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Protein

Beta-hexosaminidase subunit beta

Gene

Hexb

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Responsible for the degradation of GM2 gangliosides, and a variety of other molecules containing terminal N-acetyl hexosamines, in the brain and other tissues.By similarity

Catalytic activityi

Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei333 – 3331Proton donorBy similarity

GO - Molecular functioni

  1. beta-N-acetylglucosaminidase activity Source: RGD
  2. carbohydrate binding Source: RGD
  3. hexosaminidase activity Source: RGD
  4. protein heterodimerization activity Source: RGD
  5. protein homodimerization activity Source: RGD

GO - Biological processi

  1. carbohydrate metabolic process Source: InterPro
  2. N-acetylglucosamine metabolic process Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Enzyme and pathway databases

SABIO-RKQ6AXR4.

Protein family/group databases

CAZyiGH20. Glycoside Hydrolase Family 20.

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-hexosaminidase subunit beta (EC:3.2.1.52)
Alternative name(s):
Beta-N-acetylhexosaminidase subunit beta
Short name:
Hexosaminidase subunit B
N-acetyl-beta-glucosaminidase subunit beta
Gene namesi
Name:Hexb
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494 Componenti: Unplaced

Organism-specific databases

RGDi1307607. Hexb.

Subcellular locationi

  1. Lysosome By similarity

GO - Cellular componenti

  1. lysosome Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Lysosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323Sequence AnalysisAdd
BLAST
Chaini24 – 537514Beta-hexosaminidase subunit betaPRO_0000012008Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi62 – 621N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi69 ↔ 115By similarity
Glycosylationi168 – 1681N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi287 ↔ 338By similarity
Glycosylationi305 – 3051N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi512 ↔ 529By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ6AXR4.
PRIDEiQ6AXR4.

PTM databases

PhosphoSiteiQ6AXR4.

Expressioni

Gene expression databases

GenevestigatoriQ6AXR4.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000044480.

Structurei

3D structure databases

ProteinModelPortaliQ6AXR4.
SMRiQ6AXR4. Positions 32-530.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyl hydrolase 20 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG3525.
HOGENOMiHOG000157972.
HOVERGENiHBG005961.
InParanoidiQ6AXR4.
KOiK12373.
PhylomeDBiQ6AXR4.

Family and domain databases

Gene3Di3.20.20.80. 1 hit.
3.30.379.10. 1 hit.
InterProiIPR025705. Beta_hexosaminidase_sua/sub.
IPR029018. Chitobiase/Hex_dom_2-like.
IPR015883. Glyco_hydro_20_cat-core.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
IPR029019. HEX_eukaryotic_N.
[Graphical view]
PfamiPF00728. Glyco_hydro_20. 1 hit.
PF14845. Glycohydro_20b2. 1 hit.
[Graphical view]
PIRSFiPIRSF001093. B-hxosamndse_ab_euk_. 1 hit.
PRINTSiPR00738. GLHYDRLASE20.
SUPFAMiSSF51445. SSF51445. 1 hit.
SSF55545. SSF55545. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6AXR4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPGSPRRAPG LLLQALVAMV SLALVAPFGL QPALWPMPRS VQVFPRLLYI
60 70 80 90 100
SPENFQIDNS PNSTAGPSCS LLLEAFRRYY NYIFGFYKRH HGPAKFQDKP
110 120 130 140 150
QLEKLLVFIN LEPQCDAFPS MSSDESYSLL VQEPVALLKA NEVWGALRGL
160 170 180 190 200
ETFSQLVYQD AYGTFTINES TIADSPRFPH RGILIDTSRH YLPVKTIFKT
210 220 230 240 250
LDAMAFNKFN VLHWHIVDDQ SFPYQSITFP ELSNKGSYSL SHVYTPNDIH
260 270 280 290 300
MVLEYARLRG IRVIPEFDSP GHTQSWGKGQ KNLLTPCFIQ KIRTQKVGPV
310 320 330 340 350
DPSLNTTYVF FDTFFKEISR VFPDQFIHLG GDEVEFECWA SNPNIQNFMK
360 370 380 390 400
KKGFGNNFRR LESFYIKKIL DIITSLKKSS IVWQDVFDDQ VELQPGTVVE
410 420 430 440 450
VWKSENYLNE LAQVTASGFP AILSAPWYLD LISYGQDWRN YYKAEPLNFE
460 470 480 490 500
GSEKQKQLVI GGEACLWGEY VDATNLIPRL WPRASAVGER LWSPRIITNL
510 520 530
ENAYRRLAVH RCRMVSRGIA AQPLFTGYCN YENKMEK
Length:537
Mass (Da):61,527
Last modified:September 13, 2004 - v1
Checksum:i1A9BB01F4AD2F6E4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC079376 mRNA. Translation: AAH79376.1.
RefSeqiNP_001011946.1. NM_001011946.1.
UniGeneiRn.203067.

Genome annotation databases

GeneIDi294673.
KEGGirno:294673.
UCSCiRGD:1307607. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC079376 mRNA. Translation: AAH79376.1.
RefSeqiNP_001011946.1. NM_001011946.1.
UniGeneiRn.203067.

3D structure databases

ProteinModelPortaliQ6AXR4.
SMRiQ6AXR4. Positions 32-530.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000044480.

Protein family/group databases

CAZyiGH20. Glycoside Hydrolase Family 20.

PTM databases

PhosphoSiteiQ6AXR4.

Proteomic databases

PaxDbiQ6AXR4.
PRIDEiQ6AXR4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi294673.
KEGGirno:294673.
UCSCiRGD:1307607. rat.

Organism-specific databases

CTDi3074.
RGDi1307607. Hexb.

Phylogenomic databases

eggNOGiCOG3525.
HOGENOMiHOG000157972.
HOVERGENiHBG005961.
InParanoidiQ6AXR4.
KOiK12373.
PhylomeDBiQ6AXR4.

Enzyme and pathway databases

SABIO-RKQ6AXR4.

Miscellaneous databases

NextBioi638387.
PROiQ6AXR4.

Gene expression databases

GenevestigatoriQ6AXR4.

Family and domain databases

Gene3Di3.20.20.80. 1 hit.
3.30.379.10. 1 hit.
InterProiIPR025705. Beta_hexosaminidase_sua/sub.
IPR029018. Chitobiase/Hex_dom_2-like.
IPR015883. Glyco_hydro_20_cat-core.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
IPR029019. HEX_eukaryotic_N.
[Graphical view]
PfamiPF00728. Glyco_hydro_20. 1 hit.
PF14845. Glycohydro_20b2. 1 hit.
[Graphical view]
PIRSFiPIRSF001093. B-hxosamndse_ab_euk_. 1 hit.
PRINTSiPR00738. GLHYDRLASE20.
SUPFAMiSSF51445. SSF51445. 1 hit.
SSF55545. SSF55545. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Kidney.

Entry informationi

Entry nameiHEXB_RAT
AccessioniPrimary (citable) accession number: Q6AXR4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2005
Last sequence update: September 13, 2004
Last modified: January 7, 2015
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.