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Protein

Renin receptor

Gene

Atp6ap2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Functions as a renin and prorenin cellular receptor. May mediate renin-dependent cellular responses by activating ERK1 and ERK2. By increasing the catalytic efficiency of renin in AGT/angiotensinogen conversion to angiotensin I, it may also play a role in the renin-angiotensin system (RAS) (By similarity).By similarity

GO - Molecular functioni

  1. aspartic-type endopeptidase activity Source: Ensembl
  2. enzyme binding Source: RGD
  3. receptor activity Source: InterPro

GO - Biological processi

  1. angiotensin maturation Source: RGD
  2. eye pigmentation Source: Ensembl
  3. head morphogenesis Source: Ensembl
  4. positive regulation of transforming growth factor beta1 production Source: Ensembl
  5. positive regulation of Wnt signaling pathway Source: Ensembl
  6. regulation of MAPK cascade Source: Ensembl
  7. rostrocaudal neural tube patterning Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Enzyme and pathway databases

ReactomeiREACT_198807. Metabolism of Angiotensinogen to Angiotensins.

Names & Taxonomyi

Protein namesi
Recommended name:
Renin receptor
Alternative name(s):
ATPase H(+)-transporting lysosomal accessory protein 2
ATPase H(+)-transporting lysosomal-interacting protein 2
Renin/prorenin receptor
Gene namesi
Name:Atp6ap2
Synonyms:Atp6ip2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome X

Organism-specific databases

RGDi1561269. Atp6ap2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini18 – 302285ExtracellularSequence AnalysisAdd
BLAST
Transmembranei303 – 32321HelicalSequence AnalysisAdd
BLAST
Topological domaini324 – 35027CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. cell body Source: RGD
  2. external side of plasma membrane Source: Ensembl
  3. extracellular vesicular exosome Source: Ensembl
  4. integral component of membrane Source: UniProtKB-KW
  5. neuron projection Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1717Sequence AnalysisAdd
BLAST
Chaini18 – 350333Renin receptorPRO_0000022206Add
BLAST

Post-translational modificationi

Phosphorylated.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ6AXS4.
PRIDEiQ6AXS4.

Expressioni

Gene expression databases

GenevestigatoriQ6AXS4.

Interactioni

Subunit structurei

Interacts with renin and the vacuolar proton-ATPase.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000005138.

Family & Domainsi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG296465.
GeneTreeiENSGT00390000008856.
HOGENOMiHOG000232083.
HOVERGENiHBG056579.
InParanoidiQ6AXS4.
OMAiNLWNMDP.
OrthoDBiEOG7R56VH.
PhylomeDBiQ6AXS4.
TreeFamiTF106137.

Family and domain databases

InterProiIPR012493. Renin_rcpt.
[Graphical view]
PANTHERiPTHR13351. PTHR13351. 1 hit.
PfamiPF07850. Renin_r. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6AXS4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAVLVVLLSS LVSSALANEF SILRSPGSVV FRNGNWPIPG DRIPDVAALS
60 70 80 90 100
MGFSVKEDLS WPGLAVGNLF HRPRATIMVT VKGVDKLALP TGSVISYPLE
110 120 130 140 150
NAVPFSLDSV ANSIHSLFSE ETPVVLQLAP SEERVYMVGK ANSVFEDLSV
160 170 180 190 200
TLRQLRNRLF QENSVLNSLP LNSLSRNNEV DLLFLSELQV LHDISSLLSR
210 220 230 240 250
HKHLAKDHSP DLYSLELAGL DELGKRYGED SEQFRDASRI LVDALQKFAD
260 270 280 290 300
DMYSLYGGNA VVELVTVKSF DTSLVRKSRT ILETKQENTQ SPYNLAYKYN
310 320 330 340 350
LEYSVVFNLV LWIMTGLALA VIITSYNIWN MDPGYDSIIY RMTNQKIRMD
Length:350
Mass (Da):39,082
Last modified:September 13, 2004 - v1
Checksum:i9845898BC3E260CF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB188298 mRNA. Translation: BAD67178.1.
BC079339 mRNA. Translation: AAH79339.1.
RefSeqiNP_001007092.1. NM_001007091.1.
UniGeneiRn.12944.

Genome annotation databases

EnsembliENSRNOT00000005138; ENSRNOP00000005138; ENSRNOG00000003858.
GeneIDi302526.
KEGGirno:302526.
UCSCiRGD:1561269. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB188298 mRNA. Translation: BAD67178.1.
BC079339 mRNA. Translation: AAH79339.1.
RefSeqiNP_001007092.1. NM_001007091.1.
UniGeneiRn.12944.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000005138.

Proteomic databases

PaxDbiQ6AXS4.
PRIDEiQ6AXS4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000005138; ENSRNOP00000005138; ENSRNOG00000003858.
GeneIDi302526.
KEGGirno:302526.
UCSCiRGD:1561269. rat.

Organism-specific databases

CTDi10159.
RGDi1561269. Atp6ap2.

Phylogenomic databases

eggNOGiNOG296465.
GeneTreeiENSGT00390000008856.
HOGENOMiHOG000232083.
HOVERGENiHBG056579.
InParanoidiQ6AXS4.
OMAiNLWNMDP.
OrthoDBiEOG7R56VH.
PhylomeDBiQ6AXS4.
TreeFamiTF106137.

Enzyme and pathway databases

ReactomeiREACT_198807. Metabolism of Angiotensinogen to Angiotensins.

Miscellaneous databases

NextBioi649783.
PROiQ6AXS4.

Gene expression databases

GenevestigatoriQ6AXS4.

Family and domain databases

InterProiIPR012493. Renin_rcpt.
[Graphical view]
PANTHERiPTHR13351. PTHR13351. 1 hit.
PfamiPF07850. Renin_r. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Inhibition of diabetic nephropathy by a decoy peptide corresponding to the 'handle' region for nonproteolytic activation of prorenin."
    Ichihara A., Hayashi M., Kaneshiro Y., Suzuki F., Nakagawa T., Tada Y., Koura Y., Nishiyama A., Okada H., Uddin M.N., Nabi A.H.M.N., Ishida Y., Inagami T., Saruta T.
    J. Clin. Invest. 114:1128-1135(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Kidney.

Entry informationi

Entry nameiRENR_RAT
AccessioniPrimary (citable) accession number: Q6AXS4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2005
Last sequence update: September 13, 2004
Last modified: January 7, 2015
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.