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Protein

Protein orai-3

Gene

Orai3

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Key regulator or component of store-operated Ca2+ channel and transcription factor NFAT nuclear import.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Protein orai-3
Alternative name(s):
Transmembrane protein 142C
Gene namesi
Name:Orai3
Synonyms:Tmem142c
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi1306538. Orai3.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei63 – 82HelicalSequence analysisAdd BLAST20
Transmembranei95 – 115HelicalSequence analysisAdd BLAST21
Transmembranei157 – 177HelicalSequence analysisAdd BLAST21
Transmembranei239 – 259HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002343971 – 290Protein orai-3Add BLAST290

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei42PhosphoserineBy similarity1
Modified residuei45PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ6AXR8.

PTM databases

PhosphoSitePlusiQ6AXR8.

Expressioni

Gene expression databases

BgeeiENSRNOG00000039730.
GenevisibleiQ6AXR8. RN.

Interactioni

Subunit structurei

Interacts with CRACR2A/EFCAB4B.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000025732.

Family & Domainsi

Sequence similaritiesi

Belongs to the Orai family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4298. Eukaryota.
ENOG4110DSB. LUCA.
HOGENOMiHOG000246925.
HOVERGENiHBG081343.
InParanoidiQ6AXR8.
KOiK16058.
OrthoDBiEOG091G0E4P.
PhylomeDBiQ6AXR8.
TreeFamiTF313576.

Family and domain databases

InterProiIPR012446. CRAC_channel.
IPR030032. Orai-3.
[Graphical view]
PANTHERiPTHR31501. PTHR31501. 2 hits.
PTHR31501:SF6. PTHR31501:SF6. 2 hits.
PfamiPF07856. Orai-1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6AXR8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKGGEGDTGE QAPLNPEVDS PAGSATYREF VHRGYLDLMG ASQHSLRALS
60 70 80 90 100
WRRLYLSRAK LKASSRTSAL LSGFAMVAMV EVQLESDHEY PPGLLVAFSA
110 120 130 140 150
CTTVLVAVHL FALMVSTCLL PHIEAVSNIH NLNSVHQSPH QRLHRYVELA
160 170 180 190 200
WGFSTALGTF LFLAEVVLVG WVKFVPIGAP MDKPAPVVPM SQVPPVTVSL
210 220 230 240 250
SLASNLTPSS ASVATTQQPP KACPPRQVCG SAHGPGWQAA MASTAIMVPV
260 270 280 290
GLVFMAFALH FYRSLVAHKT DRHKQELEEL SRLQGELQAV
Length:290
Mass (Da):31,311
Last modified:September 13, 2004 - v1
Checksum:i6E7F2E8C113BFBE7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC079355 mRNA. Translation: AAH79355.1.
RefSeqiNP_001014046.1. NM_001014024.1.
UniGeneiRn.42186.

Genome annotation databases

GeneIDi309000.
KEGGirno:309000.
UCSCiRGD:1306538. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC079355 mRNA. Translation: AAH79355.1.
RefSeqiNP_001014046.1. NM_001014024.1.
UniGeneiRn.42186.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000025732.

PTM databases

PhosphoSitePlusiQ6AXR8.

Proteomic databases

PaxDbiQ6AXR8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi309000.
KEGGirno:309000.
UCSCiRGD:1306538. rat.

Organism-specific databases

CTDi93129.
RGDi1306538. Orai3.

Phylogenomic databases

eggNOGiKOG4298. Eukaryota.
ENOG4110DSB. LUCA.
HOGENOMiHOG000246925.
HOVERGENiHBG081343.
InParanoidiQ6AXR8.
KOiK16058.
OrthoDBiEOG091G0E4P.
PhylomeDBiQ6AXR8.
TreeFamiTF313576.

Miscellaneous databases

PROiQ6AXR8.

Gene expression databases

BgeeiENSRNOG00000039730.
GenevisibleiQ6AXR8. RN.

Family and domain databases

InterProiIPR012446. CRAC_channel.
IPR030032. Orai-3.
[Graphical view]
PANTHERiPTHR31501. PTHR31501. 2 hits.
PTHR31501:SF6. PTHR31501:SF6. 2 hits.
PfamiPF07856. Orai-1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiORAI3_RAT
AccessioniPrimary (citable) accession number: Q6AXR8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 16, 2006
Last sequence update: September 13, 2004
Last modified: November 2, 2016
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.