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Protein

SUMO-activating enzyme subunit 1

Gene

Sae1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

The heterodimer acts as an E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2 (By similarity).By similarity

Pathwayi: protein sumoylation

This protein is involved in the pathway protein sumoylation, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein sumoylation and in Protein modification.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigase
Biological processUbl conjugation pathway

Enzyme and pathway databases

ReactomeiR-RNO-3065676 SUMO is conjugated to E1 (UBA2:SAE1)
R-RNO-3065678 SUMO is transferred from E1 to E2 (UBE2I, UBC9)
UniPathwayiUPA00886

Names & Taxonomyi

Protein namesi
Recommended name:
SUMO-activating enzyme subunit 1
Alternative name(s):
Ubiquitin-like 1-activating enzyme E1A
Cleaved into the following chain:
Gene namesi
Name:Sae1
Synonyms:Uble1a
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi1306098 Sae1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002688681 – 349SUMO-activating enzyme subunit 1Add BLAST349
Initiator methionineiRemoved; alternateBy similarity
ChainiPRO_00004232932 – 349SUMO-activating enzyme subunit 1, N-terminally processedAdd BLAST348

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1
Modified residuei2N-acetylvaline; in SUMO-activating enzyme subunit 1, N-terminally processedBy similarity1
Modified residuei15PhosphoserineBy similarity1
Modified residuei201N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ6AXQ0
PRIDEiQ6AXQ0

PTM databases

iPTMnetiQ6AXQ0
PhosphoSitePlusiQ6AXQ0

Expressioni

Gene expression databases

BgeeiENSRNOG00000015128
GenevisibleiQ6AXQ0 RN

Interactioni

Subunit structurei

Heterodimer of SAE1 and UBA2/SAE2. The heterodimer corresponds to the two domains that are encoded on a single polypeptide chain in ubiquitin-activating enzyme E1. Interacts with UBE2I (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi258986, 1 interactor
STRINGi10116.ENSRNOP00000020402

Structurei

3D structure databases

ProteinModelPortaliQ6AXQ0
SMRiQ6AXQ0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ubiquitin-activating E1 family.Curated

Phylogenomic databases

eggNOGiKOG2014 Eukaryota
COG0476 LUCA
GeneTreeiENSGT00550000075007
HOGENOMiHOG000172217
HOVERGENiHBG080782
InParanoidiQ6AXQ0
KOiK10684
OMAiSYCFSEM
OrthoDBiEOG091G0DZ1
PhylomeDBiQ6AXQ0
TreeFamiTF315037

Family and domain databases

InterProiView protein in InterPro
IPR000594 ThiF_NAD_FAD-bd
IPR035985 Ubiquitin-activating_enz
IPR000011 UBQ/SUMO-activ_enz_E1-like
PfamiView protein in Pfam
PF00899 ThiF, 1 hit
PRINTSiPR01849 UBIQUITINACT
SUPFAMiSSF69572 SSF69572, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6AXQ0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVEKEEVSGG GGGISEEEAA QYDRQIRLWG LEAQKRLRAS RVLIVGMKGL
60 70 80 90 100
GAEIAKNLIL AGVKGLTMLD HEQVSPEDLG AQFLIRTGSV GQNRAEASLE
110 120 130 140 150
RAQNLNPMVD VKVDTEDIEK KPESFFTEFD AVCLTCCSKD VIIKVDQICH
160 170 180 190 200
RNSIKFFTGD VFGYHGYTFA NLGEHEFVEE KTKVTKVSQG VEDGPDAKRA
210 220 230 240 250
KLDSSETTMV KKKVLFCPVK EALAVDWSGE KAQAALKRTA PDYFLLQVLL
260 270 280 290 300
KFRTDKGRDP TSDSYSEDAE LLLQIRNDVF DSLGVSPDLL PDDFVRYCFS
310 320 330 340
EMAPVCAVVG GILAQEIVKA LSQRDPPHNN FFFFDGMKGS GIVECLGPQ
Length:349
Mass (Da):38,513
Last modified:September 13, 2004 - v1
Checksum:iEBCF5C53436B2DDD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC079411 mRNA Translation: AAH79411.1
RefSeqiNP_001012063.1, NM_001012063.1
UniGeneiRn.9014

Genome annotation databases

EnsembliENSRNOT00000020402; ENSRNOP00000020402; ENSRNOG00000015128
GeneIDi308384
KEGGirno:308384
UCSCiRGD:1306098 rat

Similar proteinsi

Entry informationi

Entry nameiSAE1_RAT
AccessioniPrimary (citable) accession number: Q6AXQ0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: September 13, 2004
Last modified: May 23, 2018
This is version 115 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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