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Q6AXS5

- PAIRB_RAT

UniProt

Q6AXS5 - PAIRB_RAT

Protein

Plasminogen activator inhibitor 1 RNA-binding protein

Gene

Serbp1

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 80 (01 Oct 2014)
      Sequence version 2 (27 Sep 2004)
      Previous versions | rss
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    Functioni

    May play a role in the regulation of mRNA stability. Binds to the 3'-most 134 nt of the SERPINE1/PAI1 mRNA, a region which confers cyclic nucleotide regulation of message decay By similarity.By similarity

    GO - Molecular functioni

    1. mRNA 3'-UTR binding Source: HGNC

    GO - Biological processi

    1. regulation of apoptotic process Source: RGD

    Keywords - Ligandi

    RNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Plasminogen activator inhibitor 1 RNA-binding protein
    Alternative name(s):
    PAI1 RNA-binding protein 1
    Short name:
    PAI-RBP1
    RDA288
    SERPINE1 mRNA-binding protein 1
    Cleaved into the following chain:
    Gene namesi
    Name:Serbp1
    Synonyms:Pairbp1, Rda288
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 4

    Organism-specific databases

    RGDi619907. Serbp1.

    Subcellular locationi

    Cytoplasm By similarity. Nucleus By similarity. Cytoplasmperinuclear region By similarity

    GO - Cellular componenti

    1. cytoplasm Source: RGD
    2. nucleus Source: UniProtKB-SubCell
    3. perinuclear region of cytoplasm Source: UniProtKB-SubCell
    4. plasma membrane Source: RGD

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 407407Plasminogen activator inhibitor 1 RNA-binding proteinPRO_0000058184Add
    BLAST
    Initiator methioninei1 – 11Removed; alternateBy similarity
    Chaini2 – 407406Plasminogen activator inhibitor 1 RNA-binding protein, N-terminally processedPRO_0000421791Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei25 – 251PhosphoserineBy similarity
    Modified residuei52 – 521N6-acetyllysineBy similarity
    Modified residuei68 – 681N6-acetyllysineBy similarity
    Modified residuei122 – 1221N6-acetyllysineBy similarity
    Modified residuei140 – 1401N6-acetyllysineBy similarity
    Modified residuei211 – 2111N6-acetyllysineBy similarity
    Modified residuei234 – 2341PhosphoserineBy similarity
    Modified residuei328 – 3281N6-acetyllysineBy similarity
    Modified residuei329 – 3291PhosphoserineBy similarity
    Modified residuei391 – 3911PhosphoserineBy similarity
    Modified residuei393 – 3931PhosphoserineBy similarity

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    PaxDbiQ6AXS5.
    PRIDEiQ6AXS5.

    PTM databases

    PhosphoSiteiQ6AXS5.

    Expressioni

    Gene expression databases

    GenevestigatoriQ6AXS5.

    Interactioni

    Subunit structurei

    Interacts with CHD3 and TDRD3. Interacts with SPIN1 By similarity.By similarity

    Protein-protein interaction databases

    IntActiQ6AXS5. 2 interactions.
    MINTiMINT-1346644.
    STRINGi10116.ENSRNOP00000009503.

    Family & Domainsi

    Phylogenomic databases

    eggNOGiNOG321910.
    GeneTreeiENSGT00520000055591.
    HOGENOMiHOG000220826.
    HOVERGENiHBG056357.
    InParanoidiQ6AXS5.
    KOiK13199.
    OMAiPNRGIRT.
    OrthoDBiEOG71P2BG.
    PhylomeDBiQ6AXS5.
    TreeFamiTF318374.

    Family and domain databases

    InterProiIPR006861. HABP4_PAIRBP1-bd.
    IPR027205. SERBP1.
    [Graphical view]
    PANTHERiPTHR12299:SF22. PTHR12299:SF22. 1 hit.
    PfamiPF04774. HABP4_PAI-RBP1. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q6AXS5-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MPGHLQEGFG CVVTNRFDQL FDDESDPFEV LKAAENKKKE AGGGGVGGPG    50
    AKSAAQAAAQ TNSNAAGKQL RKESQKDRKN PLPPSVGVAD KKEETQPPVA 100
    LKKEGIRRVG RRPDQQLQGD GKIIDRRPER RPPRERRFEK PLEEKGEGGE 150
    FSVDRPIIER PIRGRGGLGR GRGGRGRGMG RGDGFDSRGK REFDRHSGSD 200
    RSSFSHYSGL KHEDKRGGSG SHNWGTVKDE LTESPKYIQK QISYNCSDLE 250
    QSNVTEETPE GEEHPVADTE NKENEVEEVK EEGPKEMTLD EWKAIQNKDR 300
    AKVEFNIRKP NEGADGQWKK GFVLHKSKSE EAHAEDSVMD HHFRKPANDI 350
    TSQLEINFGD LGRPGRGGRG GRGGRGRGGR PNRGSRTDKS SASAPDVDDP 400
    EAFPALA 407
    Length:407
    Mass (Da):44,754
    Last modified:September 27, 2004 - v2
    Checksum:i0553B5D4DED617A9
    GO
    Isoform 2 (identifier: Q6AXS5-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         233-247: Missing.

    Show »
    Length:392
    Mass (Da):42,984
    Checksum:iFE74FB0091096BD4
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti55 – 551A → V.1 Publication

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei233 – 24715Missing in isoform 2. 2 PublicationsVSP_011636Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF388527 mRNA. Translation: AAL57768.1.
    BC079337 mRNA. Translation: AAH79337.1.
    RefSeqiNP_659554.1. NM_145086.1. [Q6AXS5-2]
    XP_006236678.1. XM_006236616.1. [Q6AXS5-1]
    UniGeneiRn.203108.

    Genome annotation databases

    EnsembliENSRNOT00000009503; ENSRNOP00000009503; ENSRNOG00000005890. [Q6AXS5-1]
    GeneIDi246303.
    KEGGirno:246303.
    UCSCiRGD:619907. rat. [Q6AXS5-1]

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF388527 mRNA. Translation: AAL57768.1 .
    BC079337 mRNA. Translation: AAH79337.1 .
    RefSeqi NP_659554.1. NM_145086.1. [Q6AXS5-2 ]
    XP_006236678.1. XM_006236616.1. [Q6AXS5-1 ]
    UniGenei Rn.203108.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q6AXS5. 2 interactions.
    MINTi MINT-1346644.
    STRINGi 10116.ENSRNOP00000009503.

    PTM databases

    PhosphoSitei Q6AXS5.

    Proteomic databases

    PaxDbi Q6AXS5.
    PRIDEi Q6AXS5.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000009503 ; ENSRNOP00000009503 ; ENSRNOG00000005890 . [Q6AXS5-1 ]
    GeneIDi 246303.
    KEGGi rno:246303.
    UCSCi RGD:619907. rat. [Q6AXS5-1 ]

    Organism-specific databases

    CTDi 26135.
    RGDi 619907. Serbp1.

    Phylogenomic databases

    eggNOGi NOG321910.
    GeneTreei ENSGT00520000055591.
    HOGENOMi HOG000220826.
    HOVERGENi HBG056357.
    InParanoidi Q6AXS5.
    KOi K13199.
    OMAi PNRGIRT.
    OrthoDBi EOG71P2BG.
    PhylomeDBi Q6AXS5.
    TreeFami TF318374.

    Miscellaneous databases

    NextBioi 623710.
    PROi Q6AXS5.

    Gene expression databases

    Genevestigatori Q6AXS5.

    Family and domain databases

    InterProi IPR006861. HABP4_PAIRBP1-bd.
    IPR027205. SERBP1.
    [Graphical view ]
    PANTHERi PTHR12299:SF22. PTHR12299:SF22. 1 hit.
    Pfami PF04774. HABP4_PAI-RBP1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), VARIANT VAL-55.
      Strain: Sprague-Dawley.
      Tissue: Oligodendrocyte.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Kidney.
    3. "Identification and cDNA cloning of a novel RNA-binding protein that interacts with the cyclic nucleotide-responsive sequence in the type-1 plasminogen activator inhibitor mRNA."
      Heaton J.H., Dlakic W.M., Dlakic M., Gelehrter T.D.
      J. Biol. Chem. 276:3341-3347(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 1-19.
    4. "Involvement of an unnamed protein, RDA288, in the mechanism through which progesterone mediates its antiapoptotic action in spontaneously immortalized granulosa cells."
      Peluso J.J., Pappalardo A., Fernandez G., Wu C.A.
      Endocrinology 145:3014-3022(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 17-32; 40-67; 79-91; 93-102; 112-122; 137-145; 209-216; 225-236; 286-293 AND 329-344, IDENTIFICATION OF ISOFORM 1, FUNCTION.

    Entry informationi

    Entry nameiPAIRB_RAT
    AccessioniPrimary (citable) accession number: Q6AXS5
    Secondary accession number(s): Q8VHU3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 27, 2004
    Last sequence update: September 27, 2004
    Last modified: October 1, 2014
    This is version 80 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    External Data

    Dasty 3