Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q6AXS4

- RENR_RAT

UniProt

Q6AXS4 - RENR_RAT

Protein

Renin receptor

Gene

Atp6ap2

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 78 (01 Oct 2014)
      Sequence version 1 (13 Sep 2004)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Functions as a renin and prorenin cellular receptor. May mediate renin-dependent cellular responses by activating ERK1 and ERK2. By increasing the catalytic efficiency of renin in AGT/angiotensinogen conversion to angiotensin I, it may also play a role in the renin-angiotensin system (RAS) By similarity.By similarity

    GO - Molecular functioni

    1. aspartic-type endopeptidase activity Source: Ensembl
    2. enzyme binding Source: RGD
    3. receptor activity Source: InterPro

    GO - Biological processi

    1. angiotensin maturation Source: RGD
    2. positive regulation of transforming growth factor beta1 production Source: Ensembl
    3. regulation of MAPK cascade Source: Ensembl

    Keywords - Molecular functioni

    Receptor

    Enzyme and pathway databases

    ReactomeiREACT_198807. Metabolism of Angiotensinogen to Angiotensins.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Renin receptor
    Alternative name(s):
    ATPase H(+)-transporting lysosomal accessory protein 2
    ATPase H(+)-transporting lysosomal-interacting protein 2
    Renin/prorenin receptor
    Gene namesi
    Name:Atp6ap2
    Synonyms:Atp6ip2
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome X

    Organism-specific databases

    RGDi1561269. Atp6ap2.

    Subcellular locationi

    GO - Cellular componenti

    1. cell body Source: RGD
    2. external side of plasma membrane Source: Ensembl
    3. integral component of membrane Source: UniProtKB-KW
    4. neuron projection Source: RGD

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1717Sequence AnalysisAdd
    BLAST
    Chaini18 – 350333Renin receptorPRO_0000022206Add
    BLAST

    Post-translational modificationi

    Phosphorylated.By similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PaxDbiQ6AXS4.
    PRIDEiQ6AXS4.

    Expressioni

    Gene expression databases

    GenevestigatoriQ6AXS4.

    Interactioni

    Subunit structurei

    Interacts with renin and the vacuolar proton-ATPase.By similarity

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000005138.

    Structurei

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini18 – 302285ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini324 – 35027CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei303 – 32321HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG296465.
    GeneTreeiENSGT00390000008856.
    HOGENOMiHOG000232083.
    HOVERGENiHBG056579.
    InParanoidiQ6AXS4.
    OMAiFRDGNWP.
    OrthoDBiEOG7R56VH.
    PhylomeDBiQ6AXS4.
    TreeFamiTF106137.

    Family and domain databases

    InterProiIPR012493. Renin_rcpt.
    [Graphical view]
    PANTHERiPTHR13351. PTHR13351. 1 hit.
    PfamiPF07850. Renin_r. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q6AXS4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAVLVVLLSS LVSSALANEF SILRSPGSVV FRNGNWPIPG DRIPDVAALS    50
    MGFSVKEDLS WPGLAVGNLF HRPRATIMVT VKGVDKLALP TGSVISYPLE 100
    NAVPFSLDSV ANSIHSLFSE ETPVVLQLAP SEERVYMVGK ANSVFEDLSV 150
    TLRQLRNRLF QENSVLNSLP LNSLSRNNEV DLLFLSELQV LHDISSLLSR 200
    HKHLAKDHSP DLYSLELAGL DELGKRYGED SEQFRDASRI LVDALQKFAD 250
    DMYSLYGGNA VVELVTVKSF DTSLVRKSRT ILETKQENTQ SPYNLAYKYN 300
    LEYSVVFNLV LWIMTGLALA VIITSYNIWN MDPGYDSIIY RMTNQKIRMD 350
    Length:350
    Mass (Da):39,082
    Last modified:September 13, 2004 - v1
    Checksum:i9845898BC3E260CF
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB188298 mRNA. Translation: BAD67178.1.
    BC079339 mRNA. Translation: AAH79339.1.
    RefSeqiNP_001007092.1. NM_001007091.1.
    UniGeneiRn.12944.

    Genome annotation databases

    EnsembliENSRNOT00000005138; ENSRNOP00000005138; ENSRNOG00000003858.
    GeneIDi302526.
    KEGGirno:302526.
    UCSCiRGD:1561269. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB188298 mRNA. Translation: BAD67178.1 .
    BC079339 mRNA. Translation: AAH79339.1 .
    RefSeqi NP_001007092.1. NM_001007091.1.
    UniGenei Rn.12944.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000005138.

    Proteomic databases

    PaxDbi Q6AXS4.
    PRIDEi Q6AXS4.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000005138 ; ENSRNOP00000005138 ; ENSRNOG00000003858 .
    GeneIDi 302526.
    KEGGi rno:302526.
    UCSCi RGD:1561269. rat.

    Organism-specific databases

    CTDi 10159.
    RGDi 1561269. Atp6ap2.

    Phylogenomic databases

    eggNOGi NOG296465.
    GeneTreei ENSGT00390000008856.
    HOGENOMi HOG000232083.
    HOVERGENi HBG056579.
    InParanoidi Q6AXS4.
    OMAi FRDGNWP.
    OrthoDBi EOG7R56VH.
    PhylomeDBi Q6AXS4.
    TreeFami TF106137.

    Enzyme and pathway databases

    Reactomei REACT_198807. Metabolism of Angiotensinogen to Angiotensins.

    Miscellaneous databases

    NextBioi 649783.
    PROi Q6AXS4.

    Gene expression databases

    Genevestigatori Q6AXS4.

    Family and domain databases

    InterProi IPR012493. Renin_rcpt.
    [Graphical view ]
    PANTHERi PTHR13351. PTHR13351. 1 hit.
    Pfami PF07850. Renin_r. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Inhibition of diabetic nephropathy by a decoy peptide corresponding to the 'handle' region for nonproteolytic activation of prorenin."
      Ichihara A., Hayashi M., Kaneshiro Y., Suzuki F., Nakagawa T., Tada Y., Koura Y., Nishiyama A., Okada H., Uddin M.N., Nabi A.H.M.N., Ishida Y., Inagami T., Saruta T.
      J. Clin. Invest. 114:1128-1135(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Kidney.

    Entry informationi

    Entry nameiRENR_RAT
    AccessioniPrimary (citable) accession number: Q6AXS4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 10, 2005
    Last sequence update: September 13, 2004
    Last modified: October 1, 2014
    This is version 78 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    External Data

    Dasty 3