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Q6AXR4 (HEXB_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 77. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Beta-hexosaminidase subunit beta

EC=3.2.1.52
Alternative name(s):
Beta-N-acetylhexosaminidase subunit beta
Short name=Hexosaminidase subunit B
N-acetyl-beta-glucosaminidase subunit beta
Gene names
Name:Hexb
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length537 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Responsible for the degradation of GM2 gangliosides, and a variety of other molecules containing terminal N-acetyl hexosamines, in the brain and other tissues By similarity.

Catalytic activity

Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides.

Subcellular location

Lysosome By similarity.

Sequence similarities

Belongs to the glycosyl hydrolase 20 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2323 Potential
Chain24 – 537514Beta-hexosaminidase subunit beta
PRO_0000012008

Sites

Active site3331Proton donor By similarity

Amino acid modifications

Glycosylation621N-linked (GlcNAc...) Potential
Glycosylation1681N-linked (GlcNAc...) Potential
Glycosylation3051N-linked (GlcNAc...) Potential
Disulfide bond69 ↔ 115 By similarity
Disulfide bond287 ↔ 338 By similarity
Disulfide bond512 ↔ 529 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q6AXR4 [UniParc].

Last modified September 13, 2004. Version 1.
Checksum: 1A9BB01F4AD2F6E4

FASTA53761,527
        10         20         30         40         50         60 
MPGSPRRAPG LLLQALVAMV SLALVAPFGL QPALWPMPRS VQVFPRLLYI SPENFQIDNS 

        70         80         90        100        110        120 
PNSTAGPSCS LLLEAFRRYY NYIFGFYKRH HGPAKFQDKP QLEKLLVFIN LEPQCDAFPS 

       130        140        150        160        170        180 
MSSDESYSLL VQEPVALLKA NEVWGALRGL ETFSQLVYQD AYGTFTINES TIADSPRFPH 

       190        200        210        220        230        240 
RGILIDTSRH YLPVKTIFKT LDAMAFNKFN VLHWHIVDDQ SFPYQSITFP ELSNKGSYSL 

       250        260        270        280        290        300 
SHVYTPNDIH MVLEYARLRG IRVIPEFDSP GHTQSWGKGQ KNLLTPCFIQ KIRTQKVGPV 

       310        320        330        340        350        360 
DPSLNTTYVF FDTFFKEISR VFPDQFIHLG GDEVEFECWA SNPNIQNFMK KKGFGNNFRR 

       370        380        390        400        410        420 
LESFYIKKIL DIITSLKKSS IVWQDVFDDQ VELQPGTVVE VWKSENYLNE LAQVTASGFP 

       430        440        450        460        470        480 
AILSAPWYLD LISYGQDWRN YYKAEPLNFE GSEKQKQLVI GGEACLWGEY VDATNLIPRL 

       490        500        510        520        530 
WPRASAVGER LWSPRIITNL ENAYRRLAVH RCRMVSRGIA AQPLFTGYCN YENKMEK 

« Hide

References

[1]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Kidney.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC079376 mRNA. Translation: AAH79376.1.
RefSeqNP_001011946.1. NM_001011946.1.
UniGeneRn.203067.

3D structure databases

ProteinModelPortalQ6AXR4.
SMRQ6AXR4. Positions 32-530.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10116.ENSRNOP00000044480.

Protein family/group databases

CAZyGH20. Glycoside Hydrolase Family 20.

PTM databases

PhosphoSiteQ6AXR4.

Proteomic databases

PaxDbQ6AXR4.
PRIDEQ6AXR4.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID294673.
KEGGrno:294673.
UCSCRGD:1307607. rat.

Organism-specific databases

CTD3074.
RGD1307607. Hexb.

Phylogenomic databases

eggNOGCOG3525.
HOGENOMHOG000157972.
HOVERGENHBG005961.
InParanoidQ6AXR4.
KOK12373.
PhylomeDBQ6AXR4.

Enzyme and pathway databases

SABIO-RKQ6AXR4.

Gene expression databases

GenevestigatorQ6AXR4.

Family and domain databases

Gene3D3.20.20.80. 1 hit.
InterProIPR025705. Beta_hexosaminidase_sua/sub.
IPR015883. Glyco_hydro_20_cat-core.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PfamPF00728. Glyco_hydro_20. 1 hit.
[Graphical view]
PIRSFPIRSF001093. B-hxosamndse_ab_euk_. 1 hit.
PRINTSPR00738. GLHYDRLASE20.
SUPFAMSSF51445. SSF51445. 1 hit.
ProtoNetSearch...

Other

NextBio638387.
PROQ6AXR4.

Entry information

Entry nameHEXB_RAT
AccessionPrimary (citable) accession number: Q6AXR4
Entry history
Integrated into UniProtKB/Swiss-Prot: May 10, 2005
Last sequence update: September 13, 2004
Last modified: April 16, 2014
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Glycosyl hydrolases

Classification of glycosyl hydrolase families and list of entries