEGIRRVG RRPDQQLQGD GKIIDRRPER RPPRERRFEK PLEEKGEGGE
160 170 180 190 200
FSVDRPIIER PIRGRGGLGR GRGGRGRGMG RGDGFDSRGK REFDRHSGSD
210 220 230 240 250
RSSFSHYSGL KHEDKRGGSG SHNWGTVKDE LTESPKYIQK QISYNCSDLE
260 270 280 290 300
QSNVTEETPE GEEHPVADTE NKENEVEEVK EEGPKEMTLD EWKAIQNKDR
310 320 330 340 350
AKVEFNIRKP NEGADGQWKK GFVLHKSKSE EAHAEDSVMD HHFRKPANDI
360 370 380 390 400
TSQLEINFGD LGRPGRGGRG GRGGRGRGGR PNRGSRTDKS SASAPDVDDP

EAFPALA
Length:407
Mass (Da):44,754
Last modified:September 27, 2004 - v2
Checksum:i0553B5D4DED617A9
GO
Isoform 2 (identifier: Q6AXS5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     233-247: Missing.

Show »
Length:392
Mass (Da):42,984
Checksum:iFE74FB0091096BD4
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti55A → V.1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_011636233 – 247Missing in isoform 2. 2 PublicationsAdd BLAST15

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF388527 mRNA. Translation: AAL57768.1.
BC079337 mRNA. Translation: AAH79337.1.
RefSeqiNP_659554.1. NM_145086.1. [Q6AXS5-2]
XP_006236678.1. XM_006236616.2. [Q6AXS5-1]
UniGeneiRn.203108.

Genome annotation databases

EnsembliENSRNOT00000009503; ENSRNOP00000009503; ENSRNOG00000005890. [Q6AXS5-2]
GeneIDi246303.
KEGGirno:246303.
UCSCiRGD:619907. rat. [Q6AXS5-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF388527 mRNA. Translation: AAL57768.1.
BC079337 mRNA. Translation: AAH79337.1.
RefSeqiNP_659554.1. NM_145086.1. [Q6AXS5-2]
XP_006236678.1. XM_006236616.2. [Q6AXS5-1]
UniGeneiRn.203108.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ6AXS5. 2 interactors.
MINTiMINT-1346644.
STRINGi10116.ENSRNOP00000009503.

PTM databases

iPTMnetiQ6AXS5.
PhosphoSitePlusiQ6AXS5.

Proteomic databases

PaxDbiQ6AXS5.
PRIDEiQ6AXS5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000009503; ENSRNOP00000009503; ENSRNOG00000005890. [Q6AXS5-2]
GeneIDi246303.
KEGGirno:246303.
UCSCiRGD:619907. rat. [Q6AXS5-1]

Organism-specific databases

CTDi26135.
RGDi619907. Serbp1.

Phylogenomic databases

eggNOGiKOG2945. Eukaryota.
ENOG410YBHR. LUCA.
GeneTreeiENSGT00520000055591.
HOGENOMiHOG000220826.
HOVERGENiHBG056357.
InParanoidiQ6AXS5.
KOiK13199.
OMAiPNRGIRT.
OrthoDBiEOG091G0UA9.
PhylomeDBiQ6AXS5.
TreeFamiTF318374.

Miscellaneous databases

PROiQ6AXS5.

Gene expression databases

BgeeiENSRNOG00000005890.
GenevisibleiQ6AXS5. RN.

Family and domain databases

InterProiIPR006861. HABP4_PAIRBP1-bd.
IPR032381. IHABP4_N.
IPR027205. SERBP1.
[Graphical view]
PANTHERiPTHR12299:SF29. PTHR12299:SF29. 1 hit.
PfamiPF04774. HABP4_PAI-RBP1. 1 hit.
PF16174. IHABP4_N. 1 hit.
[Graphical view]
SMARTiSM01233. HABP4_PAI-RBP1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPAIRB_RAT
AccessioniPrimary (citable) accession number: Q6AXS5
Secondary accession number(s): Q8VHU3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 27, 2004
Last sequence update: September 27, 2004
Last modified: November 30, 2016
This is version 98 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.