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Q6AXS5 (PAIRB_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 79. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein namesRecommended name:
Plasminogen activator inhibitor 1 RNA-binding protein
Alternative name(s):
PAI1 RNA-binding protein 1
Short name=PAI-RBP1
RDA288
SERPINE1 mRNA-binding protein 1
Gene names
Name:Serbp1
Synonyms:Pairbp1, Rda288
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length407 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

May play a role in the regulation of mRNA stability. Binds to the 3'-most 134 nt of the SERPINE1/PAI1 mRNA, a region which confers cyclic nucleotide regulation of message decay By similarity. Ref.4

Subunit structure

Interacts with CHD3 and TDRD3. Interacts with SPIN1 By similarity.

Subcellular location

Cytoplasm By similarity. Nucleus By similarity. Cytoplasmperinuclear region By similarity.

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q6AXS5-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q6AXS5-2)

The sequence of this isoform differs from the canonical sequence as follows:
     233-247: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 407407Plasminogen activator inhibitor 1 RNA-binding protein
PRO_0000058184
Initiator methionine11Removed; alternate By similarity
Chain2 – 407406Plasminogen activator inhibitor 1 RNA-binding protein, N-terminally processed
PRO_0000421791

Amino acid modifications

Modified residue251Phosphoserine By similarity
Modified residue521N6-acetyllysine By similarity
Modified residue681N6-acetyllysine By similarity
Modified residue1221N6-acetyllysine By similarity
Modified residue1401N6-acetyllysine By similarity
Modified residue2111N6-acetyllysine By similarity
Modified residue2341Phosphoserine By similarity
Modified residue3281N6-acetyllysine By similarity
Modified residue3291Phosphoserine By similarity
Modified residue3911Phosphoserine By similarity
Modified residue3931Phosphoserine By similarity

Natural variations

Alternative sequence233 – 24715Missing in isoform 2.
VSP_011636
Natural variant551A → V. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified September 27, 2004. Version 2.
Checksum: 0553B5D4DED617A9

FASTA40744,754
        10         20         30         40         50         60 
MPGHLQEGFG CVVTNRFDQL FDDESDPFEV LKAAENKKKE AGGGGVGGPG AKSAAQAAAQ 

        70         80         90        100        110        120 
TNSNAAGKQL RKESQKDRKN PLPPSVGVAD KKEETQPPVA LKKEGIRRVG RRPDQQLQGD 

       130        140        150        160        170        180 
GKIIDRRPER RPPRERRFEK PLEEKGEGGE FSVDRPIIER PIRGRGGLGR GRGGRGRGMG 

       190        200        210        220        230        240 
RGDGFDSRGK REFDRHSGSD RSSFSHYSGL KHEDKRGGSG SHNWGTVKDE LTESPKYIQK 

       250        260        270        280        290        300 
QISYNCSDLE QSNVTEETPE GEEHPVADTE NKENEVEEVK EEGPKEMTLD EWKAIQNKDR 

       310        320        330        340        350        360 
AKVEFNIRKP NEGADGQWKK GFVLHKSKSE EAHAEDSVMD HHFRKPANDI TSQLEINFGD 

       370        380        390        400 
LGRPGRGGRG GRGGRGRGGR PNRGSRTDKS SASAPDVDDP EAFPALA 

« Hide

Isoform 2 [UniParc].

Checksum: FE74FB0091096BD4
Show »

FASTA39242,984

References

« Hide 'large scale' references
[1]"Stage-specific gene expression in early differentiating oligodendrocytes."
Blasi F., Ciarrocchi A., Luddi A., Strazza M., Riccio M., Santi S., Arcone R., Pietropaolo C., D'Angelo R., Costantino-Ceccarini E., Melli M.
Glia 39:114-123(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), VARIANT VAL-55.
Strain: Sprague-Dawley.
Tissue: Oligodendrocyte.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
Tissue: Kidney.
[3]"Identification and cDNA cloning of a novel RNA-binding protein that interacts with the cyclic nucleotide-responsive sequence in the type-1 plasminogen activator inhibitor mRNA."
Heaton J.H., Dlakic W.M., Dlakic M., Gelehrter T.D.
J. Biol. Chem. 276:3341-3347(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 1-19.
[4]"Involvement of an unnamed protein, RDA288, in the mechanism through which progesterone mediates its antiapoptotic action in spontaneously immortalized granulosa cells."
Peluso J.J., Pappalardo A., Fernandez G., Wu C.A.
Endocrinology 145:3014-3022(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 17-32; 40-67; 79-91; 93-102; 112-122; 137-145; 209-216; 225-236; 286-293 AND 329-344, IDENTIFICATION OF ISOFORM 1, FUNCTION.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF388527 mRNA. Translation: AAL57768.1.
BC079337 mRNA. Translation: AAH79337.1.
RefSeqNP_659554.1. NM_145086.1. [Q6AXS5-2]
XP_006236678.1. XM_006236616.1. [Q6AXS5-1]
UniGeneRn.203108.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActQ6AXS5. 2 interactions.
MINTMINT-1346644.
STRING10116.ENSRNOP00000009503.

PTM databases

PhosphoSiteQ6AXS5.

Proteomic databases

PaxDbQ6AXS5.
PRIDEQ6AXS5.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000009503; ENSRNOP00000009503; ENSRNOG00000005890. [Q6AXS5-1]
GeneID246303.
KEGGrno:246303.
UCSCRGD:619907. rat. [Q6AXS5-1]

Organism-specific databases

CTD26135.
RGD619907. Serbp1.

Phylogenomic databases

eggNOGNOG321910.
GeneTreeENSGT00520000055591.
HOGENOMHOG000220826.
HOVERGENHBG056357.
InParanoidQ6AXS5.
KOK13199.
OMAPNRGIRT.
OrthoDBEOG71P2BG.
PhylomeDBQ6AXS5.
TreeFamTF318374.

Gene expression databases

GenevestigatorQ6AXS5.

Family and domain databases

InterProIPR006861. HABP4_PAIRBP1-bd.
IPR027205. SERBP1.
[Graphical view]
PANTHERPTHR12299:SF22. PTHR12299:SF22. 1 hit.
PfamPF04774. HABP4_PAI-RBP1. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio623710.
PROQ6AXS5.

Entry information

Entry namePAIRB_RAT
AccessionPrimary (citable) accession number: Q6AXS5
Secondary accession number(s): Q8VHU3
Entry history
Integrated into UniProtKB/Swiss-Prot: September 27, 2004
Last sequence update: September 27, 2004
Last modified: June 11, 2014
This is version 79 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program