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Protein

Cation channel sperm-associated protein 2

Gene

Catsper2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Voltage-gated calcium channel that plays a central role in sperm cell hyperactivation. Controls calcium entry to mediate the hyperactivated motility, a step needed for sperm motility which is essential late in the preparation of sperm for fertilization. Activated by intracellular alkalinization (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Calcium channel, Developmental protein, Ion channel, Voltage-gated channel

Keywords - Biological processi

Calcium transport, Differentiation, Ion transport, Spermatogenesis, Transport

Keywords - Ligandi

Calcium

Enzyme and pathway databases

ReactomeiR-RNO-1300642. Sperm Motility And Taxes.

Names & Taxonomyi

Protein namesi
Recommended name:
Cation channel sperm-associated protein 2
Short name:
CatSper2
Gene namesi
Name:Catsper2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 3

Organism-specific databases

RGDi1307620. Catsper2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 106106CytoplasmicSequence analysisAdd
BLAST
Transmembranei107 – 12721Helical; Name=Segment S1Sequence analysisAdd
BLAST
Topological domaini128 – 14922ExtracellularSequence analysisAdd
BLAST
Transmembranei150 – 17021Helical; Name=Segment S2Sequence analysisAdd
BLAST
Topological domaini171 – 1766CytoplasmicSequence analysis
Transmembranei177 – 19721Helical; Name=Segment S3Sequence analysisAdd
BLAST
Topological domaini198 – 2036ExtracellularSequence analysis
Transmembranei204 – 22421Helical; Name=Segment S4Sequence analysisAdd
BLAST
Topological domaini225 – 24016CytoplasmicSequence analysisAdd
BLAST
Transmembranei241 – 26121Helical; Name=Segment S5Sequence analysisAdd
BLAST
Topological domaini262 – 28019ExtracellularSequence analysisAdd
BLAST
Intramembranei281 – 30121Helical; Pore-formingSequence analysisAdd
BLAST
Topological domaini302 – 31817ExtracellularSequence analysisAdd
BLAST
Transmembranei319 – 33921Helical; Name=Segment S6Sequence analysisAdd
BLAST
Topological domaini340 – 584245CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cell projection, Cilium, Flagellum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 584584Cation channel sperm-associated protein 2PRO_0000295678Add
BLAST

Proteomic databases

PaxDbiQ6AXP6.
PRIDEiQ6AXP6.

PTM databases

PhosphoSiteiQ6AXP6.

Expressioni

Gene expression databases

GenevisibleiQ6AXP6. RN.

Interactioni

Subunit structurei

Heterotetramer; possibly composed of CATSPER1, CATSPER2, CATSPER3 and CATSPER4 (Potential). Component of the CatSper complex. Interacts with Ca(v)3.3/CACNA1I, leading to suppress T-type calcium channel activity (By similarity).By similarityCurated

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000038712.

Structurei

3D structure databases

ProteinModelPortaliQ6AXP6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi396 – 42934Asp-richAdd
BLAST

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2301. Eukaryota.
ENOG4111GC6. LUCA.
GeneTreeiENSGT00760000119325.
HOGENOMiHOG000007710.
HOVERGENiHBG107782.
InParanoidiQ6AXP6.
KOiK16890.
OMAiWAGWVLE.
OrthoDBiEOG761BTM.
PhylomeDBiQ6AXP6.
TreeFamiTF343585.

Family and domain databases

Gene3Di1.20.120.350. 1 hit.
InterProiIPR028747. CatSper2.
IPR027359. Channel_four-helix_dom.
IPR005821. Ion_trans_dom.
[Graphical view]
PANTHERiPTHR10037:SF189. PTHR10037:SF189. 2 hits.
PfamiPF00520. Ion_trans. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6AXP6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAHERGHLQL PRADAIRSKL IDTFSLIEHL QGLSQAVPRH TLREILDPAC
60 70 80 90 100
QKKLMLGDQE QLVRFSIRAR RMGHITHAQR LLSRLRVRCG GRPPLSLWAG
110 120 130 140 150
WVLDSSIFSN FIISLIFLNT FVLMVEIELM NSTNTSLWPL KLALEVTDWF
160 170 180 190 200
ILLSFIVEIL LMWLASFFLF WKNAWSVFDF VVTMLSLLPE FVVLIGVSAD
210 220 230 240 250
SVWLQLLRVS RVLRSLKLFA RFPQIKVILL ALVRALKSMT FLLMLLLIFF
260 270 280 290 300
YVFAVAGVYF FKEYSRSTIE NLEYNMFFSD LLNSLVTVFI LFTLDHWYAV
310 320 330 340 350
LQDVWKVPEA SRVFSSIYVI LWLLLGSIIF RNIIVAMMVT NFQNIRNELH
360 370 380 390 400
EEMTHLEVQY KADIFKRRII QRRQQSESLR GTSQGKVSED ITETSEATDE
410 420 430 440 450
EKSEAEESEE EKSEEEKSDV EKSDEEKNDE EKSDEEENDE EKSDVEKSDE
460 470 480 490 500
EKNDEEKGYT EKVYSGRTFV ERSYAERSFA GKAENEKVQK ELKEKAYPGS
510 520 530 540 550
PPNSSSHDEA FAADDTYLEN LDWETLVHEN LPGLMDMDQD DRVVWPRDSL
560 570 580
FRYFELLESL QYNLEERKRL QEFAVQALMN FEDK
Length:584
Mass (Da):68,266
Last modified:September 13, 2004 - v1
Checksum:i36E0993AF87E5233
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC079422 mRNA. Translation: AAH79422.1.
RefSeqiNP_001012220.1. NM_001012220.1.
XP_008760409.1. XM_008762187.1.
UniGeneiRn.198648.

Genome annotation databases

EnsembliENSRNOT00000030019; ENSRNOP00000038712; ENSRNOG00000023064.
GeneIDi366174.
KEGGirno:366174.
UCSCiRGD:1307620. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC079422 mRNA. Translation: AAH79422.1.
RefSeqiNP_001012220.1. NM_001012220.1.
XP_008760409.1. XM_008762187.1.
UniGeneiRn.198648.

3D structure databases

ProteinModelPortaliQ6AXP6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000038712.

PTM databases

PhosphoSiteiQ6AXP6.

Proteomic databases

PaxDbiQ6AXP6.
PRIDEiQ6AXP6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000030019; ENSRNOP00000038712; ENSRNOG00000023064.
GeneIDi366174.
KEGGirno:366174.
UCSCiRGD:1307620. rat.

Organism-specific databases

CTDi117155.
RGDi1307620. Catsper2.

Phylogenomic databases

eggNOGiKOG2301. Eukaryota.
ENOG4111GC6. LUCA.
GeneTreeiENSGT00760000119325.
HOGENOMiHOG000007710.
HOVERGENiHBG107782.
InParanoidiQ6AXP6.
KOiK16890.
OMAiWAGWVLE.
OrthoDBiEOG761BTM.
PhylomeDBiQ6AXP6.
TreeFamiTF343585.

Enzyme and pathway databases

ReactomeiR-RNO-1300642. Sperm Motility And Taxes.

Miscellaneous databases

NextBioi688882.
PROiQ6AXP6.

Gene expression databases

GenevisibleiQ6AXP6. RN.

Family and domain databases

Gene3Di1.20.120.350. 1 hit.
InterProiIPR028747. CatSper2.
IPR027359. Channel_four-helix_dom.
IPR005821. Ion_trans_dom.
[Graphical view]
PANTHERiPTHR10037:SF189. PTHR10037:SF189. 2 hits.
PfamiPF00520. Ion_trans. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.
  2. "A voltage-gated ion channel expressed specifically in spermatozoa."
    Quill T.A., Ren D., Clapham D.E., Garbers D.L.
    Proc. Natl. Acad. Sci. U.S.A. 98:12527-12531(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.

Entry informationi

Entry nameiCTSR2_RAT
AccessioniPrimary (citable) accession number: Q6AXP6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 24, 2007
Last sequence update: September 13, 2004
Last modified: May 11, 2016
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.