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Protein

Protein DEK

Gene

Dek

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Involved in chromatin organization.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi340 – 354By similarityAdd BLAST15
DNA bindingi370 – 374By similarity5

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Chromatin regulator

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

ReactomeiR-RNO-5250924. B-WICH complex positively regulates rRNA expression.
R-RNO-8864260. Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein DEK
Gene namesi
Name:Dek
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 17

Organism-specific databases

RGDi1303246. Dek.

Subcellular locationi

  • Nucleus

  • Note: Enriched in regions where chromatin is decondensed or sparse in the interphase nuclei.By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000798601 – 378Protein DEKAdd BLAST378

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei14PhosphothreonineBy similarity1
Modified residuei16PhosphothreonineCombined sources1
Modified residuei20PhosphoserineCombined sources1
Modified residuei33PhosphoserineCombined sources1
Modified residuei53PhosphoserineBy similarity1
Modified residuei74PhosphoserineBy similarity1
Modified residuei123PhosphoserineBy similarity1
Modified residuei124PhosphoserineBy similarity1
Modified residuei161PhosphoserineBy similarity1
Modified residuei203PhosphoserineBy similarity1
Modified residuei206PhosphoserineBy similarity1
Modified residuei212PhosphoserineBy similarity1
Modified residuei229PhosphoserineBy similarity1
Modified residuei232PhosphoserineBy similarity1
Modified residuei233PhosphoserineBy similarity1
Modified residuei234PhosphoserineBy similarity1
Modified residuei245PhosphoserineCombined sources1
Modified residuei246PhosphoserineCombined sources1
Modified residuei253PhosphoserineCombined sources1
Modified residuei290PhosphoserineBy similarity1
Modified residuei291PhosphoserineBy similarity1
Modified residuei292PhosphothreonineBy similarity1
Modified residuei293PhosphothreonineBy similarity1
Modified residuei299PhosphoserineBy similarity1
Modified residuei304PhosphoserineBy similarity1
Modified residuei306PhosphoserineBy similarity1
Modified residuei309PhosphoserineBy similarity1
Modified residuei310PhosphoserineCombined sources1

Post-translational modificationi

Phosphorylated by CK2. Phosphorylation fluctuates during the cell cycle with a moderate peak during G1 phase, and weakens the binding of DEK to DNA (By similarity).By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ6AXS3.
PRIDEiQ6AXS3.

PTM databases

iPTMnetiQ6AXS3.
PhosphoSitePlusiQ6AXS3.

Expressioni

Gene expression databases

BgeeiENSRNOG00000016152.
GenevisibleiQ6AXS3. RN.

Interactioni

Subunit structurei

Found in a mRNA splicing-dependent exon junction complex (EJC) with DEK, RBM8A, RNPS1, SRRM1 and ALYREF/THOC4. Interacts with histones H2A, H2B, H3, H4, acetylated histone H4, non-phosphorylated DAXX and HDAC2. Component of the B-WICH complex, at least composed of SMARCA5/SNF2H, BAZ1B/WSTF, SF3B1, DEK, MYO1C, ERCC6, MYBBP1A and DDX21. Binds DNA (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000021751.

Structurei

3D structure databases

ProteinModelPortaliQ6AXS3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini149 – 183SAPAdd BLAST35

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi207 – 223Nuclear localization signalSequence analysisAdd BLAST17

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi31 – 51Asp/Glu-rich (highly acidic)Add BLAST21
Compositional biasi230 – 238Asp/Glu-rich (acidic)9
Compositional biasi243 – 256Asp/Glu-rich (acidic)Add BLAST14
Compositional biasi303 – 313Asp/Glu-rich (acidic)Add BLAST11

Sequence similaritiesi

Contains 1 SAP domain.Curated

Phylogenomic databases

eggNOGiKOG2266. Eukaryota.
ENOG410XTU9. LUCA.
GeneTreeiENSGT00390000017282.
HOGENOMiHOG000059552.
HOVERGENiHBG004944.
InParanoidiQ6AXS3.
KOiK17046.
OMAiXPLPKSK.
OrthoDBiEOG091G0UKX.
PhylomeDBiQ6AXS3.
TreeFamiTF324696.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR014876. DEK_C.
IPR009057. Homeodomain-like.
IPR003034. SAP_dom.
[Graphical view]
PfamiPF08766. DEK_C. 1 hit.
[Graphical view]
SMARTiSM00513. SAP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6AXS3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSAAAAPAAE GEDTPTPPAS EKEPEMPGPR EESEEEEEED DDDEDEEEEK
60 70 80 90 100
EKSLIVEGKR EKRKVERLTM QVSSLQREPF TIAQGKGQKL CEIERIHFFL
110 120 130 140 150
SKKKTDELRN LHKLLYNRPG TVSSLKKNVG QFSGFPFEKG STQYKKKEEM
160 170 180 190 200
LKKYRNAMLK SICEVLDLER SGVNSELVKR ILNFLMHPKP SGKPLPKSKK
210 220 230 240 250
SSSKGSKKER NSSGTTRKSK QTKCPEILSD ESSSDEDEKK NKDESSEDEE
260 270 280 290 300
KESEEEQPPK KTSKKEKAKQ KATTKSKKSV KSANVKKADS STTKKNQNSS
310 320 330 340 350
KKESGSEDSS DDEPLIKKLK KPPTDEELKE TVKKLLADAN LEEVTMKQIC
360 370
KEVYENYPAY DLTERKDFIK TTVKELIS
Length:378
Mass (Da):42,892
Last modified:September 13, 2004 - v1
Checksum:iE3FE3DA24D0D2B05
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC079344 mRNA. Translation: AAH79344.1.
RefSeqiNP_001004255.1. NM_001004255.1.
UniGeneiRn.25099.

Genome annotation databases

EnsembliENSRNOT00000021751; ENSRNOP00000021751; ENSRNOG00000016152.
GeneIDi306817.
KEGGirno:306817.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC079344 mRNA. Translation: AAH79344.1.
RefSeqiNP_001004255.1. NM_001004255.1.
UniGeneiRn.25099.

3D structure databases

ProteinModelPortaliQ6AXS3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000021751.

PTM databases

iPTMnetiQ6AXS3.
PhosphoSitePlusiQ6AXS3.

Proteomic databases

PaxDbiQ6AXS3.
PRIDEiQ6AXS3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000021751; ENSRNOP00000021751; ENSRNOG00000016152.
GeneIDi306817.
KEGGirno:306817.

Organism-specific databases

CTDi7913.
RGDi1303246. Dek.

Phylogenomic databases

eggNOGiKOG2266. Eukaryota.
ENOG410XTU9. LUCA.
GeneTreeiENSGT00390000017282.
HOGENOMiHOG000059552.
HOVERGENiHBG004944.
InParanoidiQ6AXS3.
KOiK17046.
OMAiXPLPKSK.
OrthoDBiEOG091G0UKX.
PhylomeDBiQ6AXS3.
TreeFamiTF324696.

Enzyme and pathway databases

ReactomeiR-RNO-5250924. B-WICH complex positively regulates rRNA expression.
R-RNO-8864260. Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors.

Miscellaneous databases

PROiQ6AXS3.

Gene expression databases

BgeeiENSRNOG00000016152.
GenevisibleiQ6AXS3. RN.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR014876. DEK_C.
IPR009057. Homeodomain-like.
IPR003034. SAP_dom.
[Graphical view]
PfamiPF08766. DEK_C. 1 hit.
[Graphical view]
SMARTiSM00513. SAP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDEK_RAT
AccessioniPrimary (citable) accession number: Q6AXS3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 16, 2005
Last sequence update: September 13, 2004
Last modified: November 2, 2016
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.