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Protein

Renin receptor

Gene

Atp6ap2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Functions as a renin and prorenin cellular receptor. May mediate renin-dependent cellular responses by activating ERK1 and ERK2. By increasing the catalytic efficiency of renin in AGT/angiotensinogen conversion to angiotensin I, it may also play a role in the renin-angiotensin system (RAS) (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionReceptor

Enzyme and pathway databases

ReactomeiR-RNO-2022377 Metabolism of Angiotensinogen to Angiotensins
R-RNO-6798695 Neutrophil degranulation

Names & Taxonomyi

Protein namesi
Recommended name:
Renin receptor
Alternative name(s):
ATPase H(+)-transporting lysosomal accessory protein 2
ATPase H(+)-transporting lysosomal-interacting protein 2
Renin/prorenin receptor
Gene namesi
Name:Atp6ap2
Synonyms:Atp6ip2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome X

Organism-specific databases

RGDi1561269 Atp6ap2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini18 – 302ExtracellularSequence analysisAdd BLAST285
Transmembranei303 – 323HelicalSequence analysisAdd BLAST21
Topological domaini324 – 350CytoplasmicSequence analysisAdd BLAST27

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 17Sequence analysisAdd BLAST17
ChainiPRO_000002220618 – 350Renin receptorAdd BLAST333

Post-translational modificationi

Phosphorylated.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ6AXS4
PRIDEiQ6AXS4

Expressioni

Gene expression databases

BgeeiENSRNOG00000003858
GenevisibleiQ6AXS4 RN

Interactioni

Subunit structurei

Interacts with renin and the vacuolar proton-ATPase.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000005138

Family & Domainsi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4737 Eukaryota
ENOG4111F0U LUCA
GeneTreeiENSGT00390000008856
HOGENOMiHOG000232083
HOVERGENiHBG056579
InParanoidiQ6AXS4
KOiK19514
OMAiFRDGNWP
OrthoDBiEOG091G0HQ3
PhylomeDBiQ6AXS4
TreeFamiTF106137

Family and domain databases

InterProiView protein in InterPro
IPR012493 Renin_rcpt
PANTHERiPTHR13351 PTHR13351, 1 hit
PfamiView protein in Pfam
PF07850 Renin_r, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6AXS4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAVLVVLLSS LVSSALANEF SILRSPGSVV FRNGNWPIPG DRIPDVAALS
60 70 80 90 100
MGFSVKEDLS WPGLAVGNLF HRPRATIMVT VKGVDKLALP TGSVISYPLE
110 120 130 140 150
NAVPFSLDSV ANSIHSLFSE ETPVVLQLAP SEERVYMVGK ANSVFEDLSV
160 170 180 190 200
TLRQLRNRLF QENSVLNSLP LNSLSRNNEV DLLFLSELQV LHDISSLLSR
210 220 230 240 250
HKHLAKDHSP DLYSLELAGL DELGKRYGED SEQFRDASRI LVDALQKFAD
260 270 280 290 300
DMYSLYGGNA VVELVTVKSF DTSLVRKSRT ILETKQENTQ SPYNLAYKYN
310 320 330 340 350
LEYSVVFNLV LWIMTGLALA VIITSYNIWN MDPGYDSIIY RMTNQKIRMD
Length:350
Mass (Da):39,082
Last modified:September 13, 2004 - v1
Checksum:i9845898BC3E260CF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB188298 mRNA Translation: BAD67178.1
BC079339 mRNA Translation: AAH79339.1
RefSeqiNP_001007092.1, NM_001007091.1
UniGeneiRn.12944

Genome annotation databases

EnsembliENSRNOT00000005138; ENSRNOP00000005138; ENSRNOG00000003858
GeneIDi302526
KEGGirno:302526
UCSCiRGD:1561269 rat

Similar proteinsi

Entry informationi

Entry nameiRENR_RAT
AccessioniPrimary (citable) accession number: Q6AXS4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 10, 2005
Last sequence update: September 13, 2004
Last modified: May 23, 2018
This is version 96 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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