Q6AXR5 (S35A3_RAT) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
UDP-N-acetylglucosamine transporter

Alternative name(s):
Golgi UDP-GlcNAc transporter
Solute carrier family 35 member A3

Gene names

Name:

Slc35a3

Organism

Rattus norvegicus (Rat) [Reference proteome]

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	326 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Uridine diphosphate-N-acetylglucosamine transporter in the Golgi apparatus By similarity.
Subcellular location	Golgi apparatus membrane; Multi-pass membrane protein By similarity.
Sequence similarities	Belongs to the nucleotide-sugar transporter family. SLC35A subfamily.

Ontologies

Keywords
Biological process	Sugar transport Transport
Cellular component	Golgi apparatus Membrane
Domain	Transmembrane Transmembrane helix
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	nucleotide-sugar transport Inferred from electronic annotation. Source: InterPro
Cellular_component	Golgi membrane Inferred from electronic annotation. Source: UniProtKB-SubCell integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	nucleotide-sugar transmembrane transporter activity Inferred from electronic annotation. Source: InterPro sugar:hydrogen symporter activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 326	326	UDP-N-acetylglucosamine transporter		PRO_0000213359
Regions
	Transmembrane	4 – 24	21	Helical; Potential
	Transmembrane	38 – 58	21	Helical; Potential
	Transmembrane	136 – 156	21	Helical; Potential
	Transmembrane	174 – 194	21	Helical; Potential
	Transmembrane	212 – 232	21	Helical; Potential
	Transmembrane	243 – 263	21	Helical; Potential
	Transmembrane	269 – 289	21	Helical; Potential
	Transmembrane	293 – 313	21	Helical; Potential

Sequences

	Sequence		Length	Mass (Da)
	Q6AXR5 [UniParc]. Last modified September 13, 2004. Version 1. Checksum: 4C1BB88723E59C24	FASTA	326	36,079
	10 20 30 40 50 60 MSANLKYLSL GILVFQTTSL VLTMRYSRTL KEEGPRYLSS TAVVVAEFLK IMACIFLVYK 70 80 90 100 110 120 DSKCSVRTLN RVLHDEILNK PMETLKLAIP SGIYTLQNNL LYVALSNLDA ATYQVTYQLK 130 140 150 160 170 180 ILTTALFSVS MLGKKLGMYQ WLSLVILMAG VAFVQWPSDS QELNSKDLST GSQFVGLMAV 190 200 210 220 230 240 LIACFSSGFA GVYFEKILKE TKQSVWIRNI QLGFFGSIFG LMGVYVYDGE LVSKNGFFQG 250 260 270 280 290 300 YNQLTWIVVV LQALGGLVIA AVIKYADNIL KGFATSLSII LSTIISYFWL QDFVPTSVFF 310 320 LGAILVIAAT FLYGYDPKPA GNPTKA

References

[1]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Kidney.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC079371 mRNA. Translation: AAH79371.1.
IPI	IPI00369143.
RefSeq	NP_001012082.1. NM_001012082.1.
UniGene	Rn.162630.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	10116.ENSRNOP00000021676.
Proteomic databases
PaxDb	Q6AXR5.
PRIDE	Q6AXR5.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	310808.
KEGG	rno:310808.
UCSC	RGD:1308615. rat.
Organism-specific databases
CTD	23443.
RGD	1308615. Slc35a3.
Phylogenomic databases
eggNOG	COG0697.
HOGENOM	HOG000216649.
HOVERGEN	HBG054025.
InParanoid	Q6AXR5.
KO	K15272.
OMA	WPSDSQL.
OrthoDB	EOG4V9TR3.
Gene expression databases
Genevestigator	Q6AXR5.
GermOnline	ENSRNOG00000015627. Rattus norvegicus.
Family and domain databases
InterPro	IPR007271. Nuc_sug_transpt. IPR021189. UDP/CMP-sugar_transptr. IPR004689. UDPgal_transpt. [Graphical view]
PANTHER	PTHR10231. PTHR10231. 1 hit.
Pfam	PF04142. Nuc_sug_transp. 1 hit. [Graphical view]
PIRSF	PIRSF005799. UDP-gal_transpt. 1 hit.
TIGRFAMs	TIGR00803. nst. 1 hit.
ProtoNet	Search...
Other
NextBio	662681.

Entry information

Entry name

S35A3_RAT

Accession

Primary (citable) accession number: Q6AXR5

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 15, 2005
Last sequence update:	September 13, 2004
Last modified:	May 1, 2013
This is version 71 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program