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Protein

Nucleoporin NDC1

Gene

Ndc1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Component of the nuclear pore complex (NPC), which plays a key role in de novo assembly and insertion of NPC in the nuclear envelope. Required for NPC and nuclear envelope assembly, possibly by forming a link between the nuclear envelope membrane and soluble nucleoporins, thereby anchoring the NPC in the membrane (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

mRNA transport, Protein transport, Translocation, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Nucleoporin NDC1
Alternative name(s):
Transmembrane protein 48
Gene namesi
Name:Ndc1
Synonyms:Tmem48
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi1560173. Ndc1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 25CytoplasmicSequence analysisAdd BLAST25
Transmembranei26 – 46Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini47 – 71Perinuclear spaceSequence analysisAdd BLAST25
Transmembranei72 – 92Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini93 – 115CytoplasmicSequence analysisAdd BLAST23
Transmembranei116 – 136Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini137 – 166Perinuclear spaceSequence analysisAdd BLAST30
Transmembranei167 – 187Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini188 – 226CytoplasmicSequence analysisAdd BLAST39
Transmembranei227 – 247Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini248 – 273Perinuclear spaceSequence analysisAdd BLAST26
Transmembranei274 – 294Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini295 – 673CytoplasmicSequence analysisAdd BLAST379

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Nuclear pore complex, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002352431 – 673Nucleoporin NDC1Add BLAST673

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei407PhosphoserineBy similarity1
Modified residuei415PhosphothreonineBy similarity1
Modified residuei438PhosphoserineBy similarity1
Modified residuei439PhosphothreonineBy similarity1
Modified residuei444PhosphoserineBy similarity1
Modified residuei448PhosphothreonineBy similarity1
Modified residuei470PhosphoserineBy similarity1
Modified residuei473PhosphoserineBy similarity1

Post-translational modificationi

Phosphorylated.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ6AXN4.
PRIDEiQ6AXN4.

PTM databases

PhosphoSitePlusiQ6AXN4.

Expressioni

Gene expression databases

BgeeiENSRNOG00000010620.
GenevisibleiQ6AXN4. RN.

Interactioni

Subunit structurei

Interacts with the NUP35/NUP53.1 Publication

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000014275.

Family & Domainsi

Sequence similaritiesi

Belongs to the NDC1 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4358. Eukaryota.
ENOG4110XEC. LUCA.
HOGENOMiHOG000231135.
HOVERGENiHBG080133.
InParanoidiQ6AXN4.
KOiK14315.
OrthoDBiEOG091G0MME.
PhylomeDBiQ6AXN4.

Family and domain databases

InterProiIPR019049. Nucleoporin_prot_Ndc1/Nup.
[Graphical view]
PfamiPF09531. Ndc1_Nup. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6AXN4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATAASGPCA GGSPRDILWR VLGWRIVTSV VWSVLLLPVC ITAFIVFSSI
60 70 80 90 100
DLFHPIQWLS DSLNEFYSSQ VIFYLLLLAV VIIIISIFNV EFYTVVPSIP
110 120 130 140 150
GSRLALIARI LHPQQLTHSF IHAVMGMAVA WCAAIMTKGQ SRSLVVPCTG
160 170 180 190 200
TESLDSPAAQ TCMNEYHLFF LLSGAFMGYS YSLLYFINNM NYLPFPIIQQ
210 220 230 240 250
YKFLRFRRSL LLLVKHSCVE SLFMVRNFCI VYYFFGHIPK AWISTALDLR
260 270 280 290 300
TDEQAHRPLD TIGGLLNVSL LYHVWLCGVF LLMTWYISWI LFKIYATEAY
310 320 330 340 350
MFPVQPPFAE ESDECLPKVL NSNPPLIIKY LALQDLMLLS QYSPSRRQEV
360 370 380 390 400
FSLSQPGGHP HNWTAISREC LSLLNDMTQK LVLYQEAAAT NGRMYSSYSV
410 420 430 440 450
EPKRLSSPEE TAFQTPKPSQ MPSVPPLVKT SLFSPKLSTP DGSSPFGTPF
460 470 480 490 500
GSSVVNRMAG IFDVNTCCGS PQSPQLVRRG PRLWTHTSDQ QVSAVSNPSP
510 520 530 540 550
CASVTAEGKT VRQPSVLYSW IQNKREQIKN FLSKRVLIMY FFSKHPEASI
560 570 580 590 600
QAVFSDAQMH IWALEGLSHL VAASFTEDRF GVVQTTLPAI LNTLLTLQEA
610 620 630 640 650
VDKYFKLPHA SSKPPRTSGS LVDTSYKTLR FAFRASLKTA IYRITTTFGE
660 670
HLNAVQASAE HQKRLQQFLE FKE
Length:673
Mass (Da):75,713
Last modified:September 13, 2004 - v1
Checksum:i6BF73F12AFFE4C0A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC079443 mRNA. Translation: AAH79443.1.
RefSeqiNP_001020194.1. NM_001025023.1.
UniGeneiRn.162075.

Genome annotation databases

GeneIDi362557.
KEGGirno:362557.
UCSCiRGD:1560173. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC079443 mRNA. Translation: AAH79443.1.
RefSeqiNP_001020194.1. NM_001025023.1.
UniGeneiRn.162075.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000014275.

PTM databases

PhosphoSitePlusiQ6AXN4.

Proteomic databases

PaxDbiQ6AXN4.
PRIDEiQ6AXN4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi362557.
KEGGirno:362557.
UCSCiRGD:1560173. rat.

Organism-specific databases

CTDi55706.
RGDi1560173. Ndc1.

Phylogenomic databases

eggNOGiKOG4358. Eukaryota.
ENOG4110XEC. LUCA.
HOGENOMiHOG000231135.
HOVERGENiHBG080133.
InParanoidiQ6AXN4.
KOiK14315.
OrthoDBiEOG091G0MME.
PhylomeDBiQ6AXN4.

Miscellaneous databases

PROiQ6AXN4.

Gene expression databases

BgeeiENSRNOG00000010620.
GenevisibleiQ6AXN4. RN.

Family and domain databases

InterProiIPR019049. Nucleoporin_prot_Ndc1/Nup.
[Graphical view]
PfamiPF09531. Ndc1_Nup. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiNDC1_RAT
AccessioniPrimary (citable) accession number: Q6AXN4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 16, 2006
Last sequence update: September 13, 2004
Last modified: November 2, 2016
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.