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Q6AXR4

- HEXB_RAT

UniProt

Q6AXR4 - HEXB_RAT

Protein

Beta-hexosaminidase subunit beta

Gene

Hexb

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 79 (01 Oct 2014)
      Sequence version 1 (13 Sep 2004)
      Previous versions | rss
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    Functioni

    Responsible for the degradation of GM2 gangliosides, and a variety of other molecules containing terminal N-acetyl hexosamines, in the brain and other tissues.By similarity

    Catalytic activityi

    Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei333 – 3331Proton donorBy similarity

    GO - Molecular functioni

    1. beta-N-acetylglucosaminidase activity Source: RGD
    2. carbohydrate binding Source: RGD
    3. hexosaminidase activity Source: RGD
    4. protein heterodimerization activity Source: RGD
    5. protein homodimerization activity Source: RGD

    GO - Biological processi

    1. carbohydrate metabolic process Source: InterPro
    2. N-acetylglucosamine metabolic process Source: RGD

    Keywords - Molecular functioni

    Glycosidase, Hydrolase

    Enzyme and pathway databases

    SABIO-RKQ6AXR4.

    Protein family/group databases

    CAZyiGH20. Glycoside Hydrolase Family 20.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Beta-hexosaminidase subunit beta (EC:3.2.1.52)
    Alternative name(s):
    Beta-N-acetylhexosaminidase subunit beta
    Short name:
    Hexosaminidase subunit B
    N-acetyl-beta-glucosaminidase subunit beta
    Gene namesi
    Name:Hexb
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Unplaced

    Organism-specific databases

    RGDi1307607. Hexb.

    Subcellular locationi

    Lysosome By similarity

    GO - Cellular componenti

    1. lysosome Source: RGD

    Keywords - Cellular componenti

    Lysosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2323Sequence AnalysisAdd
    BLAST
    Chaini24 – 537514Beta-hexosaminidase subunit betaPRO_0000012008Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi62 – 621N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi69 ↔ 115By similarity
    Glycosylationi168 – 1681N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi287 ↔ 338By similarity
    Glycosylationi305 – 3051N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi512 ↔ 529By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiQ6AXR4.
    PRIDEiQ6AXR4.

    PTM databases

    PhosphoSiteiQ6AXR4.

    Expressioni

    Gene expression databases

    GenevestigatoriQ6AXR4.

    Interactioni

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000044480.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6AXR4.
    SMRiQ6AXR4. Positions 32-530.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the glycosyl hydrolase 20 family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiCOG3525.
    HOGENOMiHOG000157972.
    HOVERGENiHBG005961.
    InParanoidiQ6AXR4.
    KOiK12373.
    PhylomeDBiQ6AXR4.

    Family and domain databases

    Gene3Di3.20.20.80. 1 hit.
    3.30.379.10. 1 hit.
    InterProiIPR025705. Beta_hexosaminidase_sua/sub.
    IPR029018. Chitobiase/Hex_dom_2-like.
    IPR015883. Glyco_hydro_20_cat-core.
    IPR013781. Glyco_hydro_catalytic_dom.
    IPR017853. Glycoside_hydrolase_SF.
    IPR029019. HEX_eukaryotic_N.
    [Graphical view]
    PfamiPF00728. Glyco_hydro_20. 1 hit.
    PF14845. Glycohydro_20b2. 1 hit.
    [Graphical view]
    PIRSFiPIRSF001093. B-hxosamndse_ab_euk_. 1 hit.
    PRINTSiPR00738. GLHYDRLASE20.
    SUPFAMiSSF51445. SSF51445. 1 hit.
    SSF55545. SSF55545. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q6AXR4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPGSPRRAPG LLLQALVAMV SLALVAPFGL QPALWPMPRS VQVFPRLLYI    50
    SPENFQIDNS PNSTAGPSCS LLLEAFRRYY NYIFGFYKRH HGPAKFQDKP 100
    QLEKLLVFIN LEPQCDAFPS MSSDESYSLL VQEPVALLKA NEVWGALRGL 150
    ETFSQLVYQD AYGTFTINES TIADSPRFPH RGILIDTSRH YLPVKTIFKT 200
    LDAMAFNKFN VLHWHIVDDQ SFPYQSITFP ELSNKGSYSL SHVYTPNDIH 250
    MVLEYARLRG IRVIPEFDSP GHTQSWGKGQ KNLLTPCFIQ KIRTQKVGPV 300
    DPSLNTTYVF FDTFFKEISR VFPDQFIHLG GDEVEFECWA SNPNIQNFMK 350
    KKGFGNNFRR LESFYIKKIL DIITSLKKSS IVWQDVFDDQ VELQPGTVVE 400
    VWKSENYLNE LAQVTASGFP AILSAPWYLD LISYGQDWRN YYKAEPLNFE 450
    GSEKQKQLVI GGEACLWGEY VDATNLIPRL WPRASAVGER LWSPRIITNL 500
    ENAYRRLAVH RCRMVSRGIA AQPLFTGYCN YENKMEK 537
    Length:537
    Mass (Da):61,527
    Last modified:September 13, 2004 - v1
    Checksum:i1A9BB01F4AD2F6E4
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC079376 mRNA. Translation: AAH79376.1.
    RefSeqiNP_001011946.1. NM_001011946.1.
    UniGeneiRn.203067.

    Genome annotation databases

    GeneIDi294673.
    KEGGirno:294673.
    UCSCiRGD:1307607. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC079376 mRNA. Translation: AAH79376.1 .
    RefSeqi NP_001011946.1. NM_001011946.1.
    UniGenei Rn.203067.

    3D structure databases

    ProteinModelPortali Q6AXR4.
    SMRi Q6AXR4. Positions 32-530.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000044480.

    Protein family/group databases

    CAZyi GH20. Glycoside Hydrolase Family 20.

    PTM databases

    PhosphoSitei Q6AXR4.

    Proteomic databases

    PaxDbi Q6AXR4.
    PRIDEi Q6AXR4.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 294673.
    KEGGi rno:294673.
    UCSCi RGD:1307607. rat.

    Organism-specific databases

    CTDi 3074.
    RGDi 1307607. Hexb.

    Phylogenomic databases

    eggNOGi COG3525.
    HOGENOMi HOG000157972.
    HOVERGENi HBG005961.
    InParanoidi Q6AXR4.
    KOi K12373.
    PhylomeDBi Q6AXR4.

    Enzyme and pathway databases

    SABIO-RK Q6AXR4.

    Miscellaneous databases

    NextBioi 638387.
    PROi Q6AXR4.

    Gene expression databases

    Genevestigatori Q6AXR4.

    Family and domain databases

    Gene3Di 3.20.20.80. 1 hit.
    3.30.379.10. 1 hit.
    InterProi IPR025705. Beta_hexosaminidase_sua/sub.
    IPR029018. Chitobiase/Hex_dom_2-like.
    IPR015883. Glyco_hydro_20_cat-core.
    IPR013781. Glyco_hydro_catalytic_dom.
    IPR017853. Glycoside_hydrolase_SF.
    IPR029019. HEX_eukaryotic_N.
    [Graphical view ]
    Pfami PF00728. Glyco_hydro_20. 1 hit.
    PF14845. Glycohydro_20b2. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF001093. B-hxosamndse_ab_euk_. 1 hit.
    PRINTSi PR00738. GLHYDRLASE20.
    SUPFAMi SSF51445. SSF51445. 1 hit.
    SSF55545. SSF55545. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Kidney.

    Entry informationi

    Entry nameiHEXB_RAT
    AccessioniPrimary (citable) accession number: Q6AXR4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 10, 2005
    Last sequence update: September 13, 2004
    Last modified: October 1, 2014
    This is version 79 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Glycosyl hydrolases
      Classification of glycosyl hydrolase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3