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Q6AXS4 (RENR_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 76. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Renin receptor
Alternative name(s):
ATPase H(+)-transporting lysosomal accessory protein 2
ATPase H(+)-transporting lysosomal-interacting protein 2
Renin/prorenin receptor
Gene names
Name:Atp6ap2
Synonyms:Atp6ip2
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length350 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Functions as a renin and prorenin cellular receptor. May mediate renin-dependent cellular responses by activating ERK1 and ERK2. By increasing the catalytic efficiency of renin in AGT/angiotensinogen conversion to angiotensin I, it may also play a role in the renin-angiotensin system (RAS) By similarity.

Subunit structure

Interacts with renin and the vacuolar proton-ATPase By similarity.

Subcellular location

Membrane; Single-pass type I membrane protein Potential.

Post-translational modification

Phosphorylated By similarity.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1717 Potential
Chain18 – 350333Renin receptor
PRO_0000022206

Regions

Topological domain18 – 302285Extracellular Potential
Transmembrane303 – 32321Helical; Potential
Topological domain324 – 35027Cytoplasmic Potential

Sequences

Sequence LengthMass (Da)Tools
Q6AXS4 [UniParc].

Last modified September 13, 2004. Version 1.
Checksum: 9845898BC3E260CF

FASTA35039,082
        10         20         30         40         50         60 
MAVLVVLLSS LVSSALANEF SILRSPGSVV FRNGNWPIPG DRIPDVAALS MGFSVKEDLS 

        70         80         90        100        110        120 
WPGLAVGNLF HRPRATIMVT VKGVDKLALP TGSVISYPLE NAVPFSLDSV ANSIHSLFSE 

       130        140        150        160        170        180 
ETPVVLQLAP SEERVYMVGK ANSVFEDLSV TLRQLRNRLF QENSVLNSLP LNSLSRNNEV 

       190        200        210        220        230        240 
DLLFLSELQV LHDISSLLSR HKHLAKDHSP DLYSLELAGL DELGKRYGED SEQFRDASRI 

       250        260        270        280        290        300 
LVDALQKFAD DMYSLYGGNA VVELVTVKSF DTSLVRKSRT ILETKQENTQ SPYNLAYKYN 

       310        320        330        340        350 
LEYSVVFNLV LWIMTGLALA VIITSYNIWN MDPGYDSIIY RMTNQKIRMD 

« Hide

References

« Hide 'large scale' references
[1]"Inhibition of diabetic nephropathy by a decoy peptide corresponding to the 'handle' region for nonproteolytic activation of prorenin."
Ichihara A., Hayashi M., Kaneshiro Y., Suzuki F., Nakagawa T., Tada Y., Koura Y., Nishiyama A., Okada H., Uddin M.N., Nabi A.H.M.N., Ishida Y., Inagami T., Saruta T.
J. Clin. Invest. 114:1128-1135(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Kidney.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB188298 mRNA. Translation: BAD67178.1.
BC079339 mRNA. Translation: AAH79339.1.
RefSeqNP_001007092.1. NM_001007091.1.
UniGeneRn.12944.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10116.ENSRNOP00000005138.

Proteomic databases

PaxDbQ6AXS4.
PRIDEQ6AXS4.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000005138; ENSRNOP00000005138; ENSRNOG00000003858.
GeneID302526.
KEGGrno:302526.
UCSCRGD:1561269. rat.

Organism-specific databases

CTD10159.
RGD1561269. Atp6ap2.

Phylogenomic databases

eggNOGNOG296465.
GeneTreeENSGT00390000008856.
HOGENOMHOG000232083.
HOVERGENHBG056579.
InParanoidQ6AXS4.
OMAFRDGNWP.
OrthoDBEOG7R56VH.
PhylomeDBQ6AXS4.
TreeFamTF106137.

Gene expression databases

GenevestigatorQ6AXS4.

Family and domain databases

InterProIPR012493. Renin_rcpt.
[Graphical view]
PANTHERPTHR13351. PTHR13351. 1 hit.
PfamPF07850. Renin_r. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio649783.
PROQ6AXS4.

Entry information

Entry nameRENR_RAT
AccessionPrimary (citable) accession number: Q6AXS4
Entry history
Integrated into UniProtKB/Swiss-Prot: May 10, 2005
Last sequence update: September 13, 2004
Last modified: April 16, 2014
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program