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Q6AXR5

- S35A3_RAT

UniProt

Q6AXR5 - S35A3_RAT

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Protein
UDP-N-acetylglucosamine transporter
Gene
Slc35a3
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at transcript leveli

Functioni

Uridine diphosphate-N-acetylglucosamine (UDP-GlcNAc) transporter in the Golgi apparatus. May supply UDP-GlcNAc as substrate for Golgi-resident glycosyltransferases that generate branching of diantennary oligosaccharides By similarity.

GO - Molecular functioni

  1. nucleotide-sugar transmembrane transporter activity Source: InterPro
  2. sugar:proton symporter activity Source: InterPro

GO - Biological processi

  1. UDP-N-acetylglucosamine transport Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Sugar transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
UDP-N-acetylglucosamine transporter
Alternative name(s):
Golgi UDP-GlcNAc transporter
Solute carrier family 35 member A3
Gene namesi
Name:Slc35a3
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Unplaced

Organism-specific databases

RGDi1308615. Slc35a3.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei4 – 2421Helical; Reviewed prediction
Add
BLAST
Transmembranei38 – 5821Helical; Reviewed prediction
Add
BLAST
Transmembranei136 – 15621Helical; Reviewed prediction
Add
BLAST
Transmembranei174 – 19421Helical; Reviewed prediction
Add
BLAST
Transmembranei212 – 23221Helical; Reviewed prediction
Add
BLAST
Transmembranei243 – 26321Helical; Reviewed prediction
Add
BLAST
Transmembranei269 – 28921Helical; Reviewed prediction
Add
BLAST
Transmembranei293 – 31321Helical; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. Golgi membrane Source: UniProtKB-SubCell
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 326326UDP-N-acetylglucosamine transporter
PRO_0000213359Add
BLAST

Proteomic databases

PaxDbiQ6AXR5.
PRIDEiQ6AXR5.

Expressioni

Gene expression databases

GenevestigatoriQ6AXR5.

Interactioni

Subunit structurei

Interacts with SLC35A2 By similarity.

Protein-protein interaction databases

MINTiMINT-4572437.
STRINGi10116.ENSRNOP00000021676.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0697.
HOGENOMiHOG000216649.
HOVERGENiHBG054025.
InParanoidiQ6AXR5.
KOiK15272.
OrthoDBiEOG7NCV4D.
PhylomeDBiQ6AXR5.
TreeFamiTF315345.

Family and domain databases

InterProiIPR007271. Nuc_sug_transpt.
IPR021189. UDP/CMP-sugar_transptr.
IPR004689. UDPgal_transpt.
[Graphical view]
PANTHERiPTHR10231. PTHR10231. 1 hit.
PfamiPF04142. Nuc_sug_transp. 1 hit.
[Graphical view]
PIRSFiPIRSF005799. UDP-gal_transpt. 1 hit.
TIGRFAMsiTIGR00803. nst. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6AXR5-1 [UniParc]FASTAAdd to Basket

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MSANLKYLSL GILVFQTTSL VLTMRYSRTL KEEGPRYLSS TAVVVAEFLK    50
IMACIFLVYK DSKCSVRTLN RVLHDEILNK PMETLKLAIP SGIYTLQNNL 100
LYVALSNLDA ATYQVTYQLK ILTTALFSVS MLGKKLGMYQ WLSLVILMAG 150
VAFVQWPSDS QELNSKDLST GSQFVGLMAV LIACFSSGFA GVYFEKILKE 200
TKQSVWIRNI QLGFFGSIFG LMGVYVYDGE LVSKNGFFQG YNQLTWIVVV 250
LQALGGLVIA AVIKYADNIL KGFATSLSII LSTIISYFWL QDFVPTSVFF 300
LGAILVIAAT FLYGYDPKPA GNPTKA 326
Length:326
Mass (Da):36,079
Last modified:September 13, 2004 - v1
Checksum:i4C1BB88723E59C24
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC079371 mRNA. Translation: AAH79371.1.
RefSeqiNP_001012082.1. NM_001012082.1.
UniGeneiRn.162630.

Genome annotation databases

GeneIDi310808.
KEGGirno:310808.
UCSCiRGD:1308615. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC079371 mRNA. Translation: AAH79371.1 .
RefSeqi NP_001012082.1. NM_001012082.1.
UniGenei Rn.162630.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

MINTi MINT-4572437.
STRINGi 10116.ENSRNOP00000021676.

Proteomic databases

PaxDbi Q6AXR5.
PRIDEi Q6AXR5.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 310808.
KEGGi rno:310808.
UCSCi RGD:1308615. rat.

Organism-specific databases

CTDi 23443.
RGDi 1308615. Slc35a3.

Phylogenomic databases

eggNOGi COG0697.
HOGENOMi HOG000216649.
HOVERGENi HBG054025.
InParanoidi Q6AXR5.
KOi K15272.
OrthoDBi EOG7NCV4D.
PhylomeDBi Q6AXR5.
TreeFami TF315345.

Miscellaneous databases

NextBioi 662681.
PROi Q6AXR5.

Gene expression databases

Genevestigatori Q6AXR5.

Family and domain databases

InterProi IPR007271. Nuc_sug_transpt.
IPR021189. UDP/CMP-sugar_transptr.
IPR004689. UDPgal_transpt.
[Graphical view ]
PANTHERi PTHR10231. PTHR10231. 1 hit.
Pfami PF04142. Nuc_sug_transp. 1 hit.
[Graphical view ]
PIRSFi PIRSF005799. UDP-gal_transpt. 1 hit.
TIGRFAMsi TIGR00803. nst. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Kidney.

Entry informationi

Entry nameiS35A3_RAT
AccessioniPrimary (citable) accession number: Q6AXR5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 15, 2005
Last sequence update: September 13, 2004
Last modified: July 9, 2014
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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